GREMLIN Database
HupE_UreJ - HupE / UreJ protein
PFAM: PF04955 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 179 (174)
Sequences: 12850 (9094)
Seq/√Len: 689.4
META: 0.891

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_L140_E3.1641.00
65_M68_G3.1111.00
52_R56_L2.8641.00
80_G83_P2.6761.00
27_E31_T2.3721.00
129_A132_P2.3461.00
120_F124_G2.2001.00
62_T144_L2.1821.00
84_G117_F2.1771.00
129_A133_L2.1341.00
69_A72_G2.1151.00
41_A172_I2.0821.00
55_W58_P2.0571.00
62_T140_E2.0291.00
57_L111_V1.9791.00
85_I121_A1.9021.00
69_A73_L1.9011.00
160_R163_R1.8741.00
26_F142_G1.8171.00
135_F139_F1.8061.00
58_P61_F1.8041.00
64_A112_F1.7751.00
41_A92_L1.7621.00
42_V111_V1.7551.00
146_L150_G1.7461.00
88_S118_H1.6951.00
45_L107_A1.6921.00
81_V120_F1.6611.00
136_N140_E1.6561.00
152_A156_L1.5881.00
36_L146_L1.5841.00
53_A56_L1.5321.00
143_Q147_H1.5011.00
166_R169_G1.4891.00
59_T63_L1.4821.00
24_S27_E1.4581.00
155_L158_R1.4501.00
130_G134_L1.4471.00
155_L159_R1.4211.00
164_A167_V1.4041.00
156_L159_R1.4031.00
8_A11_L1.3881.00
136_N139_F1.3851.00
170_A173_A1.3851.00
58_P62_T1.3801.00
23_L27_E1.3771.00
64_A67_A1.3761.00
15_G18_G1.3731.00
60_A112_F1.3671.00
109_A113_L1.3601.00
169_G172_I1.3591.00
156_L160_R1.3551.00
37_L175_A1.3401.00
167_V170_A1.3341.00
168_A171_A1.3191.00
16_H20_G1.3071.00
59_T62_T1.2811.00
14_T18_G1.2751.00
152_A155_L1.2701.00
62_T65_M1.2681.00
61_F115_G1.2671.00
130_G133_L1.2631.00
56_L108_A1.2611.00
135_F140_E1.2551.00
103_P106_A1.2511.00
140_E143_Q1.2511.00
94_L98_L1.2471.00
69_A139_F1.2331.00
37_L89_I1.2301.00
167_V171_A1.2301.00
83_P86_A1.2031.00
95_L100_R1.1941.00
171_A174_A1.1911.00
165_V169_G1.1681.00
39_M139_F1.1561.00
63_L67_A1.1531.00
14_T17_G1.1491.00
70_A74_L1.1441.00
102_L106_A1.1351.00
72_G75_G1.1331.00
151_I154_G1.1301.00
148_A152_A1.1301.00
64_A115_G1.1241.00
140_E144_L1.1131.00
64_A68_G1.0991.00
125_E128_E1.0861.00
60_A108_A1.0801.00
52_R55_W1.0631.00
74_L77_P1.0611.00
65_M143_Q1.0591.00
60_A64_A1.0451.00
165_V168_A1.0451.00
61_F65_M1.0411.00
71_L116_L1.0321.00
144_L148_A1.0281.00
44_L165_V1.0151.00
159_R162_G1.0141.00
30_L145_L1.0131.00
11_L15_G1.0051.00
145_L149_A1.0051.00
135_F143_Q0.9901.00
30_L142_G0.9801.00
39_M143_Q0.9691.00
98_L101_R0.9661.00
7_P11_L0.9621.00
41_A93_G0.9581.00
127_P130_G0.9501.00
171_A175_A0.9401.00
57_L61_F0.9301.00
55_W61_F0.9301.00
105_A108_A0.9271.00
158_R163_R0.9221.00
115_G122_H0.9031.00
44_L96_V0.9021.00
103_P107_A0.9011.00
147_H151_I0.8961.00
168_A172_I0.8921.00
87_L90_V0.8761.00
101_R104_L0.8681.00
148_A151_I0.8661.00
50_G53_A0.8661.00
21_G24_S0.8621.00
57_L107_A0.8611.00
26_F29_P0.8571.00
154_G157_L0.8551.00
36_L40_L0.8431.00
158_R161_A0.8411.00
53_A57_L0.8401.00
35_H118_H0.8371.00
129_A134_L0.8311.00
85_I88_S0.8291.00
81_V84_G0.8171.00
71_L76_V0.8161.00
72_G120_F0.8161.00
154_G158_R0.8151.00
127_P133_L0.8121.00
69_A136_N0.8071.00
131_L134_L0.8031.00
77_P80_G0.8011.00
139_F143_Q0.7921.00
65_M69_A0.7921.00
164_A168_A0.7891.00
136_N143_Q0.7801.00
46_A57_L0.7791.00
94_L97_A0.7771.00
32_G35_H0.7731.00
26_F145_L0.7711.00
56_L59_T0.7711.00
50_G54_L0.7701.00
95_L98_L0.7681.00
122_H139_F0.7661.00
166_R170_A0.7601.00
157_L161_A0.7591.00
54_L151_I0.7561.00
164_A169_G0.7531.00
51_G54_L0.7461.00
153_L157_L0.7421.00
151_I155_L0.7361.00
40_L146_L0.7311.00
147_H150_G0.7281.00
170_A174_A0.7261.00
149_A152_A0.7261.00
82_E85_I0.7231.00
39_M147_H0.7211.00
22_F137_L0.7191.00
49_L57_L0.7161.00
61_F64_A0.7051.00
126_L136_N0.6991.00
77_P120_F0.6931.00
87_L91_V0.6891.00
15_G27_E0.6881.00
15_G19_A0.6841.00
64_A116_L0.6811.00
118_H122_H0.6791.00
16_H19_A0.6781.00
142_G145_L0.6771.00
86_A93_G0.6751.00
17_G20_G0.6731.00
31_T125_E0.6731.00
6_L9_P0.6711.00
29_P142_G0.6661.00
41_A45_L0.6631.00
158_R162_G0.6621.00
75_G78_L0.6591.00
122_H125_E0.6591.00
24_S31_T0.6561.00
43_G46_A0.6531.00
54_L58_P0.6531.00
139_F142_G0.6531.00
66_L69_A0.6501.00
106_A109_A0.6491.00
22_F26_F0.6461.00
68_G72_G0.6441.00
27_E30_L0.6441.00
91_V95_L0.6421.00
104_L107_A0.6391.00
128_E131_L0.6351.00
32_G118_H0.6351.00
47_A154_G0.6341.00
96_V169_G0.6341.00
157_L160_R0.6311.00
11_L14_T0.6301.00
126_L135_F0.6281.00
23_L26_F0.6271.00
81_V121_A0.6271.00
38_F92_L0.6231.00
24_S129_A0.6181.00
99_A102_L0.6171.00
169_G173_A0.6171.00
126_L130_G0.6131.00
156_L161_A0.6101.00
170_A177_L0.6091.00
104_L108_A0.6031.00
37_L48_Q0.6001.00
174_A177_L0.6001.00
144_L147_H0.5971.00
28_H35_H0.5961.00
34_D82_E0.5951.00
169_G176_G0.5931.00
98_L103_P0.5931.00
139_F147_H0.5931.00
97_A100_R0.5931.00
73_L132_P0.5931.00
49_L53_A0.5921.00
40_L150_G0.5911.00
22_F141_L0.5901.00
34_D38_F0.5811.00
172_I175_A0.5801.00
90_V176_G0.5791.00
43_G154_G0.5781.00
14_T19_A0.5761.00
83_P87_L0.5761.00
165_V170_A0.5741.00
143_Q150_G0.5731.00
80_G84_G0.5701.00
145_L148_A0.5631.00
127_P135_F0.5621.00
39_M42_V0.5601.00
113_L117_F0.5541.00
43_G47_A0.5511.00
60_A63_L0.5511.00
55_W62_T0.5511.00
159_R163_R0.5511.00
53_A58_P0.5481.00
96_V99_A0.5481.00
14_T20_G0.5421.00
98_L102_L0.5421.00
9_P14_T0.5371.00
150_G154_G0.5351.00
95_L99_A0.5321.00
102_L107_A0.5301.00
38_F114_F0.5281.00
26_F30_L0.5271.00
92_L95_L0.5231.00
4_L7_P0.5180.99
37_L41_A0.5170.99
72_G77_P0.5120.99
19_A23_L0.5070.99
72_G123_G0.5050.99
108_A112_F0.5020.99
125_E129_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l2tA 2 0.2458 5.6 0.933 Contact Map
4cz8A 2 0.8156 4.9 0.936 Contact Map
4ldsA 2 0.4134 3.6 0.939 Contact Map
2jwaA 2 0.2458 3.3 0.94 Contact Map
4gc0A 1 0.4525 3 0.942 Contact Map
2ks1B 1 0.2402 2.7 0.943 Contact Map
2nq2A 2 0.6145 2.7 0.943 Contact Map
4czbA 2 0.8212 2.3 0.946 Contact Map
4bwzA 2 0.514 2.1 0.947 Contact Map
2qi9A 2 0.6872 1.9 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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