GREMLIN Database
MASE1 - MASE1
PFAM: PF05231 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 300 (283)
Sequences: 19436 (16040)
Seq/√Len: 953.5
META: 0.889

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_V112_F3.2891.00
133_V140_W3.2081.00
126_T147_W3.1311.00
45_L49_V2.8481.00
198_A202_V2.7281.00
238_G241_G2.5721.00
199_A203_A2.4671.00
9_Y14_K2.4281.00
40_A165_L2.4131.00
230_L289_G2.3281.00
164_L247_L2.2631.00
35_T158_I2.2341.00
128_G150_W2.2321.00
195_L199_A2.2201.00
107_R111_A2.1951.00
168_W244_L2.1731.00
9_Y13_A2.1641.00
39_L89_G2.0631.00
197_L201_L2.0411.00
233_A245_A2.0251.00
42_L90_A2.0211.00
255_W259_H2.0161.00
167_L243_A2.0141.00
168_W240_R1.9721.00
201_L204_V1.9461.00
242_A289_G1.9071.00
200_L204_V1.8971.00
13_A17_L1.8891.00
105_R108_D1.8781.00
77_G131_S1.8711.00
11_L15_L1.8331.00
9_Y16_G1.8191.00
193_A197_L1.7971.00
89_G120_A1.7931.00
9_Y17_L1.7911.00
42_L50_W1.7871.00
130_A143_F1.7691.00
180_R183_E1.7571.00
232_W236_R1.7371.00
91_W95_R1.7351.00
39_L158_I1.7291.00
44_L169_A1.7231.00
50_W87_L1.6841.00
199_A202_V1.6751.00
74_T135_A1.6741.00
11_L16_G1.6691.00
212_L215_P1.6631.00
47_R91_W1.6261.00
39_L162_A1.6121.00
10_F14_K1.6081.00
202_V205_L1.5891.00
270_N273_L1.5371.00
210_L213_F1.5371.00
193_A209_F1.5331.00
13_A60_A1.5221.00
109_V113_L1.5221.00
108_D112_F1.5201.00
49_V52_A1.5181.00
197_L205_L1.5141.00
206_V209_F1.5091.00
138_A146_A1.4961.00
42_L49_V1.4851.00
121_P155_A1.4771.00
47_R94_R1.4691.00
226_L229_P1.4651.00
203_A206_V1.4641.00
52_A56_G1.4621.00
9_Y15_L1.4441.00
12_A37_I1.4431.00
193_A204_V1.4291.00
58_F79_A1.4281.00
233_A237_F1.4181.00
10_F13_A1.4061.00
75_A79_A1.3951.00
66_L69_G1.3931.00
10_F15_L1.3911.00
200_L203_A1.3911.00
119_L122_A1.3651.00
42_L86_A1.3581.00
37_I41_A1.3261.00
195_L198_A1.3261.00
172_R176_L1.3251.00
9_Y12_A1.3051.00
6_A9_Y1.3041.00
109_V294_A1.3011.00
81_G127_I1.2771.00
199_A204_V1.2761.00
193_A205_L1.2751.00
12_A16_G1.2741.00
192_A204_V1.2661.00
10_F17_L1.2651.00
8_A12_A1.2571.00
196_L200_L1.2531.00
113_L116_A1.2511.00
133_V143_F1.2461.00
40_A162_A1.2451.00
156_L283_A1.2441.00
13_A16_G1.2401.00
195_L203_A1.2381.00
129_V143_F1.2361.00
172_R175_R1.2241.00
70_G74_T1.2211.00
191_A203_A1.2181.00
208_V211_G1.2061.00
99_G102_R1.2001.00
82_N85_E1.1991.00
269_P272_S1.1981.00
201_L205_L1.1851.00
191_A195_L1.1801.00
179_R183_E1.1761.00
118_L121_P1.1661.00
194_L197_L1.1651.00
11_L14_K1.1601.00
198_A201_L1.1591.00
85_E154_D1.1551.00
36_G157_G1.1551.00
192_A196_L1.1531.00
209_F212_L1.1531.00
179_R182_L1.1491.00
71_P74_T1.1411.00
65_N69_G1.1271.00
253_A278_L1.1251.00
176_L180_R1.1231.00
191_A199_A1.1231.00
46_G49_V1.1211.00
86_A90_A1.1001.00
194_L198_A1.1001.00
203_A207_L1.0991.00
209_F213_F1.0971.00
142_D145_S1.0931.00
204_V208_V1.0901.00
269_P273_L1.0891.00
268_S272_S1.0891.00
14_K20_A1.0851.00
191_A202_V1.0841.00
144_W148_L1.0821.00
193_A201_L1.0801.00
139_P142_D1.0761.00
36_G162_A1.0751.00
125_A129_V1.0721.00
246_L286_A1.0711.00
127_I131_S1.0661.00
183_E236_R1.0651.00
158_I162_A1.0641.00
128_G131_S1.0581.00
40_A44_L1.0571.00
151_W155_A1.0571.00
6_A10_F1.0491.00
14_K17_L1.0421.00
73_L77_G1.0331.00
164_L167_L1.0291.00
103_L106_L1.0271.00
108_D111_A1.0261.00
210_L215_P1.0261.00
56_G60_A1.0161.00
204_V207_L1.0151.00
205_L209_F1.0091.00
112_F116_A1.0061.00
84_L88_L1.0051.00
117_A121_P1.0031.00
192_A195_L1.0021.00
116_A120_A1.0011.00
250_A253_A0.9911.00
121_P158_I0.9901.00
150_W154_D0.9861.00
237_F241_G0.9841.00
202_V206_V0.9831.00
91_W94_R0.9801.00
92_L115_L0.9781.00
192_A200_L0.9721.00
57_A61_N0.9641.00
120_A158_I0.9591.00
207_L210_L0.9581.00
246_L289_G0.9581.00
124_S128_G0.9551.00
206_V210_L0.9551.00
10_F16_G0.9521.00
183_E193_A0.9501.00
226_L249_V0.9471.00
205_L208_V0.9441.00
262_G265_A0.9441.00
251_L255_W0.9431.00
97_A102_R0.9371.00
112_F115_L0.9301.00
268_S271_E0.9251.00
140_W143_F0.9201.00
112_F117_A0.9121.00
131_S135_A0.9091.00
102_R106_L0.9081.00
197_L200_L0.9061.00
41_A45_L0.9061.00
198_A203_A0.9051.00
54_L80_L0.8981.00
47_R50_W0.8971.00
231_L288_T0.8951.00
183_E197_L0.8941.00
71_P75_A0.8931.00
88_L91_W0.8861.00
102_R105_R0.8851.00
35_T38_A0.8851.00
74_T77_G0.8841.00
67_L70_G0.8821.00
197_L213_F0.8811.00
195_L211_G0.8781.00
38_A46_G0.8751.00
40_A166_L0.8701.00
38_A57_A0.8621.00
98_G101_P0.8611.00
117_A158_I0.8581.00
74_T78_I0.8561.00
198_A206_V0.8541.00
195_L202_V0.8531.00
35_T39_L0.8511.00
33_P161_V0.8491.00
36_G40_A0.8481.00
197_L209_F0.8471.00
220_Y223_L0.8421.00
100_R104_D0.8401.00
113_L117_A0.8391.00
143_F147_W0.8351.00
198_A209_F0.8351.00
284_V288_T0.8331.00
92_L96_F0.8281.00
211_G214_F0.8231.00
79_A83_T0.8191.00
209_F214_F0.8181.00
174_R177_R0.8171.00
207_L211_G0.8161.00
32_W35_T0.8151.00
195_L201_L0.8141.00
45_L53_I0.8101.00
81_G84_L0.8091.00
115_L119_L0.8081.00
243_A246_L0.8031.00
92_L95_R0.8021.00
235_L296_V0.7931.00
167_L240_R0.7861.00
192_A199_A0.7851.00
88_L123_V0.7841.00
35_T86_A0.7791.00
198_A214_F0.7721.00
76_L80_L0.7671.00
227_F285_L0.7651.00
192_A203_A0.7651.00
229_P233_A0.7591.00
47_R51_P0.7571.00
121_P125_A0.7551.00
127_I130_A0.7531.00
130_A133_V0.7531.00
115_L118_L0.7521.00
195_L205_L0.7481.00
195_L207_L0.7481.00
267_G272_S0.7441.00
198_A205_L0.7391.00
7_A11_L0.7381.00
191_A207_L0.7381.00
47_R90_A0.7361.00
38_A86_A0.7361.00
191_A205_L0.7361.00
85_E124_S0.7361.00
164_L244_L0.7261.00
22_A27_G0.7261.00
86_A89_G0.7251.00
98_G108_D0.7231.00
125_A128_G0.7191.00
169_A172_R0.7171.00
234_A242_A0.7151.00
132_L136_G0.7151.00
140_W144_W0.7141.00
84_L87_L0.7141.00
211_G215_P0.7121.00
210_L214_F0.7091.00
112_F162_A0.7091.00
10_F59_L0.7081.00
22_A30_P0.7061.00
69_G72_L0.7051.00
96_F99_G0.7031.00
168_W243_A0.7021.00
133_V138_A0.7011.00
242_A293_A0.7011.00
122_A125_A0.6961.00
252_I256_G0.6931.00
24_V27_G0.6921.00
196_L204_V0.6921.00
196_L199_A0.6911.00
5_V41_A0.6891.00
193_A200_L0.6861.00
160_V250_A0.6841.00
194_L201_L0.6841.00
101_P104_D0.6821.00
224_Y277_L0.6801.00
250_A282_L0.6801.00
73_L76_L0.6791.00
195_L206_V0.6771.00
195_L204_V0.6751.00
200_L205_L0.6711.00
12_A15_L0.6681.00
260_G264_F0.6641.00
123_V126_T0.6601.00
175_R179_R0.6601.00
194_L205_L0.6571.00
281_F285_L0.6561.00
204_V209_F0.6541.00
96_F111_A0.6541.00
47_R87_L0.6541.00
199_A206_V0.6531.00
33_P36_G0.6491.00
183_E195_L0.6491.00
87_L91_W0.6491.00
93_L97_A0.6481.00
197_L204_V0.6481.00
23_F26_G0.6471.00
162_A166_L0.6471.00
208_V212_L0.6471.00
218_S221_P0.6411.00
99_G103_L0.6401.00
65_N74_T0.6401.00
192_A207_L0.6391.00
122_A151_W0.6391.00
157_G161_V0.6391.00
177_R180_R0.6361.00
145_S149_T0.6351.00
197_L212_L0.6331.00
219_S222_L0.6331.00
197_L202_V0.6311.00
234_A296_V0.6301.00
242_A246_L0.6301.00
193_A208_V0.6281.00
6_A14_K0.6261.00
43_L166_L0.6251.00
218_S223_L0.6251.00
85_E121_P0.6211.00
191_A206_V0.6201.00
4_L8_A0.6201.00
285_L288_T0.6191.00
126_T129_V0.6171.00
226_L281_F0.6161.00
94_R100_R0.6141.00
213_F216_F0.6141.00
164_L243_A0.6121.00
65_N68_T0.6101.00
120_A124_S0.6091.00
77_G80_L0.6071.00
195_L210_L0.6051.00
12_A17_L0.6051.00
111_A115_L0.6031.00
126_T130_A0.6021.00
162_A165_L0.6001.00
198_A204_V0.6001.00
233_A241_G0.5991.00
202_V207_L0.5981.00
35_T82_N0.5981.00
124_S127_I0.5961.00
82_N86_A0.5921.00
196_L201_L0.5921.00
100_R103_L0.5881.00
6_A52_A0.5861.00
191_A201_L0.5851.00
35_T85_E0.5841.00
8_A11_L0.5841.00
43_L90_A0.5821.00
90_A94_R0.5811.00
239_P293_A0.5811.00
117_A155_A0.5811.00
251_L254_I0.5751.00
197_L203_A0.5721.00
66_L71_P0.5721.00
64_A67_L0.5691.00
255_W258_L0.5691.00
53_I56_G0.5681.00
212_L216_F0.5671.00
130_A134_L0.5671.00
239_P243_A0.5641.00
78_I81_G0.5641.00
64_A68_T0.5641.00
292_L295_L0.5631.00
88_L92_L0.5611.00
176_L182_L0.5591.00
4_L9_Y0.5581.00
201_L206_V0.5571.00
132_L135_A0.5531.00
200_L207_L0.5511.00
48_R51_P0.5481.00
51_P54_L0.5471.00
65_N75_A0.5451.00
197_L208_V0.5451.00
58_F61_N0.5451.00
11_L17_L0.5421.00
22_A25_P0.5421.00
25_P30_P0.5421.00
250_A254_I0.5411.00
156_L160_V0.5411.00
71_P137_L0.5401.00
122_A147_W0.5401.00
177_R182_L0.5381.00
46_G50_W0.5341.00
10_F67_L0.5281.00
171_R240_R0.5281.00
247_L251_L0.5281.00
129_V146_A0.5271.00
86_A93_L0.5251.00
93_L98_G0.5251.00
278_L282_L0.5241.00
61_N154_D0.5241.00
221_P224_Y0.5211.00
215_P219_S0.5211.00
231_L292_L0.5211.00
72_L75_A0.5191.00
175_R178_R0.5171.00
194_L199_A0.5161.00
125_A151_W0.5161.00
61_N65_N0.5151.00
286_A290_L0.5141.00
83_T86_A0.5131.00
41_A44_L0.5121.00
164_L168_W0.5121.00
85_E88_L0.5091.00
83_T87_L0.5081.00
43_L93_L0.5071.00
61_N153_G0.5021.00
70_G75_A0.5011.00
16_G33_P0.5011.00
28_V146_A0.5001.00
93_L99_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ksfA 1 0.3467 49.5 0.914 Contact Map
3w9iA 3 0.51 21.7 0.929 Contact Map
3ne5A 3 0.4933 10 0.939 Contact Map
4mt1A 3 0.53 9.8 0.94 Contact Map
3rlbA 1 0.3267 9.4 0.94 Contact Map
3aqpA 1 0.5 8.4 0.941 Contact Map
4dx5A 3 0.5367 8.1 0.942 Contact Map
4dveA 3 0.5767 4.7 0.948 Contact Map
4tkrA 2 0.5667 2.8 0.953 Contact Map
4k0jA 3 0.4667 2.8 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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