GREMLIN Database
DivIC - Septum formation initiator
PFAM: PF04977 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 80 (77)
Sequences: 65277 (43103)
Seq/√Len: 4912.0
META: 0.927

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_I64_E2.5981.00
33_L37_E2.4971.00
26_I30_E2.3961.00
29_L32_E1.8081.00
58_E69_K1.8071.00
40_N44_E1.8011.00
59_E63_E1.6891.00
36_L39_E1.6841.00
49_R56_Y1.6451.00
20_L24_R1.5701.00
60_I63_E1.5151.00
53_D56_Y1.4911.00
47_I51_K1.4491.00
19_Y23_R1.4151.00
48_E52_S1.3531.00
45_A49_R1.3451.00
6_V10_F1.3421.00
31_A35_E1.3371.00
49_R53_D1.3081.00
16_L20_L1.2871.00
58_E62_R1.2771.00
32_E35_E1.2591.00
25_E29_L1.2561.00
34_A37_E1.2521.00
29_L33_L1.2491.00
39_E42_R1.2421.00
17_L20_L1.2371.00
68_V74_V1.2311.00
17_L21_R1.2201.00
25_E28_E1.2101.00
35_E39_E1.2081.00
13_D17_L1.2021.00
30_E34_A1.1881.00
42_R46_E1.1871.00
37_E41_A1.1601.00
22_L26_I1.1461.00
30_E33_L1.1461.00
34_A38_A1.1381.00
18_A22_L1.1251.00
22_L25_E1.1011.00
18_A21_R1.0961.00
28_E32_E1.0921.00
23_R27_A1.0841.00
56_Y60_I1.0791.00
62_R72_E1.0731.00
38_A42_R1.0441.00
43_L46_E1.0401.00
74_V78_V1.0311.00
32_E36_L1.0281.00
20_L23_R1.0061.00
44_E48_E1.0001.00
27_A30_E0.9941.00
56_Y59_E0.9661.00
23_R26_I0.9561.00
24_R28_E0.9491.00
39_E43_L0.9481.00
26_I29_L0.9201.00
33_L40_N0.9201.00
5_L8_L0.9161.00
31_A34_A0.9111.00
36_L40_N0.9051.00
73_T76_I0.9031.00
27_A31_A0.8781.00
19_Y22_L0.8771.00
37_E40_N0.8761.00
33_L36_L0.8691.00
40_N43_L0.8631.00
13_D16_L0.8621.00
38_A41_A0.8431.00
28_E31_A0.8291.00
12_G15_G0.8191.00
43_L47_I0.8171.00
40_N47_I0.7931.00
15_G18_A0.7881.00
4_V8_L0.7651.00
69_K72_E0.7561.00
44_E47_I0.7551.00
61_A67_M0.7421.00
41_A45_A0.7281.00
46_E49_R0.7231.00
41_A44_E0.7201.00
21_R25_E0.7121.00
45_A48_E0.7081.00
15_G19_Y0.7011.00
57_I61_A0.6941.00
46_E56_Y0.6831.00
7_Y12_G0.6801.00
47_I50_L0.6791.00
35_E38_A0.6741.00
3_L7_Y0.6681.00
9_L13_D0.6621.00
14_R18_A0.6621.00
24_R27_A0.6501.00
62_R69_K0.6371.00
61_A65_L0.6331.00
7_Y11_F0.6311.00
55_D58_E0.6251.00
26_I33_L0.6241.00
60_I65_L0.6241.00
46_E50_L0.6211.00
10_F13_D0.6011.00
54_P57_I0.5981.00
47_I52_S0.5971.00
11_F14_R0.5911.00
68_V73_T0.5901.00
50_L56_Y0.5811.00
73_T77_V0.5731.00
12_G16_L0.5721.00
48_E51_K0.5431.00
7_Y10_F0.5361.00
73_T78_V0.5361.00
54_P58_E0.5281.00
5_L9_L0.5271.00
8_L13_D0.5241.00
6_V9_L0.5031.00
11_F15_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dznA 3 0.4 48.8 0.755 Contact Map
4iffA 2 0.6375 46.5 0.758 Contact Map
4cgkA 3 0.5875 34.6 0.776 Contact Map
2zqmA 5 0.7625 28.5 0.785 Contact Map
1fxkA 2 0.7 20.7 0.798 Contact Map
3rvyA 3 0.2 17.8 0.804 Contact Map
4cbcA 3 0.2 17.7 0.805 Contact Map
4etpA 1 0.7625 17.2 0.806 Contact Map
4etpB 1 0.75 16.2 0.808 Contact Map
1a93B 1 0.4 15.8 0.81 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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