ALG3 - PFAM28P - GREMLIN Contacts

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ALG3 - ALG3 protein

PFAM:	PF05208	Sequences: LLLLAEAVLCALIIWKVPYTEIDWKAYMQQVEGFLNGERDYTKIKGDTGPLVYPAGFVYIYSALYYLTDGGTNIRLAQYIFAGLYLLTLALVFAIYRKTAKVPPYVLPLLCLSKRLHSIFVLRLFNDCVAMLFLYAAILLFQRRRWTLGSLLYSLAVSVKMNVLLFAPALLVLLLLALGLLGTLRQLAICALVQVLLGLPFLLTNPVSYLSRAFDLGRVFLYKWTVNWRFLPEEIFLSKYFALALLALHLLLLLLFALTRWLRPSGGLRSLLKRGLSRPLTPNQILTTLFTSNFIGILFARSLHYQFYSWYFHTLPYLLWRTGLPPVLRLLLLAAIEYCWNVYPSTNLSS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	350 (350)
Sequences:	511 (402)
Seq/√Len:	21.5
META:	0.141

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
252_L	299_F	7.067	1.00
29_Q	47_D	5.853	1.00
222_Y	232_P	5.010	1.00
56_G	158_S	4.005	1.00
169_A	292_S	3.822	1.00
229_R	345_S	3.812	1.00
205_N	208_S	3.663	1.00
33_G	44_I	3.587	1.00
60_I	159_V	3.579	1.00
26_A	33_G	3.511	1.00
51_L	58_V	3.181	1.00
157_V	190_C	2.965	0.99
232_P	235_I	2.884	0.99
141_F	149_G	2.845	0.99
42_T	208_S	2.802	0.99
248_L	299_F	2.708	0.99
30_Q	33_G	2.671	0.99
315_L	333_L	2.615	0.98
137_A	149_G	2.606	0.98
225_T	229_R	2.582	0.98
135_Y	313_H	2.559	0.98
231_L	241_F	2.554	0.98
249_H	253_L	2.549	0.98
30_Q	57_F	2.448	0.98
225_T	345_S	2.426	0.97
84_L	132_L	2.412	0.97
140_L	152_L	2.385	0.97
40_D	205_N	2.375	0.97
91_L	136_A	2.349	0.97
61_Y	81_F	2.319	0.97
10_C	121_V	2.315	0.97
210_L	216_L	2.313	0.97
88_T	120_F	2.270	0.96
223_K	343_Y	2.270	0.96
87_L	132_L	2.229	0.96
169_A	288_T	2.183	0.95
34_F	62_S	2.178	0.95
345_S	349_S	2.151	0.95
116_L	312_F	2.105	0.94
2_L	111_C	2.061	0.93
346_T	349_S	2.053	0.93
150_S	190_C	2.052	0.93
151_L	193_V	1.995	0.92
157_V	175_L	1.960	0.92
131_M	166_F	1.918	0.91
130_A	163_V	1.911	0.90
155_L	159_V	1.897	0.90
60_I	129_V	1.862	0.89
40_D	208_S	1.849	0.89
167_A	190_C	1.844	0.89
40_D	43_K	1.832	0.88
150_S	186_Q	1.810	0.88
202_L	206_P	1.782	0.87
35_L	62_S	1.749	0.86
311_Y	315_L	1.703	0.84
302_S	340_W	1.699	0.84
59_Y	197_L	1.696	0.84
75_R	79_Y	1.680	0.84
233_E	237_L	1.660	0.83
73_N	76_L	1.648	0.82
222_Y	225_T	1.632	0.82
287_T	321_R	1.626	0.81
38_E	43_K	1.622	0.81
95_I	138_I	1.618	0.81
149_G	170_L	1.618	0.81
34_F	39_R	1.613	0.81
26_A	51_L	1.611	0.81
133_F	159_V	1.610	0.81
337_E	341_N	1.581	0.80
212_R	215_D	1.549	0.78
131_M	135_Y	1.536	0.78
30_Q	44_I	1.531	0.77
155_L	197_L	1.514	0.76
150_S	174_L	1.513	0.76
35_L	159_V	1.501	0.76
26_A	29_Q	1.499	0.76
99_T	286_L	1.491	0.75
1_L	5_A	1.483	0.75
26_A	47_D	1.480	0.75
147_T	189_I	1.470	0.74
325_P	328_L	1.457	0.74
256_F	295_I	1.449	0.73
219_V	237_L	1.444	0.73
157_V	167_A	1.443	0.73
14_I	82_A	1.440	0.73
30_Q	58_V	1.413	0.71
329_R	336_I	1.396	0.70
156_A	163_V	1.385	0.70
222_Y	230_F	1.380	0.69
146_W	149_G	1.378	0.69
225_T	346_T	1.356	0.68
102_V	106_V	1.350	0.68
85_Y	117_H	1.345	0.67
95_I	286_L	1.344	0.67
26_A	45_K	1.314	0.66
219_V	239_K	1.296	0.64
68_T	71_G	1.283	0.64
154_S	194_Q	1.266	0.63
187_L	191_A	1.258	0.62
241_F	340_W	1.258	0.62
68_T	77_A	1.256	0.62
172_V	257_A	1.241	0.61
3_L	86_L	1.241	0.61
169_A	289_L	1.215	0.59
294_F	311_Y	1.209	0.59
110_L	114_K	1.197	0.58
338_Y	342_V	1.195	0.58
173_L	244_A	1.193	0.58
144_R	173_L	1.190	0.58
25_K	47_D	1.187	0.57
51_L	214_F	1.181	0.57
228_W	340_W	1.179	0.57
138_I	289_L	1.166	0.56
48_T	52_V	1.161	0.56
88_T	184_L	1.144	0.55
221_L	225_T	1.136	0.54
193_V	197_L	1.130	0.54
225_T	349_S	1.124	0.53
136_A	152_L	1.117	0.53
243_L	247_A	1.115	0.53
116_L	120_F	1.111	0.52
26_A	30_Q	1.102	0.52
24_W	28_M	1.100	0.52
23_D	27_Y	1.100	0.52
114_K	242_A	1.095	0.51
320_W	329_R	1.083	0.51
222_Y	228_W	1.080	0.50
61_Y	156_A	1.079	0.50
133_F	155_L	1.074	0.50
315_L	336_I	1.071	0.50
32_E	36_N	1.063	0.49
33_G	57_F	1.054	0.49
340_W	345_S	1.044	0.48
131_M	313_H	1.041	0.48
231_L	238_S	1.041	0.48
32_E	65_Y	1.038	0.48
141_F	150_S	1.037	0.47
238_S	242_A	1.035	0.47
22_I	27_Y	1.033	0.47
229_R	349_S	1.033	0.47
74_I	343_Y	1.027	0.47
171_L	183_T	1.026	0.47
88_T	135_Y	1.025	0.47
195_V	210_L	1.025	0.47
69_D	76_L	1.018	0.46
28_M	48_T	1.010	0.46
9_L	112_L	1.007	0.45
52_V	224_W	1.006	0.45
29_Q	225_T	1.006	0.45
313_H	336_I	1.000	0.45
277_S	282_P	0.999	0.45
289_L	292_S	0.999	0.45
20_T	23_D	0.998	0.45
21_E	25_K	0.994	0.45
217_G	302_S	0.992	0.44
52_V	305_Y	0.992	0.44
297_I	311_Y	0.991	0.44
91_L	203_L	0.991	0.44
128_C	215_D	0.983	0.44
179_G	228_W	0.983	0.44
94_A	139_L	0.974	0.43
206_P	210_L	0.973	0.43
266_G	272_L	0.968	0.43
48_T	51_L	0.960	0.42
279_P	283_N	0.958	0.42
10_C	82_A	0.957	0.42
101_K	106_V	0.957	0.42
235_I	328_L	0.956	0.42
5_A	12_L	0.948	0.42
71_G	77_A	0.943	0.41
308_Y	336_I	0.941	0.41
65_Y	71_G	0.933	0.41
229_R	346_T	0.933	0.41
105_Y	225_T	0.933	0.41
84_L	120_F	0.932	0.41
120_F	216_L	0.929	0.40
303_L	340_W	0.920	0.40
24_W	64_L	0.917	0.40
331_L	335_A	0.917	0.40
82_A	121_V	0.913	0.39
57_F	167_A	0.910	0.39
248_L	252_L	0.909	0.39
342_V	345_S	0.909	0.39
158_S	297_I	0.908	0.39
31_V	59_Y	0.907	0.39
24_W	71_G	0.905	0.39
124_L	167_A	0.895	0.38
146_W	163_V	0.893	0.38
208_S	212_R	0.891	0.38
8_V	255_L	0.891	0.38
137_A	141_F	0.887	0.38
98_K	191_A	0.887	0.38
55_A	84_L	0.886	0.38
162_N	310_W	0.884	0.37
232_P	242_A	0.884	0.37
198_G	203_L	0.882	0.37
31_V	48_T	0.880	0.37
174_L	261_W	0.879	0.37
26_A	221_L	0.877	0.37
222_Y	233_E	0.875	0.37
137_A	186_Q	0.873	0.37
164_L	253_L	0.871	0.37
11_A	79_Y	0.865	0.36
80_I	244_A	0.862	0.36
294_F	314_T	0.860	0.36
310_W	315_L	0.859	0.36
8_V	17_V	0.856	0.36
96_Y	110_L	0.855	0.36
132_L	136_A	0.855	0.36
102_V	334_A	0.855	0.36
198_G	202_L	0.850	0.35
229_R	347_N	0.849	0.35
130_A	320_W	0.849	0.35
59_Y	158_S	0.846	0.35
2_L	239_K	0.839	0.35
342_V	349_S	0.838	0.35
332_L	345_S	0.837	0.35
69_D	73_N	0.836	0.34
14_I	172_V	0.829	0.34
135_Y	310_W	0.828	0.34
216_L	286_L	0.828	0.34
138_I	285_I	0.823	0.34
24_W	48_T	0.822	0.34
166_F	310_W	0.820	0.34
155_L	193_V	0.818	0.33
20_T	27_Y	0.817	0.33
346_T	350_S	0.817	0.33
28_M	51_L	0.816	0.33
162_N	311_Y	0.814	0.33
141_F	173_L	0.811	0.33
198_G	248_L	0.810	0.33
162_N	293_N	0.806	0.33
170_L	289_L	0.803	0.32
59_Y	62_S	0.801	0.32
262_L	267_G	0.800	0.32
26_A	34_F	0.797	0.32
149_G	343_Y	0.795	0.32
14_I	121_V	0.794	0.32
88_T	132_L	0.793	0.32
131_M	162_N	0.792	0.32
276_L	279_P	0.788	0.32
3_L	6_E	0.787	0.32
25_K	29_Q	0.785	0.31
118_S	224_W	0.782	0.31
41_Y	49_G	0.782	0.31
172_V	292_S	0.780	0.31
44_I	116_L	0.779	0.31
118_S	122_L	0.777	0.31
60_I	309_S	0.777	0.31
154_S	182_G	0.772	0.31
222_Y	237_L	0.771	0.31
34_F	294_F	0.771	0.31
342_V	346_T	0.768	0.30
98_K	184_L	0.767	0.30
94_A	143_R	0.766	0.30
44_I	57_F	0.764	0.30
2_L	93_F	0.763	0.30
125_F	306_Q	0.763	0.30
131_M	163_V	0.762	0.30
139_L	143_R	0.762	0.30
250_L	328_L	0.761	0.30
92_V	146_W	0.760	0.30
55_A	59_Y	0.759	0.30
174_L	288_T	0.759	0.30
293_N	310_W	0.758	0.30
102_V	196_L	0.756	0.30
13_I	117_H	0.754	0.30
123_R	224_W	0.753	0.30
196_L	234_E	0.753	0.30
91_L	132_L	0.744	0.29
17_V	110_L	0.744	0.29
325_P	338_Y	0.743	0.29
224_W	236_F	0.742	0.29
297_I	310_W	0.741	0.29
30_Q	45_K	0.741	0.29
88_T	339_C	0.740	0.29
21_E	74_I	0.740	0.29
178_L	186_Q	0.739	0.29
267_G	272_L	0.738	0.29
167_A	175_L	0.736	0.29
261_W	292_S	0.734	0.29
8_V	83_G	0.734	0.29
58_V	76_L	0.734	0.29
105_Y	128_C	0.733	0.29
161_M	214_F	0.732	0.28
325_P	329_R	0.731	0.28
157_V	171_L	0.728	0.28
58_V	153_Y	0.728	0.28
153_Y	250_L	0.726	0.28
285_I	288_T	0.724	0.28
228_W	249_H	0.724	0.28
19_Y	109_L	0.722	0.28
250_L	327_V	0.721	0.28
224_W	305_Y	0.721	0.28
327_V	331_L	0.720	0.28
132_L	300_A	0.719	0.28
9_L	13_I	0.718	0.28
293_N	311_Y	0.718	0.28
164_L	216_L	0.716	0.28
304_H	307_F	0.711	0.27
142_Q	286_L	0.709	0.27
5_A	13_I	0.707	0.27
311_Y	336_I	0.705	0.27
57_F	229_R	0.705	0.27
25_K	33_G	0.703	0.27
136_A	170_L	0.702	0.27
339_C	349_S	0.701	0.27
38_E	114_K	0.701	0.27
163_V	205_N	0.700	0.27
134_L	163_V	0.699	0.27
46_G	49_G	0.698	0.27
166_F	293_N	0.695	0.26
52_V	226_V	0.694	0.26
49_G	53_Y	0.691	0.26
162_N	287_T	0.686	0.26
20_T	26_A	0.686	0.26
191_A	198_G	0.683	0.26
123_R	236_F	0.683	0.26
6_E	117_H	0.681	0.26
34_F	59_Y	0.681	0.26
149_G	195_V	0.680	0.26
277_S	281_T	0.680	0.26
40_D	173_L	0.678	0.26
3_L	13_I	0.678	0.26
287_T	312_F	0.674	0.25
9_L	297_I	0.674	0.25
161_M	236_F	0.674	0.25
43_K	208_S	0.672	0.25
65_Y	76_L	0.669	0.25
148_L	178_L	0.668	0.25
35_L	152_L	0.664	0.25
136_A	324_L	0.661	0.25
239_K	242_A	0.660	0.25
144_R	189_I	0.660	0.25
193_V	250_L	0.658	0.25
179_G	183_T	0.658	0.25
16_K	322_T	0.657	0.25
67_L	348_L	0.657	0.25
228_W	241_F	0.656	0.24
137_A	231_L	0.653	0.24
15_W	79_Y	0.653	0.24
171_L	187_L	0.653	0.24
81_F	92_V	0.653	0.24
165_L	220_F	0.651	0.24
62_S	70_G	0.651	0.24
115_R	122_L	0.650	0.24
23_D	26_A	0.649	0.24
95_I	135_Y	0.648	0.24
210_L	222_Y	0.644	0.24
141_F	186_Q	0.643	0.24
119_I	230_F	0.643	0.24
226_V	305_Y	0.641	0.24
194_Q	293_N	0.639	0.24
46_G	52_V	0.639	0.24
190_C	213_A	0.637	0.24
167_A	171_L	0.637	0.24
122_L	224_W	0.637	0.24
75_R	155_L	0.635	0.23
6_E	85_Y	0.633	0.23
134_L	289_L	0.633	0.23
133_F	156_A	0.631	0.23
255_L	327_V	0.629	0.23
67_L	80_I	0.624	0.23
112_L	338_Y	0.623	0.23
182_G	250_L	0.621	0.23
17_V	234_E	0.619	0.23
3_L	171_L	0.619	0.23
22_I	52_V	0.618	0.23
48_T	224_W	0.618	0.23
211_S	215_D	0.617	0.23
275_G	278_R	0.615	0.23
40_D	200_P	0.614	0.22
65_Y	70_G	0.614	0.22
4_L	254_L	0.613	0.22
123_R	161_M	0.611	0.22
64_L	67_L	0.610	0.22
271_L	275_G	0.608	0.22
64_L	76_L	0.607	0.22
210_L	347_N	0.604	0.22
90_A	192_L	0.604	0.22
133_F	153_Y	0.603	0.22
324_L	333_L	0.603	0.22
106_V	316_P	0.602	0.22
221_L	343_Y	0.602	0.22
184_L	268_L	0.602	0.22
323_G	329_R	0.601	0.22
117_H	337_E	0.600	0.22
114_K	309_S	0.600	0.22
28_M	31_V	0.600	0.22
175_L	188_A	0.600	0.22
296_G	306_Q	0.598	0.22
34_F	58_V	0.597	0.22
123_R	227_N	0.595	0.22
203_L	206_P	0.594	0.22
13_I	166_F	0.593	0.21
56_G	95_I	0.593	0.21
79_Y	169_A	0.592	0.21
153_Y	187_L	0.592	0.21
95_I	142_Q	0.591	0.21
253_L	295_I	0.590	0.21
221_L	237_L	0.588	0.21
5_A	120_F	0.586	0.21
331_L	334_A	0.584	0.21
95_I	290_F	0.584	0.21
196_L	215_D	0.584	0.21
57_F	228_W	0.584	0.21
58_V	83_G	0.584	0.21
225_T	342_V	0.583	0.21
49_G	52_V	0.582	0.21
4_L	251_L	0.581	0.21
229_R	340_W	0.578	0.21
157_V	210_L	0.577	0.21
144_R	177_A	0.576	0.21
219_V	232_P	0.576	0.21
114_K	338_Y	0.575	0.21
161_M	165_L	0.573	0.21
24_W	31_V	0.573	0.21
84_L	89_L	0.572	0.21
186_Q	192_L	0.572	0.21
84_L	129_V	0.571	0.21
128_C	229_R	0.570	0.20
222_Y	231_L	0.570	0.20
9_L	14_I	0.569	0.20
67_L	137_A	0.567	0.20
100_A	153_Y	0.567	0.20
2_L	16_K	0.566	0.20
164_L	249_H	0.566	0.20
2_L	31_V	0.564	0.20
239_K	251_L	0.564	0.20
261_W	312_F	0.564	0.20
42_T	215_D	0.564	0.20
74_I	214_F	0.563	0.20
339_C	346_T	0.563	0.20
166_F	311_Y	0.561	0.20
38_E	288_T	0.561	0.20
280_L	284_Q	0.561	0.20
48_T	226_V	0.560	0.20
125_F	161_M	0.559	0.20
36_N	242_A	0.558	0.20
274_R	279_P	0.558	0.20
29_Q	92_V	0.558	0.20
213_A	216_L	0.557	0.20
62_S	66_Y	0.557	0.20
125_F	304_H	0.556	0.20
133_F	216_L	0.556	0.20
73_N	317_Y	0.555	0.20
125_F	236_F	0.555	0.20
35_L	71_G	0.555	0.20
319_L	338_Y	0.554	0.20
179_G	340_W	0.554	0.20
290_F	310_W	0.552	0.20
69_D	282_P	0.552	0.20
184_L	247_A	0.552	0.20
215_D	241_F	0.552	0.20
6_E	10_C	0.551	0.20
226_V	236_F	0.549	0.20
19_Y	48_T	0.548	0.20
22_I	26_A	0.548	0.20
7_A	10_C	0.547	0.19
2_L	32_E	0.546	0.19
163_V	212_R	0.546	0.19
63_A	74_I	0.545	0.19
253_L	340_W	0.544	0.19
135_Y	166_F	0.543	0.19
313_H	333_L	0.543	0.19
61_Y	74_I	0.541	0.19
239_K	243_L	0.540	0.19
196_L	285_I	0.536	0.19
317_Y	335_A	0.535	0.19
44_I	173_L	0.534	0.19
77_A	167_A	0.530	0.19
110_L	261_W	0.530	0.19
163_V	290_F	0.530	0.19
31_V	191_A	0.530	0.19
277_S	283_N	0.529	0.19
319_L	324_L	0.528	0.19
109_L	341_N	0.527	0.19
219_V	241_F	0.526	0.19
153_Y	292_S	0.526	0.19
215_D	221_L	0.526	0.19
298_L	313_H	0.525	0.19
140_L	231_L	0.525	0.19
296_G	304_H	0.525	0.19
21_E	27_Y	0.522	0.18
13_I	19_Y	0.522	0.18
229_R	342_V	0.521	0.18
91_L	197_L	0.521	0.18
301_R	306_Q	0.520	0.18
161_M	224_W	0.520	0.18
131_M	141_F	0.520	0.18
12_L	18_P	0.520	0.18
118_S	236_F	0.519	0.18
7_A	11_A	0.518	0.18
184_L	251_L	0.517	0.18
20_T	24_W	0.517	0.18
23_D	49_G	0.515	0.18
67_L	188_A	0.515	0.18
322_T	329_R	0.514	0.18
254_L	257_A	0.514	0.18
86_L	207_V	0.514	0.18
272_L	278_R	0.513	0.18
61_Y	129_V	0.512	0.18
176_L	242_A	0.512	0.18
290_F	336_I	0.512	0.18
165_L	236_F	0.512	0.18
11_A	39_R	0.511	0.18
13_I	66_Y	0.510	0.18
116_L	313_H	0.510	0.18
291_T	294_F	0.509	0.18
263_R	283_N	0.509	0.18
86_L	291_T	0.509	0.18
62_S	65_Y	0.509	0.18
324_L	328_L	0.507	0.18
153_Y	293_N	0.507	0.18
24_W	117_H	0.506	0.18
128_C	342_V	0.506	0.18
249_H	340_W	0.506	0.18
67_L	288_T	0.505	0.18
175_L	242_A	0.505	0.18
301_R	305_Y	0.505	0.18
335_A	339_C	0.505	0.18
250_L	259_T	0.504	0.18
116_L	180_L	0.503	0.18
174_L	178_L	0.503	0.18
134_L	166_F	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3wajA	1	0.7629	83.1	0.968	Contact Map
3rceA	1	0.6486	23.8	0.979	Contact Map
2fhxA	2	0.1886	9.3	0.982	Contact Map
2p97A	6	0.1886	6	0.984	Contact Map
3l6nA	1	0.1886	3.3	0.986	Contact Map
4c1hA	1	0.18	2.5	0.987	Contact Map
4c1gA	1	0.1943	2.3	0.987	Contact Map
2htgA	1	0.0743	2.3	0.987	Contact Map
2jv8A	1	0.1314	2	0.987	Contact Map
2kegA	1	0.0829	1.9	0.987	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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