GREMLIN Database
HPP - HPP family
PFAM: PF04982 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 118 (118)
Sequences: 9491 (5682)
Seq/√Len: 523.1
META: 0.799

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_H73_T3.8781.00
40_A88_Y3.0481.00
29_G65_T2.8621.00
34_S56_A2.6401.00
28_I103_L2.0651.00
41_C55_L2.0391.00
13_L27_V2.0351.00
32_L96_L2.0071.00
37_V59_L1.9191.00
27_V103_L1.8661.00
33_I59_L1.8551.00
25_R65_T1.8481.00
9_S27_V1.8051.00
6_F98_G1.7621.00
16_V21_L1.6721.00
11_V71_G1.6411.00
50_A54_G1.6121.00
95_V99_A1.5921.00
33_I63_T1.5401.00
49_A75_L1.5331.00
42_A84_H1.5111.00
109_F113_T1.5111.00
3_I95_V1.4881.00
35_A73_T1.4851.00
12_L22_A1.4731.00
36_L91_L1.4531.00
37_V55_L1.4281.00
52_A78_V1.4261.00
31_H99_A1.4101.00
46_W50_A1.3821.00
19_S22_A1.3821.00
9_S31_H1.3701.00
89_L93_V1.3691.00
25_R29_G1.3691.00
61_H66_L1.3651.00
111_N116_R1.3521.00
56_A60_M1.3381.00
41_C51_L1.3191.00
10_A14_F1.3171.00
13_L106_A1.3101.00
41_C48_A1.2901.00
16_V19_S1.2771.00
40_A44_L1.2371.00
45_F48_A1.2261.00
34_S70_A1.2241.00
93_V97_L1.2151.00
37_V41_C1.2051.00
105_V109_F1.2031.00
35_A95_V1.2021.00
91_L94_P1.1451.00
11_V66_L1.1431.00
13_L102_L1.1401.00
5_S8_A1.1371.00
39_V43_K1.1361.00
10_A102_L1.1191.00
93_V96_L1.1171.00
21_L68_P1.1081.00
111_N114_G1.0981.00
4_A76_I1.0921.00
90_F94_P1.0921.00
9_S67_H1.0661.00
11_V57_I1.0561.00
107_L111_N1.0531.00
32_L91_L1.0521.00
29_G32_L1.0381.00
41_C45_F1.0341.00
107_L110_N1.0251.00
45_F51_L1.0061.00
40_A43_K0.9951.00
35_A77_A0.9811.00
74_A78_V0.9791.00
88_Y91_L0.9751.00
38_G77_A0.9691.00
87_G90_F0.9681.00
107_L117_Y0.9651.00
8_A12_L0.9621.00
23_Q26_N0.9441.00
5_S72_A0.9341.00
42_A77_A0.9321.00
83_I87_G0.9251.00
85_A89_L0.9171.00
99_A103_L0.9071.00
7_G71_G0.8881.00
83_I86_L0.8831.00
77_A90_F0.8791.00
43_K88_Y0.8671.00
47_L50_A0.8591.00
8_A72_A0.8551.00
3_I6_F0.8521.00
48_A78_V0.8421.00
25_R64_R0.8401.00
5_S76_I0.8381.00
13_L103_L0.8231.00
34_S73_T0.8141.00
39_V77_A0.8121.00
28_I100_L0.8011.00
15_A57_I0.7991.00
110_N115_R0.7531.00
82_P87_G0.7511.00
88_Y94_P0.7501.00
38_G42_A0.7461.00
82_P85_A0.7411.00
27_V99_A0.7371.00
11_V15_A0.7361.00
41_C52_A0.7351.00
49_A78_V0.7331.00
36_L40_A0.7331.00
32_L36_L0.7211.00
49_A79_L0.7181.00
17_P22_A0.7181.00
88_Y92_L0.7121.00
58_A62_L0.7071.00
70_A74_A0.7041.00
89_L92_L0.7011.00
52_A56_A0.7001.00
108_L111_N0.6961.00
15_A61_H0.6941.00
7_G75_L0.6941.00
60_M70_A0.6931.00
39_V88_Y0.6911.00
34_S74_A0.6891.00
113_T116_R0.6871.00
73_T95_V0.6851.00
13_L17_P0.6801.00
42_A78_V0.6731.00
12_L16_V0.6681.00
4_A7_G0.6671.00
39_V91_L0.6661.00
4_A8_A0.6661.00
55_L59_L0.6601.00
56_A74_A0.6591.00
63_T66_L0.6451.00
106_A110_N0.6371.00
20_P26_N0.6371.00
73_T77_A0.6361.00
21_L26_N0.6341.00
8_A21_L0.6251.00
75_L79_L0.6111.00
31_H67_H0.6071.00
56_A71_G0.6061.00
21_L66_L0.6051.00
52_A74_A0.6051.00
6_F13_L0.6031.00
20_P64_R0.6011.00
101_L105_V0.5991.00
61_H64_R0.5971.00
41_C44_L0.5890.99
19_S26_N0.5890.99
34_S37_V0.5840.99
57_I78_V0.5780.99
74_A77_A0.5770.99
4_A72_A0.5710.99
84_H88_Y0.5690.99
24_P28_I0.5610.99
42_A81_G0.5600.99
33_I65_T0.5530.99
53_V56_A0.5510.99
18_A116_R0.5500.99
5_S31_H0.5470.99
53_V71_G0.5470.99
30_G67_H0.5470.99
16_V22_A0.5450.99
94_P97_L0.5430.99
30_G34_S0.5330.99
94_P98_G0.5280.99
29_G33_I0.5270.99
37_V40_A0.5260.99
80_G83_I0.5210.99
60_M71_G0.5190.99
96_L99_A0.5180.99
15_A66_L0.5170.99
26_N65_T0.5100.98
15_A30_G0.5030.98
104_L108_L0.5030.98
86_L89_L0.5020.98
37_V56_A0.5010.98
104_L107_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kncA 1 0.3559 22 0.885 Contact Map
2k1aA 1 0.339 17.5 0.89 Contact Map
2l8sA 1 0.3305 14.7 0.894 Contact Map
2m3eA 1 0.3559 6.2 0.91 Contact Map
2k9jB 1 0.3644 4.4 0.916 Contact Map
2kv5A 1 0.2797 4.1 0.917 Contact Map
4b19A 1 0.2542 3.6 0.919 Contact Map
1fftB 1 0.4153 3.5 0.92 Contact Map
1afoA 2 0.3305 2.4 0.927 Contact Map
4fvyA 2 0.3475 2.4 0.927 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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