GREMLIN Database
VanZ - VanZ like family
PFAM: PF04892 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 126 (119)
Sequences: 24414 (20387)
Seq/√Len: 1868.9
META: 0.817

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_G115_A6.3021.00
85_F112_T3.4401.00
96_L103_A2.9271.00
93_L96_L2.4561.00
89_L108_V2.4191.00
58_N61_H2.0961.00
85_F108_V2.0281.00
62_F117_L1.9951.00
90_L94_H1.8921.00
9_L87_Y1.8711.00
59_I63_V1.8101.00
81_L119_L1.7941.00
88_S111_N1.7761.00
81_L112_T1.6951.00
103_A108_V1.6111.00
88_S115_A1.5761.00
95_Q107_D1.5561.00
88_S112_T1.5281.00
40_A43_R1.5201.00
37_I40_A1.5051.00
70_P122_Y1.5021.00
17_S94_H1.4871.00
93_L97_F1.4481.00
105_V109_L1.4391.00
41_T44_D1.4321.00
10_A14_F1.4011.00
94_H98_V1.3771.00
11_L15_P1.3721.00
18_Q26_T1.3621.00
67_F71_L1.3591.00
88_S108_V1.3481.00
81_L116_L1.3311.00
61_H64_P1.3211.00
106_D110_L1.3101.00
4_Y8_W1.2971.00
91_D94_H1.2731.00
80_A84_G1.2441.00
51_F54_F1.2291.00
40_A44_D1.1891.00
106_D109_L1.1881.00
109_L113_L1.1711.00
65_L71_L1.1661.00
12_I91_D1.1491.00
113_L116_L1.1461.00
58_N110_L1.1441.00
65_L69_L1.1441.00
57_R110_L1.1381.00
57_R61_H1.1221.00
118_G122_Y1.1151.00
19_P22_A1.1121.00
60_A64_P1.1121.00
58_N62_F1.1021.00
119_L123_R1.1011.00
86_L90_L1.1001.00
42_I45_Y1.0991.00
59_I110_L1.0791.00
13_F94_H1.0761.00
81_L85_F1.0551.00
26_T29_F1.0481.00
84_G88_S1.0401.00
39_F43_R1.0341.00
29_F32_R1.0271.00
8_W12_I1.0151.00
25_E28_G1.0131.00
89_L93_L1.0031.00
91_D111_N0.9931.00
92_E95_Q0.9841.00
38_P43_R0.9461.00
15_P18_Q0.9421.00
28_G31_L0.9371.00
28_G32_R0.9251.00
73_F76_L0.9161.00
67_F122_Y0.9091.00
58_N111_N0.9081.00
69_L119_L0.9051.00
9_L13_F0.9041.00
15_P101_R0.8861.00
93_L103_A0.8861.00
12_I15_P0.8771.00
85_F89_L0.8721.00
107_D111_N0.8621.00
84_G112_T0.8501.00
69_L73_F0.8501.00
8_W11_L0.8501.00
59_I62_F0.8451.00
58_N64_P0.8441.00
39_F45_Y0.8441.00
17_S20_G0.8391.00
37_I43_R0.8381.00
39_F44_D0.8261.00
22_A26_T0.8251.00
70_P74_R0.8251.00
29_F33_L0.8171.00
39_F42_I0.8151.00
87_Y91_D0.7961.00
98_V101_R0.7951.00
14_F18_Q0.7941.00
23_S27_S0.7821.00
37_I41_T0.7811.00
69_L76_L0.7811.00
41_T45_Y0.7711.00
70_P76_L0.7661.00
57_R60_A0.7621.00
16_S19_P0.7521.00
77_F116_L0.7521.00
24_S28_G0.7521.00
116_L120_L0.7491.00
80_A115_A0.7481.00
68_L72_L0.7481.00
21_S24_S0.7371.00
4_Y7_L0.7331.00
90_L93_L0.7291.00
76_L79_R0.7241.00
5_L9_L0.7211.00
7_L11_L0.7191.00
71_L76_L0.7131.00
89_L105_V0.7121.00
70_P80_A0.7101.00
35_N38_P0.7091.00
92_E107_D0.7021.00
70_P119_L0.6981.00
58_N63_V0.6961.00
83_L87_Y0.6911.00
24_S27_S0.6901.00
120_L123_R0.6901.00
115_A119_L0.6891.00
60_A63_V0.6831.00
8_W15_P0.6811.00
82_L86_L0.6801.00
20_G23_S0.6761.00
35_N40_A0.6641.00
59_I117_L0.6561.00
112_T115_A0.6521.00
72_L76_L0.6501.00
5_L72_L0.6481.00
56_I59_I0.6461.00
52_A55_I0.6441.00
6_L10_A0.6431.00
12_I16_S0.6421.00
34_I38_P0.6411.00
18_Q21_S0.6411.00
11_L14_F0.6341.00
87_Y90_L0.6311.00
8_W68_L0.6301.00
65_L87_Y0.6291.00
40_A45_Y0.6291.00
25_E29_F0.6271.00
66_G118_G0.6201.00
71_L122_Y0.6061.00
88_S103_A0.6031.00
95_Q101_R0.5991.00
13_F87_Y0.5951.00
113_L117_L0.5941.00
15_P19_P0.5921.00
18_Q22_A0.5881.00
87_Y94_H0.5841.00
65_L84_G0.5791.00
15_P64_P0.5761.00
77_F119_L0.5751.00
108_V112_T0.5711.00
58_N103_A0.5711.00
38_P41_T0.5671.00
26_T32_R0.5621.00
2_W5_L0.5591.00
89_L103_A0.5571.00
95_Q102_T0.5491.00
27_S32_R0.5411.00
84_G119_L0.5391.00
109_L112_T0.5301.00
13_F90_L0.5251.00
9_L72_L0.5201.00
105_V108_V0.5131.00
21_S25_E0.5081.00
26_T31_L0.5071.00
80_A88_S0.5061.00
22_A25_E0.5041.00
58_N107_D0.5021.00
66_G70_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wd8A 3 0.4127 4.4 0.895 Contact Map
3bo0B 1 0.3968 1 0.926 Contact Map
2kv5A 1 0.1746 0.8 0.93 Contact Map
4b19A 1 0.1667 0.8 0.931 Contact Map
4njnA 4 0.9286 0.8 0.931 Contact Map
2kluA 1 0.2143 0.7 0.932 Contact Map
2nr9A 2 0.9127 0.7 0.933 Contact Map
1iijA 1 0.2222 0.7 0.933 Contact Map
4px7A 1 0.9921 0.7 0.935 Contact Map
2ksfA 1 0.5873 0.6 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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