GREMLIN Database
DUF697 - Domain of unknown function (DUF697)
PFAM: PF05128 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 162 (153)
Sequences: 7272 (4712)
Seq/√Len: 380.9
META: 0.831

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_S103_G3.8641.00
25_I64_L3.6871.00
26_I132_I3.2321.00
99_K102_L3.2231.00
99_K103_G3.0581.00
56_R60_R2.8111.00
54_Q124_T2.5771.00
19_D136_R2.5341.00
23_R132_I2.3331.00
21_E24_R2.1131.00
25_I60_R2.0491.00
105_P108_G2.0421.00
26_I128_G1.8121.00
96_S99_K1.7741.00
22_A61_L1.7671.00
97_L100_S1.7261.00
61_L64_L1.6701.00
56_R59_R1.6221.00
22_A64_L1.6051.00
59_R63_K1.6031.00
23_R129_K1.5561.00
35_G121_G1.5141.00
50_V120_A1.5091.00
99_K104_G1.5051.00
92_E95_D1.5031.00
29_Y60_R1.4891.00
48_L52_A1.4701.00
129_K132_I1.4641.00
58_I131_A1.4551.00
98_L102_L1.4411.00
152_V156_I1.4391.00
102_L105_P1.4281.00
18_R64_L1.4191.00
61_L135_F1.3921.00
118_V121_G1.3921.00
145_G148_K1.3561.00
33_V37_T1.3521.00
133_E137_P1.3391.00
94_G97_L1.3191.00
114_L117_G1.3171.00
132_I136_R1.3171.00
106_L109_T1.3141.00
91_V94_G1.2931.00
131_A135_F1.2771.00
29_Y56_R1.2701.00
75_K79_R1.2681.00
37_T120_A1.2641.00
70_S73_G1.2611.00
65_Y136_R1.2571.00
84_H88_T1.2551.00
100_S104_G1.2471.00
24_R28_R1.2421.00
40_S45_L1.2361.00
25_I57_M1.2191.00
31_R35_G1.2191.00
115_G118_V1.2051.00
85_L89_G1.1911.00
62_A135_F1.1891.00
110_L113_R1.1701.00
88_T91_V1.1701.00
23_R27_R1.1451.00
17_P20_A1.1391.00
105_P109_T1.1371.00
89_G92_E1.1181.00
153_V156_I1.0901.00
26_I57_M1.0861.00
28_R32_R1.0751.00
27_R31_R1.0701.00
29_Y53_V1.0681.00
91_V95_D1.0671.00
83_G87_A1.0641.00
113_R117_G1.0641.00
117_G120_A1.0521.00
22_A26_I1.0461.00
21_E25_I1.0211.00
22_A65_Y1.0121.00
19_D132_I1.0061.00
28_R60_R0.9891.00
37_T53_V0.9871.00
13_E16_A0.9851.00
31_R34_A0.9681.00
116_Q120_A0.9681.00
25_I61_L0.9621.00
153_V157_L0.9541.00
134_Y139_P0.9521.00
155_E158_E0.9481.00
10_A14_L0.9391.00
55_L59_R0.9371.00
27_R125_Y0.9351.00
150_K154_K0.9321.00
152_V155_E0.9301.00
109_T113_R0.9291.00
37_T49_A0.9281.00
125_Y129_K0.9211.00
44_L47_L0.9201.00
141_F145_G0.9201.00
15_L18_R0.9181.00
95_D99_K0.9111.00
49_A52_A0.9091.00
49_A53_V0.9091.00
20_A24_R0.9081.00
25_I29_Y0.9021.00
142_G145_G0.8991.00
116_Q119_V0.8901.00
154_K158_E0.8841.00
146_P152_V0.8821.00
105_P112_G0.8791.00
89_G93_L0.8771.00
73_G77_L0.8751.00
44_L48_L0.8691.00
48_L51_L0.8571.00
11_E15_L0.8551.00
13_E17_P0.8501.00
109_T112_G0.8501.00
62_A69_P0.8481.00
40_S49_A0.8461.00
122_A126_R0.8381.00
111_S115_G0.8381.00
29_Y33_V0.8361.00
42_I45_L0.8321.00
9_L13_E0.8281.00
93_L97_L0.8231.00
12_R15_L0.8231.00
16_A20_A0.8181.00
20_A23_R0.8141.00
93_L96_S0.8131.00
65_Y132_I0.8011.00
62_A131_A0.7941.00
114_L118_V0.7931.00
32_R53_V0.7921.00
149_L153_V0.7921.00
134_Y138_G0.7901.00
19_D23_R0.7851.00
72_L75_K0.7821.00
133_E146_P0.7771.00
27_R30_A0.7751.00
38_A41_P0.7661.00
30_A121_G0.7641.00
24_R27_R0.7591.00
151_E154_K0.7581.00
12_R16_A0.7581.00
16_A19_D0.7571.00
154_K157_L0.7561.00
101_L104_G0.7541.00
148_K151_E0.7541.00
18_R22_A0.7421.00
23_R26_I0.7391.00
138_G141_F0.7371.00
133_E136_R0.7371.00
97_L101_L0.7321.00
71_L75_K0.7291.00
90_A94_G0.7271.00
110_L114_L0.7271.00
95_D98_L0.7161.00
7_L11_E0.7151.00
58_I78_L0.7121.00
107_A111_S0.7111.00
119_V123_L0.7101.00
147_P150_K0.7101.00
58_I127_V0.7081.00
82_L85_L0.7041.00
73_G76_R0.7031.00
26_I61_L0.6940.99
115_G119_V0.6920.99
135_F138_G0.6910.99
151_E155_E0.6880.99
149_L152_V0.6880.99
30_A128_G0.6840.99
112_G115_G0.6770.99
149_L156_I0.6660.99
150_K153_V0.6640.99
97_L102_L0.6600.99
22_A132_I0.6540.99
90_A93_L0.6530.99
130_A134_Y0.6520.99
148_K152_V0.6490.99
107_A110_L0.6490.99
60_R63_K0.6340.99
150_K157_L0.6310.99
87_A91_V0.6280.99
86_A90_A0.6270.99
141_F144_F0.6260.99
108_G112_G0.6260.99
19_D22_A0.6230.99
6_L9_L0.6220.99
146_P154_K0.6140.99
84_H87_A0.6120.99
19_D65_Y0.6120.99
88_T92_E0.6080.99
33_V36_A0.6050.99
34_A121_G0.6000.98
15_L19_D0.6000.98
147_P151_E0.5990.98
57_M124_T0.5980.98
68_R71_L0.5960.98
34_A41_P0.5940.98
146_P149_L0.5870.98
62_A65_Y0.5850.98
52_A56_R0.5820.98
53_V56_R0.5800.98
59_R74_A0.5780.98
144_F147_P0.5770.98
33_V50_V0.5740.98
29_Y32_R0.5720.98
86_A89_G0.5710.98
103_G106_L0.5660.98
131_A134_Y0.5630.98
14_L18_R0.5620.98
107_A115_G0.5590.98
29_Y59_R0.5490.97
129_K133_E0.5470.97
8_E13_E0.5460.97
97_L103_G0.5460.97
144_F151_E0.5450.97
39_L117_G0.5420.97
79_R83_G0.5410.97
32_R35_G0.5360.97
83_G86_A0.5360.97
22_A128_G0.5310.97
96_S102_L0.5290.97
133_E155_E0.5230.96
148_K154_K0.5220.96
18_R136_R0.5210.96
147_P152_V0.5190.96
62_A66_G0.5180.96
67_V135_F0.5150.96
137_P152_V0.5100.96
131_A156_I0.5070.96
17_P21_E0.5060.96
142_G148_K0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lv5B 1 0.8765 46.2 0.885 Contact Map
4x9kA 2 0.9444 4.3 0.93 Contact Map
2okuA 2 0.3272 4.1 0.93 Contact Map
3iylA 11 0.8889 3.2 0.934 Contact Map
1o5hA 2 0.4383 2.9 0.935 Contact Map
3iykA 3 0.3642 2.9 0.935 Contact Map
4gipD 3 0.3395 2.8 0.936 Contact Map
3v7iA 2 0.7346 2.6 0.937 Contact Map
4ix1A 2 0.4568 2.5 0.937 Contact Map
3j7yb 1 0.3395 2.4 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0062 seconds.