GREMLIN Database
DUF650 - Archaeal protein of unknown function (DUF650)
PFAM: PF04894 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 269 (269)
Sequences: 2577 (1808)
Seq/√Len: 110.2
META: 0.92

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
214_D218_K5.1591.00
172_V215_I3.9781.00
160_V166_L3.7121.00
221_L225_K3.3791.00
36_V191_V3.3251.00
52_V117_V3.2261.00
172_V185_I3.0691.00
120_K143_K2.9261.00
173_L219_N2.9091.00
239_E244_R2.8501.00
196_L199_N2.7841.00
156_K178_S2.4191.00
154_P184_K2.4061.00
157_V188_A2.3011.00
118_E143_K2.2891.00
160_V174_E2.2281.00
172_V189_L2.2131.00
158_E162_Y2.1881.00
27_E118_E2.1461.00
180_V184_K2.1371.00
100_L202_L2.1101.00
252_G255_S2.0961.00
66_E181_D2.0641.00
26_K122_K2.0561.00
35_S63_D2.0091.00
69_L238_G1.9771.00
160_V194_L1.9771.00
72_S75_E1.9241.00
166_L174_E1.9041.00
229_E252_G1.8921.00
46_V92_V1.8901.00
71_K75_E1.8831.00
170_E174_E1.8781.00
101_E104_Q1.8551.00
219_N222_E1.8421.00
45_K91_N1.8171.00
111_K152_K1.7771.00
26_K143_K1.7561.00
237_E246_E1.7391.00
69_L240_Y1.7301.00
66_E183_S1.6991.00
190_S208_S1.6911.00
102_E105_E1.6651.00
50_P85_R1.6441.00
87_K139_S1.6381.00
165_D200_R1.6181.00
166_L170_E1.6141.00
188_A194_L1.6091.00
173_L216_I1.6031.00
102_E145_A1.5921.00
110_S154_P1.5831.00
233_Y250_F1.5821.00
167_K196_L1.5791.00
216_I220_L1.5721.00
28_I84_V1.5671.00
176_Y220_L1.5171.00
31_S53_P1.5151.00
189_L215_I1.5031.00
230_I249_L1.4931.00
108_L161_Y1.4731.00
108_L157_V1.4681.00
120_K141_P1.4651.00
189_L212_V1.4551.00
164_T197_K1.4511.00
113_V151_P1.4271.00
169_A219_N1.4271.00
28_I119_L1.4241.00
229_E253_P1.4221.00
147_I151_P1.4111.00
221_L224_I1.4051.00
156_K174_E1.4051.00
169_A215_I1.4011.00
172_V216_I1.3951.00
223_E226_D1.3881.00
40_R206_R1.3811.00
47_N89_R1.3771.00
266_S269_N1.3681.00
75_E78_D1.3671.00
31_S59_T1.3381.00
116_E146_K1.3291.00
2_C7_C1.3271.00
235_V246_E1.3221.00
104_Q193_L1.3211.00
114_D149_E1.3090.99
153_V158_E1.3010.99
158_E161_Y1.2980.99
108_L153_V1.2860.99
88_F99_F1.2850.99
228_P231_D1.2640.99
37_F40_R1.2590.99
47_N87_K1.2570.99
3_G7_C1.2560.99
38_V48_V1.2550.99
161_Y193_L1.2540.99
60_S67_L1.2480.99
121_K141_P1.2460.99
110_S152_K1.2440.99
100_L104_Q1.2430.99
2_C8_P1.2360.99
61_I79_F1.2360.99
189_L194_L1.2360.99
160_V171_A1.2250.99
107_A191_V1.2070.99
108_L193_L1.2020.99
210_T213_D1.2010.99
174_E178_S1.1910.99
71_K79_F1.1820.99
150_N153_V1.1740.99
52_V115_V1.1700.99
64_T181_D1.1600.99
29_F56_H1.1530.99
86_G117_V1.1520.99
63_D68_W1.1510.99
28_I52_V1.1320.98
130_D133_V1.1170.98
153_V193_L1.1170.98
155_R159_K1.1160.98
90_V100_L1.1160.98
90_V94_D1.1020.98
91_N94_D1.0990.98
169_A173_L1.0980.98
31_S57_G1.0960.98
186_Q189_L1.0880.98
183_S187_K1.0790.98
29_F114_D1.0750.98
169_A218_K1.0700.98
161_Y194_L1.0660.98
53_P59_T1.0650.98
119_L123_P1.0540.98
97_G101_E1.0520.97
61_I71_K1.0480.97
119_L140_A1.0440.97
58_D61_I1.0390.97
6_R11_V1.0380.97
153_V162_Y1.0370.97
156_K159_K1.0370.97
254_W257_E1.0340.97
48_V202_L1.0310.97
184_K187_K1.0160.97
29_F148_T1.0130.97
233_Y248_L1.0100.97
107_A187_K0.9990.97
92_V201_K0.9930.96
106_I113_V0.9930.96
234_R249_L0.9910.96
235_V248_L0.9830.96
176_Y182_V0.9810.96
167_K170_E0.9760.96
94_D97_G0.9700.96
76_I241_L0.9690.96
169_A214_D0.9640.96
114_D148_T0.9590.96
237_E244_R0.9580.96
86_G119_L0.9530.95
13_F16_L0.9500.95
64_T67_L0.9480.95
45_K89_R0.9480.95
151_P154_P0.9460.95
217_S258_L0.9450.95
219_N223_E0.9430.95
48_V90_V0.9390.95
50_P145_A0.9380.95
35_S51_L0.9350.95
55_E62_L0.9300.95
31_S56_H0.9280.95
117_V142_L0.9270.95
182_V186_Q0.9230.95
98_R102_E0.9220.95
51_L85_R0.9010.94
223_E227_Y0.9000.94
224_I227_Y0.8950.94
265_G268_W0.8920.94
264_P269_N0.8900.94
258_L269_N0.8860.93
64_T183_S0.8830.93
130_D136_F0.8820.93
247_I258_L0.8800.93
109_S151_P0.8750.93
53_P58_D0.8730.93
212_V215_I0.8710.93
15_S19_V0.8680.93
91_N95_A0.8540.92
171_A194_L0.8500.92
191_V202_L0.8490.92
209_I213_D0.8480.92
95_A100_L0.8430.92
242_G258_L0.8430.92
154_P180_V0.8420.92
31_S54_P0.8340.91
63_D80_R0.8330.91
264_P268_W0.8270.91
233_Y252_G0.8240.91
221_L226_D0.8240.91
65_P183_S0.8200.90
9_I12_K0.8180.90
170_E173_L0.8180.90
3_G9_I0.8110.90
10_L13_F0.8080.90
41_Y47_N0.8040.90
51_L83_L0.8000.89
166_L196_L0.7920.89
37_F49_G0.7900.89
39_G49_G0.7890.89
88_F103_L0.7880.89
20_K23_I0.7760.88
29_F116_E0.7750.88
98_R101_E0.7720.88
77_V81_S0.7710.87
218_K222_E0.7700.87
239_E246_E0.7640.87
109_S113_V0.7610.87
38_V103_L0.7600.87
230_I234_R0.7590.87
68_W80_R0.7570.87
38_V191_V0.7510.86
63_D79_F0.7500.86
5_P9_I0.7500.86
116_E148_T0.7490.86
256_Y266_S0.7480.86
246_E258_L0.7420.85
107_A193_L0.7400.85
9_I267_V0.7380.85
65_P68_W0.7370.85
105_E153_V0.7360.85
84_V119_L0.7330.85
54_P57_G0.7280.84
53_P62_L0.7260.84
25_S28_I0.7220.84
221_L254_W0.7140.83
103_L191_V0.7140.83
85_R245_F0.7090.83
245_F258_L0.7080.83
118_E144_K0.7050.82
13_F17_L0.7030.82
240_Y245_F0.7000.82
47_N85_R0.6990.82
15_S18_K0.6990.82
86_G142_L0.6950.81
60_S64_T0.6930.81
157_V184_K0.6920.81
14_R17_L0.6900.81
237_E245_F0.6900.81
153_V157_V0.6890.81
135_P138_P0.6880.81
181_D184_K0.6870.81
174_E177_K0.6860.81
182_V217_S0.6840.80
182_V264_P0.6840.80
104_Q161_Y0.6800.80
35_S107_A0.6790.80
159_K162_Y0.6740.79
85_R119_L0.6680.79
263_Y267_V0.6680.79
59_T62_L0.6650.79
51_L214_D0.6650.79
95_A104_Q0.6620.78
104_Q194_L0.6600.78
30_G138_P0.6570.78
18_K21_P0.6560.78
43_Y46_V0.6560.78
257_E260_E0.6530.77
90_V95_A0.6530.77
155_R158_E0.6510.77
93_K96_E0.6480.77
55_E59_T0.6480.77
37_F85_R0.6450.76
33_P36_V0.6440.76
151_P157_V0.6440.76
102_E147_I0.6410.76
186_Q212_V0.6400.76
31_S114_D0.6370.76
81_S127_L0.6320.75
140_A241_L0.6310.75
238_G258_L0.6290.75
53_P112_P0.6290.75
29_F147_I0.6250.74
183_S256_Y0.6220.74
66_E182_V0.6220.74
159_K163_D0.6210.74
37_F51_L0.6190.73
90_V202_L0.6190.73
12_K15_S0.6150.73
59_T183_S0.6150.73
123_P126_R0.6140.73
30_G59_T0.6110.73
40_R46_V0.6110.73
167_K199_N0.6110.73
49_G208_S0.6100.72
62_L79_F0.6080.72
194_L214_D0.6060.72
156_K160_V0.6040.72
181_D186_Q0.6030.72
220_L223_E0.6030.72
76_I127_L0.6020.71
247_I263_Y0.5980.71
84_V140_A0.5940.70
18_K22_L0.5900.70
25_S123_P0.5900.70
104_Q162_Y0.5900.70
88_F142_L0.5890.70
244_R247_I0.5890.70
63_D187_K0.5890.70
142_L145_A0.5870.70
98_R226_D0.5870.70
109_S150_N0.5870.70
238_G247_I0.5860.69
171_A200_R0.5850.69
70_G240_Y0.5850.69
154_P158_E0.5820.69
241_L245_F0.5810.69
71_K240_Y0.5800.69
238_G245_F0.5790.68
42_G89_R0.5790.68
164_T199_N0.5780.68
228_P232_E0.5780.68
41_Y89_R0.5770.68
258_L262_W0.5760.68
37_F50_P0.5750.68
139_S266_S0.5740.68
163_D176_Y0.5730.68
149_E187_K0.5720.68
83_L138_P0.5720.68
37_F256_Y0.5710.67
41_Y191_V0.5710.67
19_V22_L0.5680.67
117_V145_A0.5660.67
229_E232_E0.5660.67
56_H59_T0.5650.67
170_E219_N0.5650.67
206_R245_F0.5650.67
60_S112_P0.5630.66
263_Y266_S0.5620.66
40_R49_G0.5610.66
1_L7_C0.5590.66
173_L177_K0.5550.65
117_V224_I0.5540.65
39_G42_G0.5530.65
10_L14_R0.5520.65
264_P267_V0.5510.65
222_E225_K0.5510.65
157_V162_Y0.5510.65
102_E153_V0.5510.65
202_L245_F0.5490.64
185_I212_V0.5490.64
50_P119_L0.5490.64
55_E82_S0.5480.64
215_I219_N0.5480.64
85_R139_S0.5480.64
28_I33_P0.5470.64
170_E179_G0.5470.64
49_G87_K0.5470.64
245_F263_Y0.5460.64
226_D229_E0.5460.64
263_Y269_N0.5460.64
238_G244_R0.5450.64
160_V188_A0.5440.64
110_S153_V0.5400.63
214_D217_S0.5400.63
102_E106_I0.5390.63
164_T198_K0.5360.63
172_V212_V0.5360.63
115_V242_G0.5340.62
121_K124_R0.5340.62
176_Y216_I0.5330.62
254_W261_A0.5330.62
100_L193_L0.5330.62
84_V240_Y0.5320.62
129_F135_P0.5320.62
6_R9_I0.5320.62
175_L215_I0.5310.62
22_L72_S0.5290.62
149_E152_K0.5270.61
26_K121_K0.5270.61
48_V88_F0.5270.61
84_V91_N0.5260.61
239_E259_I0.5250.61
51_L115_V0.5240.61
68_W79_F0.5230.61
135_P262_W0.5230.61
13_F19_V0.5230.61
101_E254_W0.5220.61
251_P260_E0.5210.60
70_G235_V0.5200.60
12_K16_L0.5190.60
115_V118_E0.5180.60
143_K146_K0.5170.60
229_E249_L0.5150.60
189_L234_R0.5150.60
108_L188_A0.5150.60
14_R18_K0.5150.60
3_G12_K0.5110.59
188_A193_L0.5090.59
21_P25_S0.5070.58
236_Y256_Y0.5060.58
177_K196_L0.5060.58
16_L41_Y0.5050.58
103_L231_D0.5050.58
49_G214_D0.5040.58
189_L208_S0.5020.58
228_P233_Y0.5020.58
71_K76_I0.5020.58
184_K188_A0.5010.57
63_D76_I0.5010.57
91_N99_F0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qzqA 1 0.5502 27.8 0.969 Contact Map
1qgpA 1 0.2565 15.2 0.972 Contact Map
2q2kA 3 0.1673 9.5 0.975 Contact Map
3w61A 2 0.2119 8.5 0.975 Contact Map
1knvA 4 0.3011 6.1 0.977 Contact Map
2jmlA 1 0.2788 6 0.977 Contact Map
2kjfA 1 0.2119 5.8 0.977 Contact Map
4n7rA 2 0.2937 4.3 0.979 Contact Map
4im7A 1 0.3866 3.9 0.979 Contact Map
3m05A 3 0.3271 3.7 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0087 seconds.