Mannosyl_trans - PFAM28P - GREMLIN Contacts

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Mannosyl_trans - Mannosyltransferase (PIG-M)

PFAM:	PF05007	Sequences: ISTRGNAESLLCVLVLATLYALLKRRVVLAGVLLGLAVHFKIYPIIYALPILLYLDRRRRGSLRARLKRLLNRARLLFALVSLLTFLALTLLFYYLYGWEFLEETYLYHLTRRDHRHNFSPYFYLLYLTSASPSTWSSLLGLLAFLPQLLLLLVLSLAFKRDLPFCMFLQTFAFVTFNKVCTSQYFLWYLCLLPLVLPRSRLLSWRRGLLLLALWVLGQALWLAQAYLLEFLGKNTFLPLWLASLLFFLINCWILGQII	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	259 (258)
Sequences:	673 (525)
Seq/√Len:	32.7
META:	0.226

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
31_G	81_V	5.663	1.00
218_G	250_I	5.165	1.00
38_V	82_S	3.566	1.00
228_L	232_L	3.529	1.00
21_A	33_L	3.304	1.00
169_L	255_L	3.286	1.00
145_F	179_K	3.063	1.00
248_F	252_C	2.996	1.00
145_F	148_Q	2.937	1.00
47_Y	171_T	2.853	1.00
52_L	79_A	2.850	1.00
82_S	86_F	2.766	1.00
99_W	103_E	2.742	1.00
228_L	234_K	2.711	1.00
183_S	219_Q	2.639	1.00
11_L	41_K	2.559	1.00
7_A	41_K	2.536	1.00
152_L	156_S	2.517	1.00
114_D	118_N	2.455	0.99
174_F	179_K	2.441	0.99
56_D	75_R	2.304	0.99
155_L	173_A	2.261	0.99
37_A	41_K	2.202	0.99
221_L	246_L	2.193	0.99
41_K	179_K	2.147	0.99
221_L	225_Q	2.112	0.98
124_Y	128_L	2.041	0.98
121_P	181_C	1.995	0.98
121_P	245_L	1.991	0.98
6_N	50_P	1.943	0.97
171_T	179_K	1.940	0.97
207_R	257_Q	1.905	0.97
8_E	11_L	1.891	0.97
101_F	105_T	1.874	0.97
171_T	174_F	1.874	0.97
21_A	29_L	1.855	0.96
126_L	130_S	1.843	0.96
197_L	208_G	1.816	0.96
172_F	176_T	1.789	0.96
46_I	170_Q	1.788	0.96
114_D	117_H	1.759	0.95
126_L	144_A	1.740	0.95
83_L	87_L	1.686	0.94
180_V	184_Q	1.678	0.94
156_S	170_Q	1.675	0.94
20_Y	24_K	1.661	0.93
85_T	89_L	1.647	0.93
116_R	127_Y	1.625	0.93
247_F	251_N	1.593	0.92
31_G	196_V	1.591	0.92
117_H	120_S	1.588	0.92
119_F	183_S	1.578	0.92
48_A	79_A	1.562	0.91
198_P	241_W	1.526	0.90
1_I	6_N	1.476	0.89
64_R	67_L	1.457	0.88
102_L	107_L	1.443	0.87
32_V	85_T	1.421	0.87
223_L	227_Y	1.412	0.86
109_H	114_D	1.405	0.86
165_F	195_L	1.404	0.86
183_S	220_A	1.379	0.85
51_I	217_L	1.373	0.85
41_K	183_S	1.354	0.84
8_E	219_Q	1.346	0.83
41_K	187_L	1.335	0.83
227_Y	231_F	1.332	0.83
242_L	245_L	1.320	0.82
86_F	90_T	1.297	0.81
7_A	152_L	1.270	0.80
48_A	52_L	1.253	0.79
103_E	111_T	1.253	0.79
15_V	18_T	1.249	0.78
225_Q	240_L	1.243	0.78
50_P	152_L	1.240	0.78
214_L	250_I	1.214	0.76
204_S	227_Y	1.212	0.76
225_Q	239_P	1.211	0.76
48_A	100_E	1.202	0.76
2_S	106_Y	1.191	0.75
222_W	227_Y	1.191	0.75
114_D	119_F	1.189	0.75
31_G	78_F	1.178	0.74
220_A	231_F	1.165	0.73
235_N	240_L	1.151	0.72
39_H	182_T	1.132	0.71
131_A	252_C	1.126	0.71
37_A	76_L	1.122	0.70
141_G	144_A	1.114	0.70
219_Q	231_F	1.112	0.70
98_G	108_Y	1.105	0.69
53_L	160_K	1.097	0.69
215_W	219_Q	1.097	0.69
225_Q	243_A	1.096	0.69
175_V	189_Y	1.088	0.68
211_L	253_W	1.083	0.68
1_I	216_V	1.079	0.67
168_F	172_F	1.079	0.67
176_T	189_Y	1.075	0.67
101_F	106_Y	1.073	0.67
178_N	182_T	1.072	0.67
27_V	55_L	1.059	0.66
114_D	182_T	1.040	0.64
109_H	117_H	1.037	0.64
222_W	230_E	1.035	0.64
22_L	51_I	1.032	0.64
28_V	77_L	1.028	0.64
34_L	48_A	1.027	0.63
14_L	206_R	1.026	0.63
231_F	237_F	1.026	0.63
38_V	86_F	1.020	0.63
196_V	200_S	1.016	0.63
41_K	145_F	1.015	0.63
183_S	190_L	1.012	0.62
109_H	178_N	1.012	0.62
171_T	178_N	1.001	0.61
11_L	183_S	0.999	0.61
162_D	165_F	0.999	0.61
155_L	169_L	0.989	0.61
213_A	246_L	0.983	0.60
8_E	103_E	0.983	0.60
14_L	40_F	0.979	0.60
187_L	245_L	0.975	0.59
21_A	34_L	0.975	0.59
81_V	84_L	0.968	0.59
93_F	106_Y	0.964	0.59
126_L	156_S	0.960	0.58
148_Q	175_V	0.954	0.58
133_P	249_L	0.954	0.58
205_W	209_L	0.953	0.58
141_G	179_K	0.953	0.58
87_L	92_L	0.953	0.58
78_F	81_V	0.949	0.57
117_H	182_T	0.945	0.57
1_I	50_P	0.942	0.57
10_L	14_L	0.938	0.56
102_L	220_A	0.932	0.56
176_T	227_Y	0.927	0.56
118_N	186_F	0.919	0.55
148_Q	189_Y	0.918	0.55
176_T	239_P	0.913	0.54
118_N	147_P	0.911	0.54
226_A	236_T	0.907	0.54
1_I	115_H	0.902	0.53
79_A	161_R	0.899	0.53
202_L	238_L	0.898	0.53
109_H	112_R	0.893	0.53
39_H	117_H	0.892	0.53
230_E	233_G	0.892	0.53
6_N	113_R	0.883	0.52
22_L	30_A	0.881	0.52
229_L	240_L	0.878	0.51
176_T	251_N	0.876	0.51
109_H	118_N	0.876	0.51
45_I	192_L	0.874	0.51
76_L	80_L	0.873	0.51
97_Y	127_Y	0.872	0.51
201_R	207_R	0.870	0.51
51_I	167_M	0.865	0.50
218_G	243_A	0.863	0.50
227_Y	230_E	0.861	0.50
171_T	182_T	0.861	0.50
247_F	254_I	0.859	0.50
155_L	192_L	0.853	0.49
219_Q	226_A	0.850	0.49
22_L	217_L	0.850	0.49
168_F	226_A	0.849	0.49
144_A	179_K	0.845	0.49
18_T	30_A	0.844	0.49
126_L	179_K	0.843	0.49
242_L	246_L	0.842	0.49
92_L	98_G	0.841	0.48
124_Y	241_W	0.839	0.48
106_Y	169_L	0.839	0.48
15_V	41_K	0.833	0.48
68_K	76_L	0.831	0.48
169_L	258_I	0.826	0.47
117_H	194_P	0.826	0.47
112_R	127_Y	0.825	0.47
141_G	156_S	0.824	0.47
100_E	104_E	0.824	0.47
112_R	118_N	0.822	0.47
57_R	61_G	0.821	0.47
107_L	177_F	0.819	0.47
30_A	78_F	0.818	0.47
41_K	141_G	0.813	0.46
41_K	47_Y	0.810	0.46
221_L	243_A	0.807	0.46
223_L	226_A	0.805	0.45
88_A	91_L	0.795	0.45
217_L	220_A	0.790	0.44
92_L	210_L	0.790	0.44
67_L	214_L	0.790	0.44
38_V	83_L	0.784	0.44
211_L	254_I	0.783	0.44
119_F	219_Q	0.781	0.43
37_A	226_A	0.780	0.43
109_H	186_F	0.780	0.43
117_H	230_E	0.780	0.43
214_L	218_G	0.778	0.43
123_F	165_F	0.778	0.43
96_L	163_L	0.777	0.43
241_W	245_L	0.774	0.43
115_H	118_N	0.767	0.42
173_A	255_L	0.764	0.42
76_L	244_S	0.762	0.42
121_P	125_L	0.759	0.42
82_S	85_T	0.759	0.42
117_H	175_V	0.758	0.42
103_E	108_Y	0.755	0.41
74_A	77_L	0.752	0.41
157_L	252_C	0.751	0.41
157_L	207_R	0.746	0.41
126_L	145_F	0.745	0.41
63_L	66_R	0.744	0.40
182_T	186_F	0.744	0.40
39_H	175_V	0.741	0.40
109_H	182_T	0.738	0.40
63_L	67_L	0.734	0.40
98_G	114_D	0.731	0.39
36_L	149_L	0.731	0.39
207_R	252_C	0.728	0.39
206_R	209_L	0.727	0.39
101_F	109_H	0.727	0.39
125_L	240_L	0.726	0.39
80_L	84_L	0.713	0.38
223_L	231_F	0.710	0.38
253_W	257_Q	0.705	0.37
25_R	71_L	0.704	0.37
41_K	221_L	0.704	0.37
96_L	100_E	0.704	0.37
28_V	250_I	0.703	0.37
111_T	208_G	0.703	0.37
124_Y	226_A	0.702	0.37
8_E	243_A	0.700	0.37
220_A	253_W	0.698	0.37
211_L	257_Q	0.697	0.37
19_L	231_F	0.696	0.37
70_L	108_Y	0.693	0.36
49_L	166_C	0.693	0.36
243_A	247_F	0.692	0.36
190_L	217_L	0.686	0.36
34_L	196_V	0.683	0.36
64_R	68_K	0.683	0.36
19_L	26_R	0.679	0.35
114_D	120_S	0.675	0.35
242_L	257_Q	0.673	0.35
125_L	187_L	0.673	0.35
182_T	230_E	0.672	0.35
41_K	191_C	0.671	0.35
1_I	7_A	0.668	0.35
119_F	237_F	0.664	0.34
114_D	147_P	0.664	0.34
189_Y	254_I	0.662	0.34
224_A	228_L	0.660	0.34
60_R	246_L	0.660	0.34
131_A	248_F	0.659	0.34
118_N	182_T	0.655	0.34
47_Y	179_K	0.652	0.33
130_S	248_F	0.649	0.33
118_N	223_L	0.646	0.33
150_L	245_L	0.646	0.33
80_L	213_A	0.643	0.33
15_V	168_F	0.642	0.33
117_H	186_F	0.642	0.33
25_R	179_K	0.641	0.33
104_E	183_S	0.641	0.33
45_I	48_A	0.640	0.33
181_C	189_Y	0.638	0.32
222_W	226_A	0.636	0.32
30_A	37_A	0.633	0.32
115_H	170_Q	0.633	0.32
168_F	235_N	0.632	0.32
52_L	113_R	0.630	0.32
61_G	76_L	0.630	0.32
18_T	37_A	0.629	0.32
85_T	190_L	0.626	0.32
38_V	198_P	0.625	0.31
65_A	83_L	0.625	0.31
120_S	123_F	0.624	0.31
37_A	160_K	0.623	0.31
2_S	119_F	0.623	0.31
39_H	116_R	0.621	0.31
168_F	196_V	0.617	0.31
113_R	141_G	0.616	0.31
57_R	72_N	0.616	0.31
236_T	240_L	0.616	0.31
23_L	51_I	0.614	0.31
183_S	225_Q	0.612	0.31
122_Y	145_F	0.612	0.31
177_F	248_F	0.612	0.31
155_L	248_F	0.610	0.30
123_F	142_L	0.609	0.30
175_V	182_T	0.607	0.30
96_L	102_L	0.607	0.30
62_S	87_L	0.605	0.30
37_A	149_L	0.604	0.30
81_V	85_T	0.602	0.30
137_S	209_L	0.602	0.30
13_V	75_R	0.601	0.30
8_E	152_L	0.600	0.30
42_I	47_Y	0.598	0.30
52_L	71_L	0.596	0.29
51_I	226_A	0.595	0.29
92_L	95_Y	0.595	0.29
7_A	34_L	0.593	0.29
225_Q	228_L	0.593	0.29
88_A	92_L	0.591	0.29
178_N	185_Y	0.589	0.29
14_L	227_Y	0.589	0.29
32_V	92_L	0.588	0.29
144_A	173_A	0.583	0.29
39_H	186_F	0.583	0.29
58_R	62_S	0.582	0.28
19_L	139_L	0.581	0.28
243_A	246_L	0.581	0.28
118_N	175_V	0.577	0.28
10_L	244_S	0.577	0.28
36_L	89_L	0.576	0.28
48_A	121_P	0.575	0.28
95_Y	146_L	0.574	0.28
242_L	249_L	0.574	0.28
109_H	127_Y	0.574	0.28
178_N	184_Q	0.570	0.28
29_L	153_L	0.569	0.28
147_P	222_W	0.569	0.28
90_T	93_F	0.566	0.27
41_K	115_H	0.565	0.27
236_T	250_I	0.563	0.27
34_L	106_Y	0.563	0.27
17_A	33_L	0.562	0.27
32_V	36_L	0.562	0.27
49_L	235_N	0.561	0.27
114_D	175_V	0.559	0.27
52_L	144_A	0.558	0.27
121_P	240_L	0.557	0.27
35_G	39_H	0.557	0.27
24_K	195_L	0.556	0.27
42_I	71_L	0.552	0.26
244_S	256_G	0.551	0.26
1_I	160_K	0.551	0.26
114_D	230_E	0.550	0.26
174_F	184_Q	0.546	0.26
51_I	55_L	0.546	0.26
108_Y	117_H	0.544	0.26
141_G	145_F	0.540	0.26
122_Y	147_P	0.538	0.26
2_S	126_L	0.538	0.26
199_R	204_S	0.537	0.26
8_E	115_H	0.535	0.25
77_L	214_L	0.534	0.25
70_L	217_L	0.534	0.25
53_L	156_S	0.534	0.25
65_A	68_K	0.533	0.25
39_H	114_D	0.532	0.25
52_L	160_K	0.532	0.25
84_L	213_A	0.531	0.25
112_R	120_S	0.530	0.25
245_L	258_I	0.528	0.25
12_C	191_C	0.528	0.25
31_G	85_T	0.527	0.25
187_L	202_L	0.527	0.25
60_R	68_K	0.526	0.25
160_K	166_C	0.522	0.25
221_L	226_A	0.522	0.25
242_L	254_I	0.520	0.24
41_K	174_F	0.520	0.24
15_V	33_L	0.515	0.24
162_D	166_C	0.515	0.24
229_L	237_F	0.512	0.24
149_L	152_L	0.511	0.24
116_R	182_T	0.511	0.24
34_L	42_I	0.510	0.24
56_D	59_R	0.510	0.24
73_R	80_L	0.509	0.24
7_A	15_V	0.508	0.24
246_L	250_I	0.507	0.24
73_R	77_L	0.507	0.24
169_L	254_I	0.506	0.24
76_L	107_L	0.506	0.24
200_S	208_G	0.505	0.24
32_V	140_L	0.505	0.24
179_K	184_Q	0.503	0.23
51_I	54_Y	0.503	0.23
161_R	169_L	0.502	0.23
86_F	89_L	0.501	0.23
7_A	40_F	0.500	0.23

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ne5A	3	0.2278	4.6	0.971	Contact Map
1vk4A	1	0.2046	3.7	0.972	Contact Map
3aqpA	1	0.2162	3.7	0.972	Contact Map
4k8kA	2	0.2317	3.4	0.972	Contact Map
3hj6A	2	0.1351	3.2	0.973	Contact Map
3w9iA	3	0.2317	2.8	0.974	Contact Map
1jxhA	2	0.2355	2.6	0.974	Contact Map
4mt1A	3	0.2239	2.3	0.975	Contact Map
3wajA	1	0.7452	2.3	0.975	Contact Map
2m20A	2	0.2278	2.2	0.975	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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