GREMLIN Database
SURF6 - Surfeit locus protein 6
PFAM: PF04935 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 207 (196)
Sequences: 679 (543)
Seq/√Len: 38.8
META: 0.218

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_K160_K4.8891.00
117_E121_K3.9101.00
189_A193_E2.9241.00
190_K194_E2.9121.00
178_A182_K2.8171.00
103_K106_E2.7041.00
19_K23_R2.5551.00
98_P101_L2.4181.00
175_K179_E2.4051.00
181_Q184_R2.3921.00
106_E149_K2.3811.00
161_K165_E2.2761.00
7_E10_R2.2220.99
108_K127_D2.1670.99
188_I191_R2.1400.99
172_G176_K2.1200.99
132_A135_R2.1150.99
55_S58_P1.8900.98
170_K177_K1.8470.98
131_K135_R1.8390.98
196_K199_K1.8160.98
172_G175_K1.7730.97
95_G98_P1.7660.97
97_D155_K1.7500.97
112_L115_L1.7100.97
171_E174_E1.6950.96
119_K123_I1.6910.96
98_P105_L1.6720.96
21_K25_E1.6660.96
20_K23_R1.6260.95
203_A206_K1.6240.95
105_L145_P1.5930.95
198_K202_K1.5870.95
141_V147_L1.5560.94
94_T98_P1.5450.94
101_L105_L1.5360.94
16_R27_A1.5130.93
52_S55_S1.5020.93
129_W187_N1.4880.93
97_D100_Q1.4710.92
53_E56_P1.4670.92
116_D119_K1.4620.92
92_G97_D1.4600.92
10_R13_K1.4530.92
18_R22_E1.4470.92
9_R12_R1.4320.91
184_R188_I1.4150.91
98_P152_L1.4040.90
57_S60_K1.3980.90
15_E18_R1.3700.89
21_K26_K1.3630.89
184_R187_N1.3530.89
6_L11_K1.3480.88
109_K145_P1.3460.88
17_K23_R1.3260.88
159_K193_E1.3170.87
193_E197_E1.3140.87
49_K52_S1.3100.87
26_K30_E1.3080.87
13_K17_K1.2940.86
12_R23_R1.2920.86
158_K162_S1.2810.86
200_K204_K1.2780.86
120_A124_E1.2670.85
110_E114_E1.2540.84
201_K204_K1.2520.84
150_K198_K1.2400.84
116_D120_A1.2300.83
153_K159_K1.2150.82
134_K139_E1.2070.82
68_N72_G1.1860.81
183_K187_N1.1850.81
183_K186_E1.1820.81
76_F150_K1.1780.80
200_K203_A1.1750.80
104_K110_E1.1740.80
44_E49_K1.1720.80
150_K162_S1.1670.80
100_Q103_K1.1620.80
21_K30_E1.1470.79
46_E49_K1.1380.78
99_K156_E1.1350.78
72_G75_D1.1330.78
164_K177_K1.1320.78
12_R17_K1.1280.77
151_A155_K1.1260.77
43_E51_A1.1090.76
144_D147_L1.1070.76
12_R20_K1.1060.76
50_S53_E1.1040.76
163_K167_K1.1030.76
10_R14_E1.1020.76
67_G74_V1.0950.75
23_R28_K1.0890.75
135_R141_V1.0850.75
21_K27_A1.0830.75
89_K119_K1.0820.74
185_E189_A1.0750.74
129_W184_R1.0660.73
105_L109_K1.0490.72
85_K88_K1.0490.72
182_K186_E1.0480.72
45_E51_A1.0430.72
11_K152_L1.0420.72
29_K33_R1.0300.71
47_A51_A1.0180.70
117_E120_A1.0130.69
46_E50_S1.0080.69
105_L134_K0.9950.68
111_K139_E0.9790.67
53_E58_P0.9690.66
19_K30_E0.9590.65
174_E178_A0.9570.65
196_K200_K0.9550.65
101_L104_K0.9510.64
53_E57_S0.9450.64
101_L145_P0.9440.64
109_K113_E0.9380.63
18_R28_K0.9360.63
61_P64_E0.9340.63
108_K133_L0.9290.63
74_V203_A0.9150.61
105_L186_E0.9110.61
118_E121_K0.9060.61
157_K178_A0.9020.60
99_K109_K0.9010.60
47_A52_S0.9000.60
192_K203_A0.8930.60
115_L164_K0.8930.60
127_D176_K0.8920.59
119_K122_E0.8910.59
76_F177_K0.8880.59
191_R194_E0.8860.59
131_K190_K0.8840.59
49_K54_S0.8820.59
98_P155_K0.8790.58
183_K199_K0.8670.57
69_L74_V0.8640.57
17_K21_K0.8460.55
19_K27_A0.8460.55
90_K174_E0.8420.55
48_E63_E0.8380.55
19_K32_A0.8330.54
78_D92_G0.8320.54
48_E51_A0.8320.54
75_D151_A0.8300.54
57_S61_P0.8300.54
46_E52_S0.8210.53
32_A59_P0.8180.53
61_P144_D0.8100.52
97_D129_W0.8090.52
104_K108_K0.8030.52
119_K126_K0.7940.51
23_R27_A0.7920.51
150_K159_K0.7890.50
179_E197_E0.7880.50
88_K177_K0.7860.50
56_P59_P0.7790.49
76_F97_D0.7740.49
78_D144_D0.7740.49
111_K130_L0.7730.49
110_E122_E0.7710.49
47_A50_S0.7700.49
170_K174_E0.7690.48
182_K189_A0.7660.48
113_E170_K0.7650.48
179_E182_K0.7650.48
43_E49_K0.7640.48
192_K199_K0.7630.48
154_R162_S0.7620.48
115_L120_A0.7400.46
22_E151_A0.7360.46
177_K190_K0.7340.45
136_A175_K0.7310.45
131_K141_V0.7310.45
191_R195_K0.7300.45
88_K202_K0.7290.45
99_K103_K0.7290.45
16_R28_K0.7280.45
87_K90_K0.7280.45
28_K180_R0.7250.45
80_E86_K0.7250.45
46_E51_A0.7220.44
69_L73_K0.7190.44
46_E56_P0.7170.44
106_E144_D0.7160.44
192_K196_K0.7130.43
126_K173_V0.7080.43
188_I192_K0.7000.42
152_L162_S0.6990.42
52_S61_P0.6980.42
98_P151_A0.6940.42
165_E206_K0.6930.42
179_E189_A0.6890.41
51_A57_S0.6830.41
134_K150_K0.6830.41
8_K11_K0.6770.40
126_K135_R0.6720.40
90_K206_K0.6710.40
162_S176_K0.6710.40
43_E59_P0.6680.40
11_K32_A0.6670.39
15_E19_K0.6590.39
111_K174_E0.6540.38
13_K18_R0.6510.38
15_E22_E0.6510.38
130_L134_K0.6460.38
81_L84_K0.6430.37
103_K141_V0.6420.37
67_G75_D0.6410.37
107_A122_E0.6390.37
47_A111_K0.6380.37
72_G189_A0.6330.37
168_E194_E0.6320.36
147_L154_R0.6320.36
137_E145_P0.6290.36
44_E50_S0.6280.36
13_K29_K0.6270.36
171_E175_K0.6210.36
173_V180_R0.6200.35
24_K42_K0.6200.35
111_K127_D0.6190.35
128_K175_K0.6180.35
16_R154_R0.6180.35
59_P63_E0.6180.35
92_G185_E0.6170.35
7_E32_A0.6140.35
174_E182_K0.6130.35
58_P61_P0.6100.35
75_D199_K0.6100.35
191_R196_K0.6050.34
157_K200_K0.6050.34
168_E189_A0.6050.34
86_K188_I0.6050.34
124_E197_E0.6050.34
28_K121_K0.6050.34
76_F79_G0.6010.34
15_E30_E0.5930.33
105_L124_E0.5860.33
197_E205_K0.5850.33
170_K173_V0.5810.32
25_E30_E0.5790.32
105_L154_R0.5780.32
45_E48_E0.5770.32
190_K199_K0.5740.32
20_K119_K0.5740.32
131_K136_A0.5730.32
13_K22_E0.5720.32
13_K21_K0.5690.31
75_D196_K0.5680.31
153_K156_E0.5670.31
151_A185_E0.5620.31
124_E162_S0.5600.31
142_K148_L0.5590.31
47_A53_E0.5570.30
165_E168_E0.5560.30
15_E20_K0.5540.30
94_T100_Q0.5500.30
74_V77_G0.5470.30
49_K53_E0.5470.30
8_K16_R0.5460.30
54_S58_P0.5450.30
12_R22_E0.5450.30
168_E191_R0.5420.29
18_R168_E0.5420.29
126_K152_L0.5420.29
20_K33_R0.5420.29
97_D148_L0.5410.29
19_K134_K0.5390.29
49_K56_P0.5360.29
59_P66_E0.5330.29
166_W169_R0.5300.28
11_K16_R0.5270.28
72_G76_F0.5260.28
84_K88_K0.5260.28
22_E28_K0.5230.28
161_K203_A0.5230.28
44_E48_E0.5170.27
98_P144_D0.5160.27
135_R183_K0.5150.27
79_G165_E0.5110.27
12_R24_K0.5090.27
27_A30_E0.5070.27
132_A193_E0.5070.27
17_K27_A0.5060.27
71_F133_L0.5060.27
19_K22_E0.5060.27
97_D156_E0.5040.27
64_E70_V0.5030.26
18_R23_R0.5020.26
81_L85_K0.5020.26
11_K15_E0.5010.26
42_K46_E0.5010.26
174_E177_K0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2enkA 1 0.1691 1.2 0.961 Contact Map
4a17T 1 0 0.9 0.963 Contact Map
4kp3E 1 0.0676 0.7 0.966 Contact Map
3j39W 1 0.2174 0.7 0.966 Contact Map
4w20W 1 0 0.6 0.967 Contact Map
3vhjA 1 0.2415 0.6 0.967 Contact Map
4lx2B 1 0.058 0.6 0.968 Contact Map
3fgxA 2 0.1739 0.6 0.968 Contact Map
3m91A 2 0.0821 0.6 0.968 Contact Map
2ygvE 1 0.0966 0.6 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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