GREMLIN Database
FtsL - Cell division protein FtsL
PFAM: PF04999 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 97 (82)
Sequences: 12673 (8099)
Seq/√Len: 894.4
META: 0.919

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_E79_R2.8831.00
77_I81_R2.8171.00
76_R80_E2.8071.00
51_R55_E2.3641.00
58_W62_Q2.3021.00
73_R77_I2.2071.00
47_L50_E2.1821.00
88_D91_Q1.9991.00
36_Q40_L1.9711.00
65_Q69_A1.9461.00
36_Q39_Q1.9341.00
38_R42_V1.8641.00
85_V91_Q1.8541.00
44_L48_Q1.7741.00
57_E60_R1.7671.00
32_Y36_Q1.7051.00
40_L43_E1.7031.00
56_E59_G1.6891.00
48_Q51_R1.6211.00
50_E53_Q1.6191.00
64_E67_T1.4571.00
38_R41_F1.4201.00
37_S41_F1.4121.00
31_V34_Q1.3371.00
29_G32_Y1.3151.00
62_Q65_Q1.3151.00
45_E48_Q1.3091.00
54_L57_E1.2681.00
33_S37_S1.2571.00
55_E58_W1.2341.00
72_A76_R1.1841.00
39_Q42_V1.1661.00
85_V88_D1.1171.00
47_L51_R1.1141.00
35_H39_Q1.1101.00
68_L73_R1.1071.00
39_Q43_E1.0991.00
56_E60_R1.0461.00
52_D55_E1.0381.00
79_R86_P1.0271.00
26_S30_V1.0141.00
30_V33_S1.0051.00
62_Q66_S0.9941.00
29_G33_S0.9651.00
64_E68_L0.9611.00
46_R50_E0.9471.00
53_Q57_E0.9471.00
53_Q56_E0.9261.00
43_E46_R0.9181.00
35_H38_R0.9011.00
63_L67_T0.8971.00
37_S40_L0.8791.00
46_R49_A0.8731.00
22_A26_S0.8721.00
49_A53_Q0.8581.00
34_Q38_R0.8301.00
75_E86_P0.8251.00
51_R54_L0.8191.00
55_E59_G0.8191.00
31_V35_H0.8181.00
79_R85_V0.7841.00
65_Q68_L0.7801.00
27_A31_V0.7781.00
19_L26_S0.7771.00
36_Q42_V0.7701.00
43_E47_L0.7631.00
26_S33_S0.7621.00
41_F45_E0.7611.00
38_R43_E0.7541.00
58_W65_Q0.7531.00
23_V30_V0.7421.00
44_L47_L0.7301.00
30_V34_Q0.7261.00
34_Q37_S0.7151.00
89_P92_V0.7091.00
24_L28_L0.7071.00
21_L24_L0.7051.00
25_A29_G0.6871.00
74_I78_A0.6851.00
69_A73_R0.6841.00
14_R18_L0.6811.00
20_L30_V0.6691.00
49_A52_D0.6641.00
36_Q41_F0.6591.00
60_R67_T0.6561.00
68_L74_I0.6561.00
66_S69_A0.6481.00
15_L18_L0.6321.00
23_V27_A0.6321.00
60_R64_E0.6291.00
45_E49_A0.6221.00
68_L77_I0.6131.00
20_L61_L0.6131.00
36_Q43_E0.5991.00
78_A84_M0.5991.00
74_I82_L0.5941.00
28_L31_V0.5921.00
29_G34_Q0.5911.00
27_A30_V0.5851.00
14_R17_L0.5841.00
87_P91_Q0.5791.00
60_R63_L0.5701.00
35_H41_F0.5671.00
19_L23_V0.5621.00
50_E54_L0.5591.00
18_L21_L0.5561.00
70_S73_R0.5551.00
52_D56_E0.5501.00
17_L21_L0.5481.00
28_L37_S0.5391.00
17_L22_A0.5371.00
69_A74_I0.5361.00
16_N19_L0.5321.00
16_N20_L0.5211.00
59_G63_L0.5191.00
25_A28_L0.5191.00
16_N24_L0.5161.00
72_A75_E0.5111.00
16_N22_A0.5111.00
77_I80_E0.5081.00
48_Q52_D0.5021.00
59_G62_Q0.5011.00
24_L31_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dznA 3 0.3299 39.1 0.823 Contact Map
2j5uA 4 0.5052 17.9 0.85 Contact Map
2kogA 1 0.3711 14.5 0.856 Contact Map
2oa5A 4 0.5052 13.1 0.859 Contact Map
3u06A 2 0.6701 11.9 0.861 Contact Map
1dipA 2 0.7113 11.8 0.861 Contact Map
3c3gA 2 0.2062 10.3 0.866 Contact Map
4cgkA 3 0.4742 10.3 0.866 Contact Map
1kd8A 1 0.3608 10 0.866 Contact Map
2wq1A 3 0.3299 10 0.866 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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