GREMLIN Database
TM2 - TM2 domain
PFAM: PF05154 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 51 (49)
Sequences: 31414 (18683)
Seq/√Len: 2669.1
META: 0.91

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_R30_T2.6991.00
27_K30_T2.4101.00
8_A25_L2.2321.00
22_R34_Y2.1841.00
5_K9_L2.0091.00
23_F35_L1.9471.00
45_W49_D1.8731.00
23_F31_G1.8561.00
21_H34_Y1.8441.00
12_A21_H1.7331.00
15_L20_I1.7091.00
22_R27_K1.6311.00
11_L24_Y1.5481.00
9_L12_A1.4851.00
29_G33_L1.3851.00
32_I36_L1.3471.00
28_T32_I1.3331.00
34_Y45_W1.2461.00
7_V11_L1.1891.00
12_A50_L1.1731.00
8_A24_Y1.1581.00
4_S7_V1.1571.00
6_L10_L1.1071.00
3_K24_Y1.0681.00
41_G45_W1.0591.00
9_L50_L1.0401.00
18_L46_W0.9711.00
46_W50_L0.9641.00
30_T34_Y0.9601.00
9_L13_I0.9471.00
13_I50_L0.9451.00
40_G43_G0.8781.00
42_F45_W0.8721.00
37_T41_G0.8711.00
6_L9_L0.8541.00
23_F28_T0.8021.00
27_K34_Y0.8011.00
37_T42_F0.7901.00
17_G46_W0.7851.00
5_K8_A0.7331.00
29_G32_I0.7261.00
38_L42_F0.7201.00
11_L15_L0.7161.00
10_L14_F0.6931.00
37_T40_G0.6871.00
5_K12_A0.6831.00
2_D5_K0.6781.00
46_W49_D0.6771.00
33_L37_T0.6761.00
15_L18_L0.6661.00
19_G31_G0.6611.00
44_I48_I0.6371.00
20_I23_F0.6321.00
32_I35_L0.6311.00
8_A12_A0.6291.00
11_L20_I0.5831.00
48_I51_I0.5811.00
33_L36_L0.5751.00
3_K8_A0.5741.00
8_A11_L0.5651.00
9_L25_L0.5611.00
7_V24_Y0.5501.00
16_G19_G0.5481.00
37_T43_G0.5411.00
12_A46_W0.5351.00
43_G47_L0.5351.00
20_I24_Y0.5331.00
43_G49_D0.5321.00
10_L13_I0.5261.00
14_F20_I0.5241.00
30_T33_L0.5171.00
28_T31_G0.5141.00
7_V10_L0.5001.00
41_G44_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gsmA 1 1 3.3 0.848 Contact Map
1v54A 1 1 2.7 0.854 Contact Map
2yevA 1 1 1.9 0.866 Contact Map
3s8fA 1 1 1.8 0.868 Contact Map
2jafA 3 0.9804 1.8 0.868 Contact Map
1eysM 1 0.8235 1.7 0.869 Contact Map
4px7A 1 1 1.6 0.872 Contact Map
1h4rA 2 0.5294 1.5 0.874 Contact Map
4yl8A 1 0.5098 1.4 0.875 Contact Map
4hyjA 2 0.9804 1.4 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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