GREMLIN Database
Phage_tail_S - Phage virion morphogenesis family
PFAM: PF05069 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 148 (143)
Sequences: 5289 (4326)
Seq/√Len: 361.7
META: 0.732

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_I107_G4.8121.00
44_A48_T3.6951.00
34_S135_D3.0731.00
77_R97_V3.0651.00
87_D90_S2.8331.00
102_I123_I2.7711.00
23_L143_I2.6381.00
101_A105_F2.4941.00
73_Q79_R2.4251.00
27_I139_I2.3771.00
28_G84_Y2.3751.00
30_E142_I2.3701.00
53_L71_I2.3651.00
42_Q71_I2.1511.00
28_G91_V2.1501.00
39_F50_W2.1111.00
30_E138_E2.0151.00
104_Q127_P1.8551.00
42_Q73_Q1.8441.00
37_E41_A1.8351.00
82_I128_F1.8231.00
20_R23_L1.8041.00
32_R36_Q1.7191.00
38_R43_G1.6961.00
24_M86_A1.6541.00
36_Q79_R1.6031.00
95_T100_A1.6001.00
31_L93_V1.5121.00
107_G123_I1.4931.00
54_K57_T1.4351.00
38_R44_A1.4061.00
104_Q128_F1.3921.00
21_R88_A1.3641.00
26_E142_I1.3551.00
133_D136_E1.3241.00
32_R84_Y1.3111.00
55_P59_R1.2951.00
12_R16_R1.2861.00
44_A127_P1.2621.00
115_S118_G1.2531.00
57_T60_A1.2501.00
34_S132_S1.2291.00
27_I143_I1.2221.00
38_R130_G1.2111.00
100_A128_F1.2041.00
132_S135_D1.1971.00
35_T38_R1.1911.00
140_L144_L1.1871.00
136_E140_L1.1841.00
85_Q92_V1.1741.00
24_M91_V1.1631.00
25_R84_Y1.1531.00
70_K73_Q1.1411.00
73_Q76_G1.1351.00
116_R119_P1.1331.00
30_E34_S1.1221.00
19_D22_P1.1011.00
23_L142_I1.1011.00
38_R135_D1.0921.00
53_L61_K1.0901.00
21_R25_R1.0731.00
38_R132_S1.0571.00
118_G121_V1.0381.00
78_L99_Y1.0301.00
9_A12_R1.0121.00
103_H125_A1.0061.00
23_L27_I1.0021.00
35_T129_L0.9821.00
81_S95_T0.9791.00
29_E32_R0.9791.00
114_V117_G0.9621.00
24_M90_S0.9391.00
8_A12_R0.9381.00
115_S120_K0.9361.00
29_E84_Y0.9271.00
35_T93_V0.9201.00
78_L100_A0.9171.00
111_R114_V0.9121.00
103_H123_I0.9111.00
7_E11_A0.9111.00
112_D118_G0.9041.00
17_P20_R0.9031.00
40_E79_R0.9011.00
107_G121_V0.8931.00
78_L81_S0.8921.00
99_Y103_H0.8921.00
4_E8_A0.8911.00
109_A112_D0.8831.00
44_A132_S0.8801.00
28_G86_A0.8781.00
35_T130_G0.8751.00
66_K74_K0.8751.00
5_E8_A0.8741.00
32_R82_I0.8681.00
38_R46_D0.8601.00
115_S121_V0.8471.00
108_K122_T0.8421.00
65_G68_G0.8381.00
138_E142_I0.8211.00
33_R36_Q0.8211.00
20_R24_M0.8211.00
16_R146_H0.8201.00
82_I95_T0.8091.00
11_A15_A0.8081.00
87_D92_V0.8071.00
28_G32_R0.8051.00
35_T128_F0.7931.00
109_A121_V0.7901.00
21_R86_A0.7861.00
77_R80_R0.7861.00
44_A50_W0.7841.00
104_Q125_A0.7821.00
19_D88_A0.7781.00
42_Q70_K0.7711.00
138_E141_D0.7681.00
112_D119_P0.7661.00
116_R120_K0.7641.00
11_A14_L0.7551.00
46_D132_S0.7541.00
115_S119_P0.7521.00
114_V119_P0.7481.00
112_D120_K0.7311.00
44_A47_G0.7281.00
30_E33_R0.7231.00
81_S96_N0.7231.00
55_P58_L0.7150.99
35_T82_I0.7110.99
23_L146_H0.7090.99
39_F79_R0.7080.99
86_A91_V0.7070.99
119_P122_T0.7040.99
60_A64_R0.7030.99
53_L58_L0.7030.99
131_L139_I0.7020.99
60_A74_K0.7010.99
34_S38_R0.6930.99
12_R15_A0.6920.99
69_G74_K0.6910.99
53_L57_T0.6900.99
35_T104_Q0.6880.99
76_G79_R0.6870.99
45_P135_D0.6850.99
107_G122_T0.6830.99
83_T96_N0.6790.99
51_A71_I0.6710.99
31_L135_D0.6570.99
29_E33_R0.6560.99
71_I74_K0.6540.99
31_L139_I0.6520.99
131_L136_E0.6500.99
101_A107_G0.6480.99
42_Q50_W0.6430.99
33_R37_E0.6400.99
27_I30_E0.6390.99
134_E138_E0.6360.99
111_R122_T0.6340.99
76_G80_R0.6340.99
57_T61_K0.6330.99
46_D130_G0.6330.99
130_G135_D0.6240.99
31_L34_S0.6200.99
86_A90_S0.6190.98
44_A130_G0.6130.98
58_L61_K0.6070.98
37_E40_E0.6040.98
117_G120_K0.6000.98
67_R74_K0.5960.98
25_R29_E0.5960.98
30_E139_I0.5930.98
112_D116_R0.5900.98
99_Y102_I0.5900.98
20_R88_A0.5890.98
14_L18_A0.5890.98
57_T65_G0.5880.98
112_D121_V0.5870.98
63_G66_K0.5820.98
104_Q129_L0.5810.98
112_D117_G0.5790.98
26_E30_E0.5770.98
31_L91_V0.5770.98
102_I105_F0.5760.98
52_P58_L0.5680.97
43_G49_P0.5670.97
31_L131_L0.5660.97
131_L135_D0.5640.97
72_L75_T0.5630.97
26_E146_H0.5590.97
38_R45_P0.5580.97
109_A120_K0.5530.97
56_S60_A0.5530.97
117_G121_V0.5460.97
135_D138_E0.5440.97
72_L103_H0.5440.97
114_V118_G0.5430.97
110_G117_G0.5400.96
106_G125_A0.5380.96
84_Y91_V0.5370.96
51_A124_P0.5340.96
82_I93_V0.5310.96
66_K69_G0.5300.96
94_G129_L0.5300.96
4_E7_E0.5300.96
137_E140_L0.5280.96
139_I143_I0.5270.96
111_R120_K0.5230.96
110_G116_R0.5200.96
24_M88_A0.5180.96
56_S59_R0.5090.95
98_P101_A0.5080.95
66_K75_T0.5070.95
34_S130_G0.5070.95
38_R41_A0.5040.95
114_V120_K0.5040.95
111_R118_G0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bolA 2 0.3919 8.6 0.921 Contact Map
3d2yA 3 0.4122 5.2 0.928 Contact Map
3ebbA 2 0.2162 4.3 0.931 Contact Map
4w7sA 2 0.8919 4.3 0.931 Contact Map
4bxjA 4 0.4054 3.8 0.933 Contact Map
3omsA 2 0.3243 3.4 0.934 Contact Map
2f95B 2 0 3.4 0.935 Contact Map
4n4pA 3 0.8108 3.2 0.935 Contact Map
1gotG 1 0.3378 3.2 0.935 Contact Map
3zifN 3 0.223 3.2 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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