GREMLIN Database
Kri1 - KRI1-like family
PFAM: PF05178 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 103 (99)
Sequences: 681 (526)
Seq/√Len: 52.9
META: 0.317

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_K66_K3.9451.00
1_E5_E3.5361.00
4_E8_E3.2131.00
12_E15_K3.1561.00
3_K6_E3.1031.00
17_L20_L2.7641.00
5_E9_E2.6751.00
10_K36_A2.6411.00
74_D77_Y2.2201.00
86_K89_W2.1081.00
7_K11_E2.0481.00
67_E71_L1.7870.99
93_I97_D1.7870.99
93_I98_I1.7360.99
57_G63_K1.6670.99
19_N22_R1.6430.98
6_E9_E1.6240.98
67_E70_K1.5930.98
73_G77_Y1.5330.97
8_E12_E1.5210.97
16_R20_L1.4760.97
15_K22_R1.4750.97
73_G76_Y1.4670.97
66_K70_K1.4360.96
21_K24_E1.4130.96
72_F77_Y1.3400.94
59_F65_D1.3230.94
35_A61_P1.2670.93
36_A72_F1.2130.91
19_N23_E1.1860.90
72_F76_Y1.1720.89
8_E11_E1.1500.88
96_K99_V1.1390.88
64_W72_F1.1390.88
86_K91_D1.1300.88
47_D50_D1.1200.87
2_R6_E1.1160.87
29_L55_L1.1120.87
95_I98_I1.0990.86
14_L19_N1.0970.86
14_L18_K1.0900.86
22_R26_E1.0610.84
89_W92_D1.0500.83
5_E8_E1.0470.83
89_W93_I1.0430.83
27_E30_E1.0310.82
29_L34_E1.0110.81
59_F77_Y1.0110.81
27_E31_K1.0090.81
13_E20_L0.9850.79
63_K67_E0.9740.79
30_E34_E0.9570.77
59_F73_G0.9560.77
12_E19_N0.9530.77
4_E11_E0.9500.77
97_D100_P0.9300.75
29_L54_L0.9220.75
94_D97_D0.9160.74
56_E60_D0.8870.72
50_D55_L0.8780.71
1_E9_E0.8700.70
48_E52_A0.8690.70
48_E55_L0.8640.70
70_K73_G0.8530.69
95_I99_V0.8490.68
1_E42_G0.8460.68
30_E33_K0.8440.68
96_K100_P0.8330.67
11_E89_W0.8330.67
13_E24_E0.8290.66
62_E78_A0.8100.65
15_K19_N0.8090.65
47_D58_D0.7990.64
32_I50_D0.7820.62
53_D59_F0.7710.61
61_P64_W0.7690.61
94_D98_I0.7570.59
25_I61_P0.7490.59
31_K34_E0.7360.57
48_E58_D0.7310.57
62_E66_K0.7230.56
48_E53_D0.7160.55
13_E17_L0.7140.55
36_A43_L0.7040.54
40_L71_L0.7010.54
49_E52_A0.6980.53
43_L46_L0.6980.53
18_K22_R0.6950.53
64_W75_E0.6940.53
60_D63_K0.6900.52
4_E9_E0.6890.52
52_A65_D0.6890.52
57_G67_E0.6880.52
72_F95_I0.6830.52
83_D92_D0.6790.51
14_L67_E0.6740.51
88_E93_I0.6720.51
28_K54_L0.6650.50
75_E78_A0.6630.50
91_D95_I0.6580.49
19_N71_L0.6560.49
67_E73_G0.6550.49
15_K18_K0.6500.48
25_I35_A0.6440.48
31_K67_E0.6370.47
32_I61_P0.6360.47
29_L53_D0.6340.47
56_E74_D0.6220.45
10_K14_L0.6210.45
12_E16_R0.6190.45
29_L92_D0.6190.45
19_N59_F0.6180.45
78_A81_D0.6170.45
28_K68_M0.6100.44
28_K86_K0.6050.44
49_E53_D0.5970.43
45_E53_D0.5780.41
24_E44_K0.5740.40
64_W67_E0.5730.40
5_E11_E0.5650.39
4_E74_D0.5650.39
19_N61_P0.5640.39
22_R61_P0.5610.39
29_L45_E0.5600.39
6_E45_E0.5530.38
23_E67_E0.5450.37
48_E54_L0.5430.37
3_K7_K0.5410.37
23_E27_E0.5400.37
81_D84_E0.5390.37
7_K14_L0.5360.37
40_L78_A0.5340.36
27_E59_F0.5320.36
26_E57_G0.5310.36
90_D95_I0.5300.36
24_E49_E0.5290.36
33_K39_D0.5280.36
59_F63_K0.5230.35
48_E65_D0.5220.35
75_E82_D0.5210.35
39_D43_L0.5120.34
18_K93_I0.5100.34
13_E48_E0.5080.34
93_I96_K0.5080.34
24_E58_D0.5080.34
17_L24_E0.5030.33
50_D75_E0.5000.33
12_E20_L0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kblA 2 0 4.4 0.916 Contact Map
3j7yq 1 0 3.7 0.919 Contact Map
3lecA 2 0.3592 3.3 0.921 Contact Map
3kr9A 1 0.3592 3.2 0.921 Contact Map
4m9qA 1 0.1262 3.2 0.921 Contact Map
3psiA 1 0 2.8 0.924 Contact Map
4c92A 1 0.3398 2.6 0.925 Contact Map
3ilwA 2 0.4466 2.2 0.928 Contact Map
4wikA 2 0.5243 2.2 0.928 Contact Map
2inrA 2 0.4854 2.2 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0192 seconds.