GREMLIN Database
Pox_VLTF3 - Poxvirus Late Transcription Factor VLTF3 like
PFAM: PF04947 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 168 (164)
Sequences: 1941 (1333)
Seq/√Len: 104.1
META: 0.969

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_K65_L4.4411.00
15_N96_R3.5361.00
108_K163_E3.3171.00
127_K130_E3.2441.00
32_E36_K3.0551.00
31_D35_E2.9691.00
37_I59_I2.6921.00
157_W161_C2.6541.00
40_E43_K2.6441.00
88_S91_L2.5391.00
17_W122_S2.5161.00
102_I160_I2.4781.00
14_F95_L2.3921.00
110_H163_E2.3121.00
30_P68_Y2.2591.00
91_L134_E2.1971.00
123_Y154_D2.1941.00
87_I137_Y2.1321.00
25_E71_H2.1141.00
95_L128_L2.0881.00
34_I78_K2.0301.00
109_L163_E1.9961.00
37_I41_I1.9491.00
158_K162_E1.9311.00
98_M128_L1.8681.00
87_I91_L1.8031.00
36_K63_L1.7971.00
118_F124_V1.7361.00
44_E59_I1.7031.00
11_I100_K1.6481.00
135_D167_E1.6471.00
56_I76_I1.6091.00
147_R151_I1.5591.00
91_L94_K1.5401.00
102_I118_F1.5071.00
24_K92_E1.4461.00
126_Y138_L1.4301.00
22_Q92_E1.4271.00
30_P33_V1.4241.00
99_F121_Y1.4041.00
159_K162_E1.3971.00
33_V65_L1.3951.00
109_L112_P1.3641.00
44_E55_K1.3430.99
34_I74_Y1.3270.99
20_Q70_E1.3260.99
41_I59_I1.3230.99
76_I80_T1.3210.99
87_I129_C1.3080.99
123_Y127_K1.3040.99
157_W168_F1.2840.99
82_I85_P1.2770.99
127_K157_W1.2720.99
25_E74_Y1.2690.99
53_K72_I1.2520.99
23_A84_P1.2480.99
41_I56_I1.2460.99
102_I128_L1.2200.99
126_Y130_E1.2200.99
35_E39_N1.2190.99
155_E159_K1.2070.99
115_R119_L1.1710.98
22_Q91_L1.1560.98
131_L157_W1.1320.98
41_I46_I1.1190.98
146_S149_K1.1130.98
77_N84_P1.1010.98
98_M132_L1.0800.97
124_V128_L1.0660.97
21_F134_E1.0610.97
23_A73_P1.0520.97
131_L135_D1.0390.97
77_N83_P1.0300.97
159_K163_E1.0170.96
94_K97_N1.0160.96
81_G85_P1.0060.96
16_E70_E1.0060.96
123_Y168_F0.9980.96
12_N16_E0.9960.96
33_V36_K0.9960.96
37_I79_L0.9950.96
40_E62_K0.9850.96
95_L129_C0.9730.95
18_L96_R0.9690.95
91_L129_C0.9610.95
127_K154_D0.9470.95
10_R103_Q0.9270.94
129_C134_E0.9270.94
31_D38_K0.9250.94
20_Q71_H0.9220.94
151_I155_E0.9220.94
34_I38_K0.9180.94
93_E96_R0.9050.93
17_W125_L0.9040.93
56_I59_I0.9010.93
94_K98_M0.8940.93
74_Y78_K0.8940.93
17_W120_S0.8910.93
6_Y106_F0.8780.92
14_F128_L0.8770.92
129_C138_L0.8710.92
13_H117_N0.8630.91
90_E94_K0.8560.91
128_L132_L0.8560.91
119_L124_V0.8550.91
54_K58_E0.8530.91
53_K141_F0.8310.90
11_I15_N0.8300.90
129_C137_Y0.8260.89
56_I80_T0.8210.89
47_T50_K0.8170.89
53_K73_P0.8160.89
10_R107_E0.8130.89
143_L150_L0.8120.89
102_I105_P0.8010.88
55_K58_E0.7950.88
125_L129_C0.7930.87
48_L51_I0.7890.87
17_W20_Q0.7740.86
22_Q25_E0.7720.86
51_I76_I0.7640.85
46_I55_K0.7550.85
5_K15_N0.7470.84
119_L153_Q0.7460.84
56_I82_I0.7420.84
160_I163_E0.7280.83
6_Y10_R0.7260.82
95_L117_N0.7230.82
27_T71_H0.7210.82
34_I37_I0.7210.82
48_L79_L0.7170.82
10_R95_L0.7160.81
120_S153_Q0.7150.81
10_R73_P0.7150.81
33_V37_I0.7100.81
38_K79_L0.7060.81
115_R118_F0.7060.81
21_F87_I0.7030.80
20_Q118_F0.7010.80
28_D104_E0.7000.80
165_G168_F0.6990.80
53_K76_I0.6970.80
137_Y141_F0.6970.80
120_S128_L0.6950.80
88_S94_K0.6920.79
73_P77_N0.6820.78
99_F118_F0.6820.78
36_K79_L0.6810.78
89_P100_K0.6750.78
135_D138_L0.6750.78
130_E154_D0.6750.78
110_H159_K0.6730.77
152_E155_E0.6660.77
149_K153_Q0.6620.76
48_L82_I0.6610.76
98_M131_L0.6590.76
22_Q71_H0.6530.75
126_Y129_C0.6530.75
98_M134_E0.6510.75
90_E93_E0.6510.75
56_I75_I0.6500.75
77_N87_I0.6440.74
134_E137_Y0.6420.74
6_Y15_N0.6420.74
15_N19_A0.6390.74
13_H99_F0.6330.73
74_Y106_F0.6320.73
122_S125_L0.6320.73
120_S143_L0.6320.73
83_P104_E0.6220.72
23_A77_N0.6170.71
58_E86_I0.6170.71
66_N126_Y0.6160.71
8_Y16_E0.6160.71
41_I51_I0.6140.71
75_I114_D0.6130.71
37_I44_E0.6100.70
24_K86_I0.6080.70
106_F118_F0.6080.70
16_E20_Q0.6070.70
145_K149_K0.6020.69
51_I79_L0.6010.69
72_I76_I0.5960.68
87_I90_E0.5940.68
144_L149_K0.5930.68
70_E125_L0.5840.67
158_K161_C0.5830.67
84_P111_C0.5820.67
41_I80_T0.5820.67
77_N80_T0.5810.66
106_F115_R0.5770.66
41_I47_T0.5750.66
120_S155_E0.5750.66
130_E157_W0.5730.65
135_D165_G0.5720.65
96_R100_K0.5700.65
102_I156_I0.5700.65
39_N47_T0.5680.65
5_K11_I0.5630.64
104_E165_G0.5630.64
6_Y89_P0.5620.64
34_I79_L0.5620.64
9_K121_Y0.5610.64
55_K80_T0.5610.64
31_D36_K0.5600.64
97_N104_E0.5580.63
23_A74_Y0.5570.63
126_Y151_I0.5550.63
133_G167_E0.5540.63
6_Y11_I0.5530.63
144_L153_Q0.5510.62
46_I58_E0.5490.62
161_C168_F0.5480.62
36_K39_N0.5450.62
40_E59_I0.5440.61
31_D78_K0.5440.61
10_R118_F0.5420.61
57_R72_I0.5410.61
93_E100_K0.5400.61
85_P88_S0.5400.61
52_T55_K0.5390.61
10_R14_F0.5370.60
122_S141_F0.5370.60
77_N125_L0.5360.60
52_T76_I0.5340.60
164_L167_E0.5320.60
106_F156_I0.5300.59
14_F115_R0.5270.59
57_R122_S0.5200.58
55_K79_L0.5200.58
88_S165_G0.5190.58
20_Q25_E0.5190.58
104_E107_E0.5180.58
51_I82_I0.5180.58
151_I168_F0.5160.57
103_Q118_F0.5140.57
9_K12_N0.5130.57
106_F152_E0.5110.57
85_P134_E0.5090.56
18_L93_E0.5080.56
79_L151_I0.5080.56
55_K76_I0.5060.56
118_F121_Y0.5050.56
57_R96_R0.5020.55
21_F85_P0.5010.55
38_K48_L0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nl9C 1 0.3393 22.6 0.921 Contact Map
2f3nA 1 0.3631 18.4 0.924 Contact Map
2gleA 1 0.4405 17.6 0.925 Contact Map
2bsqE 2 0.4048 17.2 0.925 Contact Map
2cpgA 2 0.2679 16.3 0.926 Contact Map
3h87C 3 0.4286 14.8 0.927 Contact Map
2ovrB 1 0.4167 13.2 0.929 Contact Map
1p94A 2 0.381 13.2 0.929 Contact Map
3bq7A 3 0.3929 11.3 0.931 Contact Map
1pulA 1 0.4643 11 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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