VKG_Carbox - PFAM28P - GREMLIN Contacts

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VKG_Carbox - Vitamin K-dependent gamma-carboxylase

PFAM:	PF05090	Sequences: VFRILFGLLMLLEIIRFIATGWIERLYIEPKFHFSYYGFEWVQPLPGNGMYLLFAIMGLAALFIALGYKYRLSIILFFLSFTYVELMDKTTYLNHYYLVSLLSFLMIFLPANRYFSLDAKRNPKIRSDTVPAWTIWLLRLQLGIVYFYAGLAKLNPDWLLGAMPLKIWLPAKADLPLIGPLLQQEWVAYAFSWGGILFDLLIVPLLLWKRTRPFAFIAVVFFHLFNSILFPIGIFPYLMIAATLIFFSPDWPRKILRKLKKLFKIKKPKYSSSEVPSPKKKKLLLALLALYFLIQLLLPLRHLLYPGNVFWTEEGHRFSWRMMLREKAGYATFKVVDPETGKTFYVDPSDYLTPKQEKQMSTQPDMILQFAHYLKDEYAKKGHKDVEVYADSYVSLNGRPSQPLIDPNVDLAKEKWDSFKHKDWILP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	427 (426)
Sequences:	2394 (1975)
Seq/√Len:	95.7
META:	0.782

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
294_I	298_L	5.102	1.00
375_K	412_A	4.147	1.00
45_L	53_L	3.883	1.00
140_L	292_F	3.844	1.00
63_F	73_S	3.507	1.00
18_I	23_I	3.413	1.00
64_I	77_F	3.336	1.00
410_D	413_K	3.135	1.00
154_L	196_I	3.093	1.00
24_E	29_E	3.077	1.00
391_D	403_P	3.020	1.00
66_L	117_L	3.007	1.00
60_A	76_L	2.964	1.00
101_L	291_Y	2.899	1.00
368_L	372_H	2.830	1.00
75_I	107_I	2.741	1.00
351_Y	370_F	2.701	1.00
351_Y	377_E	2.700	1.00
64_I	74_I	2.666	1.00
132_A	136_W	2.616	1.00
82_T	100_S	2.573	1.00
201_L	205_L	2.512	1.00
331_A	392_S	2.485	1.00
338_P	387_E	2.471	1.00
8_L	65_A	2.459	1.00
77_F	103_S	2.453	1.00
234_I	238_L	2.451	1.00
141_Q	291_Y	2.436	1.00
57_M	80_S	2.423	1.00
54_F	84_V	2.374	1.00
89_K	366_M	2.326	1.00
143_G	147_F	2.291	1.00
370_F	374_L	2.269	1.00
62_L	66_L	2.268	1.00
377_E	381_K	2.129	1.00
137_L	292_F	2.129	1.00
142_L	243_T	2.120	1.00
393_Y	403_P	2.115	1.00
78_F	107_I	2.102	1.00
336_V	389_Y	2.061	1.00
130_V	134_T	2.015	1.00
143_G	203_V	2.010	1.00
78_F	104_F	1.987	1.00
136_W	139_R	1.979	1.00
69_K	121_R	1.972	1.00
337_D	340_T	1.940	1.00
112_N	118_D	1.927	1.00
74_I	107_I	1.909	1.00
336_V	343_T	1.896	1.00
210_R	213_P	1.889	1.00
140_L	144_I	1.887	1.00
5_L	241_A	1.866	1.00
205_L	215_A	1.865	1.00
11_L	58_G	1.856	1.00
314_E	421_H	1.841	1.00
285_L	289_A	1.812	1.00
63_F	66_L	1.799	1.00
109_L	138_L	1.795	1.00
227_S	237_Y	1.793	1.00
202_I	215_A	1.780	1.00
82_T	86_L	1.780	1.00
63_F	68_Y	1.778	1.00
33_H	91_T	1.773	1.00
11_L	62_L	1.748	1.00
333_F	360_M	1.731	1.00
35_S	44_P	1.728	1.00
383_H	386_V	1.693	1.00
35_S	43_Q	1.676	1.00
220_V	240_I	1.646	1.00
331_A	361_S	1.641	1.00
10_M	77_F	1.625	1.00
35_S	40_E	1.610	1.00
221_F	225_F	1.609	1.00
10_M	103_S	1.606	1.00
166_K	185_E	1.605	1.00
11_L	65_A	1.588	1.00
336_V	387_E	1.586	1.00
334_K	343_T	1.582	1.00
208_W	211_T	1.579	1.00
25_R	29_E	1.575	1.00
122_N	125_I	1.568	1.00
297_L	304_L	1.564	1.00
117_L	120_K	1.564	1.00
162_A	189_Y	1.552	1.00
348_P	357_E	1.544	1.00
141_Q	295_Q	1.544	1.00
216_F	247_F	1.536	1.00
337_D	384_K	1.535	1.00
313_E	325_R	1.526	1.00
193_W	196_I	1.523	1.00
371_A	388_V	1.518	1.00
35_S	41_W	1.501	1.00
24_E	28_I	1.483	1.00
121_R	124_K	1.477	1.00
392_S	404_L	1.472	1.00
73_S	76_L	1.448	1.00
157_D	399_R	1.446	1.00
367_I	405_I	1.433	1.00
351_Y	373_Y	1.421	1.00
117_L	121_R	1.419	0.99
45_L	50_M	1.397	0.99
113_R	119_A	1.395	0.99
68_Y	117_L	1.390	0.99
214_F	218_A	1.381	0.99
224_L	240_I	1.380	0.99
98_L	145_V	1.355	0.99
123_P	126_R	1.343	0.99
418_S	422_K	1.337	0.99
378_Y	388_V	1.332	0.99
313_E	327_K	1.325	0.99
185_E	188_A	1.306	0.99
98_L	102_L	1.304	0.99
99_V	234_I	1.298	0.99
414_E	423_D	1.293	0.99
202_I	219_V	1.291	0.99
78_F	103_S	1.278	0.99
81_F	93_L	1.273	0.99
309_V	319_S	1.265	0.99
176_P	179_G	1.264	0.99
390_A	411_L	1.264	0.99
32_F	373_Y	1.264	0.99
28_I	51_Y	1.254	0.99
164_P	168_W	1.254	0.99
414_E	422_K	1.253	0.99
307_G	312_T	1.252	0.99
119_A	125_I	1.240	0.99
163_M	167_I	1.232	0.99
316_H	325_R	1.229	0.99
60_A	80_S	1.227	0.99
9_L	241_A	1.225	0.99
399_R	402_Q	1.222	0.98
198_F	219_V	1.221	0.98
104_F	107_I	1.207	0.98
375_K	379_A	1.203	0.98
32_F	35_S	1.200	0.98
46_P	49_G	1.197	0.98
44_P	87_M	1.195	0.98
190_A	194_G	1.193	0.98
197_L	201_L	1.191	0.98
175_L	182_L	1.191	0.98
147_F	203_V	1.186	0.98
372_H	376_D	1.185	0.98
359_Q	362_T	1.185	0.98
11_L	15_I	1.182	0.98
373_Y	377_E	1.181	0.98
112_N	116_S	1.181	0.98
394_V	404_L	1.179	0.98
215_A	218_A	1.174	0.98
248_S	251_W	1.172	0.98
112_N	125_I	1.172	0.98
6_F	103_S	1.169	0.98
44_P	50_M	1.168	0.98
135_I	139_R	1.161	0.98
293_L	297_L	1.155	0.98
83_Y	87_M	1.154	0.98
70_Y	109_L	1.153	0.98
205_L	218_A	1.148	0.98
405_I	425_I	1.148	0.98
14_I	58_G	1.147	0.98
182_L	187_V	1.141	0.98
150_G	200_L	1.136	0.98
331_A	390_A	1.135	0.98
156_P	160_L	1.131	0.97
217_I	221_F	1.127	0.97
154_L	200_L	1.125	0.97
346_V	351_Y	1.122	0.97
78_F	100_S	1.121	0.97
198_F	202_I	1.119	0.97
106_M	111_A	1.118	0.97
288_L	292_F	1.117	0.97
60_A	63_F	1.114	0.97
53_L	80_S	1.108	0.97
329_G	394_V	1.105	0.97
334_K	345_Y	1.103	0.97
148_Y	300_L	1.102	0.97
137_L	288_L	1.098	0.97
310_F	321_R	1.096	0.97
375_K	385_D	1.092	0.97
132_A	139_R	1.090	0.97
38_G	41_W	1.090	0.97
201_L	204_P	1.085	0.97
49_G	52_L	1.085	0.97
417_D	422_K	1.084	0.97
143_G	207_L	1.081	0.97
165_L	168_W	1.077	0.97
105_L	141_Q	1.073	0.97
165_L	192_S	1.069	0.96
39_F	42_V	1.065	0.96
360_M	366_M	1.063	0.96
68_Y	121_R	1.057	0.96
52_L	56_I	1.056	0.96
110_P	134_T	1.054	0.96
213_P	217_I	1.049	0.96
26_L	91_T	1.048	0.96
335_V	378_Y	1.047	0.96
289_A	293_L	1.047	0.96
3_R	7_G	1.046	0.96
333_F	374_L	1.044	0.96
61_A	65_A	1.043	0.96
113_R	127_S	1.043	0.96
395_S	399_R	1.036	0.96
16_R	22_W	1.031	0.96
104_F	108_F	1.028	0.96
57_M	84_V	1.028	0.96
337_D	342_K	1.027	0.96
142_L	242_A	1.022	0.95
135_I	245_I	1.018	0.95
74_I	78_F	1.016	0.95
44_P	49_G	1.016	0.95
35_S	42_V	1.008	0.95
173_A	182_L	1.006	0.95
244_L	251_W	1.006	0.95
204_P	208_W	1.005	0.95
28_I	47_G	1.005	0.95
138_L	245_I	1.004	0.95
387_E	410_D	1.004	0.95
302_H	309_V	1.001	0.95
161_G	189_Y	0.999	0.95
6_F	10_M	0.997	0.95
226_N	322_M	0.994	0.95
305_Y	314_E	0.989	0.95
338_P	385_D	0.987	0.94
280_K	284_L	0.982	0.94
335_V	388_V	0.982	0.94
194_G	218_A	0.981	0.94
360_M	367_I	0.980	0.94
163_M	166_K	0.978	0.94
371_A	411_L	0.974	0.94
114_Y	253_R	0.972	0.94
69_K	72_L	0.969	0.94
146_Y	223_H	0.968	0.94
70_Y	111_A	0.968	0.94
403_P	426_L	0.965	0.94
50_M	84_V	0.957	0.94
300_L	303_L	0.957	0.94
109_L	134_T	0.957	0.94
370_F	373_Y	0.956	0.93
33_H	88_D	0.954	0.93
48_N	52_L	0.952	0.93
283_L	286_A	0.950	0.93
187_V	190_A	0.947	0.93
338_P	386_V	0.945	0.93
14_I	18_I	0.942	0.93
378_Y	386_V	0.939	0.93
62_L	65_A	0.939	0.93
91_T	355_K	0.936	0.93
42_V	87_M	0.935	0.93
186_W	190_A	0.932	0.93
61_A	77_F	0.928	0.92
335_V	346_V	0.925	0.92
388_V	412_A	0.918	0.92
150_G	154_L	0.918	0.92
300_L	304_L	0.917	0.92
313_E	324_L	0.915	0.92
349_S	357_E	0.908	0.92
39_F	86_L	0.907	0.92
47_G	51_Y	0.907	0.92
131_P	134_T	0.907	0.92
101_L	141_Q	0.905	0.91
15_I	58_G	0.896	0.91
50_M	87_M	0.894	0.91
402_Q	426_L	0.894	0.91
347_D	350_D	0.893	0.91
10_M	61_A	0.889	0.91
76_L	80_S	0.885	0.91
372_H	375_K	0.885	0.91
317_R	365_D	0.884	0.90
395_S	398_G	0.883	0.90
78_F	82_T	0.878	0.90
14_I	61_A	0.877	0.90
64_I	103_S	0.877	0.90
173_A	183_Q	0.876	0.90
142_L	239_M	0.872	0.90
189_Y	193_W	0.870	0.90
386_V	412_A	0.870	0.90
31_K	373_Y	0.868	0.90
155_N	310_F	0.868	0.90
417_D	420_K	0.867	0.90
280_K	283_L	0.865	0.90
63_F	69_K	0.864	0.89
175_L	178_I	0.857	0.89
144_I	292_F	0.854	0.89
20_T	24_E	0.852	0.89
302_H	314_E	0.852	0.89
144_I	148_Y	0.851	0.89
56_I	80_S	0.849	0.89
385_D	412_A	0.849	0.89
195_G	199_D	0.846	0.88
56_I	60_A	0.845	0.88
224_L	228_I	0.842	0.88
343_T	389_Y	0.841	0.88
132_A	135_I	0.840	0.88
174_D	179_G	0.838	0.88
346_V	374_L	0.837	0.88
210_R	214_F	0.835	0.88
409_V	414_E	0.829	0.87
8_L	12_L	0.826	0.87
165_L	191_F	0.826	0.87
357_E	361_S	0.825	0.87
29_E	33_H	0.825	0.87
411_L	414_E	0.825	0.87
11_L	61_A	0.823	0.87
119_A	127_S	0.820	0.87
392_S	403_P	0.819	0.87
161_G	164_P	0.816	0.87
103_S	107_I	0.815	0.87
359_Q	363_Q	0.814	0.86
352_L	370_F	0.808	0.86
69_K	122_N	0.804	0.86
338_P	383_H	0.801	0.86
113_R	125_I	0.798	0.85
163_M	168_W	0.797	0.85
348_P	370_F	0.797	0.85
14_I	57_M	0.796	0.85
187_V	194_G	0.795	0.85
382_G	385_D	0.793	0.85
306_P	421_H	0.792	0.85
89_K	369_Q	0.792	0.85
283_L	287_L	0.789	0.85
13_E	16_R	0.788	0.85
256_L	260_K	0.788	0.85
102_L	238_L	0.788	0.85
136_W	140_L	0.787	0.85
178_I	229_L	0.787	0.85
336_V	341_G	0.786	0.85
216_F	243_T	0.785	0.84
181_L	187_V	0.785	0.84
112_N	121_R	0.785	0.84
414_E	417_D	0.779	0.84
403_P	407_P	0.779	0.84
105_L	109_L	0.777	0.84
216_F	244_L	0.776	0.84
334_K	391_D	0.773	0.84
163_M	170_P	0.772	0.83
53_L	83_Y	0.771	0.83
306_P	314_E	0.771	0.83
85_E	226_N	0.771	0.83
14_I	80_S	0.770	0.83
147_F	151_L	0.768	0.83
346_V	378_Y	0.767	0.83
134_T	137_L	0.763	0.83
422_K	425_I	0.763	0.83
45_L	49_G	0.761	0.83
331_A	360_M	0.759	0.82
310_F	396_L	0.758	0.82
85_E	322_M	0.757	0.82
156_P	161_G	0.756	0.82
146_Y	199_D	0.755	0.82
137_L	140_L	0.753	0.82
80_S	83_Y	0.752	0.82
250_D	254_K	0.749	0.82
347_D	370_F	0.748	0.81
93_L	233_G	0.745	0.81
338_P	413_K	0.745	0.81
203_V	207_L	0.743	0.81
378_Y	383_H	0.741	0.81
148_Y	298_L	0.739	0.81
90_T	359_Q	0.738	0.81
159_L	193_W	0.737	0.81
105_L	292_F	0.737	0.81
57_M	60_A	0.734	0.80
74_I	103_S	0.734	0.80
316_H	322_M	0.733	0.80
344_F	378_Y	0.732	0.80
196_I	200_L	0.732	0.80
308_N	399_R	0.731	0.80
55_A	59_L	0.731	0.80
226_N	316_H	0.728	0.80
119_A	122_N	0.727	0.80
220_V	224_L	0.726	0.80
243_T	247_F	0.725	0.79
13_E	96_Y	0.722	0.79
100_S	104_F	0.721	0.79
182_L	229_L	0.720	0.79
13_E	17_F	0.720	0.79
26_L	88_D	0.718	0.79
68_Y	118_D	0.718	0.79
325_R	362_T	0.716	0.79
219_V	243_T	0.713	0.78
390_A	405_I	0.713	0.78
47_G	52_L	0.712	0.78
199_D	202_I	0.711	0.78
111_A	130_V	0.711	0.78
148_Y	297_L	0.709	0.78
209_K	248_S	0.708	0.78
282_K	285_L	0.708	0.78
353_T	356_Q	0.708	0.78
60_A	73_S	0.704	0.77
359_Q	366_M	0.703	0.77
6_F	77_F	0.703	0.77
357_E	360_M	0.702	0.77
217_I	220_V	0.699	0.77
228_I	231_P	0.699	0.77
9_L	242_A	0.697	0.77
14_I	77_F	0.696	0.77
185_E	189_Y	0.695	0.77
310_F	316_H	0.695	0.77
70_Y	106_M	0.694	0.76
105_L	108_F	0.694	0.76
70_Y	112_N	0.693	0.76
11_L	14_I	0.693	0.76
135_I	142_L	0.693	0.76
414_E	418_S	0.693	0.76
355_K	359_Q	0.692	0.76
291_Y	295_Q	0.691	0.76
1_V	5_L	0.691	0.76
254_K	258_K	0.689	0.76
338_P	389_Y	0.687	0.76
175_L	228_I	0.686	0.76
284_L	287_L	0.685	0.75
216_F	240_I	0.684	0.75
198_F	243_T	0.684	0.75
316_H	321_R	0.683	0.75
149_A	365_D	0.683	0.75
80_S	84_V	0.681	0.75
56_I	76_L	0.681	0.75
13_E	226_N	0.680	0.75
4_I	7_G	0.675	0.74
169_L	191_F	0.675	0.74
116_S	119_A	0.674	0.74
184_Q	187_V	0.673	0.74
327_K	396_L	0.672	0.74
132_A	207_L	0.672	0.74
49_G	53_L	0.671	0.74
72_L	75_I	0.671	0.74
137_L	291_Y	0.670	0.74
248_S	252_P	0.670	0.74
188_A	192_S	0.670	0.74
70_Y	74_I	0.670	0.74
105_L	137_L	0.669	0.74
180_P	184_Q	0.664	0.73
331_A	374_L	0.664	0.73
376_D	412_A	0.664	0.73
28_I	33_H	0.663	0.73
165_L	170_P	0.663	0.73
332_T	345_Y	0.662	0.73
45_L	83_Y	0.661	0.73
100_S	318_F	0.660	0.73
312_T	421_H	0.659	0.73
376_D	380_K	0.657	0.72
102_L	141_Q	0.657	0.72
224_L	227_S	0.657	0.72
387_E	413_K	0.655	0.72
325_R	359_Q	0.654	0.72
147_F	150_G	0.653	0.72
348_P	351_Y	0.653	0.72
286_A	289_A	0.652	0.72
260_K	267_K	0.651	0.72
10_M	14_I	0.651	0.72
85_E	149_A	0.649	0.72
88_D	355_K	0.646	0.71
335_V	374_L	0.646	0.71
119_A	126_R	0.646	0.71
162_A	165_L	0.644	0.71
405_I	411_L	0.643	0.71
305_Y	422_K	0.640	0.70
309_V	325_R	0.639	0.70
151_L	200_L	0.639	0.70
136_W	207_L	0.638	0.70
28_I	44_P	0.638	0.70
37_Y	368_L	0.637	0.70
214_F	217_I	0.635	0.70
405_I	426_L	0.634	0.70
346_V	370_F	0.632	0.69
149_A	322_M	0.632	0.69
35_S	87_M	0.630	0.69
252_P	256_L	0.630	0.69
377_E	380_K	0.630	0.69
307_G	421_H	0.628	0.69
184_Q	188_A	0.627	0.69
68_Y	120_K	0.626	0.69
393_Y	401_S	0.625	0.69
224_L	237_Y	0.625	0.69
2_F	138_L	0.625	0.69
13_E	322_M	0.625	0.69
3_R	6_F	0.624	0.69
244_L	248_S	0.623	0.68
360_M	370_F	0.623	0.68
331_A	348_P	0.623	0.68
187_V	191_F	0.622	0.68
201_L	218_A	0.621	0.68
33_H	87_M	0.621	0.68
239_M	242_A	0.619	0.68
16_R	26_L	0.618	0.68
199_D	239_M	0.618	0.68
10_M	99_V	0.617	0.68
93_L	168_W	0.617	0.68
114_Y	128_D	0.617	0.68
378_Y	381_K	0.617	0.68
333_F	371_A	0.616	0.68
10_M	64_I	0.615	0.67
13_E	85_E	0.614	0.67
365_D	368_L	0.612	0.67
145_V	149_A	0.607	0.66
251_W	255_I	0.606	0.66
88_D	91_T	0.606	0.66
219_V	239_M	0.606	0.66
334_K	403_P	0.606	0.66
35_S	89_K	0.603	0.66
8_L	62_L	0.603	0.66
13_E	234_I	0.603	0.66
170_P	173_A	0.602	0.66
162_A	168_W	0.601	0.66
33_H	43_Q	0.601	0.66
30_P	33_H	0.600	0.66
310_F	325_R	0.600	0.66
375_K	410_D	0.599	0.65
196_I	322_M	0.599	0.65
165_L	169_L	0.596	0.65
15_I	19_A	0.596	0.65
89_K	365_D	0.594	0.65
290_L	294_I	0.594	0.65
37_Y	417_D	0.593	0.65
374_L	377_E	0.593	0.65
74_I	77_F	0.591	0.64
13_E	316_H	0.591	0.64
61_A	64_I	0.591	0.64
2_F	242_A	0.590	0.64
21_G	30_P	0.588	0.64
270_Y	274_E	0.587	0.64
14_I	234_I	0.587	0.64
149_A	321_R	0.586	0.64
191_F	225_F	0.585	0.64
152_A	199_D	0.585	0.64
405_I	409_V	0.585	0.64
312_T	425_I	0.585	0.64
212_R	248_S	0.585	0.64
379_A	386_V	0.584	0.63
35_S	369_Q	0.584	0.63
212_R	247_F	0.583	0.63
155_N	324_L	0.583	0.63
395_S	401_S	0.582	0.63
146_Y	219_V	0.581	0.63
419_F	422_K	0.580	0.63
279_K	283_L	0.579	0.63
280_K	286_A	0.578	0.63
135_I	249_P	0.576	0.62
355_K	366_M	0.574	0.62
130_V	135_I	0.574	0.62
85_E	318_F	0.574	0.62
50_M	57_M	0.570	0.62
28_I	369_Q	0.570	0.62
43_Q	50_M	0.570	0.62
406_D	426_L	0.568	0.61
255_I	258_K	0.566	0.61
367_I	390_A	0.566	0.61
123_P	127_S	0.566	0.61
226_N	325_R	0.565	0.61
292_F	296_L	0.565	0.61
89_K	317_R	0.564	0.61
146_Y	195_G	0.564	0.61
178_I	182_L	0.563	0.61
149_A	196_I	0.562	0.60
164_P	192_S	0.561	0.60
250_D	253_R	0.560	0.60
100_S	107_I	0.559	0.60
175_L	179_G	0.559	0.60
64_I	106_M	0.559	0.60
339_E	385_D	0.558	0.60
302_H	308_N	0.558	0.60
81_F	99_V	0.557	0.60
313_E	363_Q	0.556	0.60
305_Y	368_L	0.555	0.60
58_G	61_A	0.554	0.59
335_V	386_V	0.554	0.59
372_H	414_E	0.553	0.59
316_H	324_L	0.553	0.59
388_V	411_L	0.553	0.59
108_F	284_L	0.553	0.59
351_Y	378_Y	0.553	0.59
101_L	295_Q	0.552	0.59
376_D	379_A	0.552	0.59
33_H	362_T	0.551	0.59
338_P	384_K	0.550	0.59
37_Y	419_F	0.550	0.59
33_H	44_P	0.549	0.59
16_R	93_L	0.549	0.59
60_A	64_I	0.548	0.59
270_Y	275_V	0.546	0.58
146_Y	239_M	0.544	0.58
329_G	392_S	0.544	0.58
172_K	175_L	0.543	0.58
352_L	356_Q	0.542	0.58
113_R	123_P	0.542	0.58
120_K	123_P	0.542	0.58
366_M	370_F	0.541	0.58
379_A	382_G	0.540	0.57
59_L	63_F	0.540	0.57
85_E	316_H	0.539	0.57
160_L	189_Y	0.539	0.57
101_L	292_F	0.539	0.57
213_P	247_F	0.538	0.57
24_E	51_Y	0.538	0.57
35_S	417_D	0.534	0.57
86_L	100_S	0.533	0.57
9_L	99_V	0.532	0.56
281_K	285_L	0.531	0.56
35_S	39_F	0.531	0.56
64_I	70_Y	0.531	0.56
137_L	141_Q	0.530	0.56
16_R	20_T	0.530	0.56
314_E	422_K	0.530	0.56
1_V	300_L	0.528	0.56
208_W	215_A	0.526	0.56
142_L	145_V	0.526	0.56
154_L	163_M	0.525	0.55
209_K	213_P	0.524	0.55
337_D	344_F	0.524	0.55
160_L	226_N	0.524	0.55
412_A	421_H	0.522	0.55
119_A	124_K	0.522	0.55
274_E	277_S	0.519	0.55
4_I	275_V	0.517	0.54
169_L	229_L	0.516	0.54
17_F	22_W	0.516	0.54
306_P	318_F	0.515	0.54
305_Y	418_S	0.514	0.54
334_K	389_Y	0.513	0.54
333_F	367_I	0.512	0.54
177_L	180_P	0.512	0.54
17_F	26_L	0.512	0.54
258_K	262_L	0.511	0.53
154_L	159_L	0.511	0.53
5_L	244_L	0.511	0.53
143_G	199_D	0.510	0.53
101_L	144_I	0.508	0.53
421_H	425_I	0.508	0.53
165_L	185_E	0.508	0.53
64_I	99_V	0.508	0.53
69_K	73_S	0.507	0.53
286_A	290_L	0.507	0.53
20_T	227_S	0.506	0.53
11_L	19_A	0.506	0.53
81_F	96_Y	0.506	0.53
85_E	325_R	0.504	0.52
389_Y	403_P	0.503	0.52
199_D	219_V	0.503	0.52
338_P	410_D	0.502	0.52
223_H	323_M	0.500	0.52

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2knuA	1	0.0679	22.9	0.981	Contact Map
3bmxA	1	0.2342	9	0.984	Contact Map
1k8vA	1	0.0913	6.6	0.985	Contact Map
3slzA	2	0.096	5.7	0.985	Contact Map
3tx2A	1	0.1639	5.5	0.985	Contact Map
1fmbA	2	0.1054	5	0.986	Contact Map
3ec0A	2	0.0937	4.9	0.986	Contact Map
2hwnE	2	0.0468	4.8	0.986	Contact Map
3wvqA	2	0.2155	4.6	0.986	Contact Map
2hs1A	2	0.0937	4.4	0.986	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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