GREMLIN Database
Mannosyl_trans - Mannosyltransferase (PIG-M)
PFAM: PF05007 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 259 (258)
Sequences: 673 (525)
Seq/√Len: 32.7
META: 0.226

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_G81_V5.6631.00
218_G250_I5.1651.00
38_V82_S3.5661.00
228_L232_L3.5291.00
21_A33_L3.3041.00
169_L255_L3.2861.00
145_F179_K3.0631.00
248_F252_C2.9961.00
145_F148_Q2.9371.00
47_Y171_T2.8531.00
52_L79_A2.8501.00
82_S86_F2.7661.00
99_W103_E2.7421.00
228_L234_K2.7111.00
183_S219_Q2.6391.00
11_L41_K2.5591.00
7_A41_K2.5361.00
152_L156_S2.5171.00
114_D118_N2.4550.99
174_F179_K2.4410.99
56_D75_R2.3040.99
155_L173_A2.2610.99
37_A41_K2.2020.99
221_L246_L2.1930.99
41_K179_K2.1470.99
221_L225_Q2.1120.98
124_Y128_L2.0410.98
121_P181_C1.9950.98
121_P245_L1.9910.98
6_N50_P1.9430.97
171_T179_K1.9400.97
207_R257_Q1.9050.97
8_E11_L1.8910.97
101_F105_T1.8740.97
171_T174_F1.8740.97
21_A29_L1.8550.96
126_L130_S1.8430.96
197_L208_G1.8160.96
172_F176_T1.7890.96
46_I170_Q1.7880.96
114_D117_H1.7590.95
126_L144_A1.7400.95
83_L87_L1.6860.94
180_V184_Q1.6780.94
156_S170_Q1.6750.94
20_Y24_K1.6610.93
85_T89_L1.6470.93
116_R127_Y1.6250.93
247_F251_N1.5930.92
31_G196_V1.5910.92
117_H120_S1.5880.92
119_F183_S1.5780.92
48_A79_A1.5620.91
198_P241_W1.5260.90
1_I6_N1.4760.89
64_R67_L1.4570.88
102_L107_L1.4430.87
32_V85_T1.4210.87
223_L227_Y1.4120.86
109_H114_D1.4050.86
165_F195_L1.4040.86
183_S220_A1.3790.85
51_I217_L1.3730.85
41_K183_S1.3540.84
8_E219_Q1.3460.83
41_K187_L1.3350.83
227_Y231_F1.3320.83
242_L245_L1.3200.82
86_F90_T1.2970.81
7_A152_L1.2700.80
48_A52_L1.2530.79
103_E111_T1.2530.79
15_V18_T1.2490.78
225_Q240_L1.2430.78
50_P152_L1.2400.78
214_L250_I1.2140.76
204_S227_Y1.2120.76
225_Q239_P1.2110.76
48_A100_E1.2020.76
2_S106_Y1.1910.75
222_W227_Y1.1910.75
114_D119_F1.1890.75
31_G78_F1.1780.74
220_A231_F1.1650.73
235_N240_L1.1510.72
39_H182_T1.1320.71
131_A252_C1.1260.71
37_A76_L1.1220.70
141_G144_A1.1140.70
219_Q231_F1.1120.70
98_G108_Y1.1050.69
53_L160_K1.0970.69
215_W219_Q1.0970.69
225_Q243_A1.0960.69
175_V189_Y1.0880.68
211_L253_W1.0830.68
1_I216_V1.0790.67
168_F172_F1.0790.67
176_T189_Y1.0750.67
101_F106_Y1.0730.67
178_N182_T1.0720.67
27_V55_L1.0590.66
114_D182_T1.0400.64
109_H117_H1.0370.64
222_W230_E1.0350.64
22_L51_I1.0320.64
28_V77_L1.0280.64
34_L48_A1.0270.63
14_L206_R1.0260.63
231_F237_F1.0260.63
38_V86_F1.0200.63
196_V200_S1.0160.63
41_K145_F1.0150.63
183_S190_L1.0120.62
109_H178_N1.0120.62
171_T178_N1.0010.61
11_L183_S0.9990.61
162_D165_F0.9990.61
155_L169_L0.9890.61
213_A246_L0.9830.60
8_E103_E0.9830.60
14_L40_F0.9790.60
187_L245_L0.9750.59
21_A34_L0.9750.59
81_V84_L0.9680.59
93_F106_Y0.9640.59
126_L156_S0.9600.58
148_Q175_V0.9540.58
133_P249_L0.9540.58
205_W209_L0.9530.58
141_G179_K0.9530.58
87_L92_L0.9530.58
78_F81_V0.9490.57
117_H182_T0.9450.57
1_I50_P0.9420.57
10_L14_L0.9380.56
102_L220_A0.9320.56
176_T227_Y0.9270.56
118_N186_F0.9190.55
148_Q189_Y0.9180.55
176_T239_P0.9130.54
118_N147_P0.9110.54
226_A236_T0.9070.54
1_I115_H0.9020.53
79_A161_R0.8990.53
202_L238_L0.8980.53
109_H112_R0.8930.53
39_H117_H0.8920.53
230_E233_G0.8920.53
6_N113_R0.8830.52
22_L30_A0.8810.52
229_L240_L0.8780.51
176_T251_N0.8760.51
109_H118_N0.8760.51
45_I192_L0.8740.51
76_L80_L0.8730.51
97_Y127_Y0.8720.51
201_R207_R0.8700.51
51_I167_M0.8650.50
218_G243_A0.8630.50
227_Y230_E0.8610.50
171_T182_T0.8610.50
247_F254_I0.8590.50
155_L192_L0.8530.49
219_Q226_A0.8500.49
22_L217_L0.8500.49
168_F226_A0.8490.49
144_A179_K0.8450.49
18_T30_A0.8440.49
126_L179_K0.8430.49
242_L246_L0.8420.49
92_L98_G0.8410.48
124_Y241_W0.8390.48
106_Y169_L0.8390.48
15_V41_K0.8330.48
68_K76_L0.8310.48
169_L258_I0.8260.47
117_H194_P0.8260.47
112_R127_Y0.8250.47
141_G156_S0.8240.47
100_E104_E0.8240.47
112_R118_N0.8220.47
57_R61_G0.8210.47
107_L177_F0.8190.47
30_A78_F0.8180.47
41_K141_G0.8130.46
41_K47_Y0.8100.46
221_L243_A0.8070.46
223_L226_A0.8050.45
88_A91_L0.7950.45
217_L220_A0.7900.44
92_L210_L0.7900.44
67_L214_L0.7900.44
38_V83_L0.7840.44
211_L254_I0.7830.44
119_F219_Q0.7810.43
37_A226_A0.7800.43
109_H186_F0.7800.43
117_H230_E0.7800.43
214_L218_G0.7780.43
123_F165_F0.7780.43
96_L163_L0.7770.43
241_W245_L0.7740.43
115_H118_N0.7670.42
173_A255_L0.7640.42
76_L244_S0.7620.42
121_P125_L0.7590.42
82_S85_T0.7590.42
117_H175_V0.7580.42
103_E108_Y0.7550.41
74_A77_L0.7520.41
157_L252_C0.7510.41
157_L207_R0.7460.41
126_L145_F0.7450.41
63_L66_R0.7440.40
182_T186_F0.7440.40
39_H175_V0.7410.40
109_H182_T0.7380.40
63_L67_L0.7340.40
98_G114_D0.7310.39
36_L149_L0.7310.39
207_R252_C0.7280.39
206_R209_L0.7270.39
101_F109_H0.7270.39
125_L240_L0.7260.39
80_L84_L0.7130.38
223_L231_F0.7100.38
253_W257_Q0.7050.37
25_R71_L0.7040.37
41_K221_L0.7040.37
96_L100_E0.7040.37
28_V250_I0.7030.37
111_T208_G0.7030.37
124_Y226_A0.7020.37
8_E243_A0.7000.37
220_A253_W0.6980.37
211_L257_Q0.6970.37
19_L231_F0.6960.37
70_L108_Y0.6930.36
49_L166_C0.6930.36
243_A247_F0.6920.36
190_L217_L0.6860.36
34_L196_V0.6830.36
64_R68_K0.6830.36
19_L26_R0.6790.35
114_D120_S0.6750.35
242_L257_Q0.6730.35
125_L187_L0.6730.35
182_T230_E0.6720.35
41_K191_C0.6710.35
1_I7_A0.6680.35
119_F237_F0.6640.34
114_D147_P0.6640.34
189_Y254_I0.6620.34
224_A228_L0.6600.34
60_R246_L0.6600.34
131_A248_F0.6590.34
118_N182_T0.6550.34
47_Y179_K0.6520.33
130_S248_F0.6490.33
118_N223_L0.6460.33
150_L245_L0.6460.33
80_L213_A0.6430.33
15_V168_F0.6420.33
117_H186_F0.6420.33
25_R179_K0.6410.33
104_E183_S0.6410.33
45_I48_A0.6400.33
181_C189_Y0.6380.32
222_W226_A0.6360.32
30_A37_A0.6330.32
115_H170_Q0.6330.32
168_F235_N0.6320.32
52_L113_R0.6300.32
61_G76_L0.6300.32
18_T37_A0.6290.32
85_T190_L0.6260.32
38_V198_P0.6250.31
65_A83_L0.6250.31
120_S123_F0.6240.31
37_A160_K0.6230.31
2_S119_F0.6230.31
39_H116_R0.6210.31
168_F196_V0.6170.31
113_R141_G0.6160.31
57_R72_N0.6160.31
236_T240_L0.6160.31
23_L51_I0.6140.31
183_S225_Q0.6120.31
122_Y145_F0.6120.31
177_F248_F0.6120.31
155_L248_F0.6100.30
123_F142_L0.6090.30
175_V182_T0.6070.30
96_L102_L0.6070.30
62_S87_L0.6050.30
37_A149_L0.6040.30
81_V85_T0.6020.30
137_S209_L0.6020.30
13_V75_R0.6010.30
8_E152_L0.6000.30
42_I47_Y0.5980.30
52_L71_L0.5960.29
51_I226_A0.5950.29
92_L95_Y0.5950.29
7_A34_L0.5930.29
225_Q228_L0.5930.29
88_A92_L0.5910.29
178_N185_Y0.5890.29
14_L227_Y0.5890.29
32_V92_L0.5880.29
144_A173_A0.5830.29
39_H186_F0.5830.29
58_R62_S0.5820.28
19_L139_L0.5810.28
243_A246_L0.5810.28
118_N175_V0.5770.28
10_L244_S0.5770.28
36_L89_L0.5760.28
48_A121_P0.5750.28
95_Y146_L0.5740.28
242_L249_L0.5740.28
109_H127_Y0.5740.28
178_N184_Q0.5700.28
29_L153_L0.5690.28
147_P222_W0.5690.28
90_T93_F0.5660.27
41_K115_H0.5650.27
236_T250_I0.5630.27
34_L106_Y0.5630.27
17_A33_L0.5620.27
32_V36_L0.5620.27
49_L235_N0.5610.27
114_D175_V0.5590.27
52_L144_A0.5580.27
121_P240_L0.5570.27
35_G39_H0.5570.27
24_K195_L0.5560.27
42_I71_L0.5520.26
244_S256_G0.5510.26
1_I160_K0.5510.26
114_D230_E0.5500.26
174_F184_Q0.5460.26
51_I55_L0.5460.26
108_Y117_H0.5440.26
141_G145_F0.5400.26
122_Y147_P0.5380.26
2_S126_L0.5380.26
199_R204_S0.5370.26
8_E115_H0.5350.25
77_L214_L0.5340.25
70_L217_L0.5340.25
53_L156_S0.5340.25
65_A68_K0.5330.25
39_H114_D0.5320.25
52_L160_K0.5320.25
84_L213_A0.5310.25
112_R120_S0.5300.25
245_L258_I0.5280.25
12_C191_C0.5280.25
31_G85_T0.5270.25
187_L202_L0.5270.25
60_R68_K0.5260.25
160_K166_C0.5220.25
221_L226_A0.5220.25
242_L254_I0.5200.24
41_K174_F0.5200.24
15_V33_L0.5150.24
162_D166_C0.5150.24
229_L237_F0.5120.24
149_L152_L0.5110.24
116_R182_T0.5110.24
34_L42_I0.5100.24
56_D59_R0.5100.24
73_R80_L0.5090.24
7_A15_V0.5080.24
246_L250_I0.5070.24
73_R77_L0.5070.24
169_L254_I0.5060.24
76_L107_L0.5060.24
200_S208_G0.5050.24
32_V140_L0.5050.24
179_K184_Q0.5030.23
51_I54_Y0.5030.23
161_R169_L0.5020.23
86_F89_L0.5010.23
7_A40_F0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ne5A 3 0.2278 4.6 0.971 Contact Map
1vk4A 1 0.2046 3.7 0.972 Contact Map
3aqpA 1 0.2162 3.7 0.972 Contact Map
4k8kA 2 0.2317 3.4 0.972 Contact Map
3hj6A 2 0.1351 3.2 0.973 Contact Map
3w9iA 3 0.2317 2.8 0.974 Contact Map
1jxhA 2 0.2355 2.6 0.974 Contact Map
4mt1A 3 0.2239 2.3 0.975 Contact Map
3wajA 1 0.7452 2.3 0.975 Contact Map
2m20A 2 0.2278 2.2 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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