GREMLIN Database
DUF695 - Family of unknown function (DUF695)
PFAM: PF05117 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 134 (129)
Sequences: 4102 (3432)
Seq/√Len: 302.2
META: 0.917

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_T88_R3.4701.00
13_K85_N2.6611.00
52_S55_E2.6181.00
18_R81_R2.5691.00
67_E92_F2.5131.00
34_W97_P2.3991.00
56_A60_N2.2911.00
36_L94_T2.2851.00
78_L81_R2.2751.00
42_Y51_P2.1751.00
39_T89_E2.1151.00
60_N64_D2.1061.00
39_T87_R2.0781.00
34_W122_E2.0211.00
32_Y77_L2.0181.00
76_A94_T1.9951.00
35_L91_Y1.9401.00
23_L79_V1.9101.00
65_A111_F1.6691.00
101_E105_N1.6521.00
35_L121_E1.5741.00
65_A110_K1.5711.00
10_V15_A1.5601.00
43_K55_E1.5591.00
127_E131_E1.5561.00
9_E12_G1.5361.00
37_S89_E1.5041.00
79_V93_Y1.4851.00
55_E114_Y1.4371.00
15_A82_I1.4311.00
37_S119_G1.4191.00
40_I90_F1.4081.00
99_E103_A1.3871.00
44_G86_G1.3861.00
8_A17_I1.3441.00
59_L88_R1.3231.00
40_I59_L1.3221.00
40_I62_I1.3021.00
15_A84_G1.2921.00
58_L61_E1.2601.00
7_E16_S1.2511.00
23_L77_L1.2381.00
33_P122_E1.2361.00
8_A15_A1.2121.00
41_K115_P1.2101.00
44_G52_S1.2091.00
61_E65_A1.1891.00
57_E61_E1.1791.00
42_Y45_P1.1771.00
101_E118_I1.1621.00
67_E71_E1.1581.00
99_E102_K1.1481.00
5_V18_R1.1431.00
46_D52_S1.1341.00
56_A88_R1.1251.00
102_K106_E1.1091.00
29_K32_Y1.1081.00
123_D128_T1.1051.00
26_F29_K1.1041.00
108_L116_I1.0991.00
39_T119_G1.0861.00
27_A130_L1.0461.00
34_W120_I1.0451.00
4_D19_V1.0421.00
35_L93_Y1.0351.00
58_L114_Y1.0341.00
100_F104_L1.0321.00
73_D103_A1.0301.00
105_N108_L1.0041.00
41_K117_E1.0021.00
111_F114_Y1.0011.00
57_E60_N0.9981.00
5_V16_S0.9961.00
24_R130_L0.9851.00
63_E67_E0.9831.00
20_N24_R0.9821.00
4_D21_L0.9691.00
81_R88_R0.9661.00
51_P83_T0.9571.00
23_L27_A0.9551.00
66_L90_F0.9481.00
91_Y128_T0.9461.00
45_P86_G0.9441.00
55_E58_L0.9431.00
10_V13_K0.9311.00
63_E90_F0.9301.00
63_E81_R0.9211.00
97_P120_I0.9121.00
122_E127_E0.9001.00
36_L100_F0.8991.00
42_Y59_L0.8971.00
41_K87_R0.8971.00
40_I116_I0.8871.00
75_G103_A0.8771.00
19_V80_G0.8491.00
98_E101_E0.8431.00
42_Y50_L0.8411.00
78_L90_F0.8331.00
62_I111_F0.8301.00
69_A106_E0.8281.00
37_S91_Y0.8251.00
31_S95_K0.8241.00
6_Y80_G0.8191.00
67_E78_L0.8101.00
63_E88_R0.8071.00
75_G95_K0.8001.00
62_I66_L0.7921.00
44_G54_E0.7890.99
23_L28_P0.7790.99
74_G77_L0.7710.99
4_D8_A0.7580.99
96_D99_E0.7530.99
43_K47_E0.7460.99
105_N118_I0.7450.99
28_P31_S0.7430.99
53_E57_E0.7350.99
69_A103_A0.7180.99
53_E56_A0.7180.99
35_L128_T0.7140.99
38_V66_L0.7110.99
106_E109_A0.7090.99
107_A111_F0.7070.99
109_A112_P0.7040.99
24_R29_K0.7030.99
59_L90_F0.6930.99
39_T117_E0.6920.99
82_I87_R0.6900.99
58_L62_I0.6870.99
16_S50_L0.6820.99
97_P101_E0.6810.99
81_R90_F0.6760.98
4_D7_E0.6720.98
37_S128_T0.6660.98
56_A81_R0.6650.98
34_W118_I0.6590.98
66_L92_F0.6540.98
80_G91_Y0.6510.98
72_K95_K0.6420.98
103_A106_E0.6410.98
94_T100_F0.6400.98
102_K105_N0.6370.98
30_A33_P0.6350.98
38_V90_F0.6330.98
32_Y94_T0.6210.97
60_N63_E0.6200.97
20_N40_I0.6190.97
78_L92_F0.6170.97
36_L104_L0.6160.97
87_R91_Y0.6160.97
126_W130_L0.6130.97
73_D106_E0.6120.97
22_G80_G0.6110.97
82_I91_Y0.6110.97
100_F103_A0.5990.97
26_F31_S0.5940.97
42_Y55_E0.5910.96
6_Y17_I0.5900.96
121_E128_T0.5870.96
6_Y15_A0.5830.96
22_G28_P0.5820.96
58_L113_G0.5790.96
70_L92_F0.5780.96
128_T131_E0.5740.96
104_L118_I0.5690.96
23_L126_W0.5680.96
5_V12_G0.5650.95
92_F100_F0.5600.95
70_L76_A0.5580.95
123_D126_W0.5550.95
18_R60_N0.5540.95
64_D68_A0.5540.95
89_E119_G0.5540.95
20_N23_L0.5520.95
74_G95_K0.5470.95
17_I21_L0.5340.94
104_L116_I0.5320.94
3_W6_Y0.5300.94
38_V108_L0.5280.93
6_Y19_V0.5260.93
69_A73_D0.5250.93
38_V104_L0.5230.93
69_A107_A0.5210.93
45_P55_E0.5190.93
34_W96_D0.5190.93
16_S56_A0.5170.93
122_E125_E0.5170.93
20_N80_G0.5140.93
84_G87_R0.5120.92
23_L26_F0.5120.92
42_Y52_S0.5100.92
110_K113_G0.5080.92
76_A92_F0.5050.92
20_N81_R0.5040.92
6_Y20_N0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j37A 1 0.7164 13.3 0.904 Contact Map
1ghhA 1 0.6045 7.9 0.913 Contact Map
3b3jA 1 0.0075 6.6 0.916 Contact Map
3uoaB 2 0.4403 5.8 0.919 Contact Map
1v02A 2 0.291 5.8 0.919 Contact Map
4dweA 1 0.8134 5.4 0.92 Contact Map
3dnxA 2 0.5448 4.7 0.922 Contact Map
1mliA 5 0.6567 4.3 0.923 Contact Map
2pbeA 1 0.5373 4.1 0.924 Contact Map
3kspA 2 0.6119 4.1 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0053 seconds.