GREMLIN Database
CHASE2 - CHASE2 domain
PFAM: PF05226 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 253 (241)
Sequences: 30643 (25239)
Seq/√Len: 1625.8
META: 0.897

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
188_L218_L3.4881.00
72_G135_A3.3121.00
56_L171_A3.0911.00
72_G131_L2.7991.00
38_A168_T2.7241.00
38_A192_T2.7151.00
59_L171_A2.5561.00
134_A137_R2.3961.00
61_D93_R2.3771.00
188_L211_V2.3101.00
63_L68_A2.1901.00
53_R84_D1.9931.00
198_D210_G1.9411.00
186_I218_L1.9321.00
40_D43_S1.9311.00
85_A89_E1.9301.00
46_E172_A1.8981.00
16_R20_K1.8931.00
64_A94_A1.8821.00
61_D90_A1.8761.00
21_L25_R1.8611.00
35_V185_K1.8391.00
46_E176_D1.8341.00
56_L77_F1.7841.00
55_V58_R1.7771.00
67_G183_K1.7721.00
158_N220_N1.7661.00
61_D86_A1.7591.00
62_R65_A1.7591.00
60_I73_F1.7471.00
36_I211_V1.7251.00
150_D154_R1.7151.00
36_I215_A1.7091.00
56_L73_F1.7041.00
160_R216_N1.6911.00
57_A90_A1.6761.00
70_V186_I1.6611.00
66_A180_E1.6591.00
172_A176_D1.6541.00
200_F210_G1.6471.00
22_Y26_F1.6321.00
219_E227_D1.6071.00
216_N220_N1.6021.00
136_A218_L1.5811.00
35_V169_V1.5791.00
167_P181_A1.5651.00
218_L222_L1.5501.00
190_G211_V1.5411.00
10_R13_G1.5321.00
89_E93_R1.5291.00
37_V174_V1.5281.00
139_A186_I1.5281.00
74_D210_G1.5251.00
136_A221_L1.5241.00
42_A172_A1.5151.00
169_V182_F1.5081.00
160_R219_E1.5051.00
41_E45_A1.4941.00
40_D170_S1.4621.00
135_A186_I1.4531.00
235_P243_L1.4471.00
129_P137_R1.4351.00
66_A182_F1.4321.00
169_V181_A1.4261.00
132_A214_H1.4261.00
35_V182_F1.4001.00
243_L247_L1.3991.00
60_I71_I1.3901.00
235_P238_W1.3771.00
112_D119_R1.3721.00
54_S58_R1.3701.00
42_A173_D1.3571.00
74_D198_D1.3401.00
54_S86_A1.3381.00
132_A217_A1.3291.00
155_L217_A1.3251.00
178_P181_A1.2981.00
136_A140_L1.2961.00
18_E25_R1.2941.00
37_V171_A1.2671.00
89_E92_A1.2661.00
168_T212_E1.2611.00
43_S51_W1.2601.00
59_L189_I1.2351.00
134_A138_V1.2221.00
188_L215_A1.2221.00
200_F213_I1.2191.00
64_A71_I1.2101.00
180_E183_K1.2031.00
208_M212_E1.1951.00
235_P240_L1.1921.00
73_F171_A1.1911.00
29_R158_N1.1901.00
36_I212_E1.1851.00
23_D118_R1.1851.00
71_I189_I1.1771.00
68_A182_F1.1741.00
56_L87_L1.1731.00
43_S172_A1.1691.00
170_S173_D1.1641.00
159_Y203_P1.1551.00
64_A96_N1.1541.00
22_Y156_L1.1481.00
87_L91_L1.1441.00
68_A187_V1.1241.00
58_R62_R1.1171.00
202_T208_M1.1031.00
157_I216_N1.1031.00
191_A196_L1.1021.00
58_R61_D1.0991.00
8_L12_L1.0981.00
73_F189_I1.0851.00
69_K184_G1.0841.00
61_D65_A1.0831.00
70_V139_A1.0771.00
117_V213_I1.0701.00
240_L243_L1.0691.00
86_A89_E1.0631.00
68_A71_I1.0591.00
63_L182_F1.0581.00
157_I217_A1.0581.00
41_E193_A1.0561.00
70_V135_A1.0551.00
240_L248_L1.0521.00
239_A243_L1.0481.00
34_I215_A1.0391.00
60_I87_L1.0331.00
9_L13_G1.0331.00
72_G188_L1.0291.00
132_A218_L1.0261.00
135_A218_L1.0241.00
9_L12_L1.0201.00
42_A46_E1.0111.00
129_P134_A1.0071.00
42_A45_A1.0001.00
34_I219_E0.9901.00
199_L207_L0.9891.00
21_L24_L0.9861.00
39_I75_I0.9811.00
34_I218_L0.9791.00
94_A97_V0.9771.00
98_V138_V0.9721.00
62_R66_A0.9601.00
61_D64_A0.9521.00
135_A188_L0.9511.00
88_A91_L0.9511.00
232_R235_P0.9481.00
106_F130_S0.9441.00
18_E21_L0.9401.00
208_M216_N0.9391.00
37_V187_V0.9361.00
69_K139_A0.9331.00
214_H217_A0.9261.00
192_T209_P0.9251.00
169_V177_V0.9221.00
136_A222_L0.9221.00
159_Y213_I0.9151.00
76_L107_V0.9131.00
69_K186_I0.9121.00
40_D172_A0.9061.00
114_D118_R0.9021.00
58_R86_A0.9021.00
70_V138_V0.8931.00
59_L174_V0.8921.00
209_P212_E0.8911.00
16_R19_L0.8891.00
57_A86_A0.8831.00
157_I220_N0.8781.00
73_F87_L0.8761.00
120_P123_V0.8751.00
236_P240_L0.8741.00
19_L113_P0.8721.00
166_F219_E0.8661.00
237_W241_L0.8651.00
116_V201_A0.8621.00
51_W171_A0.8581.00
103_G134_A0.8561.00
35_V187_V0.8551.00
59_L175_L0.8541.00
193_A196_L0.8511.00
236_P239_A0.8501.00
64_A90_A0.8461.00
88_A100_A0.8431.00
179_P183_K0.8391.00
197_G200_F0.8391.00
106_F123_V0.8321.00
37_V63_L0.8261.00
217_A220_N0.8251.00
63_L66_A0.8241.00
117_V200_F0.8231.00
103_G138_V0.8181.00
112_D118_R0.8181.00
92_A100_A0.8161.00
35_V38_A0.8151.00
131_L135_A0.8101.00
41_E194_P0.8091.00
166_F216_N0.8031.00
158_N229_R0.8011.00
130_S133_L0.7981.00
70_V98_V0.7971.00
205_G208_M0.7961.00
236_P243_L0.7941.00
130_S214_H0.7861.00
24_L28_L0.7851.00
26_F158_N0.7771.00
48_R79_E0.7751.00
36_I168_T0.7741.00
146_R149_T0.7731.00
86_A90_A0.7691.00
111_P117_V0.7661.00
24_L27_R0.7661.00
48_R82_R0.7661.00
38_A191_A0.7651.00
52_P55_V0.7581.00
63_L187_V0.7581.00
59_L63_L0.7571.00
66_A177_V0.7541.00
119_R156_L0.7531.00
177_V182_F0.7511.00
44_L193_A0.7501.00
186_I222_L0.7491.00
88_A92_A0.7441.00
91_L97_V0.7431.00
160_R229_R0.7411.00
238_W243_L0.7381.00
72_G186_I0.7281.00
7_L10_R0.7241.00
171_A174_V0.7231.00
22_Y25_R0.7221.00
171_A175_L0.7211.00
232_R236_P0.7201.00
64_A68_A0.7181.00
109_V117_V0.7171.00
62_R175_L0.7101.00
64_A93_R0.7101.00
98_V103_G0.7091.00
238_W241_L0.7091.00
8_L11_S0.7081.00
235_P239_A0.7081.00
19_L156_L0.7081.00
166_F215_A0.7041.00
202_T213_I0.7011.00
231_L235_P0.7001.00
124_R127_L0.6971.00
157_I213_I0.6931.00
51_W55_V0.6921.00
194_P197_G0.6901.00
234_V238_W0.6901.00
43_S171_A0.6901.00
26_F30_P0.6891.00
60_I90_A0.6861.00
8_L13_G0.6851.00
85_A88_A0.6851.00
15_E19_L0.6841.00
55_V171_A0.6821.00
65_A68_A0.6811.00
74_D214_H0.6791.00
90_A94_A0.6721.00
20_K24_L0.6721.00
76_L79_E0.6711.00
119_R154_R0.6711.00
163_P205_G0.6681.00
102_A138_V0.6661.00
174_V182_F0.6641.00
25_R28_L0.6621.00
53_R77_F0.6601.00
167_P185_K0.6601.00
44_L196_L0.6581.00
227_D230_F0.6581.00
155_L220_N0.6541.00
244_L248_L0.6521.00
26_F29_R0.6461.00
168_T192_T0.6431.00
239_A247_L0.6411.00
227_D235_P0.6411.00
37_V59_L0.6361.00
63_L189_I0.6331.00
35_V181_A0.6321.00
131_L214_H0.6261.00
34_I186_I0.6261.00
90_A93_R0.6251.00
60_I68_A0.6251.00
243_L248_L0.6231.00
34_I188_L0.6221.00
161_G165_T0.6171.00
66_A178_P0.6161.00
49_W52_P0.6151.00
60_I91_L0.6151.00
168_T209_P0.6151.00
25_R29_R0.6131.00
47_G50_P0.6111.00
243_L246_L0.6101.00
74_D211_V0.6101.00
44_L49_W0.6091.00
227_D233_P0.6061.00
7_L11_S0.6051.00
160_R220_N0.6041.00
61_D89_E0.6021.00
80_P83_D0.5991.00
35_V167_P0.5951.00
56_L60_I0.5951.00
59_L62_R0.5901.00
72_G218_L0.5891.00
217_A221_L0.5881.00
77_F87_L0.5881.00
18_E22_Y0.5851.00
234_V239_A0.5851.00
48_R81_D0.5821.00
177_V181_A0.5791.00
49_W196_L0.5761.00
30_P204_F0.5741.00
234_V240_L0.5741.00
191_A197_G0.5731.00
42_A170_S0.5711.00
233_P236_P0.5711.00
212_E216_N0.5701.00
240_L247_L0.5691.00
237_W240_L0.5651.00
56_L189_I0.5651.00
75_I191_A0.5641.00
202_T205_G0.5591.00
244_L247_L0.5581.00
136_A186_I0.5571.00
135_A138_V0.5561.00
239_A242_L0.5561.00
12_L15_E0.5561.00
44_L195_G0.5551.00
156_L233_P0.5551.00
91_L94_A0.5541.00
182_F185_K0.5531.00
52_P83_D0.5531.00
121_L133_L0.5501.00
120_P217_A0.5491.00
227_D236_P0.5481.00
54_S83_D0.5461.00
132_A135_A0.5451.00
39_I49_W0.5441.00
66_A181_A0.5411.00
240_L244_L0.5391.00
66_A179_P0.5331.00
204_F208_M0.5331.00
233_P239_A0.5331.00
245_L248_L0.5321.00
34_I222_L0.5321.00
56_L59_L0.5321.00
55_V175_L0.5321.00
155_L221_L0.5281.00
174_V177_V0.5271.00
41_E195_G0.5241.00
60_I94_A0.5231.00
51_W56_L0.5221.00
182_F187_V0.5221.00
34_I166_F0.5181.00
56_L75_I0.5151.00
39_I51_W0.5131.00
37_V169_V0.5091.00
231_L234_V0.5081.00
129_P132_A0.5071.00
15_E18_E0.5061.00
105_G131_L0.5051.00
213_I217_A0.5041.00
133_L137_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jwkA 2 0.2688 2.9 0.958 Contact Map
1dc7A 1 0.4585 2.8 0.959 Contact Map
5a4aA 1 0.6087 2.6 0.959 Contact Map
1t5bA 2 0.3913 2.5 0.96 Contact Map
1xhfA 2 0.4506 2.5 0.96 Contact Map
3grcA 3 0.419 2.3 0.96 Contact Map
1irzA 1 0.2332 2.3 0.96 Contact Map
3lteA 3 0.4585 2.1 0.961 Contact Map
3hdgA 2 0.415 2.1 0.961 Contact Map
3ktoA 3 0.4111 2.1 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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