GREMLIN Database
ALG3 - ALG3 protein
PFAM: PF05208 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 350 (350)
Sequences: 511 (402)
Seq/√Len: 21.5
META: 0.141

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
252_L299_F7.0671.00
29_Q47_D5.8531.00
222_Y232_P5.0101.00
56_G158_S4.0051.00
169_A292_S3.8221.00
229_R345_S3.8121.00
205_N208_S3.6631.00
33_G44_I3.5871.00
60_I159_V3.5791.00
26_A33_G3.5111.00
51_L58_V3.1811.00
157_V190_C2.9650.99
232_P235_I2.8840.99
141_F149_G2.8450.99
42_T208_S2.8020.99
248_L299_F2.7080.99
30_Q33_G2.6710.99
315_L333_L2.6150.98
137_A149_G2.6060.98
225_T229_R2.5820.98
135_Y313_H2.5590.98
231_L241_F2.5540.98
249_H253_L2.5490.98
30_Q57_F2.4480.98
225_T345_S2.4260.97
84_L132_L2.4120.97
140_L152_L2.3850.97
40_D205_N2.3750.97
91_L136_A2.3490.97
61_Y81_F2.3190.97
10_C121_V2.3150.97
210_L216_L2.3130.97
88_T120_F2.2700.96
223_K343_Y2.2700.96
87_L132_L2.2290.96
169_A288_T2.1830.95
34_F62_S2.1780.95
345_S349_S2.1510.95
116_L312_F2.1050.94
2_L111_C2.0610.93
346_T349_S2.0530.93
150_S190_C2.0520.93
151_L193_V1.9950.92
157_V175_L1.9600.92
131_M166_F1.9180.91
130_A163_V1.9110.90
155_L159_V1.8970.90
60_I129_V1.8620.89
40_D208_S1.8490.89
167_A190_C1.8440.89
40_D43_K1.8320.88
150_S186_Q1.8100.88
202_L206_P1.7820.87
35_L62_S1.7490.86
311_Y315_L1.7030.84
302_S340_W1.6990.84
59_Y197_L1.6960.84
75_R79_Y1.6800.84
233_E237_L1.6600.83
73_N76_L1.6480.82
222_Y225_T1.6320.82
287_T321_R1.6260.81
38_E43_K1.6220.81
95_I138_I1.6180.81
149_G170_L1.6180.81
34_F39_R1.6130.81
26_A51_L1.6110.81
133_F159_V1.6100.81
337_E341_N1.5810.80
212_R215_D1.5490.78
131_M135_Y1.5360.78
30_Q44_I1.5310.77
155_L197_L1.5140.76
150_S174_L1.5130.76
35_L159_V1.5010.76
26_A29_Q1.4990.76
99_T286_L1.4910.75
1_L5_A1.4830.75
26_A47_D1.4800.75
147_T189_I1.4700.74
325_P328_L1.4570.74
256_F295_I1.4490.73
219_V237_L1.4440.73
157_V167_A1.4430.73
14_I82_A1.4400.73
30_Q58_V1.4130.71
329_R336_I1.3960.70
156_A163_V1.3850.70
222_Y230_F1.3800.69
146_W149_G1.3780.69
225_T346_T1.3560.68
102_V106_V1.3500.68
85_Y117_H1.3450.67
95_I286_L1.3440.67
26_A45_K1.3140.66
219_V239_K1.2960.64
68_T71_G1.2830.64
154_S194_Q1.2660.63
187_L191_A1.2580.62
241_F340_W1.2580.62
68_T77_A1.2560.62
172_V257_A1.2410.61
3_L86_L1.2410.61
169_A289_L1.2150.59
294_F311_Y1.2090.59
110_L114_K1.1970.58
338_Y342_V1.1950.58
173_L244_A1.1930.58
144_R173_L1.1900.58
25_K47_D1.1870.57
51_L214_F1.1810.57
228_W340_W1.1790.57
138_I289_L1.1660.56
48_T52_V1.1610.56
88_T184_L1.1440.55
221_L225_T1.1360.54
193_V197_L1.1300.54
225_T349_S1.1240.53
136_A152_L1.1170.53
243_L247_A1.1150.53
116_L120_F1.1110.52
26_A30_Q1.1020.52
24_W28_M1.1000.52
23_D27_Y1.1000.52
114_K242_A1.0950.51
320_W329_R1.0830.51
222_Y228_W1.0800.50
61_Y156_A1.0790.50
133_F155_L1.0740.50
315_L336_I1.0710.50
32_E36_N1.0630.49
33_G57_F1.0540.49
340_W345_S1.0440.48
131_M313_H1.0410.48
231_L238_S1.0410.48
32_E65_Y1.0380.48
141_F150_S1.0370.47
238_S242_A1.0350.47
22_I27_Y1.0330.47
229_R349_S1.0330.47
74_I343_Y1.0270.47
171_L183_T1.0260.47
88_T135_Y1.0250.47
195_V210_L1.0250.47
69_D76_L1.0180.46
28_M48_T1.0100.46
9_L112_L1.0070.45
52_V224_W1.0060.45
29_Q225_T1.0060.45
313_H336_I1.0000.45
277_S282_P0.9990.45
289_L292_S0.9990.45
20_T23_D0.9980.45
21_E25_K0.9940.45
217_G302_S0.9920.44
52_V305_Y0.9920.44
297_I311_Y0.9910.44
91_L203_L0.9910.44
128_C215_D0.9830.44
179_G228_W0.9830.44
94_A139_L0.9740.43
206_P210_L0.9730.43
266_G272_L0.9680.43
48_T51_L0.9600.42
279_P283_N0.9580.42
10_C82_A0.9570.42
101_K106_V0.9570.42
235_I328_L0.9560.42
5_A12_L0.9480.42
71_G77_A0.9430.41
308_Y336_I0.9410.41
65_Y71_G0.9330.41
229_R346_T0.9330.41
105_Y225_T0.9330.41
84_L120_F0.9320.41
120_F216_L0.9290.40
303_L340_W0.9200.40
24_W64_L0.9170.40
331_L335_A0.9170.40
82_A121_V0.9130.39
57_F167_A0.9100.39
248_L252_L0.9090.39
342_V345_S0.9090.39
158_S297_I0.9080.39
31_V59_Y0.9070.39
24_W71_G0.9050.39
124_L167_A0.8950.38
146_W163_V0.8930.38
208_S212_R0.8910.38
8_V255_L0.8910.38
137_A141_F0.8870.38
98_K191_A0.8870.38
55_A84_L0.8860.38
162_N310_W0.8840.37
232_P242_A0.8840.37
198_G203_L0.8820.37
31_V48_T0.8800.37
174_L261_W0.8790.37
26_A221_L0.8770.37
222_Y233_E0.8750.37
137_A186_Q0.8730.37
164_L253_L0.8710.37
11_A79_Y0.8650.36
80_I244_A0.8620.36
294_F314_T0.8600.36
310_W315_L0.8590.36
8_V17_V0.8560.36
96_Y110_L0.8550.36
132_L136_A0.8550.36
102_V334_A0.8550.36
198_G202_L0.8500.35
229_R347_N0.8490.35
130_A320_W0.8490.35
59_Y158_S0.8460.35
2_L239_K0.8390.35
342_V349_S0.8380.35
332_L345_S0.8370.35
69_D73_N0.8360.34
14_I172_V0.8290.34
135_Y310_W0.8280.34
216_L286_L0.8280.34
138_I285_I0.8230.34
24_W48_T0.8220.34
166_F310_W0.8200.34
155_L193_V0.8180.33
20_T27_Y0.8170.33
346_T350_S0.8170.33
28_M51_L0.8160.33
162_N311_Y0.8140.33
141_F173_L0.8110.33
198_G248_L0.8100.33
162_N293_N0.8060.33
170_L289_L0.8030.32
59_Y62_S0.8010.32
262_L267_G0.8000.32
26_A34_F0.7970.32
149_G343_Y0.7950.32
14_I121_V0.7940.32
88_T132_L0.7930.32
131_M162_N0.7920.32
276_L279_P0.7880.32
3_L6_E0.7870.32
25_K29_Q0.7850.31
118_S224_W0.7820.31
41_Y49_G0.7820.31
172_V292_S0.7800.31
44_I116_L0.7790.31
118_S122_L0.7770.31
60_I309_S0.7770.31
154_S182_G0.7720.31
222_Y237_L0.7710.31
34_F294_F0.7710.31
342_V346_T0.7680.30
98_K184_L0.7670.30
94_A143_R0.7660.30
44_I57_F0.7640.30
2_L93_F0.7630.30
125_F306_Q0.7630.30
131_M163_V0.7620.30
139_L143_R0.7620.30
250_L328_L0.7610.30
92_V146_W0.7600.30
55_A59_Y0.7590.30
174_L288_T0.7590.30
293_N310_W0.7580.30
102_V196_L0.7560.30
13_I117_H0.7540.30
123_R224_W0.7530.30
196_L234_E0.7530.30
91_L132_L0.7440.29
17_V110_L0.7440.29
325_P338_Y0.7430.29
224_W236_F0.7420.29
297_I310_W0.7410.29
30_Q45_K0.7410.29
88_T339_C0.7400.29
21_E74_I0.7400.29
178_L186_Q0.7390.29
267_G272_L0.7380.29
167_A175_L0.7360.29
261_W292_S0.7340.29
8_V83_G0.7340.29
58_V76_L0.7340.29
105_Y128_C0.7330.29
161_M214_F0.7320.28
325_P329_R0.7310.28
157_V171_L0.7280.28
58_V153_Y0.7280.28
153_Y250_L0.7260.28
285_I288_T0.7240.28
228_W249_H0.7240.28
19_Y109_L0.7220.28
250_L327_V0.7210.28
224_W305_Y0.7210.28
327_V331_L0.7200.28
132_L300_A0.7190.28
9_L13_I0.7180.28
293_N311_Y0.7180.28
164_L216_L0.7160.28
304_H307_F0.7110.27
142_Q286_L0.7090.27
5_A13_I0.7070.27
311_Y336_I0.7050.27
57_F229_R0.7050.27
25_K33_G0.7030.27
136_A170_L0.7020.27
339_C349_S0.7010.27
38_E114_K0.7010.27
163_V205_N0.7000.27
134_L163_V0.6990.27
46_G49_G0.6980.27
166_F293_N0.6950.26
52_V226_V0.6940.26
49_G53_Y0.6910.26
162_N287_T0.6860.26
20_T26_A0.6860.26
191_A198_G0.6830.26
123_R236_F0.6830.26
6_E117_H0.6810.26
34_F59_Y0.6810.26
149_G195_V0.6800.26
277_S281_T0.6800.26
40_D173_L0.6780.26
3_L13_I0.6780.26
287_T312_F0.6740.25
9_L297_I0.6740.25
161_M236_F0.6740.25
43_K208_S0.6720.25
65_Y76_L0.6690.25
148_L178_L0.6680.25
35_L152_L0.6640.25
136_A324_L0.6610.25
239_K242_A0.6600.25
144_R189_I0.6600.25
193_V250_L0.6580.25
179_G183_T0.6580.25
16_K322_T0.6570.25
67_L348_L0.6570.25
228_W241_F0.6560.24
137_A231_L0.6530.24
15_W79_Y0.6530.24
171_L187_L0.6530.24
81_F92_V0.6530.24
165_L220_F0.6510.24
62_S70_G0.6510.24
115_R122_L0.6500.24
23_D26_A0.6490.24
95_I135_Y0.6480.24
210_L222_Y0.6440.24
141_F186_Q0.6430.24
119_I230_F0.6430.24
226_V305_Y0.6410.24
194_Q293_N0.6390.24
46_G52_V0.6390.24
190_C213_A0.6370.24
167_A171_L0.6370.24
122_L224_W0.6370.24
75_R155_L0.6350.23
6_E85_Y0.6330.23
134_L289_L0.6330.23
133_F156_A0.6310.23
255_L327_V0.6290.23
67_L80_I0.6240.23
112_L338_Y0.6230.23
182_G250_L0.6210.23
17_V234_E0.6190.23
3_L171_L0.6190.23
22_I52_V0.6180.23
48_T224_W0.6180.23
211_S215_D0.6170.23
275_G278_R0.6150.23
40_D200_P0.6140.22
65_Y70_G0.6140.22
4_L254_L0.6130.22
123_R161_M0.6110.22
64_L67_L0.6100.22
271_L275_G0.6080.22
64_L76_L0.6070.22
210_L347_N0.6040.22
90_A192_L0.6040.22
133_F153_Y0.6030.22
324_L333_L0.6030.22
106_V316_P0.6020.22
221_L343_Y0.6020.22
184_L268_L0.6020.22
323_G329_R0.6010.22
117_H337_E0.6000.22
114_K309_S0.6000.22
28_M31_V0.6000.22
175_L188_A0.6000.22
296_G306_Q0.5980.22
34_F58_V0.5970.22
123_R227_N0.5950.22
203_L206_P0.5940.22
13_I166_F0.5930.21
56_G95_I0.5930.21
79_Y169_A0.5920.21
153_Y187_L0.5920.21
95_I142_Q0.5910.21
253_L295_I0.5900.21
221_L237_L0.5880.21
5_A120_F0.5860.21
331_L334_A0.5840.21
95_I290_F0.5840.21
196_L215_D0.5840.21
57_F228_W0.5840.21
58_V83_G0.5840.21
225_T342_V0.5830.21
49_G52_V0.5820.21
4_L251_L0.5810.21
229_R340_W0.5780.21
157_V210_L0.5770.21
144_R177_A0.5760.21
219_V232_P0.5760.21
114_K338_Y0.5750.21
161_M165_L0.5730.21
24_W31_V0.5730.21
84_L89_L0.5720.21
186_Q192_L0.5720.21
84_L129_V0.5710.21
128_C229_R0.5700.20
222_Y231_L0.5700.20
9_L14_I0.5690.20
67_L137_A0.5670.20
100_A153_Y0.5670.20
2_L16_K0.5660.20
164_L249_H0.5660.20
2_L31_V0.5640.20
239_K251_L0.5640.20
261_W312_F0.5640.20
42_T215_D0.5640.20
74_I214_F0.5630.20
339_C346_T0.5630.20
166_F311_Y0.5610.20
38_E288_T0.5610.20
280_L284_Q0.5610.20
48_T226_V0.5600.20
125_F161_M0.5590.20
36_N242_A0.5580.20
274_R279_P0.5580.20
29_Q92_V0.5580.20
213_A216_L0.5570.20
62_S66_Y0.5570.20
125_F304_H0.5560.20
133_F216_L0.5560.20
73_N317_Y0.5550.20
125_F236_F0.5550.20
35_L71_G0.5550.20
319_L338_Y0.5540.20
179_G340_W0.5540.20
290_F310_W0.5520.20
69_D282_P0.5520.20
184_L247_A0.5520.20
215_D241_F0.5520.20
6_E10_C0.5510.20
226_V236_F0.5490.20
19_Y48_T0.5480.20
22_I26_A0.5480.20
7_A10_C0.5470.19
2_L32_E0.5460.19
163_V212_R0.5460.19
63_A74_I0.5450.19
253_L340_W0.5440.19
135_Y166_F0.5430.19
313_H333_L0.5430.19
61_Y74_I0.5410.19
239_K243_L0.5400.19
196_L285_I0.5360.19
317_Y335_A0.5350.19
44_I173_L0.5340.19
77_A167_A0.5300.19
110_L261_W0.5300.19
163_V290_F0.5300.19
31_V191_A0.5300.19
277_S283_N0.5290.19
319_L324_L0.5280.19
109_L341_N0.5270.19
219_V241_F0.5260.19
153_Y292_S0.5260.19
215_D221_L0.5260.19
298_L313_H0.5250.19
140_L231_L0.5250.19
296_G304_H0.5250.19
21_E27_Y0.5220.18
13_I19_Y0.5220.18
229_R342_V0.5210.18
91_L197_L0.5210.18
301_R306_Q0.5200.18
161_M224_W0.5200.18
131_M141_F0.5200.18
12_L18_P0.5200.18
118_S236_F0.5190.18
7_A11_A0.5180.18
184_L251_L0.5170.18
20_T24_W0.5170.18
23_D49_G0.5150.18
67_L188_A0.5150.18
322_T329_R0.5140.18
254_L257_A0.5140.18
86_L207_V0.5140.18
272_L278_R0.5130.18
61_Y129_V0.5120.18
176_L242_A0.5120.18
290_F336_I0.5120.18
165_L236_F0.5120.18
11_A39_R0.5110.18
13_I66_Y0.5100.18
116_L313_H0.5100.18
291_T294_F0.5090.18
263_R283_N0.5090.18
86_L291_T0.5090.18
62_S65_Y0.5090.18
324_L328_L0.5070.18
153_Y293_N0.5070.18
24_W117_H0.5060.18
128_C342_V0.5060.18
249_H340_W0.5060.18
67_L288_T0.5050.18
175_L242_A0.5050.18
301_R305_Y0.5050.18
335_A339_C0.5050.18
250_L259_T0.5040.18
116_L180_L0.5030.18
174_L178_L0.5030.18
134_L166_F0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wajA 1 0.7629 83.1 0.968 Contact Map
3rceA 1 0.6486 23.8 0.979 Contact Map
2fhxA 2 0.1886 9.3 0.982 Contact Map
2p97A 6 0.1886 6 0.984 Contact Map
3l6nA 1 0.1886 3.3 0.986 Contact Map
4c1hA 1 0.18 2.5 0.987 Contact Map
4c1gA 1 0.1943 2.3 0.987 Contact Map
2htgA 1 0.0743 2.3 0.987 Contact Map
2jv8A 1 0.1314 2 0.987 Contact Map
2kegA 1 0.0829 1.9 0.987 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0104 seconds.