GREMLIN Database
EBP - Emopamil binding protein
PFAM: PF05241 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 177 (172)
Sequences: 838 (571)
Seq/√Len: 43.5
META: 0.291

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
108_H167_S5.8551.00
151_F155_L3.4271.00
150_V154_A2.6591.00
122_T157_V2.5621.00
77_F124_L2.5171.00
59_Q62_K2.4991.00
171_I175_F2.4321.00
112_L164_L2.4181.00
52_L86_V2.4151.00
107_R111_Q2.3921.00
51_F79_V2.3451.00
99_A106_Y2.2581.00
4_L10_L2.2441.00
145_F150_V2.2331.00
6_A9_A2.2081.00
89_W117_G2.1761.00
95_L99_A2.1541.00
82_E85_T2.1361.00
63_E148_Y2.1331.00
154_A158_V2.0490.99
48_E82_E1.9250.99
71_Y125_Y1.8960.99
8_A11_L1.8430.99
15_W19_G1.8310.98
86_V118_Q1.8280.98
65_A72_L1.7700.98
125_Y128_T1.7680.98
30_D107_R1.7620.98
134_G137_L1.7310.98
119_L157_V1.6600.97
118_Q121_G1.6370.97
48_E67_A1.6350.97
50_Y58_A1.6330.97
37_F115_S1.6330.97
85_T121_G1.5580.96
44_H48_E1.5310.95
33_L163_L1.5290.95
63_E66_K1.5060.95
40_D125_Y1.4560.94
44_H49_G1.4490.94
48_E51_F1.4100.93
13_A19_G1.3700.92
112_L171_I1.3680.92
71_Y128_T1.3650.92
67_A82_E1.3560.91
108_H170_E1.3470.91
105_P172_A1.3130.90
75_D79_V1.3030.90
109_P112_L1.2860.89
81_L84_L1.2820.89
45_L94_L1.2800.89
37_F40_D1.2750.89
44_H90_G1.2660.88
16_L27_S1.2490.88
41_G93_S1.2140.86
7_S11_L1.1920.85
97_V100_I1.1730.84
141_N144_Y1.1690.84
9_A16_L1.1670.84
70_R160_P1.1670.84
51_F55_S1.1670.84
52_L81_L1.1630.84
40_D93_S1.1620.83
19_G31_R1.1520.83
98_Y102_K1.1350.82
47_L57_F1.1310.82
61_W82_E1.1300.82
107_R163_L1.1290.82
43_I118_Q1.1270.82
120_Y124_L1.1040.80
8_A17_L1.1000.80
13_A16_L1.0920.79
113_V168_W1.0900.79
5_A13_A1.0890.79
155_L159_I1.0800.79
16_L21_L1.0730.78
167_S170_E1.0660.78
69_S136_N1.0510.77
15_W35_C1.0460.76
61_W65_A1.0400.76
147_V151_F1.0180.74
14_A21_L1.0130.74
36_W160_P1.0130.74
156_W160_P1.0100.74
41_G51_F1.0030.73
134_G139_T0.9920.72
12_L16_L0.9900.72
43_I78_V0.9870.72
44_H85_T0.9830.72
115_S164_L0.9740.71
48_E153_N0.9710.71
77_F125_Y0.9660.70
122_T155_L0.9660.70
111_Q166_D0.9480.69
8_A28_R0.9450.69
142_P147_V0.9310.68
80_S127_A0.9290.67
44_H93_S0.9270.67
48_E120_Y0.9250.67
5_A103_R0.9250.67
15_W20_R0.9240.67
10_L16_L0.9210.67
109_P168_W0.9040.65
16_L171_I0.8950.64
38_A97_V0.8950.64
51_F85_T0.8870.64
15_W21_L0.8820.63
118_Q125_Y0.8770.63
70_R90_G0.8760.63
30_D100_I0.8750.63
108_H111_Q0.8660.62
14_A18_S0.8610.61
19_G173_R0.8520.61
82_E153_N0.8500.60
13_A18_S0.8490.60
153_N156_W0.8420.60
28_R32_L0.8410.60
5_A11_L0.8400.60
12_L17_L0.8370.59
37_F93_S0.8360.59
142_P145_F0.8360.59
77_F120_Y0.8340.59
118_Q122_T0.8330.59
98_Y162_L0.8330.59
44_H160_P0.8330.59
84_L119_L0.8320.59
113_V116_V0.8170.57
41_G94_L0.8140.57
9_A12_L0.8130.57
4_L123_V0.8080.57
82_E86_V0.7990.56
108_H115_S0.7970.56
5_A38_A0.7970.56
5_A9_A0.7950.55
24_K28_R0.7940.55
100_I111_Q0.7930.55
118_Q123_V0.7910.55
48_E85_T0.7850.54
61_W148_Y0.7780.54
82_E90_G0.7780.54
28_R165_Y0.7770.54
17_L28_R0.7650.52
64_Y68_D0.7570.52
9_A22_L0.7560.52
63_E69_S0.7540.51
9_A13_A0.7510.51
133_G138_S0.7450.51
88_L92_L0.7450.51
17_L29_A0.7440.50
119_L164_L0.7330.49
128_T148_Y0.7320.49
59_Q66_K0.7280.49
6_A10_L0.7220.48
130_W134_G0.7200.48
163_L166_D0.7200.48
168_W172_A0.7160.48
58_A61_W0.7080.47
163_L167_S0.7070.47
34_F97_V0.7050.47
67_A137_L0.7050.47
119_L161_L0.7030.47
78_V84_L0.7010.46
11_L20_R0.6940.46
162_L165_Y0.6920.46
96_L114_V0.6870.45
29_A33_L0.6830.45
92_L102_K0.6810.44
61_W85_T0.6790.44
81_L86_V0.6770.44
5_A12_L0.6750.44
15_W83_T0.6750.44
44_H118_Q0.6730.44
36_W41_G0.6710.44
18_S21_L0.6680.43
26_L30_D0.6680.43
14_A17_L0.6670.43
21_L29_A0.6660.43
12_L102_K0.6630.43
85_T120_Y0.6620.43
100_I175_F0.6550.42
99_A104_K0.6520.42
11_L15_W0.6500.42
61_W75_D0.6470.41
28_R94_L0.6460.41
12_L27_S0.6450.41
147_V152_M0.6440.41
71_Y153_N0.6430.41
11_L18_S0.6430.41
129_E149_F0.6370.40
62_K71_Y0.6360.40
93_S96_L0.6360.40
13_A23_P0.6270.39
9_A159_I0.6270.39
44_H70_R0.6250.39
62_K148_Y0.6240.39
17_L27_S0.6210.39
51_F58_A0.6140.38
40_D128_T0.6090.38
109_P164_L0.6050.37
122_T125_Y0.6030.37
30_D97_V0.6030.37
39_F171_I0.5990.37
6_A11_L0.5990.37
8_A24_K0.5990.37
32_L159_I0.5960.37
78_V82_E0.5920.36
106_Y168_W0.5900.36
47_L144_Y0.5900.36
68_D82_E0.5850.36
48_E111_Q0.5840.36
151_F157_V0.5820.35
46_F104_K0.5810.35
92_L107_R0.5730.35
32_L164_L0.5710.34
37_F114_V0.5710.34
4_L14_A0.5670.34
24_K27_S0.5670.34
26_L100_I0.5660.34
16_L20_R0.5640.34
9_A24_K0.5630.34
93_S97_V0.5630.34
49_G85_T0.5580.33
33_L37_F0.5530.33
10_L19_G0.5530.33
4_L32_L0.5510.33
67_A149_F0.5470.32
7_S10_L0.5460.32
122_T126_F0.5450.32
11_L14_A0.5450.32
60_L152_M0.5430.32
68_D153_N0.5410.32
18_S31_R0.5410.32
89_W93_S0.5400.32
84_L88_L0.5400.32
33_L107_R0.5400.32
13_A24_K0.5380.32
41_G44_H0.5340.31
9_A174_A0.5320.31
108_H163_L0.5310.31
8_A12_L0.5300.31
79_V131_L0.5290.31
33_L56_L0.5270.31
9_A14_A0.5270.31
135_P138_S0.5250.31
48_E52_L0.5240.31
7_S15_W0.5210.30
85_T90_G0.5210.30
9_A19_G0.5200.30
96_L107_R0.5130.30
64_Y156_W0.5130.30
81_L122_T0.5100.29
5_A20_R0.5100.29
20_R23_P0.5100.29
125_Y134_G0.5060.29
117_G120_Y0.5050.29
12_L94_L0.5040.29
44_H75_D0.5010.29
77_F150_V0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4zwjA 1 0.9096 17 0.934 Contact Map
4yayA 1 0.5763 10.5 0.94 Contact Map
4ymuD 2 0.6328 6.4 0.946 Contact Map
4xk8I 1 0.1469 6.1 0.946 Contact Map
3v2yA 1 0.9096 6 0.946 Contact Map
2wscI 1 0.1525 5 0.949 Contact Map
1u19A 2 0.9096 4.1 0.951 Contact Map
2z73A 2 0.9153 3.6 0.952 Contact Map
3vw7A 1 0.904 3.4 0.953 Contact Map
4z35A 1 0.9379 3.4 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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