MASE1 - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

MASE1 - MASE1

PFAM:	PF05231	Sequences: WLLLVAAAYFLAAKLGLSLALAFVPGGVSPVWPPTGIALAALLLLGRRVWPAILLGAFLANLAANLLTGGPLLTALGIALGNTLEALLGAWLLRRFAGGRPRLDRLRDVLAFLLLAALLAPAVSATIGVASLVLAGLAPWADFWSAWLTWWLGDALGILVVAPLLLLWARRRRRRLRRRRLLERALAAAAAAALLLLAALLVAVLVLVFLGLFFPFASSYPLLYLLFPPLLWAALRFGPRGAALALLLVALIAIWGTLHGRGPFAGGSPNESLRVLLLQLFLAVLALTGLLLAALVAERR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	300 (283)
Sequences:	19436 (16040)
Seq/√Len:	953.5
META:	0.889

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
109_V	112_F	3.289	1.00
133_V	140_W	3.208	1.00
126_T	147_W	3.131	1.00
45_L	49_V	2.848	1.00
198_A	202_V	2.728	1.00
238_G	241_G	2.572	1.00
199_A	203_A	2.467	1.00
9_Y	14_K	2.428	1.00
40_A	165_L	2.413	1.00
230_L	289_G	2.328	1.00
164_L	247_L	2.263	1.00
35_T	158_I	2.234	1.00
128_G	150_W	2.232	1.00
195_L	199_A	2.220	1.00
107_R	111_A	2.195	1.00
168_W	244_L	2.173	1.00
9_Y	13_A	2.164	1.00
39_L	89_G	2.063	1.00
197_L	201_L	2.041	1.00
233_A	245_A	2.025	1.00
42_L	90_A	2.021	1.00
255_W	259_H	2.016	1.00
167_L	243_A	2.014	1.00
168_W	240_R	1.972	1.00
201_L	204_V	1.946	1.00
242_A	289_G	1.907	1.00
200_L	204_V	1.897	1.00
13_A	17_L	1.889	1.00
105_R	108_D	1.878	1.00
77_G	131_S	1.871	1.00
11_L	15_L	1.833	1.00
9_Y	16_G	1.819	1.00
193_A	197_L	1.797	1.00
89_G	120_A	1.793	1.00
9_Y	17_L	1.791	1.00
42_L	50_W	1.787	1.00
130_A	143_F	1.769	1.00
180_R	183_E	1.757	1.00
232_W	236_R	1.737	1.00
91_W	95_R	1.735	1.00
39_L	158_I	1.729	1.00
44_L	169_A	1.723	1.00
50_W	87_L	1.684	1.00
199_A	202_V	1.675	1.00
74_T	135_A	1.674	1.00
11_L	16_G	1.669	1.00
212_L	215_P	1.663	1.00
47_R	91_W	1.626	1.00
39_L	162_A	1.612	1.00
10_F	14_K	1.608	1.00
202_V	205_L	1.589	1.00
270_N	273_L	1.537	1.00
210_L	213_F	1.537	1.00
193_A	209_F	1.533	1.00
13_A	60_A	1.522	1.00
109_V	113_L	1.522	1.00
108_D	112_F	1.520	1.00
49_V	52_A	1.518	1.00
197_L	205_L	1.514	1.00
206_V	209_F	1.509	1.00
138_A	146_A	1.496	1.00
42_L	49_V	1.485	1.00
121_P	155_A	1.477	1.00
47_R	94_R	1.469	1.00
226_L	229_P	1.465	1.00
203_A	206_V	1.464	1.00
52_A	56_G	1.462	1.00
9_Y	15_L	1.444	1.00
12_A	37_I	1.443	1.00
193_A	204_V	1.429	1.00
58_F	79_A	1.428	1.00
233_A	237_F	1.418	1.00
10_F	13_A	1.406	1.00
75_A	79_A	1.395	1.00
66_L	69_G	1.393	1.00
10_F	15_L	1.391	1.00
200_L	203_A	1.391	1.00
119_L	122_A	1.365	1.00
42_L	86_A	1.358	1.00
37_I	41_A	1.326	1.00
195_L	198_A	1.326	1.00
172_R	176_L	1.325	1.00
9_Y	12_A	1.305	1.00
6_A	9_Y	1.304	1.00
109_V	294_A	1.301	1.00
81_G	127_I	1.277	1.00
199_A	204_V	1.276	1.00
193_A	205_L	1.275	1.00
12_A	16_G	1.274	1.00
192_A	204_V	1.266	1.00
10_F	17_L	1.265	1.00
8_A	12_A	1.257	1.00
196_L	200_L	1.253	1.00
113_L	116_A	1.251	1.00
133_V	143_F	1.246	1.00
40_A	162_A	1.245	1.00
156_L	283_A	1.244	1.00
13_A	16_G	1.240	1.00
195_L	203_A	1.238	1.00
129_V	143_F	1.236	1.00
172_R	175_R	1.224	1.00
70_G	74_T	1.221	1.00
191_A	203_A	1.218	1.00
208_V	211_G	1.206	1.00
99_G	102_R	1.200	1.00
82_N	85_E	1.199	1.00
269_P	272_S	1.198	1.00
201_L	205_L	1.185	1.00
191_A	195_L	1.180	1.00
179_R	183_E	1.176	1.00
118_L	121_P	1.166	1.00
194_L	197_L	1.165	1.00
11_L	14_K	1.160	1.00
198_A	201_L	1.159	1.00
85_E	154_D	1.155	1.00
36_G	157_G	1.155	1.00
192_A	196_L	1.153	1.00
209_F	212_L	1.153	1.00
179_R	182_L	1.149	1.00
71_P	74_T	1.141	1.00
65_N	69_G	1.127	1.00
253_A	278_L	1.125	1.00
176_L	180_R	1.123	1.00
191_A	199_A	1.123	1.00
46_G	49_V	1.121	1.00
86_A	90_A	1.100	1.00
194_L	198_A	1.100	1.00
203_A	207_L	1.099	1.00
209_F	213_F	1.097	1.00
142_D	145_S	1.093	1.00
204_V	208_V	1.090	1.00
269_P	273_L	1.089	1.00
268_S	272_S	1.089	1.00
14_K	20_A	1.085	1.00
191_A	202_V	1.084	1.00
144_W	148_L	1.082	1.00
193_A	201_L	1.080	1.00
139_P	142_D	1.076	1.00
36_G	162_A	1.075	1.00
125_A	129_V	1.072	1.00
246_L	286_A	1.071	1.00
127_I	131_S	1.066	1.00
183_E	236_R	1.065	1.00
158_I	162_A	1.064	1.00
128_G	131_S	1.058	1.00
40_A	44_L	1.057	1.00
151_W	155_A	1.057	1.00
6_A	10_F	1.049	1.00
14_K	17_L	1.042	1.00
73_L	77_G	1.033	1.00
164_L	167_L	1.029	1.00
103_L	106_L	1.027	1.00
108_D	111_A	1.026	1.00
210_L	215_P	1.026	1.00
56_G	60_A	1.016	1.00
204_V	207_L	1.015	1.00
205_L	209_F	1.009	1.00
112_F	116_A	1.006	1.00
84_L	88_L	1.005	1.00
117_A	121_P	1.003	1.00
192_A	195_L	1.002	1.00
116_A	120_A	1.001	1.00
250_A	253_A	0.991	1.00
121_P	158_I	0.990	1.00
150_W	154_D	0.986	1.00
237_F	241_G	0.984	1.00
202_V	206_V	0.983	1.00
91_W	94_R	0.980	1.00
92_L	115_L	0.978	1.00
192_A	200_L	0.972	1.00
57_A	61_N	0.964	1.00
120_A	158_I	0.959	1.00
207_L	210_L	0.958	1.00
246_L	289_G	0.958	1.00
124_S	128_G	0.955	1.00
206_V	210_L	0.955	1.00
10_F	16_G	0.952	1.00
183_E	193_A	0.950	1.00
226_L	249_V	0.947	1.00
205_L	208_V	0.944	1.00
262_G	265_A	0.944	1.00
251_L	255_W	0.943	1.00
97_A	102_R	0.937	1.00
112_F	115_L	0.930	1.00
268_S	271_E	0.925	1.00
140_W	143_F	0.920	1.00
112_F	117_A	0.912	1.00
131_S	135_A	0.909	1.00
102_R	106_L	0.908	1.00
197_L	200_L	0.906	1.00
41_A	45_L	0.906	1.00
198_A	203_A	0.905	1.00
54_L	80_L	0.898	1.00
47_R	50_W	0.897	1.00
231_L	288_T	0.895	1.00
183_E	197_L	0.894	1.00
71_P	75_A	0.893	1.00
88_L	91_W	0.886	1.00
102_R	105_R	0.885	1.00
35_T	38_A	0.885	1.00
74_T	77_G	0.884	1.00
67_L	70_G	0.882	1.00
197_L	213_F	0.881	1.00
195_L	211_G	0.878	1.00
38_A	46_G	0.875	1.00
40_A	166_L	0.870	1.00
38_A	57_A	0.862	1.00
98_G	101_P	0.861	1.00
117_A	158_I	0.858	1.00
74_T	78_I	0.856	1.00
198_A	206_V	0.854	1.00
195_L	202_V	0.853	1.00
35_T	39_L	0.851	1.00
33_P	161_V	0.849	1.00
36_G	40_A	0.848	1.00
197_L	209_F	0.847	1.00
220_Y	223_L	0.842	1.00
100_R	104_D	0.840	1.00
113_L	117_A	0.839	1.00
143_F	147_W	0.835	1.00
198_A	209_F	0.835	1.00
284_V	288_T	0.833	1.00
92_L	96_F	0.828	1.00
211_G	214_F	0.823	1.00
79_A	83_T	0.819	1.00
209_F	214_F	0.818	1.00
174_R	177_R	0.817	1.00
207_L	211_G	0.816	1.00
32_W	35_T	0.815	1.00
195_L	201_L	0.814	1.00
45_L	53_I	0.810	1.00
81_G	84_L	0.809	1.00
115_L	119_L	0.808	1.00
243_A	246_L	0.803	1.00
92_L	95_R	0.802	1.00
235_L	296_V	0.793	1.00
167_L	240_R	0.786	1.00
192_A	199_A	0.785	1.00
88_L	123_V	0.784	1.00
35_T	86_A	0.779	1.00
198_A	214_F	0.772	1.00
76_L	80_L	0.767	1.00
227_F	285_L	0.765	1.00
192_A	203_A	0.765	1.00
229_P	233_A	0.759	1.00
47_R	51_P	0.757	1.00
121_P	125_A	0.755	1.00
127_I	130_A	0.753	1.00
130_A	133_V	0.753	1.00
115_L	118_L	0.752	1.00
195_L	205_L	0.748	1.00
195_L	207_L	0.748	1.00
267_G	272_S	0.744	1.00
198_A	205_L	0.739	1.00
7_A	11_L	0.738	1.00
191_A	207_L	0.738	1.00
47_R	90_A	0.736	1.00
38_A	86_A	0.736	1.00
191_A	205_L	0.736	1.00
85_E	124_S	0.736	1.00
164_L	244_L	0.726	1.00
22_A	27_G	0.726	1.00
86_A	89_G	0.725	1.00
98_G	108_D	0.723	1.00
125_A	128_G	0.719	1.00
169_A	172_R	0.717	1.00
234_A	242_A	0.715	1.00
132_L	136_G	0.715	1.00
140_W	144_W	0.714	1.00
84_L	87_L	0.714	1.00
211_G	215_P	0.712	1.00
210_L	214_F	0.709	1.00
112_F	162_A	0.709	1.00
10_F	59_L	0.708	1.00
22_A	30_P	0.706	1.00
69_G	72_L	0.705	1.00
96_F	99_G	0.703	1.00
168_W	243_A	0.702	1.00
133_V	138_A	0.701	1.00
242_A	293_A	0.701	1.00
122_A	125_A	0.696	1.00
252_I	256_G	0.693	1.00
24_V	27_G	0.692	1.00
196_L	204_V	0.692	1.00
196_L	199_A	0.691	1.00
5_V	41_A	0.689	1.00
193_A	200_L	0.686	1.00
160_V	250_A	0.684	1.00
194_L	201_L	0.684	1.00
101_P	104_D	0.682	1.00
224_Y	277_L	0.680	1.00
250_A	282_L	0.680	1.00
73_L	76_L	0.679	1.00
195_L	206_V	0.677	1.00
195_L	204_V	0.675	1.00
200_L	205_L	0.671	1.00
12_A	15_L	0.668	1.00
260_G	264_F	0.664	1.00
123_V	126_T	0.660	1.00
175_R	179_R	0.660	1.00
194_L	205_L	0.657	1.00
281_F	285_L	0.656	1.00
204_V	209_F	0.654	1.00
96_F	111_A	0.654	1.00
47_R	87_L	0.654	1.00
199_A	206_V	0.653	1.00
33_P	36_G	0.649	1.00
183_E	195_L	0.649	1.00
87_L	91_W	0.649	1.00
93_L	97_A	0.648	1.00
197_L	204_V	0.648	1.00
23_F	26_G	0.647	1.00
162_A	166_L	0.647	1.00
208_V	212_L	0.647	1.00
218_S	221_P	0.641	1.00
99_G	103_L	0.640	1.00
65_N	74_T	0.640	1.00
192_A	207_L	0.639	1.00
122_A	151_W	0.639	1.00
157_G	161_V	0.639	1.00
177_R	180_R	0.636	1.00
145_S	149_T	0.635	1.00
197_L	212_L	0.633	1.00
219_S	222_L	0.633	1.00
197_L	202_V	0.631	1.00
234_A	296_V	0.630	1.00
242_A	246_L	0.630	1.00
193_A	208_V	0.628	1.00
6_A	14_K	0.626	1.00
43_L	166_L	0.625	1.00
218_S	223_L	0.625	1.00
85_E	121_P	0.621	1.00
191_A	206_V	0.620	1.00
4_L	8_A	0.620	1.00
285_L	288_T	0.619	1.00
126_T	129_V	0.617	1.00
226_L	281_F	0.616	1.00
94_R	100_R	0.614	1.00
213_F	216_F	0.614	1.00
164_L	243_A	0.612	1.00
65_N	68_T	0.610	1.00
120_A	124_S	0.609	1.00
77_G	80_L	0.607	1.00
195_L	210_L	0.605	1.00
12_A	17_L	0.605	1.00
111_A	115_L	0.603	1.00
126_T	130_A	0.602	1.00
162_A	165_L	0.600	1.00
198_A	204_V	0.600	1.00
233_A	241_G	0.599	1.00
202_V	207_L	0.598	1.00
35_T	82_N	0.598	1.00
124_S	127_I	0.596	1.00
82_N	86_A	0.592	1.00
196_L	201_L	0.592	1.00
100_R	103_L	0.588	1.00
6_A	52_A	0.586	1.00
191_A	201_L	0.585	1.00
35_T	85_E	0.584	1.00
8_A	11_L	0.584	1.00
43_L	90_A	0.582	1.00
90_A	94_R	0.581	1.00
239_P	293_A	0.581	1.00
117_A	155_A	0.581	1.00
251_L	254_I	0.575	1.00
197_L	203_A	0.572	1.00
66_L	71_P	0.572	1.00
64_A	67_L	0.569	1.00
255_W	258_L	0.569	1.00
53_I	56_G	0.568	1.00
212_L	216_F	0.567	1.00
130_A	134_L	0.567	1.00
239_P	243_A	0.564	1.00
78_I	81_G	0.564	1.00
64_A	68_T	0.564	1.00
292_L	295_L	0.563	1.00
88_L	92_L	0.561	1.00
176_L	182_L	0.559	1.00
4_L	9_Y	0.558	1.00
201_L	206_V	0.557	1.00
132_L	135_A	0.553	1.00
200_L	207_L	0.551	1.00
48_R	51_P	0.548	1.00
51_P	54_L	0.547	1.00
65_N	75_A	0.545	1.00
197_L	208_V	0.545	1.00
58_F	61_N	0.545	1.00
11_L	17_L	0.542	1.00
22_A	25_P	0.542	1.00
25_P	30_P	0.542	1.00
250_A	254_I	0.541	1.00
156_L	160_V	0.541	1.00
71_P	137_L	0.540	1.00
122_A	147_W	0.540	1.00
177_R	182_L	0.538	1.00
46_G	50_W	0.534	1.00
10_F	67_L	0.528	1.00
171_R	240_R	0.528	1.00
247_L	251_L	0.528	1.00
129_V	146_A	0.527	1.00
86_A	93_L	0.525	1.00
93_L	98_G	0.525	1.00
278_L	282_L	0.524	1.00
61_N	154_D	0.524	1.00
221_P	224_Y	0.521	1.00
215_P	219_S	0.521	1.00
231_L	292_L	0.521	1.00
72_L	75_A	0.519	1.00
175_R	178_R	0.517	1.00
194_L	199_A	0.516	1.00
125_A	151_W	0.516	1.00
61_N	65_N	0.515	1.00
286_A	290_L	0.514	1.00
83_T	86_A	0.513	1.00
41_A	44_L	0.512	1.00
164_L	168_W	0.512	1.00
85_E	88_L	0.509	1.00
83_T	87_L	0.508	1.00
43_L	93_L	0.507	1.00
61_N	153_G	0.502	1.00
70_G	75_A	0.501	1.00
16_G	33_P	0.501	1.00
28_V	146_A	0.500	1.00
93_L	99_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ksfA	1	0.3467	49.5	0.914	Contact Map
3w9iA	3	0.51	21.7	0.929	Contact Map
3ne5A	3	0.4933	10	0.939	Contact Map
4mt1A	3	0.53	9.8	0.94	Contact Map
3rlbA	1	0.3267	9.4	0.94	Contact Map
3aqpA	1	0.5	8.4	0.941	Contact Map
4dx5A	3	0.5367	8.1	0.942	Contact Map
4dveA	3	0.5767	4.7	0.948	Contact Map
4tkrA	2	0.5667	2.8	0.953	Contact Map
4k0jA	3	0.4667	2.8	0.953	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.009 seconds.