GREMLIN Database
BTP - Chlorhexidine efflux transporter
PFAM: PF05232 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 64 (63)
Sequences: 4515 (2866)
Seq/√Len: 361.1
META: 0.647

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_R8_L3.1361.00
3_L52_F3.0511.00
31_I36_A2.2601.00
52_F56_W2.0781.00
3_L7_I1.9281.00
32_S35_E1.9171.00
10_A52_F1.8211.00
26_A33_L1.7541.00
58_F63_P1.7441.00
18_L44_S1.7091.00
59_D62_F1.6671.00
45_L49_V1.6181.00
31_I35_E1.6061.00
25_L36_A1.6021.00
56_W60_R1.5191.00
53_V56_W1.4961.00
57_A61_L1.4811.00
2_S5_R1.4431.00
47_A51_N1.4111.00
37_L40_D1.3661.00
49_V53_V1.2051.00
53_V57_A1.1461.00
21_L43_L1.1371.00
42_G46_F1.1261.00
3_L56_W1.1141.00
5_R58_F1.1091.00
1_R47_A1.0991.00
4_K8_L1.0931.00
58_F62_F1.0841.00
10_A48_L1.0751.00
23_P26_A1.0751.00
21_L25_L1.0571.00
15_G19_L1.0161.00
4_K7_I0.9891.00
1_R5_R0.9791.00
35_E38_V0.9471.00
41_I44_S0.9251.00
1_R8_L0.9211.00
60_R63_P0.8961.00
44_S48_L0.8901.00
5_R59_D0.8831.00
42_G45_L0.8771.00
19_L23_P0.8481.00
17_L21_L0.8261.00
12_L15_G0.8191.00
21_L24_L0.8101.00
25_L39_L0.8091.00
13_F17_L0.8031.00
20_I24_L0.8021.00
14_E48_L0.8021.00
1_R59_D0.7811.00
27_W33_L0.7751.00
18_L22_V0.7731.00
39_L55_N0.7671.00
16_G20_I0.7611.00
13_F55_N0.7581.00
6_R56_W0.7541.00
50_W54_F0.7511.00
11_V52_F0.7381.00
28_W55_N0.7321.00
24_L28_W0.7271.00
29_L36_A0.7251.00
22_V36_A0.7241.00
41_I45_L0.7190.99
11_V15_G0.7050.99
25_L29_L0.7030.99
39_L43_L0.7020.99
21_L40_D0.6960.99
38_V42_G0.6660.99
12_L16_G0.6620.99
23_P27_W0.6540.99
34_W38_V0.6430.99
40_D44_S0.6360.99
28_W58_F0.6130.98
11_V48_L0.6060.98
44_S55_N0.6010.98
51_N55_N0.5990.98
9_H54_F0.5960.98
43_L48_L0.5960.98
56_W59_D0.5760.98
9_H23_P0.5700.97
59_D63_P0.5640.97
8_L12_L0.5630.97
5_R25_L0.5620.97
57_A60_R0.5560.97
20_I44_S0.5390.96
26_A29_L0.5380.96
2_S6_R0.5360.96
21_L29_L0.5270.96
7_I11_V0.5130.95
29_L39_L0.5130.95
55_N62_F0.5090.95
12_L19_L0.5010.95
10_A51_N0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m64A 1 1 9 0.864 Contact Map
4wd8A 3 0.8594 8.7 0.866 Contact Map
3wdoA 1 1 8.5 0.866 Contact Map
2cfqA 1 1 8.5 0.866 Contact Map
4j05A 3 0.9688 8.1 0.867 Contact Map
3o7qA 1 0.9531 5.4 0.877 Contact Map
4ldsA 2 0.9219 5 0.879 Contact Map
3j09A 2 0.9844 4.3 0.884 Contact Map
1pw4A 1 0.9844 4.2 0.884 Contact Map
4pypA 1 0.9688 4.1 0.884 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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