GREMLIN Database
DUF669 - Protein of unknown function (DUF669)
PFAM: PF05037 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 138 (120)
Sequences: 3450 (2952)
Seq/√Len: 269.5
META: 0.945

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_T43_E3.0941.00
21_A111_V3.0831.00
29_K39_K2.8641.00
116_E126_E2.7321.00
39_K61_N2.6901.00
41_T56_K2.4971.00
25_E41_T2.2361.00
20_E110_R2.1671.00
16_A115_V2.1041.00
18_K110_R2.0621.00
60_D78_Q2.0281.00
26_S105_H2.0281.00
18_K112_K1.9331.00
80_S84_R1.9261.00
36_P65_T1.8861.00
43_E56_K1.8531.00
70_K73_E1.8501.00
20_E49_D1.8401.00
14_L44_I1.8281.00
73_E77_R1.7211.00
37_Y61_N1.7071.00
42_F109_L1.6671.00
114_K128_K1.6661.00
18_K131_K1.5991.00
40_L62_L1.5641.00
30_P36_P1.5601.00
115_V123_T1.5141.00
29_K37_Y1.5121.00
31_T35_G1.4921.00
115_V125_N1.4821.00
21_A42_F1.4711.00
69_P73_E1.4261.00
41_T59_F1.4101.00
57_V113_V1.3601.00
68_N71_A1.3371.00
22_V43_E1.3271.00
23_I82_I1.3211.00
49_D53_K1.2991.00
37_Y63_N1.2411.00
24_T56_K1.2281.00
22_V48_L1.2241.00
21_A44_I1.2091.00
42_F60_D1.2091.00
60_D130_Y1.2021.00
43_E54_G1.1761.00
16_A114_K1.1731.00
118_D123_T1.1721.00
34_G67_P1.1641.00
13_P115_V1.1551.00
56_K59_F1.1191.00
31_T37_Y1.1141.00
66_N71_A1.0961.00
23_I40_L1.0821.00
120_D123_T1.0751.00
26_S38_L1.0641.00
62_L75_A1.0531.00
24_T41_T1.0521.00
63_N66_N1.0491.00
42_F111_V1.0481.00
26_S40_L1.0441.00
31_T66_N1.0371.00
28_M36_P1.0331.00
21_A109_L1.0301.00
118_D124_Y1.0261.00
22_V108_P1.0231.00
71_A74_I1.0211.00
22_V106_G1.0181.00
48_L108_P1.0121.00
23_I42_F0.9911.00
125_N130_Y0.9581.00
117_K123_T0.9501.00
69_P72_V0.9431.00
86_V109_L0.9421.00
52_Y55_R0.9391.00
62_L82_I0.9271.00
14_L113_V0.9241.00
118_D121_G0.9231.00
99_D103_E0.9211.00
80_S83_C0.8951.00
25_E39_K0.8601.00
31_T34_G0.8521.00
38_L101_S0.8431.00
74_I77_R0.8360.99
110_R131_K0.8320.99
121_G124_Y0.8290.99
27_E39_K0.8280.99
81_A84_R0.8250.99
102_D105_H0.8240.99
50_G53_K0.8240.99
65_T72_V0.8150.99
117_K121_G0.8120.99
15_P52_Y0.7950.99
116_E124_Y0.7950.99
13_P55_R0.7850.99
114_K126_E0.7820.99
117_K122_E0.7760.99
71_A75_A0.7700.99
26_S101_S0.7660.99
98_P103_E0.7650.99
100_D104_L0.7620.99
63_N78_Q0.7530.99
20_E48_L0.7500.99
77_R80_S0.7220.99
30_P33_G0.7220.99
66_N72_V0.7160.98
13_P125_N0.7120.98
72_V76_R0.7110.98
35_G63_N0.7050.98
124_Y130_Y0.7030.98
118_D122_E0.7020.98
68_N74_I0.7020.98
72_V75_A0.6990.98
117_K120_D0.6970.98
77_R81_A0.6930.98
70_K74_I0.6920.98
101_S105_H0.6900.98
32_K37_Y0.6690.98
86_V107_K0.6670.98
100_D103_E0.6580.97
35_G67_P0.6580.97
125_N128_K0.6580.97
20_E108_P0.6560.97
91_G94_L0.6550.97
126_E130_Y0.6540.97
82_I109_L0.6520.97
38_L64_L0.6500.97
112_K131_K0.6490.97
28_M65_T0.6480.97
68_N72_V0.6370.97
14_L55_R0.6350.97
102_D106_G0.6340.97
64_L72_V0.6320.97
42_F127_V0.6260.96
94_L103_E0.6170.96
39_K59_F0.6130.96
42_F62_L0.6110.96
109_L130_Y0.6070.96
82_I86_V0.6030.96
40_L82_I0.6020.95
116_E119_E0.5950.95
105_H108_P0.5940.95
12_E55_R0.5920.95
57_V111_V0.5920.95
124_Y127_V0.5850.95
119_E123_T0.5830.95
55_R59_F0.5820.95
8_V80_S0.5810.95
97_L100_D0.5800.95
33_G37_Y0.5740.94
83_C87_G0.5690.94
28_M64_L0.5690.94
44_I111_V0.5640.94
78_Q81_A0.5630.94
101_S104_L0.5600.93
42_F78_Q0.5520.93
16_A112_K0.5470.93
94_L97_L0.5460.93
44_I50_G0.5430.92
42_F130_Y0.5410.92
119_E122_E0.5390.92
96_S99_D0.5380.92
15_P19_Y0.5380.92
76_R79_L0.5360.92
112_K129_G0.5340.92
61_N126_E0.5300.91
64_L79_L0.5280.91
13_P44_I0.5270.91
74_I78_Q0.5260.91
23_I26_S0.5250.91
26_S104_L0.5240.91
115_V118_D0.5230.91
57_V127_V0.5230.91
15_P44_I0.5150.90
63_N71_A0.5120.90
38_L79_L0.5120.90
113_V125_N0.5080.90
40_L60_D0.5080.90
6_S9_E0.5060.89
28_M38_L0.5030.89
76_R80_S0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v9fA 1 0.3261 33.1 0.89 Contact Map
3ottA 2 0.3986 32.9 0.89 Contact Map
3psiA 1 0 27.9 0.894 Contact Map
4a2lA 4 0.3406 27 0.895 Contact Map
3achA 1 0.4565 26.5 0.895 Contact Map
1uwwA 2 0.4493 22.1 0.899 Contact Map
1pfsA 2 0.2826 14.9 0.907 Contact Map
2x41A 1 0.3333 10.1 0.914 Contact Map
3nqhA 2 0.3333 5.8 0.923 Contact Map
3osvA 2 0.5072 5.5 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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