GREMLIN Database
DUF651 - Archaeal protein of unknown function (DUF651)
PFAM: PF04895 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 110 (110)
Sequences: 3798 (2573)
Seq/√Len: 245.3
META: 0.943

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_K109_D3.7971.00
26_Y30_I3.5991.00
70_F79_Y2.8071.00
10_A17_Y2.8001.00
68_L79_Y2.7351.00
71_D75_E2.5101.00
72_S75_E2.5061.00
19_A55_V2.5061.00
26_Y29_K2.2181.00
27_L34_A2.2061.00
54_V58_N2.1821.00
23_V36_V2.1171.00
25_E60_R2.1111.00
61_K64_K2.0591.00
50_L54_V1.9891.00
6_R10_A1.9581.00
19_A38_V1.9491.00
74_E78_E1.9201.00
18_A55_V1.9191.00
22_A60_R1.8981.00
23_V63_L1.7881.00
99_K103_T1.7651.00
52_V55_V1.5931.00
79_Y82_K1.5031.00
12_I15_G1.5011.00
81_S88_L1.4941.00
19_A59_V1.4911.00
61_K65_Q1.4701.00
73_L76_A1.4601.00
90_R93_K1.3021.00
46_Y54_V1.2981.00
15_G55_V1.2881.00
8_T11_S1.2841.00
58_N61_K1.2661.00
78_E81_S1.2191.00
55_V59_V1.2011.00
86_I91_W1.1751.00
1_E4_R1.1711.00
27_L36_V1.1371.00
18_A52_V1.0781.00
2_G16_Y1.0741.00
23_V38_V1.0731.00
52_V56_R1.0501.00
15_G54_V1.0411.00
81_S87_P1.0351.00
79_Y83_R1.0301.00
10_A13_G1.0301.00
24_L28_E1.0211.00
96_K99_K1.0171.00
40_R46_Y1.0041.00
46_Y50_L1.0001.00
42_I49_P0.9911.00
96_K100_E0.9761.00
18_A22_A0.9751.00
92_L102_L0.9741.00
74_E102_L0.9711.00
43_T85_K0.9701.00
78_E82_K0.9671.00
90_R94_K0.9641.00
81_S89_S0.9611.00
87_P90_R0.9531.00
26_Y63_L0.9501.00
37_L97_L0.9421.00
22_A25_E0.9011.00
89_S93_K0.8951.00
15_G22_A0.8881.00
75_E78_E0.8861.00
66_K69_K0.8740.99
105_K108_T0.8720.99
38_V62_A0.8700.99
15_G21_L0.8690.99
39_L76_A0.8660.99
3_Y33_Q0.8590.99
4_R7_K0.8510.99
57_E64_K0.8350.99
106_R109_D0.8320.99
84_L87_P0.8290.99
29_K64_K0.8130.99
105_K110_F0.8070.99
39_L91_W0.7980.99
22_A59_V0.7960.99
40_R54_V0.7890.99
38_V59_V0.7760.99
21_L60_R0.7710.99
65_Q68_L0.7580.99
1_E5_G0.7450.98
15_G42_I0.7410.98
46_Y62_A0.7360.98
44_P85_K0.7300.98
13_G55_V0.7240.98
43_T84_L0.7200.98
53_W91_W0.7090.98
93_K99_K0.7040.98
2_G100_E0.7020.98
12_I19_A0.7020.98
40_R55_V0.7000.98
97_L100_E0.6950.97
24_L53_W0.6870.97
70_F76_A0.6860.97
70_F77_L0.6850.97
88_L92_L0.6790.97
43_T48_A0.6670.97
44_P47_W0.6650.97
35_G97_L0.6650.97
42_I58_N0.6600.96
9_Y17_Y0.6600.96
13_G52_V0.6580.96
77_L80_I0.6510.96
100_E106_R0.6500.96
76_A80_I0.6490.96
84_L88_L0.6460.96
39_L84_L0.6460.96
5_G8_T0.6390.96
57_E60_R0.6360.96
55_V58_N0.6350.96
12_I91_W0.6340.96
17_Y52_V0.6280.95
41_E91_W0.6280.95
73_L101_L0.6250.95
15_G18_A0.6230.95
77_L98_L0.6180.95
77_L92_L0.6180.95
25_E29_K0.6140.95
30_I36_V0.6100.95
73_L98_L0.6040.94
6_R11_S0.6030.94
75_E79_Y0.5910.94
68_L82_K0.5910.94
37_L95_S0.5910.94
38_V55_V0.5810.93
9_Y16_Y0.5790.93
2_G7_K0.5750.93
41_E85_K0.5660.92
47_W53_W0.5650.92
42_I50_L0.5610.92
35_G54_V0.5610.92
6_R9_Y0.5600.92
15_G19_A0.5580.92
19_A53_W0.5520.91
5_G11_S0.5510.91
69_K82_K0.5500.91
95_S98_L0.5480.91
16_Y52_V0.5460.91
9_Y20_R0.5430.90
37_L98_L0.5420.90
15_G43_T0.5390.90
91_W94_K0.5360.90
8_T13_G0.5350.90
23_V27_L0.5250.89
71_D90_R0.5240.89
22_A56_R0.5240.89
31_K70_F0.5230.89
28_E31_K0.5230.89
18_A42_I0.5210.89
68_L75_E0.5180.88
1_E9_Y0.5180.88
2_G35_G0.5110.88
43_T54_V0.5070.87
22_A55_V0.5060.87
38_V58_N0.5040.87
96_K107_L0.5040.87
6_R16_Y0.5040.87
83_R87_P0.5040.87
4_R8_T0.5030.87
30_I63_L0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gfqA 3 0.7545 12.2 0.934 Contact Map
3ugoA 1 0.2909 6.7 0.941 Contact Map
1rxwA 1 0.6545 6.5 0.941 Contact Map
1io7A 1 0.7 6 0.942 Contact Map
2ahmE 5 0.5636 5.3 0.944 Contact Map
2hx6A 1 0.5545 5.3 0.944 Contact Map
1t35A 5 0.7636 5.2 0.944 Contact Map
1qhkA 1 0.3909 5.2 0.944 Contact Map
3ub0A 1 0.5909 5.2 0.944 Contact Map
2yy0A 6 0.3364 5.1 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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