GREMLIN Database
TrbC - TrbC/VIRB2 family
PFAM: PF04956 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 99 (90)
Sequences: 11653 (7370)
Seq/√Len: 776.8
META: 0.862

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_A86_L4.6001.00
40_T44_N2.6371.00
64_V68_M2.4861.00
65_A82_I2.4791.00
78_R81_G2.4161.00
69_L76_K2.3441.00
43_Q47_T2.2581.00
77_R81_G2.2441.00
39_E48_S2.1971.00
66_G85_G2.0631.00
54_A89_A1.8961.00
42_L56_A1.8811.00
39_E43_Q1.8051.00
43_Q46_L1.7881.00
46_L56_A1.7731.00
66_G88_I1.6981.00
65_A79_L1.5231.00
75_S78_R1.4811.00
51_G56_A1.4501.00
62_I82_I1.4171.00
46_L60_I1.3951.00
91_G96_V1.3351.00
52_P56_A1.3201.00
10_R14_L1.3071.00
67_L71_F1.3071.00
9_R12_L1.2971.00
70_A89_A1.2821.00
91_G94_S1.2501.00
28_A32_G1.2401.00
14_L17_L1.2101.00
55_K59_V1.2101.00
43_Q56_A1.2041.00
66_G89_A1.2021.00
68_M78_R1.1651.00
28_A31_Q1.1481.00
69_L81_G1.1321.00
70_A85_G1.1061.00
53_V56_A1.1051.00
29_F32_G1.0871.00
26_S29_F1.0831.00
42_L53_V1.0661.00
32_G35_G1.0481.00
9_R13_L1.0471.00
19_A23_L1.0461.00
57_I67_L1.0381.00
91_G95_I0.9791.00
61_A70_A0.9631.00
45_I60_I0.9631.00
38_W41_P0.9561.00
46_L59_V0.9551.00
48_S53_V0.9431.00
36_S40_T0.9421.00
78_R82_I0.9361.00
69_L75_S0.9281.00
63_I67_L0.9201.00
69_L73_R0.9091.00
38_W53_V0.9081.00
90_F96_V0.8961.00
24_L27_P0.8951.00
46_L50_T0.8921.00
14_L26_S0.8831.00
40_T43_Q0.8661.00
17_L22_L0.8641.00
11_L14_L0.8621.00
38_W48_S0.8501.00
12_L15_L0.8421.00
25_A28_A0.8261.00
11_L15_L0.8261.00
22_L30_A0.8251.00
25_A29_F0.8241.00
17_L20_L0.8171.00
10_R13_L0.8121.00
65_A74_G0.8091.00
81_G84_F0.7911.00
68_M74_G0.7711.00
61_A82_I0.7691.00
46_L93_S0.7671.00
20_L24_L0.7501.00
58_A91_G0.7441.00
12_L16_L0.7381.00
31_Q34_G0.7271.00
76_K81_G0.7231.00
15_L19_A0.7171.00
41_P44_N0.7121.00
67_L89_A0.7091.00
17_L21_L0.7081.00
94_S98_W0.7011.00
47_T50_T0.6991.00
19_A22_L0.6911.00
50_T93_S0.6761.00
77_R80_I0.6681.00
40_T47_T0.6561.00
20_L28_A0.6391.00
73_R77_R0.6341.00
72_G75_S0.6271.00
45_I48_S0.6211.00
55_K97_A0.6201.00
52_P55_K0.6191.00
60_I64_V0.6141.00
81_G93_S0.6101.00
21_L25_A0.6051.00
13_L25_A0.6051.00
9_R26_S0.6041.00
92_A96_V0.5991.00
61_A86_L0.5951.00
41_P87_A0.5931.00
12_L26_S0.5911.00
87_A98_W0.5871.00
65_A78_R0.5851.00
9_R14_L0.5831.00
10_R15_L0.5721.00
23_L27_P0.5711.00
94_S97_A0.5641.00
36_S39_E0.5621.00
16_L19_A0.5611.00
13_L26_S0.5591.00
21_L24_L0.5571.00
69_L79_L0.5561.00
70_A88_I0.5471.00
13_L29_F0.5471.00
63_I89_A0.5451.00
70_A73_R0.5441.00
46_L55_K0.5361.00
61_A71_F0.5331.00
22_L25_A0.5321.00
13_L18_A0.5301.00
14_L18_A0.5301.00
10_R26_S0.5131.00
58_A70_A0.5121.00
48_S52_P0.5111.00
39_E56_A0.5041.00
39_E52_P0.5041.00
54_A67_L0.5021.00
86_L90_F0.5011.00
14_L22_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wswA 3 0.9697 18.6 0.838 Contact Map
1fftB 1 0.7071 14.4 0.846 Contact Map
4px7A 1 0.9091 6 0.87 Contact Map
4ev6A 3 0.6768 5.4 0.873 Contact Map
2wh6A 1 0.8788 4.2 0.88 Contact Map
4i0uA 4 0.6566 4 0.881 Contact Map
4qi1A 3 0.9091 3.3 0.886 Contact Map
3qapA 1 0.9091 3.3 0.886 Contact Map
4fbzA 3 0.9091 3.3 0.886 Contact Map
4gc0A 1 0.9293 3.2 0.886 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0053 seconds.