GREMLIN Database
MASE2 - MASE2 domain
PFAM: PF05230 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 89 (87)
Sequences: 2612 (1877)
Seq/√Len: 201.2
META: 0.822

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_L61_R3.5061.00
37_N73_W3.1951.00
74_I88_L2.8091.00
3_Y43_H2.7391.00
3_Y7_V2.5201.00
59_E62_N2.4011.00
46_Y50_R2.3581.00
14_F39_L2.3361.00
58_A62_N2.2831.00
49_A62_N1.9131.00
41_W45_A1.8301.00
37_N69_L1.7531.00
47_L51_R1.7481.00
14_F38_A1.7361.00
75_A79_F1.7211.00
82_L85_V1.7021.00
80_N83_P1.6751.00
54_D57_R1.6511.00
45_A62_N1.6181.00
56_Y60_L1.6041.00
2_I5_P1.5691.00
36_L40_V1.5441.00
21_L26_A1.4921.00
7_V43_H1.4921.00
5_P8_L1.4251.00
28_P32_A1.3231.00
3_Y46_Y1.3201.00
77_M83_P1.3161.00
18_A31_W1.3091.00
48_L62_N1.2591.00
74_I84_S1.1951.00
23_E26_A1.1801.00
20_V23_E1.1731.00
38_A41_W1.0911.00
33_L72_A1.0611.00
14_F35_A1.0561.00
11_A15_L1.0441.00
72_A76_L1.0261.00
52_S58_A1.0221.00
10_L70_G1.0191.00
47_L50_R1.0161.00
77_M80_N1.0151.00
71_G75_A0.9931.00
38_A73_W0.9731.00
21_L30_L0.9580.99
39_L43_H0.9440.99
41_W80_N0.9370.99
2_I86_L0.9190.99
13_G17_V0.8970.99
36_L44_L0.8880.99
58_A61_R0.8830.99
32_A36_L0.8650.99
69_L72_A0.8620.99
61_R64_L0.8520.99
9_G13_G0.8490.99
15_L19_A0.8430.99
10_L13_G0.8420.99
30_L76_L0.8280.98
27_P30_L0.8210.98
8_L12_L0.8200.98
40_V44_L0.8090.98
78_G81_L0.7910.98
18_A34_L0.7900.98
26_A30_L0.7840.98
49_A59_E0.7830.98
67_S71_G0.7760.98
82_L86_L0.7750.98
29_W32_A0.7740.98
5_P56_Y0.7700.97
4_R9_G0.7630.97
20_V80_N0.7570.97
56_Y61_R0.7560.97
70_G83_P0.7540.97
73_W87_L0.7430.97
16_V22_Y0.7390.97
52_S55_P0.7310.96
57_R61_R0.7290.96
18_A22_Y0.7260.96
70_G87_L0.7110.96
49_A58_A0.7060.96
20_V77_M0.6830.95
20_V82_L0.6820.95
44_L47_L0.6750.95
50_R53_R0.6640.94
24_R53_R0.6590.94
13_G70_G0.6500.93
52_S61_R0.6430.93
77_M87_L0.6310.92
9_G41_W0.6200.92
61_R65_L0.6190.92
4_R7_V0.6180.92
10_L82_L0.6150.91
18_A26_A0.6140.91
22_Y25_G0.6130.91
85_V88_L0.6130.91
44_L61_R0.6090.91
11_A38_A0.6030.91
13_G16_V0.5950.90
63_L66_D0.5890.90
75_A84_S0.5880.89
48_L58_A0.5870.89
64_L68_A0.5840.89
41_W66_D0.5780.89
57_R60_L0.5680.88
9_G55_P0.5660.88
10_L38_A0.5650.88
2_I16_V0.5650.88
60_L63_L0.5620.87
37_N68_A0.5550.87
14_F18_A0.5540.86
48_L51_R0.5510.86
24_R30_L0.5430.85
24_R80_N0.5430.85
65_L69_L0.5430.85
17_V77_M0.5420.85
22_Y40_V0.5400.85
12_L15_L0.5390.85
14_F34_L0.5390.85
75_A78_G0.5370.85
77_M81_L0.5330.84
30_L34_L0.5290.84
16_V24_R0.5210.83
41_W70_G0.5180.83
27_P32_A0.5160.82
67_S79_F0.5150.82
70_G85_V0.5140.82
21_L34_L0.5090.82
21_L25_G0.5080.81
33_L40_V0.5080.81
59_E63_L0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p6vB 1 0.618 3.7 0.902 Contact Map
1wazA 1 0.3596 2.1 0.914 Contact Map
2xq2A 2 0.5393 1.7 0.918 Contact Map
3j08A 2 0.9775 1.4 0.922 Contact Map
3l1lA 2 0.6404 1.3 0.923 Contact Map
4x5mA 2 0.6517 1.1 0.927 Contact Map
4av3A 2 0.7079 1.1 0.927 Contact Map
4cz8A 2 0.9663 1 0.929 Contact Map
2ws91 3 0.3146 1 0.929 Contact Map
2jllA 1 0.3258 1 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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