GREMLIN Database
PigN - Phosphatidylinositolglycan class N (PIG-N)
PFAM: PF04987 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 434 (432)
Sequences: 511 (375)
Seq/√Len: 18.0
META: 0.078

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_G78_W5.4841.00
233_L238_Q5.0141.00
186_L217_M4.4381.00
14_L67_Y3.5641.00
138_L166_L3.2780.99
18_V61_Q3.2560.99
126_S133_L3.2300.99
232_G238_Q3.1410.99
372_F375_F3.1130.99
126_S421_M3.0480.99
27_A81_V2.9630.99
128_F424_N2.8890.99
128_F428_L2.7510.98
222_S237_N2.7390.98
123_L133_L2.7260.98
369_I376_L2.7230.98
171_F286_F2.7170.98
353_N356_S2.7030.98
22_Y127_F2.6810.98
124_V128_F2.6610.97
277_L368_F2.6400.97
143_W339_F2.4880.96
6_L370_P2.4400.96
291_S391_L2.4100.95
327_R333_D2.4070.95
426_F431_D2.3830.95
424_N428_L2.3740.95
121_E424_N2.3500.95
405_L409_S2.3250.94
343_F418_S2.3230.94
19_T427_F2.2710.94
290_L392_V2.2640.94
10_D22_Y2.2430.93
350_G377_M2.2230.93
298_I395_A2.2210.93
168_L395_A2.1570.92
191_L288_L2.1300.91
21_G67_Y2.0370.89
387_I392_V2.0150.89
57_F61_Q2.0060.88
363_S366_Y2.0020.88
413_L417_I1.9750.88
307_S311_K1.9380.87
353_N358_S1.9330.86
286_F350_G1.9050.86
185_I370_P1.9050.86
7_Q11_W1.8970.85
232_G237_N1.8840.85
255_S266_S1.8570.84
182_I224_V1.8490.84
307_S313_T1.8230.83
134_T420_I1.8030.82
5_Y9_Y1.7880.82
3_L25_W1.7680.81
359_S375_F1.7410.80
344_L415_L1.7320.80
6_L367_R1.7300.80
345_Q362_L1.7220.79
223_S233_L1.7210.79
11_W172_T1.7130.79
360_F374_P1.7030.78
361_S364_S1.6930.78
45_F48_A1.6600.77
15_R426_F1.6550.76
381_L393_S1.6520.76
353_N374_P1.6470.76
124_V428_L1.6260.75
163_L231_Q1.6240.75
226_S238_Q1.6170.75
366_Y377_M1.5790.73
30_L430_K1.5710.72
297_W348_F1.5540.72
353_N372_F1.5520.71
252_P347_A1.5380.71
355_A374_P1.5160.70
212_L216_S1.5130.69
93_K163_L1.4930.68
54_L260_N1.4930.68
311_K316_Q1.4910.68
113_L187_L1.4840.68
362_L367_R1.4810.68
308_S314_S1.4800.68
87_V188_G1.4610.67
364_S387_I1.4570.66
362_L368_F1.4560.66
137_F346_V1.4540.66
180_E368_F1.4500.66
4_R8_T1.4480.66
174_L188_G1.4450.66
121_E428_L1.4430.66
308_S311_K1.4400.66
42_L46_S1.4170.64
11_W136_G1.4160.64
392_V396_F1.4140.64
214_V292_L1.4080.64
185_I368_F1.4040.64
210_I213_I1.4030.63
227_L234_P1.4020.63
185_I392_V1.3910.63
383_L406_P1.3910.63
73_F77_F1.3860.62
358_S367_R1.3810.62
3_L347_A1.3750.62
179_V279_S1.3710.62
96_L334_L1.3650.61
226_S232_G1.3580.61
361_S368_F1.3360.60
17_I75_V1.3330.59
400_N403_L1.3190.59
312_S318_S1.3050.58
242_W375_F1.2950.57
43_V46_S1.2940.57
280_I361_S1.2910.57
353_N357_I1.2890.57
46_S49_L1.2780.56
277_L363_S1.2760.56
73_F127_F1.2760.56
89_Q93_K1.2730.56
294_L391_L1.2660.55
136_G342_F1.2650.55
425_F433_G1.2650.55
241_G245_L1.2490.54
317_F320_S1.2490.54
163_L319_N1.2420.54
115_L146_L1.2400.54
226_S233_L1.2360.53
307_S310_S1.2300.53
242_W352_G1.2230.53
138_L430_K1.2200.53
10_D18_V1.2160.52
190_L217_M1.2150.52
241_G345_Q1.2140.52
425_F434_S1.2080.52
6_L368_F1.2080.52
381_L426_F1.2070.52
374_P377_M1.2070.52
361_S367_R1.2020.51
384_K433_G1.1880.51
315_S318_S1.1870.50
298_I302_H1.1870.50
359_S374_P1.1860.50
413_L428_L1.1850.50
46_S50_I1.1840.50
115_L337_A1.1810.50
345_Q367_R1.1740.50
15_R381_L1.1640.49
345_Q361_S1.1630.49
420_I424_N1.1610.49
175_P282_Y1.1590.49
77_F367_R1.1410.48
287_Y367_R1.1380.47
297_W301_E1.1360.47
209_Q220_T1.1350.47
113_L320_S1.1330.47
364_S405_L1.1260.47
1_E201_F1.1230.47
182_I227_L1.1230.47
126_S220_T1.1210.46
169_S172_T1.1210.46
133_L364_S1.1200.46
421_M432_E1.1100.46
350_G359_S1.1090.46
111_G391_L1.1080.46
141_A162_A1.1070.46
361_S370_P1.1070.46
252_P365_V1.1060.46
78_W189_G1.1060.46
274_T341_L1.1050.45
57_F427_F1.0970.45
283_E353_N1.0950.45
184_L421_M1.0930.45
274_T364_S1.0920.45
172_T412_L1.0920.45
312_S317_F1.0920.45
229_A337_A1.0900.45
130_R356_S1.0850.44
45_F49_L1.0850.44
364_S378_G1.0830.44
274_T387_I1.0820.44
233_L237_N1.0800.44
406_P421_M1.0790.44
363_S400_N1.0760.44
379_A382_I1.0740.44
297_W340_F1.0740.44
174_L281_S1.0730.44
410_L431_D1.0700.43
387_I424_N1.0630.43
372_F419_D1.0610.43
35_K201_F1.0580.43
290_L414_V1.0570.43
220_T370_P1.0560.42
94_S97_G1.0550.42
241_G362_L1.0550.42
3_L418_S1.0540.42
375_F419_D1.0540.42
178_K358_S1.0480.42
241_G277_L1.0480.42
220_T368_F1.0480.42
70_Y419_D1.0470.42
156_L250_V1.0440.42
96_L398_A1.0420.42
358_S375_F1.0410.42
152_K157_L1.0390.41
312_S315_S1.0370.41
137_F341_L1.0350.41
322_D325_Q1.0320.41
290_L368_F1.0310.41
92_L160_S1.0300.41
342_F385_L1.0280.41
18_V185_I1.0250.41
230_K366_Y1.0230.41
15_R362_L1.0220.40
72_L106_L1.0190.40
377_M381_L1.0180.40
293_T343_F1.0160.40
195_I288_L1.0130.40
39_T250_V1.0080.40
208_L264_L1.0070.40
26_I255_S1.0010.39
1_E88_L1.0010.39
391_L427_F1.0010.39
193_L214_V1.0000.39
175_P180_E1.0000.39
88_L415_L0.9990.39
309_K315_S0.9990.39
365_V377_M0.9980.39
145_L187_L0.9920.39
7_Q429_V0.9910.39
171_F374_P0.9900.39
369_I378_G0.9860.38
39_T42_L0.9850.38
317_F322_D0.9840.38
69_A261_L0.9830.38
123_L364_S0.9780.38
20_L167_L0.9720.38
241_G368_F0.9720.38
345_Q368_F0.9700.37
96_L373_S0.9630.37
223_S368_F0.9600.37
137_F364_S0.9600.37
10_D21_G0.9590.37
366_Y375_F0.9580.37
77_F127_F0.9570.37
1_E404_R0.9560.37
364_S381_L0.9550.37
414_V418_S0.9530.36
184_L428_L0.9520.36
142_L149_S0.9510.36
274_T304_I0.9480.36
70_Y286_F0.9480.36
111_G117_V0.9460.36
41_L46_S0.9450.36
45_F53_L0.9440.36
286_F359_S0.9410.36
29_A368_F0.9400.36
241_G361_S0.9390.36
279_S350_G0.9380.36
357_I375_F0.9380.36
50_I113_L0.9340.35
138_L158_S0.9310.35
80_E83_A0.9300.35
130_R353_N0.9300.35
360_F380_L0.9250.35
310_S314_S0.9250.35
90_A93_K0.9240.35
60_I140_L0.9180.34
272_A291_S0.9170.34
275_F287_Y0.9160.34
290_L347_A0.9160.34
312_S316_Q0.9140.34
10_D431_D0.9140.34
223_S232_G0.9120.34
362_L370_P0.9120.34
399_L427_F0.9110.34
22_Y367_R0.9090.34
364_S424_N0.9090.34
120_L430_K0.9070.34
367_R381_L0.9060.34
122_L290_L0.9000.33
15_R29_A0.8970.33
203_L357_I0.8970.33
141_A166_L0.8960.33
242_W246_V0.8960.33
239_I279_S0.8950.33
366_Y382_I0.8900.33
278_L380_L0.8820.32
143_W176_V0.8800.32
124_V136_G0.8780.32
132_I347_A0.8780.32
297_W365_V0.8760.32
130_R283_E0.8740.32
15_R73_F0.8710.32
175_P178_K0.8690.32
10_D13_F0.8670.32
131_E385_L0.8660.32
294_L395_A0.8660.32
88_L118_L0.8630.31
337_A399_L0.8630.31
163_L167_L0.8620.31
311_K315_S0.8610.31
7_Q14_L0.8600.31
133_L336_I0.8550.31
168_L276_L0.8550.31
6_L73_F0.8540.31
426_F433_G0.8530.31
419_D423_L0.8520.31
302_H371_V0.8510.31
206_T303_E0.8500.31
184_L216_S0.8480.31
4_R431_D0.8470.31
154_N303_E0.8450.31
349_F356_S0.8440.30
370_P392_V0.8420.30
197_L371_V0.8420.30
418_S424_N0.8400.30
124_V424_N0.8390.30
371_V374_P0.8380.30
219_V222_S0.8360.30
110_L190_L0.8350.30
396_F418_S0.8340.30
171_F297_W0.8340.30
139_L142_L0.8310.30
43_V47_S0.8280.30
313_T317_F0.8130.29
98_H218_L0.8120.29
346_V350_G0.8110.29
194_L323_I0.8110.29
369_I401_K0.8100.29
107_S138_L0.8090.29
89_Q117_V0.8040.28
135_V231_Q0.8030.28
283_E374_P0.8010.28
299_R427_F0.8010.28
22_Y32_T0.8010.28
241_G370_P0.8010.28
274_T334_L0.8000.28
11_W273_P0.7990.28
396_F406_P0.7990.28
251_L343_F0.7980.28
410_L415_L0.7970.28
33_V215_L0.7950.28
21_G367_R0.7950.28
18_V386_L0.7920.28
310_S317_F0.7920.28
134_T169_S0.7910.28
163_L247_S0.7910.28
126_S354_I0.7910.28
124_V421_M0.7890.28
7_Q22_Y0.7880.28
261_L302_H0.7850.27
300_L432_E0.7840.27
420_I430_K0.7830.27
171_F355_A0.7820.27
200_L403_L0.7820.27
384_K434_S0.7810.27
18_V381_L0.7730.27
187_L325_Q0.7730.27
367_R422_T0.7700.27
146_L313_T0.7690.27
6_L345_Q0.7690.27
30_L98_H0.7660.27
279_S284_G0.7660.27
269_L280_I0.7660.27
286_F297_W0.7630.26
219_V237_N0.7600.26
39_T89_Q0.7600.26
43_V110_L0.7590.26
88_L96_L0.7590.26
95_L386_L0.7550.26
175_P367_R0.7550.26
3_L387_I0.7540.26
10_D381_L0.7540.26
105_Y250_V0.7530.26
1_E18_V0.7520.26
311_K317_F0.7510.26
20_L59_L0.7510.26
311_K314_S0.7510.26
152_K188_G0.7490.26
382_I387_I0.7480.26
193_L200_L0.7480.26
374_P434_S0.7460.26
220_T290_L0.7460.26
21_G389_F0.7430.25
97_G190_L0.7420.25
307_S312_S0.7420.25
134_T248_S0.7400.25
144_P161_W0.7390.25
137_F172_T0.7370.25
22_Y422_T0.7370.25
127_F275_F0.7370.25
312_S320_S0.7350.25
134_T306_Q0.7330.25
133_L177_G0.7330.25
185_I280_I0.7330.25
89_Q190_L0.7300.25
11_W21_G0.7270.25
139_L148_T0.7260.25
115_L167_L0.7240.25
59_L373_S0.7230.25
180_E185_I0.7230.25
156_L272_A0.7230.25
349_F355_A0.7220.24
93_K170_V0.7210.24
212_L248_S0.7200.24
144_P182_I0.7180.24
319_N325_Q0.7180.24
109_L117_V0.7180.24
56_A124_V0.7170.24
403_L422_T0.7170.24
192_M284_G0.7160.24
385_L421_M0.7160.24
23_L81_V0.7150.24
190_L250_V0.7120.24
224_V280_I0.7120.24
360_F375_F0.7120.24
73_F422_T0.7120.24
25_W419_D0.7100.24
124_V225_S0.7080.24
117_V212_L0.7080.24
11_W16_T0.7070.24
178_K223_S0.7070.24
360_F384_K0.7040.24
133_L282_Y0.7040.24
168_L290_L0.7040.24
52_V142_L0.7030.24
128_F270_T0.7030.24
243_I379_A0.7020.24
340_F422_T0.7010.24
22_Y177_G0.7000.24
282_Y385_L0.6990.23
243_I382_I0.6970.23
286_F301_E0.6970.23
363_S376_L0.6960.23
99_I187_L0.6940.23
277_L341_L0.6930.23
81_V230_K0.6920.23
368_F400_N0.6910.23
267_I386_L0.6910.23
190_L207_L0.6900.23
130_R286_F0.6900.23
314_S320_S0.6890.23
365_V375_F0.6870.23
301_E335_R0.6860.23
378_G381_L0.6850.23
142_L182_I0.6840.23
58_L61_Q0.6840.23
263_R267_I0.6820.23
3_L185_I0.6810.23
115_L166_L0.6810.23
282_Y359_S0.6810.23
158_S291_S0.6800.23
142_L224_V0.6770.23
26_I420_I0.6760.22
282_Y414_V0.6690.22
124_V173_L0.6670.22
178_K365_V0.6650.22
314_S319_N0.6630.22
192_M272_A0.6630.22
313_T316_Q0.6630.22
216_S383_L0.6610.22
425_F428_L0.6610.22
396_F421_M0.6610.22
198_L300_L0.6580.22
258_S391_L0.6570.22
286_F356_S0.6540.22
167_L289_A0.6540.22
366_Y381_L0.6530.21
280_I364_S0.6520.21
139_L318_S0.6510.21
253_L293_T0.6510.21
362_L374_P0.6500.21
195_I254_L0.6480.21
333_D340_F0.6480.21
308_S313_T0.6480.21
172_T358_S0.6480.21
223_S241_G0.6480.21
17_I71_A0.6470.21
310_S313_T0.6450.21
189_G333_D0.6450.21
10_D412_L0.6440.21
39_T97_G0.6420.21
135_V214_V0.6420.21
310_S315_S0.6410.21
44_T49_L0.6390.21
353_N375_F0.6380.21
273_P338_L0.6360.21
341_L405_L0.6350.21
203_L207_L0.6340.21
129_H339_F0.6330.21
164_S195_I0.6320.21
59_L145_L0.6310.21
148_T320_S0.6310.21
353_N359_S0.6300.21
345_Q422_T0.6290.21
6_L358_S0.6270.20
31_L84_E0.6260.20
342_F428_L0.6260.20
159_L210_I0.6250.20
251_L270_T0.6240.20
279_S363_S0.6240.20
121_E128_F0.6220.20
217_M254_L0.6220.20
17_I287_Y0.6220.20
287_Y347_A0.6210.20
165_C293_T0.6200.20
150_F248_S0.6180.20
314_S317_F0.6170.20
64_P252_P0.6170.20
171_F350_G0.6160.20
365_V389_F0.6150.20
20_L67_Y0.6140.20
339_F411_F0.6130.20
345_Q370_P0.6130.20
2_G18_V0.6120.20
349_F380_L0.6100.20
393_S431_D0.6090.20
275_F367_R0.6060.20
144_P165_C0.6060.20
73_F188_G0.6050.20
364_S397_G0.6050.20
363_S371_V0.6050.20
51_L58_L0.6040.20
125_L424_N0.6030.19
226_S237_N0.6020.19
42_L166_L0.6000.19
315_S322_D0.6000.19
97_G215_L0.5990.19
54_L225_S0.5960.19
17_I28_Y0.5950.19
411_F429_V0.5920.19
411_F431_D0.5920.19
271_F287_Y0.5920.19
123_L237_N0.5900.19
305_L330_T0.5900.19
28_Y76_F0.5880.19
109_L186_L0.5880.19
124_V425_F0.5850.19
119_G141_A0.5840.19
309_K313_T0.5840.19
184_L420_I0.5830.19
355_A375_F0.5810.19
6_L397_G0.5800.19
277_L370_P0.5800.19
241_G280_I0.5800.19
308_S316_Q0.5760.18
345_Q389_F0.5760.18
311_K321_T0.5760.18
364_S418_S0.5750.18
53_L104_S0.5740.18
49_L231_Q0.5710.18
346_V377_M0.5700.18
361_S397_G0.5690.18
340_F348_F0.5690.18
136_G172_T0.5680.18
242_W351_T0.5680.18
10_D414_V0.5670.18
195_I225_S0.5670.18
216_S317_F0.5650.18
142_L314_S0.5650.18
2_G134_T0.5650.18
307_S315_S0.5650.18
268_F294_L0.5650.18
364_S428_L0.5600.18
21_G364_S0.5590.18
363_S390_V0.5590.18
169_S420_I0.5570.18
119_G337_A0.5570.18
41_L47_S0.5560.18
11_W361_S0.5560.18
81_V329_L0.5560.18
51_L55_Y0.5550.18
8_T13_F0.5550.18
231_Q309_K0.5540.18
280_I367_R0.5540.18
363_S372_F0.5530.18
119_G133_L0.5520.18
419_D434_S0.5520.18
127_F181_N0.5510.18
67_Y429_V0.5490.17
110_L198_L0.5490.17
122_L163_L0.5490.17
389_F414_V0.5480.17
282_Y392_V0.5470.17
338_L367_R0.5460.17
10_D33_V0.5460.17
132_I430_K0.5460.17
140_L343_F0.5460.17
118_L322_D0.5430.17
99_I146_L0.5430.17
97_G194_L0.5420.17
183_N247_S0.5420.17
42_L167_L0.5420.17
358_S362_L0.5400.17
286_F374_P0.5400.17
216_S230_K0.5390.17
123_L182_I0.5390.17
21_G58_L0.5380.17
263_R365_V0.5370.17
117_V264_L0.5360.17
127_F367_R0.5350.17
353_N371_V0.5350.17
133_L136_G0.5340.17
220_T223_S0.5340.17
109_L194_L0.5330.17
73_F227_L0.5320.17
272_A367_R0.5320.17
385_L391_L0.5310.17
334_L343_F0.5310.17
277_L336_I0.5300.17
223_S370_P0.5300.17
318_S322_D0.5300.17
76_F408_S0.5300.17
90_A203_L0.5270.17
224_V284_G0.5270.17
391_L394_C0.5240.17
1_E243_I0.5240.17
46_S311_K0.5240.17
19_T375_F0.5220.17
20_L247_S0.5210.17
6_L363_S0.5210.17
134_T172_T0.5200.16
310_S319_N0.5190.16
67_Y389_F0.5180.16
50_I106_L0.5180.16
297_W349_F0.5180.16
223_S275_F0.5180.16
318_S337_A0.5180.16
51_L163_L0.5170.16
104_S110_L0.5150.16
309_K317_F0.5150.16
283_E355_A0.5140.16
307_S317_F0.5100.16
295_L343_F0.5090.16
183_N288_L0.5090.16
16_T298_I0.5090.16
168_L289_A0.5080.16
356_S380_L0.5080.16
133_L361_S0.5070.16
62_R187_L0.5070.16
258_S409_S0.5060.16
92_L386_L0.5050.16
144_P252_P0.5050.16
193_L376_L0.5050.16
39_T92_L0.5040.16
2_G5_Y0.5040.16
53_L92_L0.5020.16
304_I322_D0.5010.16
119_G338_L0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xesA 1 0.1774 37.8 0.971 Contact Map
4grvA 1 0.1659 29.7 0.972 Contact Map
4ib4A 1 0.1544 25.7 0.973 Contact Map
2z73A 2 0.1982 18.2 0.975 Contact Map
4ujpL 1 0.0599 17 0.975 Contact Map
2ks9A 1 0.2097 15.4 0.976 Contact Map
2r4rA 1 0.129 13.6 0.976 Contact Map
4mbsA 1 0.212 12 0.977 Contact Map
1u19A 2 0.2212 11.4 0.977 Contact Map
3pblA 1 0.1336 11.2 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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