GREMLIN Database
Phage_X - Phage X family
PFAM: PF05155 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 88 (84)
Sequences: 783 (554)
Seq/√Len: 60.4
META: 0.727

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_T40_R4.1841.00
36_S43_A3.5421.00
42_R53_A2.9811.00
36_S40_R2.6431.00
7_V12_A2.3621.00
43_A47_E2.1821.00
8_S11_K2.1811.00
44_R47_E2.1601.00
42_R46_L2.1261.00
10_T14_N2.0671.00
35_K39_Y1.9961.00
42_R52_I1.9451.00
34_S40_R1.9331.00
11_K14_N1.8691.00
34_S37_T1.7870.99
64_V69_R1.7660.99
11_K15_A1.6400.99
37_T41_H1.5490.98
31_K35_K1.5430.98
30_R35_K1.4500.98
58_L61_F1.4220.97
23_W52_I1.3530.96
66_P69_R1.3410.96
20_Y23_W1.3010.96
46_L52_I1.2280.94
17_A21_L1.2210.94
37_T44_R1.2120.93
4_E8_S1.1810.93
78_I84_E1.1560.92
82_Y85_P1.1500.92
22_L25_H1.1470.91
54_Q57_N1.1340.91
20_Y50_I1.1310.91
9_L13_A1.1260.91
22_L27_Y1.0960.89
65_V69_R1.0360.87
18_F22_L1.0070.85
16_T41_H1.0020.85
42_R51_D0.9840.84
3_S7_V0.9810.84
57_N60_K0.9790.83
46_L53_A0.9720.83
18_F41_H0.9660.83
30_R38_F0.9520.82
17_A20_Y0.9440.81
6_I10_T0.9390.81
23_W42_R0.9200.79
33_L41_H0.9170.79
6_I9_L0.9160.79
40_R44_R0.9040.78
60_K71_I0.8840.77
13_A44_R0.8650.75
49_G85_P0.8630.75
35_K42_R0.8500.74
61_F65_V0.8460.73
68_V74_D0.8440.73
27_Y56_Q0.8310.72
15_A44_R0.8300.72
45_L49_G0.8250.71
56_Q65_V0.8190.71
9_L12_A0.8030.69
14_N67_L0.8000.69
68_V73_V0.7980.69
29_L38_F0.7970.69
13_A48_I0.7950.69
10_T18_F0.7840.68
12_A44_R0.7820.67
67_L73_V0.7780.67
46_L51_D0.7490.64
21_L24_M0.7480.64
40_R43_A0.7460.64
12_A50_I0.7430.63
58_L62_S0.7270.62
70_V78_I0.7090.60
13_A16_T0.7040.59
53_A56_Q0.7030.59
43_A46_L0.6990.59
63_N83_Q0.6960.58
68_V76_A0.6650.55
50_I60_K0.6630.55
63_N66_P0.6620.55
62_S72_E0.6570.54
19_Y38_F0.6440.53
41_H82_Y0.6420.52
16_T29_L0.6390.52
44_R48_I0.6370.52
56_Q67_L0.6330.51
39_Y43_A0.6170.50
74_D78_I0.6080.49
21_L25_H0.6060.48
3_S66_P0.6010.48
69_R72_E0.6000.48
23_W51_D0.5990.48
20_Y63_N0.5980.47
37_T43_A0.5970.47
3_S6_I0.5960.47
7_V11_K0.5930.47
16_T65_V0.5900.46
3_S8_S0.5760.45
68_V72_E0.5740.45
7_V13_A0.5710.44
36_S39_Y0.5710.44
34_S44_R0.5680.44
80_D86_V0.5670.44
49_G58_L0.5590.43
43_A59_S0.5560.43
28_D69_R0.5520.42
10_T17_A0.5420.41
6_I17_A0.5410.41
56_Q59_S0.5360.41
77_Q80_D0.5360.41
4_E7_V0.5360.41
81_W84_E0.5310.40
63_N67_L0.5310.40
57_N68_V0.5290.40
5_G8_S0.5210.39
73_V76_A0.5190.39
26_G50_I0.5180.39
45_L57_N0.5160.38
19_Y43_A0.5150.38
38_F53_A0.5120.38
12_A31_K0.5110.38
14_N21_L0.5090.38
17_A41_H0.5090.38
80_D84_E0.5060.37
19_Y34_S0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cwcA 2 0.8068 92.6 0.812 Contact Map
3a8gA 1 0.9886 35.7 0.886 Contact Map
3qyhA 1 0.9773 31.2 0.889 Contact Map
3hhtA 1 0.9886 29.5 0.891 Contact Map
4ob1A 1 0.9886 24.2 0.895 Contact Map
4ob0A 1 0.9886 19 0.9 Contact Map
4zgjA 2 0.9659 17.6 0.902 Contact Map
3iuoA 4 0.9545 10.3 0.911 Contact Map
3ke2A 2 0.7955 9 0.913 Contact Map
2fu4A 2 0.7159 7.7 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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