DUF650 - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

DUF650 - Archaeal protein of unknown function (DUF650)

PFAM:	PF04894	Sequences: LCGKPRCPILVKFRSLLKVKPLISSKEIFGSSPPSVFVGRYGYPKVNVGPLVPPEHGDTSILDTPELWLGKSIEEIVDFRSSLVRGKFRVNVKDAEGRFLEELQEIALSSKPVDVEVELKKKPRGRLSFDDEVQPFGPSAPLKKAKITENPKVPRKVEKVYYDTDLKAAEAVLELYKSGVDVSKIQKALSVGLLGLKKNRKLVPTRWSITAVDDIISKNLLEEIKDYPEIDEYRVYEGEYLGNRFEILLFPGPWSYELIEAWYPGSVWN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	269 (269)
Sequences:	2577 (1808)
Seq/√Len:	110.2
META:	0.92

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
214_D	218_K	5.159	1.00
172_V	215_I	3.978	1.00
160_V	166_L	3.712	1.00
221_L	225_K	3.379	1.00
36_V	191_V	3.325	1.00
52_V	117_V	3.226	1.00
172_V	185_I	3.069	1.00
120_K	143_K	2.926	1.00
173_L	219_N	2.909	1.00
239_E	244_R	2.850	1.00
196_L	199_N	2.784	1.00
156_K	178_S	2.419	1.00
154_P	184_K	2.406	1.00
157_V	188_A	2.301	1.00
118_E	143_K	2.289	1.00
160_V	174_E	2.228	1.00
172_V	189_L	2.213	1.00
158_E	162_Y	2.188	1.00
27_E	118_E	2.146	1.00
180_V	184_K	2.137	1.00
100_L	202_L	2.110	1.00
252_G	255_S	2.096	1.00
66_E	181_D	2.064	1.00
26_K	122_K	2.056	1.00
35_S	63_D	2.009	1.00
69_L	238_G	1.977	1.00
160_V	194_L	1.977	1.00
72_S	75_E	1.924	1.00
166_L	174_E	1.904	1.00
229_E	252_G	1.892	1.00
46_V	92_V	1.890	1.00
71_K	75_E	1.883	1.00
170_E	174_E	1.878	1.00
101_E	104_Q	1.855	1.00
219_N	222_E	1.842	1.00
45_K	91_N	1.817	1.00
111_K	152_K	1.777	1.00
26_K	143_K	1.756	1.00
237_E	246_E	1.739	1.00
69_L	240_Y	1.730	1.00
66_E	183_S	1.699	1.00
190_S	208_S	1.691	1.00
102_E	105_E	1.665	1.00
50_P	85_R	1.644	1.00
87_K	139_S	1.638	1.00
165_D	200_R	1.618	1.00
166_L	170_E	1.614	1.00
188_A	194_L	1.609	1.00
173_L	216_I	1.603	1.00
102_E	145_A	1.592	1.00
110_S	154_P	1.583	1.00
233_Y	250_F	1.582	1.00
167_K	196_L	1.579	1.00
216_I	220_L	1.572	1.00
28_I	84_V	1.567	1.00
176_Y	220_L	1.517	1.00
31_S	53_P	1.515	1.00
189_L	215_I	1.503	1.00
230_I	249_L	1.493	1.00
108_L	161_Y	1.473	1.00
108_L	157_V	1.468	1.00
120_K	141_P	1.465	1.00
189_L	212_V	1.455	1.00
164_T	197_K	1.451	1.00
113_V	151_P	1.427	1.00
169_A	219_N	1.427	1.00
28_I	119_L	1.424	1.00
229_E	253_P	1.422	1.00
147_I	151_P	1.411	1.00
221_L	224_I	1.405	1.00
156_K	174_E	1.405	1.00
169_A	215_I	1.401	1.00
172_V	216_I	1.395	1.00
223_E	226_D	1.388	1.00
40_R	206_R	1.381	1.00
47_N	89_R	1.377	1.00
266_S	269_N	1.368	1.00
75_E	78_D	1.367	1.00
31_S	59_T	1.338	1.00
116_E	146_K	1.329	1.00
2_C	7_C	1.327	1.00
235_V	246_E	1.322	1.00
104_Q	193_L	1.321	1.00
114_D	149_E	1.309	0.99
153_V	158_E	1.301	0.99
158_E	161_Y	1.298	0.99
108_L	153_V	1.286	0.99
88_F	99_F	1.285	0.99
228_P	231_D	1.264	0.99
37_F	40_R	1.259	0.99
47_N	87_K	1.257	0.99
3_G	7_C	1.256	0.99
38_V	48_V	1.255	0.99
161_Y	193_L	1.254	0.99
60_S	67_L	1.248	0.99
121_K	141_P	1.246	0.99
110_S	152_K	1.244	0.99
100_L	104_Q	1.243	0.99
2_C	8_P	1.236	0.99
61_I	79_F	1.236	0.99
189_L	194_L	1.236	0.99
160_V	171_A	1.225	0.99
107_A	191_V	1.207	0.99
108_L	193_L	1.202	0.99
210_T	213_D	1.201	0.99
174_E	178_S	1.191	0.99
71_K	79_F	1.182	0.99
150_N	153_V	1.174	0.99
52_V	115_V	1.170	0.99
64_T	181_D	1.160	0.99
29_F	56_H	1.153	0.99
86_G	117_V	1.152	0.99
63_D	68_W	1.151	0.99
28_I	52_V	1.132	0.98
130_D	133_V	1.117	0.98
153_V	193_L	1.117	0.98
155_R	159_K	1.116	0.98
90_V	100_L	1.116	0.98
90_V	94_D	1.102	0.98
91_N	94_D	1.099	0.98
169_A	173_L	1.098	0.98
31_S	57_G	1.096	0.98
186_Q	189_L	1.088	0.98
183_S	187_K	1.079	0.98
29_F	114_D	1.075	0.98
169_A	218_K	1.070	0.98
161_Y	194_L	1.066	0.98
53_P	59_T	1.065	0.98
119_L	123_P	1.054	0.98
97_G	101_E	1.052	0.97
61_I	71_K	1.048	0.97
119_L	140_A	1.044	0.97
58_D	61_I	1.039	0.97
6_R	11_V	1.038	0.97
153_V	162_Y	1.037	0.97
156_K	159_K	1.037	0.97
254_W	257_E	1.034	0.97
48_V	202_L	1.031	0.97
184_K	187_K	1.016	0.97
29_F	148_T	1.013	0.97
233_Y	248_L	1.010	0.97
107_A	187_K	0.999	0.97
92_V	201_K	0.993	0.96
106_I	113_V	0.993	0.96
234_R	249_L	0.991	0.96
235_V	248_L	0.983	0.96
176_Y	182_V	0.981	0.96
167_K	170_E	0.976	0.96
94_D	97_G	0.970	0.96
76_I	241_L	0.969	0.96
169_A	214_D	0.964	0.96
114_D	148_T	0.959	0.96
237_E	244_R	0.958	0.96
86_G	119_L	0.953	0.95
13_F	16_L	0.950	0.95
64_T	67_L	0.948	0.95
45_K	89_R	0.948	0.95
151_P	154_P	0.946	0.95
217_S	258_L	0.945	0.95
219_N	223_E	0.943	0.95
48_V	90_V	0.939	0.95
50_P	145_A	0.938	0.95
35_S	51_L	0.935	0.95
55_E	62_L	0.930	0.95
31_S	56_H	0.928	0.95
117_V	142_L	0.927	0.95
182_V	186_Q	0.923	0.95
98_R	102_E	0.922	0.95
51_L	85_R	0.901	0.94
223_E	227_Y	0.900	0.94
224_I	227_Y	0.895	0.94
265_G	268_W	0.892	0.94
264_P	269_N	0.890	0.94
258_L	269_N	0.886	0.93
64_T	183_S	0.883	0.93
130_D	136_F	0.882	0.93
247_I	258_L	0.880	0.93
109_S	151_P	0.875	0.93
53_P	58_D	0.873	0.93
212_V	215_I	0.871	0.93
15_S	19_V	0.868	0.93
91_N	95_A	0.854	0.92
171_A	194_L	0.850	0.92
191_V	202_L	0.849	0.92
209_I	213_D	0.848	0.92
95_A	100_L	0.843	0.92
242_G	258_L	0.843	0.92
154_P	180_V	0.842	0.92
31_S	54_P	0.834	0.91
63_D	80_R	0.833	0.91
264_P	268_W	0.827	0.91
233_Y	252_G	0.824	0.91
221_L	226_D	0.824	0.91
65_P	183_S	0.820	0.90
9_I	12_K	0.818	0.90
170_E	173_L	0.818	0.90
3_G	9_I	0.811	0.90
10_L	13_F	0.808	0.90
41_Y	47_N	0.804	0.90
51_L	83_L	0.800	0.89
166_L	196_L	0.792	0.89
37_F	49_G	0.790	0.89
39_G	49_G	0.789	0.89
88_F	103_L	0.788	0.89
20_K	23_I	0.776	0.88
29_F	116_E	0.775	0.88
98_R	101_E	0.772	0.88
77_V	81_S	0.771	0.87
218_K	222_E	0.770	0.87
239_E	246_E	0.764	0.87
109_S	113_V	0.761	0.87
38_V	103_L	0.760	0.87
230_I	234_R	0.759	0.87
68_W	80_R	0.757	0.87
38_V	191_V	0.751	0.86
63_D	79_F	0.750	0.86
5_P	9_I	0.750	0.86
116_E	148_T	0.749	0.86
256_Y	266_S	0.748	0.86
246_E	258_L	0.742	0.85
107_A	193_L	0.740	0.85
9_I	267_V	0.738	0.85
65_P	68_W	0.737	0.85
105_E	153_V	0.736	0.85
84_V	119_L	0.733	0.85
54_P	57_G	0.728	0.84
53_P	62_L	0.726	0.84
25_S	28_I	0.722	0.84
221_L	254_W	0.714	0.83
103_L	191_V	0.714	0.83
85_R	245_F	0.709	0.83
245_F	258_L	0.708	0.83
118_E	144_K	0.705	0.82
13_F	17_L	0.703	0.82
240_Y	245_F	0.700	0.82
47_N	85_R	0.699	0.82
15_S	18_K	0.699	0.82
86_G	142_L	0.695	0.81
60_S	64_T	0.693	0.81
157_V	184_K	0.692	0.81
14_R	17_L	0.690	0.81
237_E	245_F	0.690	0.81
153_V	157_V	0.689	0.81
135_P	138_P	0.688	0.81
181_D	184_K	0.687	0.81
174_E	177_K	0.686	0.81
182_V	217_S	0.684	0.80
182_V	264_P	0.684	0.80
104_Q	161_Y	0.680	0.80
35_S	107_A	0.679	0.80
159_K	162_Y	0.674	0.79
85_R	119_L	0.668	0.79
263_Y	267_V	0.668	0.79
59_T	62_L	0.665	0.79
51_L	214_D	0.665	0.79
95_A	104_Q	0.662	0.78
104_Q	194_L	0.660	0.78
30_G	138_P	0.657	0.78
18_K	21_P	0.656	0.78
43_Y	46_V	0.656	0.78
257_E	260_E	0.653	0.77
90_V	95_A	0.653	0.77
155_R	158_E	0.651	0.77
93_K	96_E	0.648	0.77
55_E	59_T	0.648	0.77
37_F	85_R	0.645	0.76
33_P	36_V	0.644	0.76
151_P	157_V	0.644	0.76
102_E	147_I	0.641	0.76
186_Q	212_V	0.640	0.76
31_S	114_D	0.637	0.76
81_S	127_L	0.632	0.75
140_A	241_L	0.631	0.75
238_G	258_L	0.629	0.75
53_P	112_P	0.629	0.75
29_F	147_I	0.625	0.74
183_S	256_Y	0.622	0.74
66_E	182_V	0.622	0.74
159_K	163_D	0.621	0.74
37_F	51_L	0.619	0.73
90_V	202_L	0.619	0.73
12_K	15_S	0.615	0.73
59_T	183_S	0.615	0.73
123_P	126_R	0.614	0.73
30_G	59_T	0.611	0.73
40_R	46_V	0.611	0.73
167_K	199_N	0.611	0.73
49_G	208_S	0.610	0.72
62_L	79_F	0.608	0.72
194_L	214_D	0.606	0.72
156_K	160_V	0.604	0.72
181_D	186_Q	0.603	0.72
220_L	223_E	0.603	0.72
76_I	127_L	0.602	0.71
247_I	263_Y	0.598	0.71
84_V	140_A	0.594	0.70
18_K	22_L	0.590	0.70
25_S	123_P	0.590	0.70
104_Q	162_Y	0.590	0.70
88_F	142_L	0.589	0.70
244_R	247_I	0.589	0.70
63_D	187_K	0.589	0.70
142_L	145_A	0.587	0.70
98_R	226_D	0.587	0.70
109_S	150_N	0.587	0.70
238_G	247_I	0.586	0.69
171_A	200_R	0.585	0.69
70_G	240_Y	0.585	0.69
154_P	158_E	0.582	0.69
241_L	245_F	0.581	0.69
71_K	240_Y	0.580	0.69
238_G	245_F	0.579	0.68
42_G	89_R	0.579	0.68
164_T	199_N	0.578	0.68
228_P	232_E	0.578	0.68
41_Y	89_R	0.577	0.68
258_L	262_W	0.576	0.68
37_F	50_P	0.575	0.68
139_S	266_S	0.574	0.68
163_D	176_Y	0.573	0.68
149_E	187_K	0.572	0.68
83_L	138_P	0.572	0.68
37_F	256_Y	0.571	0.67
41_Y	191_V	0.571	0.67
19_V	22_L	0.568	0.67
117_V	145_A	0.566	0.67
229_E	232_E	0.566	0.67
56_H	59_T	0.565	0.67
170_E	219_N	0.565	0.67
206_R	245_F	0.565	0.67
60_S	112_P	0.563	0.66
263_Y	266_S	0.562	0.66
40_R	49_G	0.561	0.66
1_L	7_C	0.559	0.66
173_L	177_K	0.555	0.65
117_V	224_I	0.554	0.65
39_G	42_G	0.553	0.65
10_L	14_R	0.552	0.65
264_P	267_V	0.551	0.65
222_E	225_K	0.551	0.65
157_V	162_Y	0.551	0.65
102_E	153_V	0.551	0.65
202_L	245_F	0.549	0.64
185_I	212_V	0.549	0.64
50_P	119_L	0.549	0.64
55_E	82_S	0.548	0.64
215_I	219_N	0.548	0.64
85_R	139_S	0.548	0.64
28_I	33_P	0.547	0.64
170_E	179_G	0.547	0.64
49_G	87_K	0.547	0.64
245_F	263_Y	0.546	0.64
226_D	229_E	0.546	0.64
263_Y	269_N	0.546	0.64
238_G	244_R	0.545	0.64
160_V	188_A	0.544	0.64
110_S	153_V	0.540	0.63
214_D	217_S	0.540	0.63
102_E	106_I	0.539	0.63
164_T	198_K	0.536	0.63
172_V	212_V	0.536	0.63
115_V	242_G	0.534	0.62
121_K	124_R	0.534	0.62
176_Y	216_I	0.533	0.62
254_W	261_A	0.533	0.62
100_L	193_L	0.533	0.62
84_V	240_Y	0.532	0.62
129_F	135_P	0.532	0.62
6_R	9_I	0.532	0.62
175_L	215_I	0.531	0.62
22_L	72_S	0.529	0.62
149_E	152_K	0.527	0.61
26_K	121_K	0.527	0.61
48_V	88_F	0.527	0.61
84_V	91_N	0.526	0.61
239_E	259_I	0.525	0.61
51_L	115_V	0.524	0.61
68_W	79_F	0.523	0.61
135_P	262_W	0.523	0.61
13_F	19_V	0.523	0.61
101_E	254_W	0.522	0.61
251_P	260_E	0.521	0.60
70_G	235_V	0.520	0.60
12_K	16_L	0.519	0.60
115_V	118_E	0.518	0.60
143_K	146_K	0.517	0.60
229_E	249_L	0.515	0.60
189_L	234_R	0.515	0.60
108_L	188_A	0.515	0.60
14_R	18_K	0.515	0.60
3_G	12_K	0.511	0.59
188_A	193_L	0.509	0.59
21_P	25_S	0.507	0.58
236_Y	256_Y	0.506	0.58
177_K	196_L	0.506	0.58
16_L	41_Y	0.505	0.58
103_L	231_D	0.505	0.58
49_G	214_D	0.504	0.58
189_L	208_S	0.502	0.58
228_P	233_Y	0.502	0.58
71_K	76_I	0.502	0.58
184_K	188_A	0.501	0.57
63_D	76_I	0.501	0.57
91_N	99_F	0.500	0.57

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qzqA	1	0.5502	27.8	0.969	Contact Map
1qgpA	1	0.2565	15.2	0.972	Contact Map
2q2kA	3	0.1673	9.5	0.975	Contact Map
3w61A	2	0.2119	8.5	0.975	Contact Map
1knvA	4	0.3011	6.1	0.977	Contact Map
2jmlA	1	0.2788	6	0.977	Contact Map
2kjfA	1	0.2119	5.8	0.977	Contact Map
4n7rA	2	0.2937	4.3	0.979	Contact Map
4im7A	1	0.3866	3.9	0.979	Contact Map
3m05A	3	0.3271	3.7	0.979	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0085 seconds.