GREMLIN Database
Yip1 - Yip1 domain
PFAM: PF04893 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 172 (166)
Sequences: 27265 (22137)
Seq/√Len: 1718.2
META: 0.889

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_E150_V4.3301.00
4_S7_E4.0451.00
149_P156_T3.1141.00
96_S99_Q2.9801.00
103_V147_G2.6731.00
22_W25_P2.6201.00
142_Y146_I2.5821.00
139_W143_L2.2431.00
95_G152_H2.2341.00
99_Q102_A2.1761.00
155_S158_K2.0461.00
166_P170_L2.0201.00
111_L140_S1.9761.00
145_Y160_L1.9521.00
100_A152_H1.9331.00
25_P28_L1.8941.00
6_R150_V1.8651.00
159_A163_V1.8511.00
103_V151_V1.7791.00
77_V105_A1.7611.00
145_Y156_T1.7581.00
70_Y74_L1.7531.00
81_A101_L1.7391.00
138_I142_Y1.6811.00
23_L27_L1.6661.00
87_L90_L1.6341.00
66_A70_Y1.6331.00
82_L97_F1.6271.00
82_L85_H1.5931.00
24_L28_L1.5831.00
154_L159_A1.5551.00
93_G154_L1.5161.00
95_G100_A1.5031.00
6_R10_E1.5011.00
13_A153_K1.4871.00
107_A144_L1.4761.00
82_L86_L1.4731.00
67_I70_Y1.4421.00
110_P113_L1.4241.00
85_H89_R1.4181.00
114_A136_F1.4141.00
26_L105_A1.4131.00
80_L84_L1.4101.00
145_Y149_P1.4061.00
77_V101_L1.4001.00
21_L25_P1.3941.00
160_L164_L1.3871.00
52_E56_R1.3821.00
97_F101_L1.3711.00
59_L63_L1.3601.00
77_V81_A1.3161.00
100_A148_L1.3141.00
56_R59_L1.3081.00
85_H97_F1.3051.00
101_L105_A1.3051.00
107_A147_G1.2971.00
8_T12_I1.2971.00
110_P140_S1.2691.00
156_T160_L1.2641.00
58_G62_A1.2211.00
45_G49_G1.2021.00
21_L24_L1.1861.00
60_G64_G1.1861.00
86_L90_L1.1821.00
47_S50_G1.1771.00
145_Y159_A1.1701.00
8_T11_R1.1661.00
7_E10_E1.1581.00
85_H95_G1.1581.00
110_P143_L1.1471.00
43_L46_G1.1461.00
85_H152_H1.1411.00
55_A58_G1.1361.00
55_A59_L1.1311.00
47_S51_G1.1301.00
116_L120_L1.1051.00
10_E13_A1.1011.00
166_P169_L1.0911.00
78_F97_F1.0801.00
94_K153_K1.0791.00
158_K161_L1.0761.00
107_A110_P1.0731.00
109_T112_I1.0681.00
11_R15_E1.0541.00
81_A85_H1.0521.00
69_G73_A1.0501.00
59_L62_A1.0301.00
93_G152_H1.0221.00
81_A100_A1.0031.00
53_Q56_R0.9981.00
84_L148_L0.9931.00
99_Q151_V0.9861.00
70_Y73_A0.9861.00
62_A66_A0.9821.00
46_G50_G0.9771.00
6_R146_I0.9601.00
24_L27_L0.9551.00
146_I150_V0.9541.00
98_K102_A0.9511.00
53_Q57_L0.9511.00
78_F101_L0.9461.00
10_E14_A0.9401.00
152_H162_A0.9311.00
88_A92_G0.9221.00
81_A97_F0.9151.00
85_H100_A0.9131.00
160_L163_V0.9131.00
26_L29_L0.9021.00
66_A69_G0.8941.00
9_F143_L0.8881.00
157_G161_L0.8821.00
117_L120_L0.8691.00
87_L92_G0.8661.00
31_L34_A0.8651.00
149_P159_A0.8591.00
21_L26_L0.8561.00
122_L125_L0.8431.00
7_E11_R0.8411.00
26_L30_A0.8361.00
62_A65_A0.8281.00
13_A99_Q0.8261.00
25_P29_L0.8201.00
52_E55_A0.8061.00
27_L30_A0.7981.00
23_L26_L0.7961.00
33_G37_G0.7901.00
35_V39_I0.7861.00
87_L162_A0.7791.00
161_L165_L0.7751.00
56_R60_G0.7731.00
85_H96_S0.7701.00
111_L115_G0.7691.00
83_I86_L0.7671.00
45_G50_G0.7671.00
108_S111_L0.7621.00
22_W26_L0.7611.00
44_I49_G0.7501.00
133_G136_F0.7501.00
42_L46_G0.7481.00
12_I106_Y0.7441.00
36_A40_G0.7401.00
139_W142_Y0.7391.00
44_I47_S0.7331.00
60_G63_L0.7321.00
154_L158_K0.7271.00
114_A118_L0.7201.00
156_T159_A0.7171.00
84_L104_V0.7161.00
104_V144_L0.7141.00
42_L45_G0.7111.00
78_F81_A0.7091.00
43_L47_S0.7051.00
58_G61_S0.7051.00
68_G72_L0.7011.00
109_T113_L0.6971.00
86_L89_R0.6901.00
68_G71_V0.6871.00
46_G49_G0.6851.00
9_F12_I0.6851.00
11_R14_A0.6831.00
146_I156_T0.6831.00
9_F147_G0.6821.00
161_L164_L0.6741.00
134_L138_I0.6731.00
88_A148_L0.6711.00
65_A69_G0.6631.00
21_L28_L0.6611.00
78_F82_L0.6611.00
145_Y163_V0.6591.00
61_S65_A0.6591.00
17_R98_K0.6581.00
103_V107_A0.6551.00
130_L134_L0.6501.00
63_L67_I0.6501.00
100_A103_V0.6441.00
158_K162_A0.6411.00
2_L109_T0.6401.00
89_R92_G0.6341.00
104_V108_S0.6331.00
28_L32_I0.6311.00
60_G65_A0.6291.00
88_A162_A0.6231.00
12_I102_A0.6211.00
149_P155_S0.6181.00
146_I149_P0.6181.00
25_P33_G0.6171.00
28_L40_G0.6161.00
67_I71_V0.6131.00
76_G80_L0.6121.00
28_L70_Y0.6101.00
22_W40_G0.6101.00
57_L65_A0.6101.00
48_L51_G0.6091.00
24_L38_L0.6091.00
57_L61_S0.6081.00
116_L119_L0.6051.00
34_A38_L0.6051.00
32_I36_A0.6041.00
148_L163_V0.5991.00
43_L50_G0.5951.00
45_G48_L0.5941.00
89_R94_K0.5931.00
130_L133_G0.5921.00
9_F13_A0.5911.00
31_L35_V0.5891.00
79_I82_L0.5861.00
87_L91_F0.5861.00
63_L66_A0.5841.00
42_L51_G0.5811.00
56_R61_S0.5801.00
134_L137_G0.5791.00
115_G118_L0.5731.00
17_R102_A0.5711.00
88_A91_F0.5711.00
54_A59_L0.5701.00
84_L144_L0.5691.00
121_P125_L0.5681.00
57_L62_A0.5681.00
131_L135_L0.5681.00
128_A132_L0.5621.00
113_L117_L0.5611.00
2_L8_T0.5601.00
151_V154_L0.5541.00
61_S64_G0.5511.00
54_A57_L0.5511.00
43_L49_G0.5431.00
136_F140_S0.5391.00
121_P124_A0.5381.00
57_L60_G0.5361.00
13_A151_V0.5321.00
119_L122_L0.5301.00
118_L122_L0.5301.00
30_A34_A0.5241.00
140_S144_L0.5241.00
88_A93_G0.5231.00
123_L126_G0.5221.00
23_L30_A0.5201.00
137_G140_S0.5191.00
118_L121_P0.5181.00
89_R95_G0.5161.00
159_A162_A0.5161.00
88_A152_H0.5151.00
22_W30_A0.5141.00
36_A39_I0.5121.00
124_A127_G0.5101.00
75_I78_F0.5071.00
43_L48_L0.5061.00
131_L134_L0.5011.00
167_W170_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pjzA 2 0.4535 4.9 0.899 Contact Map
3hi7A 2 0.3372 3.4 0.907 Contact Map
4xp4A 1 0.9186 2.8 0.91 Contact Map
4o6yA 2 0.4651 2.6 0.912 Contact Map
4us3A 1 0.8663 2.1 0.917 Contact Map
3mk7A 1 0.8895 2.1 0.917 Contact Map
2ksfA 1 0.2384 1.8 0.92 Contact Map
4nv5A 1 0.8372 1.4 0.924 Contact Map
3klyA 3 0.8488 1.4 0.924 Contact Map
3kcuA 3 0.8256 1.4 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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