GREMLIN Database
VKG_Carbox - Vitamin K-dependent gamma-carboxylase
PFAM: PF05090 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 427 (426)
Sequences: 2394 (1975)
Seq/√Len: 95.7
META: 0.782

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
294_I298_L5.1021.00
375_K412_A4.1471.00
45_L53_L3.8831.00
140_L292_F3.8441.00
63_F73_S3.5071.00
18_I23_I3.4131.00
64_I77_F3.3361.00
410_D413_K3.1351.00
154_L196_I3.0931.00
24_E29_E3.0771.00
391_D403_P3.0201.00
66_L117_L3.0071.00
60_A76_L2.9641.00
101_L291_Y2.8991.00
368_L372_H2.8301.00
75_I107_I2.7411.00
351_Y370_F2.7011.00
351_Y377_E2.7001.00
64_I74_I2.6661.00
132_A136_W2.6161.00
82_T100_S2.5731.00
201_L205_L2.5121.00
331_A392_S2.4851.00
338_P387_E2.4711.00
8_L65_A2.4591.00
77_F103_S2.4531.00
234_I238_L2.4511.00
141_Q291_Y2.4361.00
57_M80_S2.4231.00
54_F84_V2.3741.00
89_K366_M2.3261.00
143_G147_F2.2911.00
370_F374_L2.2691.00
62_L66_L2.2681.00
377_E381_K2.1291.00
137_L292_F2.1291.00
142_L243_T2.1201.00
393_Y403_P2.1151.00
78_F107_I2.1021.00
336_V389_Y2.0611.00
130_V134_T2.0151.00
143_G203_V2.0101.00
78_F104_F1.9871.00
136_W139_R1.9791.00
69_K121_R1.9721.00
337_D340_T1.9401.00
112_N118_D1.9271.00
74_I107_I1.9091.00
336_V343_T1.8961.00
210_R213_P1.8891.00
140_L144_I1.8871.00
5_L241_A1.8661.00
205_L215_A1.8651.00
11_L58_G1.8561.00
314_E421_H1.8411.00
285_L289_A1.8121.00
63_F66_L1.7991.00
109_L138_L1.7951.00
227_S237_Y1.7931.00
202_I215_A1.7801.00
82_T86_L1.7801.00
63_F68_Y1.7781.00
33_H91_T1.7731.00
11_L62_L1.7481.00
333_F360_M1.7311.00
35_S44_P1.7281.00
383_H386_V1.6931.00
35_S43_Q1.6761.00
220_V240_I1.6461.00
331_A361_S1.6411.00
10_M77_F1.6251.00
35_S40_E1.6101.00
221_F225_F1.6091.00
10_M103_S1.6061.00
166_K185_E1.6051.00
11_L65_A1.5881.00
336_V387_E1.5861.00
334_K343_T1.5821.00
208_W211_T1.5791.00
25_R29_E1.5751.00
122_N125_I1.5681.00
297_L304_L1.5641.00
117_L120_K1.5641.00
162_A189_Y1.5521.00
348_P357_E1.5441.00
141_Q295_Q1.5441.00
216_F247_F1.5361.00
337_D384_K1.5351.00
313_E325_R1.5261.00
193_W196_I1.5231.00
371_A388_V1.5181.00
35_S41_W1.5011.00
24_E28_I1.4831.00
121_R124_K1.4771.00
392_S404_L1.4721.00
73_S76_L1.4481.00
157_D399_R1.4461.00
367_I405_I1.4331.00
351_Y373_Y1.4211.00
117_L121_R1.4190.99
45_L50_M1.3970.99
113_R119_A1.3950.99
68_Y117_L1.3900.99
214_F218_A1.3810.99
224_L240_I1.3800.99
98_L145_V1.3550.99
123_P126_R1.3430.99
418_S422_K1.3370.99
378_Y388_V1.3320.99
313_E327_K1.3250.99
185_E188_A1.3060.99
98_L102_L1.3040.99
99_V234_I1.2980.99
414_E423_D1.2930.99
202_I219_V1.2910.99
78_F103_S1.2780.99
81_F93_L1.2730.99
309_V319_S1.2650.99
176_P179_G1.2640.99
390_A411_L1.2640.99
32_F373_Y1.2640.99
28_I51_Y1.2540.99
164_P168_W1.2540.99
414_E422_K1.2530.99
307_G312_T1.2520.99
119_A125_I1.2400.99
163_M167_I1.2320.99
316_H325_R1.2290.99
60_A80_S1.2270.99
9_L241_A1.2250.99
399_R402_Q1.2220.98
198_F219_V1.2210.98
104_F107_I1.2070.98
375_K379_A1.2030.98
32_F35_S1.2000.98
46_P49_G1.1970.98
44_P87_M1.1950.98
190_A194_G1.1930.98
197_L201_L1.1910.98
175_L182_L1.1910.98
147_F203_V1.1860.98
372_H376_D1.1850.98
359_Q362_T1.1850.98
11_L15_I1.1820.98
373_Y377_E1.1810.98
112_N116_S1.1810.98
394_V404_L1.1790.98
215_A218_A1.1740.98
248_S251_W1.1720.98
112_N125_I1.1720.98
6_F103_S1.1690.98
44_P50_M1.1680.98
135_I139_R1.1610.98
293_L297_L1.1550.98
83_Y87_M1.1540.98
70_Y109_L1.1530.98
205_L218_A1.1480.98
405_I425_I1.1480.98
14_I58_G1.1470.98
182_L187_V1.1410.98
150_G200_L1.1360.98
331_A390_A1.1350.98
156_P160_L1.1310.97
217_I221_F1.1270.97
154_L200_L1.1250.97
346_V351_Y1.1220.97
78_F100_S1.1210.97
198_F202_I1.1190.97
106_M111_A1.1180.97
288_L292_F1.1170.97
60_A63_F1.1140.97
53_L80_S1.1080.97
329_G394_V1.1050.97
334_K345_Y1.1030.97
148_Y300_L1.1020.97
137_L288_L1.0980.97
310_F321_R1.0960.97
375_K385_D1.0920.97
132_A139_R1.0900.97
38_G41_W1.0900.97
201_L204_P1.0850.97
49_G52_L1.0850.97
417_D422_K1.0840.97
143_G207_L1.0810.97
165_L168_W1.0770.97
105_L141_Q1.0730.97
165_L192_S1.0690.96
39_F42_V1.0650.96
360_M366_M1.0630.96
68_Y121_R1.0570.96
52_L56_I1.0560.96
110_P134_T1.0540.96
213_P217_I1.0490.96
26_L91_T1.0480.96
335_V378_Y1.0470.96
289_A293_L1.0470.96
3_R7_G1.0460.96
333_F374_L1.0440.96
61_A65_A1.0430.96
113_R127_S1.0430.96
395_S399_R1.0360.96
16_R22_W1.0310.96
104_F108_F1.0280.96
57_M84_V1.0280.96
337_D342_K1.0270.96
142_L242_A1.0220.95
135_I245_I1.0180.95
74_I78_F1.0160.95
44_P49_G1.0160.95
35_S42_V1.0080.95
173_A182_L1.0060.95
244_L251_W1.0060.95
204_P208_W1.0050.95
28_I47_G1.0050.95
138_L245_I1.0040.95
387_E410_D1.0040.95
302_H309_V1.0010.95
161_G189_Y0.9990.95
6_F10_M0.9970.95
226_N322_M0.9940.95
305_Y314_E0.9890.95
338_P385_D0.9870.94
280_K284_L0.9820.94
335_V388_V0.9820.94
194_G218_A0.9810.94
360_M367_I0.9800.94
163_M166_K0.9780.94
371_A411_L0.9740.94
114_Y253_R0.9720.94
69_K72_L0.9690.94
146_Y223_H0.9680.94
70_Y111_A0.9680.94
403_P426_L0.9650.94
50_M84_V0.9570.94
300_L303_L0.9570.94
109_L134_T0.9570.94
370_F373_Y0.9560.93
33_H88_D0.9540.93
48_N52_L0.9520.93
283_L286_A0.9500.93
187_V190_A0.9470.93
338_P386_V0.9450.93
14_I18_I0.9420.93
378_Y386_V0.9390.93
62_L65_A0.9390.93
91_T355_K0.9360.93
42_V87_M0.9350.93
186_W190_A0.9320.93
61_A77_F0.9280.92
335_V346_V0.9250.92
388_V412_A0.9180.92
150_G154_L0.9180.92
300_L304_L0.9170.92
313_E324_L0.9150.92
349_S357_E0.9080.92
39_F86_L0.9070.92
47_G51_Y0.9070.92
131_P134_T0.9070.92
101_L141_Q0.9050.91
15_I58_G0.8960.91
50_M87_M0.8940.91
402_Q426_L0.8940.91
347_D350_D0.8930.91
10_M61_A0.8890.91
76_L80_S0.8850.91
372_H375_K0.8850.91
317_R365_D0.8840.90
395_S398_G0.8830.90
78_F82_T0.8780.90
14_I61_A0.8770.90
64_I103_S0.8770.90
173_A183_Q0.8760.90
142_L239_M0.8720.90
189_Y193_W0.8700.90
386_V412_A0.8700.90
31_K373_Y0.8680.90
155_N310_F0.8680.90
417_D420_K0.8670.90
280_K283_L0.8650.90
63_F69_K0.8640.89
175_L178_I0.8570.89
144_I292_F0.8540.89
20_T24_E0.8520.89
302_H314_E0.8520.89
144_I148_Y0.8510.89
56_I80_S0.8490.89
385_D412_A0.8490.89
195_G199_D0.8460.88
56_I60_A0.8450.88
224_L228_I0.8420.88
343_T389_Y0.8410.88
132_A135_I0.8400.88
174_D179_G0.8380.88
346_V374_L0.8370.88
210_R214_F0.8350.88
409_V414_E0.8290.87
8_L12_L0.8260.87
165_L191_F0.8260.87
357_E361_S0.8250.87
29_E33_H0.8250.87
411_L414_E0.8250.87
11_L61_A0.8230.87
119_A127_S0.8200.87
392_S403_P0.8190.87
161_G164_P0.8160.87
103_S107_I0.8150.87
359_Q363_Q0.8140.86
352_L370_F0.8080.86
69_K122_N0.8040.86
338_P383_H0.8010.86
113_R125_I0.7980.85
163_M168_W0.7970.85
348_P370_F0.7970.85
14_I57_M0.7960.85
187_V194_G0.7950.85
382_G385_D0.7930.85
306_P421_H0.7920.85
89_K369_Q0.7920.85
283_L287_L0.7890.85
13_E16_R0.7880.85
256_L260_K0.7880.85
102_L238_L0.7880.85
136_W140_L0.7870.85
178_I229_L0.7870.85
336_V341_G0.7860.85
216_F243_T0.7850.84
181_L187_V0.7850.84
112_N121_R0.7850.84
414_E417_D0.7790.84
403_P407_P0.7790.84
105_L109_L0.7770.84
216_F244_L0.7760.84
334_K391_D0.7730.84
163_M170_P0.7720.83
53_L83_Y0.7710.83
306_P314_E0.7710.83
85_E226_N0.7710.83
14_I80_S0.7700.83
147_F151_L0.7680.83
346_V378_Y0.7670.83
134_T137_L0.7630.83
422_K425_I0.7630.83
45_L49_G0.7610.83
331_A360_M0.7590.82
310_F396_L0.7580.82
85_E322_M0.7570.82
156_P161_G0.7560.82
146_Y199_D0.7550.82
137_L140_L0.7530.82
80_S83_Y0.7520.82
250_D254_K0.7490.82
347_D370_F0.7480.81
93_L233_G0.7450.81
338_P413_K0.7450.81
203_V207_L0.7430.81
378_Y383_H0.7410.81
148_Y298_L0.7390.81
90_T359_Q0.7380.81
159_L193_W0.7370.81
105_L292_F0.7370.81
57_M60_A0.7340.80
74_I103_S0.7340.80
316_H322_M0.7330.80
344_F378_Y0.7320.80
196_I200_L0.7320.80
308_N399_R0.7310.80
55_A59_L0.7310.80
226_N316_H0.7280.80
119_A122_N0.7270.80
220_V224_L0.7260.80
243_T247_F0.7250.79
13_E96_Y0.7220.79
100_S104_F0.7210.79
182_L229_L0.7200.79
13_E17_F0.7200.79
26_L88_D0.7180.79
68_Y118_D0.7180.79
325_R362_T0.7160.79
219_V243_T0.7130.78
390_A405_I0.7130.78
47_G52_L0.7120.78
199_D202_I0.7110.78
111_A130_V0.7110.78
148_Y297_L0.7090.78
209_K248_S0.7080.78
282_K285_L0.7080.78
353_T356_Q0.7080.78
60_A73_S0.7040.77
359_Q366_M0.7030.77
6_F77_F0.7030.77
357_E360_M0.7020.77
217_I220_V0.6990.77
228_I231_P0.6990.77
9_L242_A0.6970.77
14_I77_F0.6960.77
185_E189_Y0.6950.77
310_F316_H0.6950.77
70_Y106_M0.6940.76
105_L108_F0.6940.76
70_Y112_N0.6930.76
11_L14_I0.6930.76
135_I142_L0.6930.76
414_E418_S0.6930.76
355_K359_Q0.6920.76
291_Y295_Q0.6910.76
1_V5_L0.6910.76
254_K258_K0.6890.76
338_P389_Y0.6870.76
175_L228_I0.6860.76
284_L287_L0.6850.75
216_F240_I0.6840.75
198_F243_T0.6840.75
316_H321_R0.6830.75
149_A365_D0.6830.75
80_S84_V0.6810.75
56_I76_L0.6810.75
13_E226_N0.6800.75
4_I7_G0.6750.74
169_L191_F0.6750.74
116_S119_A0.6740.74
184_Q187_V0.6730.74
327_K396_L0.6720.74
132_A207_L0.6720.74
49_G53_L0.6710.74
72_L75_I0.6710.74
137_L291_Y0.6700.74
248_S252_P0.6700.74
188_A192_S0.6700.74
70_Y74_I0.6700.74
105_L137_L0.6690.74
180_P184_Q0.6640.73
331_A374_L0.6640.73
376_D412_A0.6640.73
28_I33_H0.6630.73
165_L170_P0.6630.73
332_T345_Y0.6620.73
45_L83_Y0.6610.73
100_S318_F0.6600.73
312_T421_H0.6590.73
376_D380_K0.6570.72
102_L141_Q0.6570.72
224_L227_S0.6570.72
387_E413_K0.6550.72
325_R359_Q0.6540.72
147_F150_G0.6530.72
348_P351_Y0.6530.72
286_A289_A0.6520.72
260_K267_K0.6510.72
10_M14_I0.6510.72
85_E149_A0.6490.72
88_D355_K0.6460.71
335_V374_L0.6460.71
119_A126_R0.6460.71
162_A165_L0.6440.71
405_I411_L0.6430.71
305_Y422_K0.6400.70
309_V325_R0.6390.70
151_L200_L0.6390.70
136_W207_L0.6380.70
28_I44_P0.6380.70
37_Y368_L0.6370.70
214_F217_I0.6350.70
405_I426_L0.6340.70
346_V370_F0.6320.69
149_A322_M0.6320.69
35_S87_M0.6300.69
252_P256_L0.6300.69
377_E380_K0.6300.69
307_G421_H0.6280.69
184_Q188_A0.6270.69
68_Y120_K0.6260.69
393_Y401_S0.6250.69
224_L237_Y0.6250.69
2_F138_L0.6250.69
13_E322_M0.6250.69
3_R6_F0.6240.69
244_L248_S0.6230.68
360_M370_F0.6230.68
331_A348_P0.6230.68
187_V191_F0.6220.68
201_L218_A0.6210.68
33_H87_M0.6210.68
239_M242_A0.6190.68
16_R26_L0.6180.68
199_D239_M0.6180.68
10_M99_V0.6170.68
93_L168_W0.6170.68
114_Y128_D0.6170.68
378_Y381_K0.6170.68
333_F371_A0.6160.68
10_M64_I0.6150.67
13_E85_E0.6140.67
365_D368_L0.6120.67
145_V149_A0.6070.66
251_W255_I0.6060.66
88_D91_T0.6060.66
219_V239_M0.6060.66
334_K403_P0.6060.66
35_S89_K0.6030.66
8_L62_L0.6030.66
13_E234_I0.6030.66
170_P173_A0.6020.66
162_A168_W0.6010.66
33_H43_Q0.6010.66
30_P33_H0.6000.66
310_F325_R0.6000.66
375_K410_D0.5990.65
196_I322_M0.5990.65
165_L169_L0.5960.65
15_I19_A0.5960.65
89_K365_D0.5940.65
290_L294_I0.5940.65
37_Y417_D0.5930.65
374_L377_E0.5930.65
74_I77_F0.5910.64
13_E316_H0.5910.64
61_A64_I0.5910.64
2_F242_A0.5900.64
21_G30_P0.5880.64
270_Y274_E0.5870.64
14_I234_I0.5870.64
149_A321_R0.5860.64
191_F225_F0.5850.64
152_A199_D0.5850.64
405_I409_V0.5850.64
312_T425_I0.5850.64
212_R248_S0.5850.64
379_A386_V0.5840.63
35_S369_Q0.5840.63
212_R247_F0.5830.63
155_N324_L0.5830.63
395_S401_S0.5820.63
146_Y219_V0.5810.63
419_F422_K0.5800.63
279_K283_L0.5790.63
280_K286_A0.5780.63
135_I249_P0.5760.62
355_K366_M0.5740.62
130_V135_I0.5740.62
85_E318_F0.5740.62
50_M57_M0.5700.62
28_I369_Q0.5700.62
43_Q50_M0.5700.62
406_D426_L0.5680.61
255_I258_K0.5660.61
367_I390_A0.5660.61
123_P127_S0.5660.61
226_N325_R0.5650.61
292_F296_L0.5650.61
89_K317_R0.5640.61
146_Y195_G0.5640.61
178_I182_L0.5630.61
149_A196_I0.5620.60
164_P192_S0.5610.60
250_D253_R0.5600.60
100_S107_I0.5590.60
175_L179_G0.5590.60
64_I106_M0.5590.60
339_E385_D0.5580.60
302_H308_N0.5580.60
81_F99_V0.5570.60
313_E363_Q0.5560.60
305_Y368_L0.5550.60
58_G61_A0.5540.59
335_V386_V0.5540.59
372_H414_E0.5530.59
316_H324_L0.5530.59
388_V411_L0.5530.59
108_F284_L0.5530.59
351_Y378_Y0.5530.59
101_L295_Q0.5520.59
376_D379_A0.5520.59
33_H362_T0.5510.59
338_P384_K0.5500.59
37_Y419_F0.5500.59
33_H44_P0.5490.59
16_R93_L0.5490.59
60_A64_I0.5480.59
270_Y275_V0.5460.58
146_Y239_M0.5440.58
329_G392_S0.5440.58
172_K175_L0.5430.58
352_L356_Q0.5420.58
113_R123_P0.5420.58
120_K123_P0.5420.58
366_M370_F0.5410.58
379_A382_G0.5400.57
59_L63_F0.5400.57
85_E316_H0.5390.57
160_L189_Y0.5390.57
101_L292_F0.5390.57
213_P247_F0.5380.57
24_E51_Y0.5380.57
35_S417_D0.5340.57
86_L100_S0.5330.57
9_L99_V0.5320.56
281_K285_L0.5310.56
35_S39_F0.5310.56
64_I70_Y0.5310.56
137_L141_Q0.5300.56
16_R20_T0.5300.56
314_E422_K0.5300.56
1_V300_L0.5280.56
208_W215_A0.5260.56
142_L145_V0.5260.56
154_L163_M0.5250.55
209_K213_P0.5240.55
337_D344_F0.5240.55
160_L226_N0.5240.55
412_A421_H0.5220.55
119_A124_K0.5220.55
274_E277_S0.5190.55
4_I275_V0.5170.54
169_L229_L0.5160.54
17_F22_W0.5160.54
306_P318_F0.5150.54
305_Y418_S0.5140.54
334_K389_Y0.5130.54
333_F367_I0.5120.54
177_L180_P0.5120.54
17_F26_L0.5120.54
258_K262_L0.5110.53
154_L159_L0.5110.53
5_L244_L0.5110.53
143_G199_D0.5100.53
101_L144_I0.5080.53
421_H425_I0.5080.53
165_L185_E0.5080.53
64_I99_V0.5080.53
69_K73_S0.5070.53
286_A290_L0.5070.53
20_T227_S0.5060.53
11_L19_A0.5060.53
81_F96_Y0.5060.53
85_E325_R0.5040.52
389_Y403_P0.5030.52
199_D219_V0.5030.52
338_P410_D0.5020.52
223_H323_M0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2knuA 1 0.0679 22.9 0.981 Contact Map
3bmxA 1 0.2342 9 0.984 Contact Map
1k8vA 1 0.0913 6.6 0.985 Contact Map
3slzA 2 0.096 5.7 0.985 Contact Map
3tx2A 1 0.1639 5.5 0.985 Contact Map
1fmbA 2 0.1054 5 0.986 Contact Map
3ec0A 2 0.0937 4.9 0.986 Contact Map
2hwnE 2 0.0468 4.8 0.986 Contact Map
3wvqA 2 0.2155 4.6 0.986 Contact Map
2hs1A 2 0.0937 4.4 0.986 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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