GREMLIN Database
GvpK - Gas vesicle protein K
PFAM: PF05121 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 85 (83)
Sequences: 4028 (1572)
Seq/√Len: 172.6
META: 0.911

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_K71_P4.8521.00
77_D83_R3.2081.00
45_E48_R2.9801.00
59_R62_E2.9021.00
61_E64_K2.8881.00
51_L55_R2.8501.00
42_T45_E2.4331.00
61_E71_P1.9431.00
44_E48_R1.8571.00
55_R58_E1.8571.00
22_E25_R1.8521.00
27_L30_R1.7661.00
12_G15_Q1.7631.00
14_A67_F1.6021.00
5_D8_D1.5671.00
14_A66_R1.5211.00
8_D12_G1.3991.00
60_M64_K1.3861.00
22_E56_L1.3721.00
33_I36_M1.3501.00
21_V60_M1.3461.00
41_L46_I1.3161.00
25_R56_L1.3031.00
62_E66_R1.2941.00
52_A59_R1.2391.00
47_E51_L1.2021.00
43_D46_I1.1901.00
10_E14_A1.1741.00
36_M46_I1.1611.00
36_M53_L1.1441.00
55_R59_R1.1341.00
54_M57_E1.1301.00
26_Q30_R1.1241.00
17_V20_L1.1121.00
20_L23_L1.1031.00
9_V52_A1.0751.00
53_L56_L1.0721.00
14_A21_V1.0701.00
28_M53_L1.0551.00
59_R66_R1.0531.00
28_M38_G1.0360.99
15_Q19_T1.0100.99
35_R45_E0.9800.99
57_E61_E0.9750.99
39_G43_D0.9740.99
22_E26_Q0.9590.99
77_D82_G0.9260.99
4_A8_D0.9150.99
69_L73_D0.9070.99
23_L75_N0.9030.98
65_E70_T0.9010.98
20_L24_L0.8750.98
33_I37_E0.8730.98
6_P9_V0.8680.98
79_G82_G0.8660.98
40_T53_L0.8640.98
32_A49_L0.8330.97
49_L53_L0.8320.97
19_T23_L0.8210.97
32_A50_G0.8120.97
75_N79_G0.7900.96
75_N82_G0.7880.96
10_E59_R0.7670.96
76_L79_G0.7460.95
22_E53_L0.7440.95
61_E65_E0.7420.95
25_R53_L0.7390.95
2_I12_G0.7330.95
29_E34_R0.7240.94
39_G42_T0.7210.94
77_D80_P0.7120.94
26_Q75_N0.6930.93
38_G46_I0.6930.93
25_R60_M0.6920.93
18_L25_R0.6860.93
28_M32_A0.6820.92
13_L21_V0.6810.92
54_M66_R0.6800.92
2_I13_L0.6780.92
4_A12_G0.6760.92
26_Q57_E0.6730.92
12_G28_M0.6730.92
38_G83_R0.6700.92
7_E11_R0.6590.91
31_Q52_A0.6560.91
30_R59_R0.6520.91
8_D11_R0.6280.89
57_E71_P0.6280.89
75_N84_L0.6280.89
6_P55_R0.6210.88
45_E49_L0.6190.88
13_L60_M0.5820.85
43_D61_E0.5770.84
48_R68_G0.5740.84
76_L80_P0.5720.84
48_R51_L0.5720.84
14_A20_L0.5670.83
11_R68_G0.5660.83
66_R70_T0.5600.83
64_K69_L0.5540.82
58_E61_E0.5530.82
4_A19_T0.5510.82
22_E60_M0.5500.81
25_R31_Q0.5440.81
51_L54_M0.5410.80
48_R70_T0.5400.80
63_L70_T0.5370.80
30_R34_R0.5320.79
2_I10_E0.5320.79
37_E40_T0.5310.79
10_E21_V0.5300.79
16_L19_T0.5260.78
5_D9_V0.5260.78
39_G44_E0.5250.78
19_T75_N0.5200.78
18_L21_V0.5200.78
15_Q74_L0.5190.78
77_D81_L0.5170.77
38_G49_L0.5160.77
19_T64_K0.5100.76
39_G63_L0.5080.76
6_P48_R0.5020.75
63_L66_R0.5000.75
3_N8_D0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gofA 2 0.6118 32.2 0.885 Contact Map
4asvA 2 0.7294 31.6 0.885 Contact Map
4cpgA 2 0.7059 30.1 0.887 Contact Map
3zdmA 4 0.7176 24.7 0.891 Contact Map
2l0kA 1 0.5647 14.1 0.903 Contact Map
3lsgA 2 0.8706 12.8 0.905 Contact Map
3mn2A 1 0.9176 11.5 0.907 Contact Map
3oouA 1 0.9059 10.6 0.908 Contact Map
4qu2A 2 0.5529 8.1 0.913 Contact Map
3qx3A 2 0.9647 7.9 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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