GREMLIN Database
Wzy_C - O-Antigen ligase
PFAM: PF04932 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 156 (143)
Sequences: 124159 (108971)
Seq/√Len: 9112.6
META: 0.899

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_I144_L4.9021.00
104_H109_V4.8581.00
147_L151_G3.3791.00
142_Q146_E2.8101.00
144_L152_L2.7301.00
101_I149_I2.4541.00
136_A142_Q2.3571.00
98_L102_K2.3381.00
94_W141_L2.3171.00
100_M109_V2.2681.00
135_H142_Q2.0201.00
97_A136_A1.9941.00
62_R65_R1.8851.00
97_A141_L1.8641.00
109_V145_A1.7401.00
96_A99_E1.6541.00
102_K105_P1.6461.00
28_V32_L1.6211.00
53_L57_L1.5651.00
29_L33_L1.5621.00
139_D142_Q1.5051.00
63_L66_L1.4491.00
100_M145_A1.4471.00
91_L95_R1.4361.00
65_R68_S1.4281.00
62_R66_L1.4211.00
104_H107_L1.4121.00
54_L58_V1.3751.00
150_V154_L1.3701.00
52_L56_L1.3651.00
41_L44_L1.3631.00
100_M103_D1.3601.00
8_L12_L1.3521.00
40_R44_L1.3361.00
60_S65_R1.3261.00
95_R99_E1.3231.00
114_F118_Y1.3191.00
97_A145_A1.3071.00
15_S18_A1.2741.00
150_V153_L1.2631.00
92_E95_R1.2571.00
99_E102_K1.2531.00
54_L57_L1.2211.00
143_I147_L1.2121.00
113_G117_F1.2031.00
60_S64_E1.1951.00
59_L62_R1.1941.00
116_A119_F1.1901.00
98_L101_I1.1881.00
25_A29_L1.1491.00
89_G93_I1.1401.00
53_L56_L1.1361.00
93_I133_V1.1321.00
30_L34_L1.1301.00
140_Y152_L1.1181.00
69_I72_A1.1141.00
65_R69_I1.1121.00
59_L63_L1.1001.00
17_G21_A1.0971.00
113_G116_A1.0871.00
96_A100_M1.0801.00
139_D143_I1.0801.00
135_H139_D1.0661.00
49_G53_L1.0591.00
87_L91_L1.0541.00
93_I137_H1.0431.00
115_G119_F1.0411.00
144_L149_I1.0351.00
84_D87_L1.0031.00
64_E67_G1.0021.00
101_I105_P0.9811.00
143_I152_L0.9761.00
116_A120_A0.9741.00
34_L38_R0.9701.00
88_S91_L0.9691.00
61_S65_R0.9671.00
10_L18_A0.9621.00
56_L60_S0.9591.00
102_K149_I0.9561.00
138_N141_L0.9561.00
93_I136_A0.9511.00
118_Y121_Y0.9511.00
61_S64_E0.9451.00
66_L69_I0.9391.00
143_I155_F0.9301.00
115_G118_Y0.9241.00
120_A123_Y0.9131.00
113_G118_Y0.9101.00
115_G120_A0.9031.00
6_L9_A0.9031.00
86_S91_L0.9001.00
103_D109_V0.8961.00
119_F122_L0.8911.00
97_A101_I0.8891.00
114_F117_F0.8801.00
63_L68_S0.8671.00
62_R67_G0.8651.00
14_G19_W0.8641.00
115_G121_Y0.8631.00
99_E103_D0.8561.00
34_L37_R0.8541.00
10_L22_L0.8511.00
46_A50_V0.8501.00
113_G119_F0.8501.00
23_L27_L0.8501.00
114_F120_A0.8491.00
50_V54_L0.8471.00
94_W138_N0.8421.00
41_L45_L0.8411.00
101_I150_V0.8391.00
42_L45_L0.8331.00
43_L46_A0.8281.00
33_L37_R0.8261.00
35_R38_R0.8161.00
101_I145_A0.8131.00
117_F120_A0.8081.00
92_E96_A0.8001.00
55_A59_L0.7991.00
66_L70_T0.7981.00
60_S63_L0.7951.00
40_R43_L0.7891.00
84_D88_S0.7881.00
5_L9_A0.7871.00
27_L31_L0.7841.00
31_L35_R0.7831.00
25_A32_L0.7821.00
57_L60_S0.7721.00
85_G88_S0.7721.00
117_F121_Y0.7691.00
52_L55_A0.7651.00
50_V53_L0.7651.00
121_Y124_Y0.7581.00
63_L67_G0.7561.00
26_L30_L0.7521.00
101_I152_L0.7451.00
49_G52_L0.7451.00
55_A58_V0.7391.00
67_G70_T0.7351.00
122_L125_A0.7341.00
61_S66_L0.7301.00
121_Y125_A0.7251.00
86_S89_G0.7231.00
57_L61_S0.7221.00
147_L154_L0.7201.00
39_R42_L0.7111.00
136_A145_A0.7101.00
114_F119_F0.7071.00
44_L47_L0.7031.00
113_G120_A0.7021.00
136_A139_D0.6991.00
113_G122_L0.6911.00
3_L7_L0.6841.00
97_A100_M0.6821.00
90_R137_H0.6771.00
91_L94_W0.6771.00
48_L52_L0.6751.00
46_A49_G0.6741.00
21_A25_A0.6701.00
118_Y122_L0.6681.00
131_G134_D0.6641.00
97_A144_L0.6631.00
58_V62_R0.6631.00
117_F123_Y0.6581.00
124_Y127_S0.6571.00
63_L69_I0.6551.00
3_L6_L0.6551.00
123_Y126_Y0.6511.00
64_E68_S0.6411.00
47_L50_V0.6401.00
42_L57_L0.6361.00
42_L46_A0.6341.00
9_A13_T0.6331.00
7_L22_L0.6311.00
45_L49_G0.6231.00
59_L65_R0.6221.00
136_A141_L0.6201.00
137_H142_Q0.6111.00
147_L150_V0.6051.00
119_F123_Y0.6031.00
51_L54_L0.6031.00
110_G146_E0.6011.00
49_G56_L0.6001.00
51_L55_A0.5991.00
113_G121_Y0.5981.00
144_L150_V0.5911.00
39_R43_L0.5861.00
31_L34_L0.5851.00
33_L36_R0.5851.00
136_A146_E0.5841.00
68_S72_A0.5821.00
64_E69_I0.5771.00
43_L47_L0.5751.00
62_R68_S0.5701.00
85_G89_G0.5701.00
139_D155_F0.5671.00
98_L141_L0.5591.00
68_S71_F0.5511.00
25_A28_V0.5451.00
62_R69_I0.5441.00
120_A124_Y0.5411.00
44_L48_L0.5391.00
27_L30_L0.5391.00
10_L13_T0.5321.00
149_I153_L0.5301.00
140_Y143_I0.5291.00
88_S92_E0.5291.00
9_A12_L0.5181.00
59_L66_L0.5171.00
93_I96_A0.5141.00
122_L126_Y0.5101.00
93_I135_H0.5081.00
89_G137_H0.5061.00
107_L150_V0.5011.00
4_L8_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wxwA 1 0.4038 10.6 0.884 Contact Map
2w3zA 1 0.4103 4.1 0.904 Contact Map
1afoA 2 0.1923 2.3 0.915 Contact Map
2ks1B 1 0.2244 1.9 0.919 Contact Map
3dl8E 1 0.3782 1.5 0.924 Contact Map
2jwaA 2 0.2179 1.5 0.924 Contact Map
5a63B 1 0.4744 1.3 0.927 Contact Map
3l1lA 2 0.4551 1.2 0.929 Contact Map
4ry2A 2 0.8846 1.1 0.93 Contact Map
4a82A 2 0.8846 1.1 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0055 seconds.