GREMLIN Database
GvpG - Gas vesicle protein G
PFAM: PF05120 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 79 (72)
Sequences: 5402 (2803)
Seq/√Len: 330.3
META: 0.915

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_R48_E2.9171.00
40_L57_R2.7441.00
50_S53_E2.7411.00
18_K21_E2.5701.00
20_A24_E2.4021.00
44_L54_F2.3751.00
22_A25_R2.2061.00
44_L51_E1.9861.00
57_R60_E1.9631.00
42_M46_L1.9511.00
33_I61_L1.9411.00
39_E43_R1.7691.00
4_L7_A1.7661.00
40_L54_F1.7321.00
12_V16_A1.6521.00
36_E57_R1.5311.00
41_Q45_E1.4551.00
43_R57_R1.4491.00
51_E55_A1.4451.00
30_E72_R1.4151.00
36_E39_E1.4001.00
33_I65_L1.3641.00
22_A26_E1.3591.00
13_R17_E1.2921.00
41_Q54_F1.2691.00
24_E28_Y1.2191.00
2_L5_P1.1801.00
3_T6_L1.1201.00
35_E39_E1.1121.00
10_R13_R1.1111.00
17_E21_E1.0871.00
16_A20_A1.0011.00
40_L49_I0.9991.00
37_L58_E0.9901.00
42_M45_E0.9811.00
68_I71_R0.9681.00
30_E68_I0.9601.00
30_E34_R0.9491.00
3_T10_R0.9471.00
17_E20_A0.9371.00
29_D32_A0.9301.00
28_Y68_I0.9281.00
20_A23_A0.9231.00
62_L66_R0.9221.00
13_R16_A0.9051.00
32_A36_E0.9001.00
2_L6_L0.8851.00
36_E64_R0.8831.00
21_E25_R0.8751.00
56_E60_E0.8731.00
3_T7_A0.8731.00
59_A63_A0.8701.00
6_L10_R0.8141.00
2_L7_A0.7791.00
63_A67_E0.7731.00
14_W18_K0.7711.00
11_G14_W0.7410.99
12_V15_V0.7410.99
67_E71_R0.7400.99
38_L41_Q0.7380.99
34_R38_L0.7180.99
39_E46_L0.7120.99
9_V16_A0.7080.99
30_E69_R0.7000.99
7_A11_G0.6910.99
18_K22_A0.6860.99
28_Y71_R0.6780.99
44_L58_E0.6670.99
15_V19_I0.6600.99
53_E56_E0.6580.99
28_Y67_E0.6440.98
28_Y33_I0.6430.98
63_A66_R0.6390.98
31_A35_E0.6380.98
7_A14_W0.6290.98
33_I64_R0.6160.98
69_R73_E0.6160.98
54_F58_E0.6130.98
65_L69_R0.6100.98
41_Q58_E0.6070.98
5_P10_R0.6070.98
32_A35_E0.6030.98
11_G15_V0.5980.97
54_F66_R0.5970.97
14_W17_E0.5960.97
70_E73_E0.5930.97
44_L66_R0.5900.97
68_I72_R0.5890.97
66_R70_E0.5860.97
49_I53_E0.5840.97
49_I57_R0.5830.97
44_L49_I0.5830.97
23_A26_E0.5770.97
40_L61_L0.5600.96
58_E62_L0.5570.96
39_E42_M0.5540.96
53_E57_R0.5490.96
36_E61_L0.5480.96
54_F62_L0.5450.96
35_E38_L0.5400.95
31_A34_R0.5380.95
29_D64_R0.5370.95
43_R46_L0.5340.95
60_E64_R0.5340.95
33_I68_I0.5300.95
64_R67_E0.5170.94
26_E29_D0.5170.94
19_I24_E0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wsbB 1 0.6203 72.1 0.786 Contact Map
4wrtB 1 0.5949 54.6 0.809 Contact Map
4kisA 2 1 31.9 0.834 Contact Map
3a1gA 1 0.7342 14.1 0.859 Contact Map
3sgiA 1 0.6962 7.8 0.875 Contact Map
4glxA 1 0.6456 7.5 0.875 Contact Map
4glwA 2 0.3797 6.4 0.879 Contact Map
4kqtA 1 1 6.1 0.88 Contact Map
4lh6A 1 0.7468 6.1 0.881 Contact Map
3jslA 2 0.6582 5.8 0.882 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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