GREMLIN Database
FUN14 - FUN14 family
PFAM: PF04930 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 90 (90)
Sequences: 2870 (2210)
Seq/√Len: 233.0
META: 0.802

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_Y39_Q3.5501.00
41_I52_A3.1691.00
29_F32_L2.2811.00
45_N48_K2.1141.00
47_D50_E1.9811.00
28_L32_L1.9731.00
33_L42_I1.8981.00
13_Y17_K1.7871.00
41_I49_L1.7511.00
34_Q37_E1.7401.00
50_E54_S1.7171.00
80_G84_A1.6631.00
4_G78_F1.6581.00
3_G7_I1.6261.00
63_G67_A1.5971.00
58_D62_D1.5841.00
5_F9_F1.5671.00
30_F34_Q1.5601.00
79_A83_A1.5511.00
63_G66_G1.5481.00
75_N79_A1.5041.00
12_G17_K1.4901.00
10_L23_A1.4511.00
78_F81_G1.4421.00
63_G68_A1.4041.00
56_A60_W1.3701.00
81_G84_A1.3521.00
60_W66_G1.3481.00
64_L67_A1.3451.00
62_D66_G1.3321.00
14_A24_V1.2941.00
71_F75_N1.2441.00
14_A28_L1.2341.00
60_W64_L1.1901.00
60_W65_V1.1871.00
14_A27_G1.1861.00
62_D67_A1.1551.00
55_S58_D1.1441.00
84_A88_L1.1361.00
9_F13_Y1.0981.00
24_V27_G1.0721.00
69_L75_N1.0691.00
60_W63_G1.0661.00
65_V68_A1.0661.00
29_F33_L1.0631.00
11_V82_F1.0591.00
41_I48_K1.0391.00
3_G6_V1.0151.00
58_D61_G1.0141.00
48_K52_A1.0111.00
15_L37_E0.9811.00
36_L42_I0.9701.00
36_L41_I0.9641.00
14_A31_A0.9641.00
7_I10_L0.9581.00
33_L44_V0.9571.00
83_A87_L0.9541.00
38_Y75_N0.9441.00
31_A35_Y0.9381.00
15_L86_F0.9361.00
2_G5_F0.9291.00
59_T68_A0.9151.00
23_A34_Q0.9131.00
57_L60_W0.9111.00
61_G64_L0.9091.00
51_S54_S0.8980.99
5_F85_G0.8960.99
58_D63_G0.8940.99
17_K21_I0.8820.99
13_Y20_K0.8740.99
60_W67_A0.8700.99
77_P81_G0.8580.99
77_P80_G0.8410.99
75_N78_F0.8390.99
31_A34_Q0.8080.99
64_L68_A0.8050.99
87_L90_F0.8010.99
85_G89_G0.8000.99
61_G66_G0.7870.99
59_T62_D0.7840.99
74_S78_F0.7670.98
21_I24_V0.7470.98
58_D68_A0.7300.98
5_F38_Y0.7190.98
13_Y24_V0.7090.97
19_L22_A0.7070.97
32_L36_L0.7020.97
61_G68_A0.7000.97
4_G8_G0.6970.97
35_Y38_Y0.6920.97
3_G53_V0.6910.97
59_T65_V0.6890.97
24_V29_F0.6770.96
80_G83_A0.6750.96
60_W68_A0.6660.96
4_G36_L0.6660.96
10_L24_V0.6650.96
84_A87_L0.6640.96
14_A46_W0.6520.96
23_A27_G0.6490.96
16_K82_F0.6410.95
57_L64_L0.6370.95
40_G53_V0.6320.95
72_L75_N0.6300.95
18_V21_I0.6240.94
53_V63_G0.6210.94
18_V24_V0.6160.94
75_N81_G0.6150.94
25_I29_F0.6110.94
26_V31_A0.6080.94
69_L72_L0.6010.93
71_F74_S0.5930.93
9_F19_L0.5800.92
62_D65_V0.5770.92
17_K89_G0.5720.91
59_T63_G0.5710.91
76_L80_G0.5710.91
58_D67_A0.5700.91
47_D52_A0.5550.90
57_L61_G0.5460.90
19_L78_F0.5430.89
7_I30_F0.5320.88
71_F81_G0.5170.87
24_V28_L0.5160.87
46_W50_E0.5140.87
8_G12_G0.5140.87
86_F90_F0.5130.86
15_L52_A0.5120.86
28_L52_A0.5100.86
13_Y21_I0.5100.86
20_K80_G0.5050.86
9_F88_L0.5030.85
48_K51_S0.5020.85
5_F77_P0.5010.85
3_G30_F0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.8778 3.6 0.886 Contact Map
4od4A 1 0.9333 3.3 0.888 Contact Map
4tq3A 1 0.9444 2.9 0.892 Contact Map
4citA 1 0.3 2.8 0.892 Contact Map
4fc4A 3 0.4111 2.5 0.896 Contact Map
4ymuD 2 0.4667 2.4 0.896 Contact Map
3kd6A 2 0.6 1.8 0.904 Contact Map
3tdsE 3 0.4333 1.8 0.904 Contact Map
2nq2A 2 0.6556 1.8 0.904 Contact Map
2pkfA 2 0.7111 1.7 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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