GREMLIN Database
ResB - ResB-like family
PFAM: PF05140 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 480 (445)
Sequences: 3844 (2643)
Seq/√Len: 125.3
META: 0.642

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
211_D231_T5.6761.00
35_F42_A4.6251.00
120_R132_R4.5911.00
245_R248_H3.8401.00
214_T229_D3.8051.00
162_V435_G3.6691.00
402_Y405_P3.4991.00
358_L415_V3.2601.00
111_S114_E3.1911.00
45_L50_L3.1521.00
405_P409_Q3.0821.00
227_A243_T3.0311.00
49_G57_W2.9791.00
230_V244_I2.9221.00
302_F363_L2.9151.00
211_D241_E2.8871.00
119_A456_V2.7851.00
251_R256_R2.7421.00
430_P434_L2.7401.00
105_E461_V2.6851.00
117_A132_R2.6761.00
166_G431_W2.5851.00
405_P408_L2.5811.00
227_A245_R2.5191.00
33_Q37_D2.5111.00
89_R131_R2.5111.00
229_D243_T2.4821.00
313_F317_V2.4621.00
302_F329_R2.4601.00
234_D253_G2.3791.00
208_V257_V2.3591.00
22_P25_S2.2941.00
218_Y224_K2.2761.00
15_A59_F2.2671.00
212_D229_D2.1581.00
210_L419_S2.1451.00
209_R231_T2.1441.00
225_D245_R2.1321.00
50_L53_V2.1301.00
303_T414_D2.1051.00
186_T209_R2.1031.00
44_V47_R2.0881.00
231_T241_E2.0781.00
74_I161_V2.0271.00
402_Y406_V2.0191.00
130_V141_V2.0071.00
52_D55_S1.9901.00
110_A115_A1.9801.00
132_R141_V1.9781.00
67_F164_L1.9551.00
390_F393_G1.9461.00
373_G377_G1.9431.00
79_P83_R1.9421.00
110_A118_R1.9401.00
40_F44_V1.9251.00
410_L413_F1.8871.00
244_I421_L1.8561.00
114_E117_A1.8401.00
229_D241_E1.8381.00
159_A438_L1.8371.00
112_P460_T1.8341.00
209_R233_T1.8321.00
14_A58_W1.7981.00
166_G432_V1.7961.00
260_S420_G1.7771.00
166_G435_G1.7751.00
404_A407_L1.7551.00
183_E210_L1.7501.00
242_A248_H1.7401.00
403_G406_V1.7341.00
81_H151_L1.6821.00
113_E117_A1.6771.00
402_Y407_L1.6721.00
44_V48_L1.6651.00
30_Y33_Q1.6531.00
24_R46_D1.6481.00
117_A121_A1.6471.00
392_Q395_L1.6351.00
301_V316_P1.6301.00
49_G56_S1.6221.00
181_V421_L1.6191.00
74_I158_L1.6161.00
214_T227_A1.6151.00
98_R105_E1.5871.00
107_T461_V1.5801.00
404_A409_Q1.5751.00
475_F479_F1.5731.00
155_V445_L1.5551.00
105_E463_E1.5531.00
403_G407_L1.5511.00
219_P359_N1.5501.00
324_T342_T1.5461.00
4_A73_C1.5251.00
78_T82_W1.5241.00
100_L465_A1.5241.00
116_L120_R1.4971.00
342_T355_F1.4851.00
17_P50_L1.4731.00
210_L228_S1.4721.00
93_A140_S1.4681.00
35_F46_D1.4621.00
213_F419_S1.4621.00
183_E416_V1.4591.00
230_V242_A1.4481.00
228_S259_Q1.4381.00
261_G420_G1.4351.00
116_L458_V1.4331.00
57_W61_A1.4331.00
45_L51_F1.4271.00
123_L143_A1.4211.00
82_W85_L1.4201.00
208_V421_L1.4191.00
406_V409_Q1.4151.00
78_T158_L1.4111.00
14_A62_I1.4081.00
300_P307_P1.4041.00
134_E137_G1.3951.00
43_P47_R1.3831.00
402_Y409_Q1.3751.00
297_G300_P1.3701.00
303_T314_M1.3621.00
232_V240_R1.3491.00
115_A460_T1.3471.00
110_A114_E1.3471.00
122_L126_R1.3371.00
233_T237_G1.3341.00
437_L441_L1.3331.00
181_V187_F1.3331.00
390_F395_L1.3321.00
244_I250_L1.3241.00
452_R478_E1.3171.00
230_V250_L1.3131.00
306_D310_E1.3111.00
393_G396_N1.3101.00
466_G475_F1.3101.00
34_Y45_L1.3081.00
340_L343_A1.2931.00
298_Y302_F1.2721.00
166_G428_G1.2621.00
97_L465_A1.2611.00
343_A362_A1.2581.00
24_R52_D1.2541.00
39_P43_P1.2531.00
212_D417_Q1.2511.00
444_F448_Y1.2461.00
25_S29_N1.2381.00
34_Y42_A1.2260.99
179_V187_F1.2260.99
11_L66_L1.2260.99
391_E394_A1.2180.99
313_F316_P1.2140.99
232_V252_Y1.2130.99
404_A408_L1.2120.99
232_V250_L1.2110.99
46_D51_F1.2050.99
57_W60_S1.1980.99
390_F394_A1.1970.99
1_M8_L1.1920.99
401_N405_P1.1850.99
254_G425_R1.1820.99
262_F323_F1.1800.99
257_V423_V1.1750.99
41_L45_L1.1630.99
74_I78_T1.1600.99
116_L132_R1.1540.99
375_D378_R1.1510.99
392_Q396_N1.1470.99
208_V232_V1.1460.99
132_R139_T1.1430.99
300_P304_V1.1430.99
170_G426_D1.1400.99
71_I161_V1.1270.99
215_A417_Q1.1250.99
394_A398_L1.1190.99
218_Y222_Q1.1190.99
26_P29_N1.1150.99
459_T463_E1.1140.99
30_Y38_G1.1120.99
301_V416_V1.1060.99
232_V242_A1.0950.99
54_Y435_G1.0910.99
346_D350_G1.0880.99
35_F39_P1.0860.99
355_F359_N1.0770.99
5_L9_L1.0760.99
30_Y37_D1.0730.99
121_A125_R1.0670.99
259_Q419_S1.0630.98
81_H154_L1.0630.98
339_F342_T1.0620.98
216_E225_D1.0620.98
120_R141_V1.0610.98
152_G442_G1.0580.98
216_E224_K1.0560.98
223_P226_F1.0550.98
230_V421_L1.0540.98
319_Q323_F1.0520.98
82_W86_R1.0510.98
445_L449_V1.0500.98
214_T243_T1.0470.98
305_R311_V1.0470.98
242_A250_L1.0470.98
340_L351_F1.0460.98
312_V315_G1.0450.98
314_M317_V1.0390.98
236_G253_G1.0370.98
32_A36_A1.0340.98
27_D30_Y1.0320.98
401_N407_L1.0310.98
389_R392_Q1.0280.98
234_D237_G1.0280.98
67_F160_L1.0270.98
400_F403_G1.0240.98
175_F255_V1.0240.98
97_L103_H1.0210.98
373_G376_S1.0200.98
126_R478_E1.0110.98
435_G438_L1.0070.98
210_L421_L1.0070.98
135_D138_G1.0070.98
403_G408_L1.0010.98
301_V312_V1.0000.98
31_V34_Y0.9920.98
102_H476_E0.9910.98
56_S60_S0.9900.98
233_T239_V0.9870.98
403_G409_Q0.9830.97
21_L41_L0.9820.97
346_D352_L0.9800.97
60_S64_L0.9790.97
103_H463_E0.9780.97
401_N404_A0.9780.97
401_N406_V0.9730.97
53_V58_W0.9710.97
85_L151_L0.9710.97
207_S233_T0.9700.97
458_V462_V0.9690.97
144_E147_Y0.9660.97
399_L402_Y0.9650.97
71_I75_L0.9590.97
116_L139_T0.9560.97
81_H85_L0.9550.97
42_A46_D0.9550.97
42_A50_L0.9490.97
74_I154_L0.9480.97
26_P30_Y0.9470.97
98_R463_E0.9430.97
159_A439_L0.9420.97
381_S385_L0.9400.97
211_D229_D0.9380.97
79_P82_W0.9380.97
81_H84_A0.9330.97
174_G428_G0.9330.97
40_F43_P0.9310.96
204_L253_G0.9310.96
368_Y372_L0.9280.96
112_P458_V0.9280.96
118_R122_L0.9220.96
7_L66_L0.9210.96
306_D309_G0.9170.96
3_T69_S0.9160.96
66_L69_S0.9150.96
381_S384_S0.9150.96
456_V464_V0.9140.96
361_P365_L0.9010.96
346_D351_F0.8980.96
234_D252_Y0.8970.96
181_V186_T0.8930.96
117_A120_R0.8890.95
389_R395_L0.8890.95
441_L445_L0.8850.95
186_T207_S0.8840.95
332_Q335_F0.8830.95
213_F262_F0.8780.95
114_E118_R0.8750.95
351_F364_A0.8700.95
134_E139_T0.8700.95
374_L378_R0.8680.95
344_A354_L0.8660.95
30_Y34_Y0.8650.95
29_N32_A0.8650.95
471_D474_G0.8640.95
262_F417_Q0.8640.95
182_V299_A0.8620.95
307_P312_V0.8620.95
339_F415_V0.8590.94
433_L437_L0.8580.94
389_R393_G0.8560.94
433_L436_A0.8530.94
133_R140_S0.8520.94
119_A458_V0.8490.94
169_L173_F0.8450.94
191_L195_F0.8450.94
88_A142_A0.8410.94
348_V352_L0.8410.94
297_G302_F0.8410.94
120_R130_V0.8400.94
319_Q326_S0.8380.94
380_Q384_S0.8360.94
357_A417_Q0.8340.94
154_L158_L0.8340.94
166_G174_G0.8290.93
431_W434_L0.8280.93
4_A70_L0.8270.93
377_G381_S0.8270.93
21_L45_L0.8260.93
21_L50_L0.8250.93
29_N33_Q0.8240.93
108_V460_T0.8220.93
14_A53_V0.8210.93
325_S329_R0.8200.93
156_F443_L0.8180.93
70_L73_C0.8180.93
345_L351_F0.8180.93
240_R252_Y0.8170.93
176_R422_Q0.8140.93
355_F362_A0.8140.93
162_V438_L0.8140.93
115_A462_V0.8120.93
182_V185_E0.8100.93
163_I435_G0.8080.92
336_R387_T0.8070.92
58_W62_I0.8070.92
434_L438_L0.8060.92
299_A302_F0.8040.92
323_F327_G0.8040.92
3_T7_L0.8030.92
13_L17_P0.8000.92
339_F343_A0.7980.92
120_R124_R0.7970.92
144_E451_R0.7960.92
180_I420_G0.7940.92
24_R35_F0.7940.92
217_Y417_Q0.7940.92
208_V419_S0.7920.92
353_S361_P0.7910.92
30_Y35_F0.7840.91
464_V479_F0.7810.91
234_D240_R0.7800.91
376_S380_Q0.7790.91
234_D238_E0.7770.91
134_E138_G0.7730.91
457_R463_E0.7710.91
374_L377_G0.7700.91
254_G427_P0.7700.91
38_G43_P0.7700.91
179_V182_V0.7680.90
391_E395_L0.7670.90
338_L343_A0.7650.90
325_S328_V0.7630.90
391_E398_L0.7610.90
318_P322_N0.7590.90
378_R383_Y0.7590.90
108_V458_V0.7590.90
165_V169_L0.7580.90
374_L381_S0.7580.90
28_P31_V0.7580.90
232_V248_H0.7580.90
178_N422_Q0.7570.90
73_C250_L0.7550.90
94_P459_T0.7530.90
419_S448_Y0.7520.90
333_L337_G0.7520.90
128_Y478_E0.7510.89
238_E241_E0.7500.89
166_G224_K0.7500.89
191_L203_G0.7480.89
465_A475_F0.7480.89
366_E369_R0.7460.89
379_P382_V0.7450.89
67_F161_V0.7440.89
188_S207_S0.7440.89
116_L456_V0.7430.89
47_R320_D0.7430.89
260_S422_Q0.7410.89
344_A352_L0.7390.89
117_A124_R0.7360.88
12_A16_I0.7350.88
119_A141_V0.7330.88
402_Y408_L0.7320.88
102_H479_F0.7310.88
136_D139_T0.7290.88
169_L431_W0.7290.88
139_T458_V0.7250.88
349_G352_L0.7250.88
450_R472_D0.7230.88
213_F226_F0.7180.87
115_A458_V0.7150.87
426_D468_A0.7150.87
108_V114_E0.7140.87
35_F38_G0.7140.87
109_A112_P0.7120.87
174_G426_D0.7120.87
119_A122_L0.7100.87
324_T327_G0.7090.87
330_K333_L0.7080.86
54_Y152_G0.7070.86
473_A477_R0.7050.86
344_A360_N0.7040.86
106_W462_V0.7020.86
75_L79_P0.7000.86
63_Y167_G0.6980.86
473_A476_E0.6970.86
258_Y424_S0.6950.85
155_V438_L0.6920.85
170_G436_A0.6920.85
70_L74_I0.6910.85
25_S30_Y0.6910.85
451_R469_R0.6910.85
160_L164_L0.6880.85
342_T354_L0.6840.85
150_E153_N0.6830.84
389_R394_A0.6760.84
359_N362_A0.6750.84
304_V308_D0.6740.84
41_L44_V0.6740.84
146_G449_V0.6710.83
181_V210_L0.6710.83
302_F313_F0.6690.83
388_S391_E0.6680.83
123_L456_V0.6640.83
320_D324_T0.6640.83
183_E417_Q0.6620.83
43_P46_D0.6610.83
166_G176_R0.6600.82
15_A54_Y0.6600.82
183_E212_D0.6600.82
257_V421_L0.6590.82
100_L103_H0.6580.82
335_F340_L0.6570.82
34_Y426_D0.6560.82
431_W436_A0.6560.82
1_M76_P0.6540.82
387_T390_F0.6520.82
118_R121_A0.6490.81
428_G432_V0.6480.81
118_R124_R0.6460.81
31_V35_F0.6460.81
4_A72_G0.6450.81
54_Y222_Q0.6410.81
122_L125_R0.6400.80
345_L350_G0.6380.80
34_Y38_G0.6330.80
158_L161_V0.6330.80
145_K454_V0.6320.80
70_L76_P0.6320.80
182_V416_V0.6310.80
329_R335_F0.6310.80
208_V230_V0.6310.80
206_F255_V0.6300.79
178_N260_S0.6290.79
162_V166_G0.6290.79
174_G444_F0.6250.79
297_G305_R0.6230.79
6_V9_L0.6230.79
217_Y223_P0.6210.78
98_R121_A0.6210.78
99_R103_H0.6200.78
7_L10_L0.6200.78
146_G152_G0.6190.78
49_G52_D0.6190.78
87_S90_P0.6170.78
175_F420_G0.6170.78
236_G239_V0.6160.78
366_E370_G0.6150.78
126_R145_K0.6140.78
100_L467_L0.6130.78
158_L162_V0.6120.77
230_V419_S0.6120.77
371_D374_L0.6110.77
309_G312_V0.6100.77
96_R100_L0.6090.77
350_G355_F0.6090.77
426_D432_V0.6070.77
113_E132_R0.6060.77
171_G176_R0.6050.77
367_A370_G0.6030.76
393_G398_L0.6020.76
163_I436_A0.6020.76
166_G169_L0.5990.76
366_E394_A0.5980.76
91_P443_L0.5980.76
213_F246_V0.5970.76
432_V436_A0.5970.76
5_L66_L0.5960.76
131_R142_A0.5950.75
436_A440_L0.5940.75
315_G329_R0.5940.75
8_L153_N0.5940.75
76_P150_E0.5930.75
322_N346_D0.5920.75
35_F41_L0.5910.75
301_V304_V0.5910.75
59_F66_L0.5910.75
34_Y41_L0.5890.75
106_W115_A0.5890.75
372_L376_S0.5890.75
84_A151_L0.5880.75
399_L405_P0.5860.74
1_M4_A0.5860.74
332_Q373_G0.5860.74
228_S419_S0.5850.74
301_V314_M0.5840.74
70_L91_P0.5840.74
37_D105_E0.5830.74
116_L130_V0.5830.74
21_L24_R0.5830.74
18_G23_Q0.5830.74
357_A363_L0.5820.74
128_Y452_R0.5810.74
220_T355_F0.5810.74
210_L230_V0.5810.74
115_A119_A0.5800.74
343_A351_F0.5800.74
298_Y304_V0.5800.74
426_D436_A0.5800.74
301_V414_D0.5790.73
431_W435_G0.5770.73
123_L127_G0.5770.73
133_R136_D0.5760.73
304_V309_G0.5760.73
435_G442_G0.5760.73
370_G373_G0.5750.73
206_F446_S0.5740.73
353_S356_P0.5730.73
340_L344_A0.5730.73
15_A19_T0.5720.73
355_F466_G0.5720.73
42_A51_F0.5720.73
140_S456_V0.5720.73
255_V425_R0.5710.72
448_Y455_W0.5710.72
63_Y72_G0.5710.72
307_P310_E0.5700.72
167_G171_G0.5700.72
108_V111_S0.5690.72
147_Y150_E0.5690.72
179_V208_V0.5690.72
20_L143_A0.5680.72
470_R476_E0.5680.72
312_V317_V0.5670.72
177_G192_L0.5670.72
144_E453_R0.5670.72
31_V39_P0.5650.72
298_Y305_R0.5650.72
235_G239_V0.5650.72
382_V386_D0.5640.72
475_F478_E0.5640.72
116_L119_A0.5640.72
217_Y323_F0.5630.71
112_P115_A0.5630.71
335_F367_A0.5610.71
232_V244_I0.5610.71
156_F167_G0.5610.71
434_L437_L0.5610.71
111_S231_T0.5600.71
106_W459_T0.5600.71
159_A194_S0.5590.71
66_L73_C0.5590.71
369_R393_G0.5580.71
472_D475_F0.5580.71
73_C213_F0.5570.71
354_L362_A0.5570.71
150_E451_R0.5570.71
93_A96_R0.5570.71
333_L336_R0.5560.70
223_P262_F0.5560.70
474_G477_R0.5550.70
347_G412_D0.5540.70
1_M69_S0.5540.70
399_L404_A0.5540.70
353_S363_L0.5540.70
198_G201_V0.5520.70
236_G240_R0.5520.70
407_L411_P0.5510.70
369_R372_L0.5500.70
145_K470_R0.5500.70
22_P150_E0.5500.70
327_G330_K0.5490.70
435_G470_R0.5490.70
141_V458_V0.5480.69
215_A226_F0.5480.69
388_S392_Q0.5470.69
8_L146_G0.5450.69
11_L62_I0.5440.69
170_G429_Q0.5430.69
35_F50_L0.5420.69
90_P131_R0.5420.69
344_A348_V0.5410.68
173_F427_P0.5400.68
358_L361_P0.5400.68
79_P142_A0.5400.68
400_F408_L0.5380.68
369_R411_P0.5370.68
21_L42_A0.5360.68
68_V78_T0.5360.68
433_L447_L0.5360.68
246_V259_Q0.5350.68
215_A262_F0.5350.68
231_T239_V0.5350.68
56_S61_A0.5350.68
350_G362_A0.5340.67
92_R128_Y0.5330.67
151_L155_V0.5330.67
12_A163_I0.5310.67
10_L34_Y0.5300.67
123_L454_V0.5300.67
428_G431_W0.5300.67
1_M154_L0.5300.67
373_G378_R0.5290.67
370_G374_L0.5290.67
155_V159_A0.5280.67
319_Q322_N0.5280.67
331_P374_L0.5280.67
360_N365_L0.5280.67
75_L78_T0.5270.66
14_A123_L0.5250.66
158_L447_L0.5250.66
233_T241_E0.5240.66
420_G423_V0.5220.66
341_P345_L0.5220.66
10_L14_A0.5220.66
24_R38_G0.5210.66
175_F425_R0.5210.66
24_R45_L0.5200.65
349_G360_N0.5200.65
76_P154_L0.5200.65
67_F71_I0.5200.65
181_V223_P0.5190.65
113_E120_R0.5190.65
91_P140_S0.5190.65
223_P417_Q0.5180.65
159_A428_G0.5170.65
209_R239_V0.5160.65
82_W151_L0.5160.65
167_G170_G0.5160.65
366_E397_A0.5150.65
218_Y223_P0.5150.65
216_E227_A0.5140.65
347_G351_F0.5140.65
299_A312_V0.5120.64
468_A475_F0.5100.64
364_A367_A0.5090.64
383_Y386_D0.5090.64
323_F326_S0.5090.64
31_V38_G0.5090.64
38_G71_I0.5080.64
158_L438_L0.5080.64
428_G439_L0.5080.64
1_M72_G0.5070.63
109_A236_G0.5070.63
104_A245_R0.5060.63
474_G478_E0.5060.63
400_F404_A0.5060.63
39_P130_V0.5050.63
25_S34_Y0.5050.63
470_R475_F0.5050.63
86_R347_G0.5050.63
466_G472_D0.5050.63
148_L151_L0.5040.63
261_G418_W0.5040.63
355_F358_L0.5030.63
423_V458_V0.5030.63
104_A479_F0.5020.63
154_L226_F0.5020.63
392_Q398_L0.5020.63
63_Y298_Y0.5010.63
93_A232_V0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2akhX 1 0.1583 33.6 0.971 Contact Map
4wfeA 2 0.1688 29.7 0.972 Contact Map
3dl8E 1 0.1333 27.1 0.972 Contact Map
3dinE 1 0.1292 19.5 0.974 Contact Map
4ltoA 3 0.2458 19.4 0.974 Contact Map
2zy9A 2 0.1292 18.4 0.975 Contact Map
4twkA 2 0.1812 16.5 0.975 Contact Map
4h33A 3 0.1729 12.6 0.976 Contact Map
3vouA 4 0.2271 12.3 0.976 Contact Map
1jqkA 3 0.2208 11.6 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0121 seconds.