GREMLIN Database
NifQ - NifQ
PFAM: PF04891 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 160 (158)
Sequences: 1157 (888)
Seq/√Len: 70.7
META: 0.686

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_A115_P5.8231.00
68_A138_R4.0401.00
101_W105_E3.9771.00
69_H116_A3.7421.00
96_Q126_K3.3051.00
136_C144_C2.7591.00
110_L131_L2.6251.00
120_R130_F2.5301.00
72_G77_E2.4551.00
63_R82_A2.3421.00
92_D96_Q2.2361.00
67_L81_A2.2231.00
133_R137_E2.2061.00
115_P119_A2.1131.00
26_E78_R2.0891.00
3_A35_F1.9781.00
58_E132_Y1.9721.00
60_E64_D1.9211.00
146_A150_E1.9121.00
8_S12_G1.8921.00
69_H120_R1.8921.00
8_S13_G1.8671.00
23_S26_E1.8641.00
67_L70_R1.8261.00
120_R134_Q1.8141.00
125_M144_C1.7181.00
107_S118_A1.7071.00
67_L78_R1.6581.00
71_A116_A1.6490.99
93_H103_R1.5800.99
146_A151_V1.5750.99
5_I8_S1.5670.99
59_E87_A1.5350.99
20_L83_I1.5300.99
58_E61_D1.4970.99
126_K154_D1.4340.99
145_R148_S1.4020.98
102_S106_L1.3650.98
4_C105_E1.3550.98
69_H117_L1.3210.97
65_L135_L1.2960.97
29_A75_E1.2840.97
125_M136_C1.2620.97
148_S151_V1.2520.97
132_Y136_C1.2480.96
133_R136_C1.2290.96
110_L118_A1.2100.96
108_A112_R1.2090.96
70_R79_W1.2020.96
133_R144_C1.1560.95
6_L30_L1.1560.95
126_K160_G1.1530.94
59_E86_R1.1480.94
97_D109_L1.1410.94
134_Q137_E1.1380.94
132_Y144_C1.1370.94
123_R150_E1.1340.94
71_A77_E1.1130.93
80_L84_I1.1120.93
110_L122_T1.1100.93
134_Q145_R1.1020.93
102_S105_E1.0760.92
9_A12_G1.0610.92
74_S77_E1.0440.91
102_S107_S1.0340.91
126_K129_K1.0310.90
64_D68_A1.0260.90
65_L103_R1.0240.90
87_A96_Q1.0000.89
89_M135_L0.9940.89
104_A108_A0.9890.88
4_C83_I0.9870.88
4_C101_W0.9780.88
16_L87_A0.9770.88
156_A160_G0.9730.88
55_R148_S0.9660.87
106_L136_C0.9630.87
3_A6_L0.9620.87
144_C148_S0.9600.87
24_P28_A0.9590.87
56_D86_R0.9470.86
10_A15_A0.9460.86
73_D77_E0.9370.86
66_L84_I0.9240.85
96_Q110_L0.9090.84
91_P112_R0.9040.83
135_L138_R0.9010.83
27_F99_G0.8800.82
9_A15_A0.8780.82
129_K146_A0.8690.81
76_S79_W0.8680.81
149_C152_C0.8660.81
134_Q159_F0.8650.81
84_I110_L0.8630.81
92_D97_D0.8620.80
106_L144_C0.8600.80
142_Y148_S0.8520.80
62_L117_L0.8520.80
150_E155_Y0.8440.79
58_E136_C0.8420.79
111_R118_A0.8420.79
116_A119_A0.8350.78
129_K136_C0.8320.78
12_G17_P0.8310.78
58_E144_C0.8250.77
25_A50_P0.8250.77
27_F113_H0.8180.77
81_A84_I0.8040.76
93_H129_K0.8040.76
16_L20_L0.8000.75
154_D157_L0.7990.75
65_L117_L0.7980.75
96_Q129_K0.7940.75
139_E143_L0.7930.75
136_C146_A0.7900.74
111_R119_A0.7860.74
18_A24_P0.7830.74
97_D126_K0.7810.74
61_D138_R0.7780.73
87_A143_L0.7760.73
126_K157_L0.7760.73
97_D129_K0.7700.72
100_L118_A0.7690.72
59_E89_M0.7630.72
107_S126_K0.7610.72
33_R74_S0.7580.71
9_A18_A0.7520.71
152_C158_C0.7490.70
130_F134_Q0.7490.70
104_A124_D0.7420.70
110_L115_P0.7390.69
72_G131_L0.7340.69
58_E135_L0.7330.69
3_A7_A0.7310.69
34_H79_W0.7250.68
143_L146_A0.7240.68
90_G97_D0.7220.68
49_A53_A0.7180.67
62_L131_L0.7160.67
3_A36_P0.7130.67
47_L52_D0.7090.66
151_V156_A0.7090.66
25_A29_A0.7020.65
4_C12_G0.6990.65
64_D69_H0.6960.65
5_I80_L0.6940.64
132_Y135_L0.6930.64
81_A114_F0.6930.64
125_M129_K0.6920.64
70_R77_E0.6900.64
12_G87_A0.6900.64
72_G76_S0.6850.63
97_D147_P0.6800.63
7_A154_D0.6780.63
5_I20_L0.6760.62
4_C9_A0.6750.62
86_R113_H0.6750.62
62_L130_F0.6720.62
129_K143_L0.6710.62
59_E63_R0.6710.62
53_A85_A0.6670.61
26_E108_A0.6620.61
47_L116_A0.6510.60
58_E137_E0.6490.59
139_E142_Y0.6490.59
58_E106_L0.6460.59
9_A20_L0.6410.58
93_H121_N0.6390.58
45_A73_D0.6380.58
27_F34_H0.6380.58
6_L20_L0.6320.57
96_Q143_L0.6310.57
56_D62_L0.6300.57
135_L145_R0.6280.57
47_L50_P0.6280.57
58_E114_F0.6250.56
96_Q157_L0.6250.56
61_D137_E0.6230.56
35_F107_S0.6180.56
125_M133_R0.6170.56
14_G17_P0.6160.55
86_R133_R0.6100.55
34_H76_S0.6070.54
146_A153_S0.6070.54
98_L146_A0.6060.54
84_I123_R0.6040.54
7_A35_F0.6040.54
144_C147_P0.6040.54
106_L132_Y0.5970.53
133_R145_R0.5950.53
89_M131_L0.5930.53
5_I83_I0.5930.53
20_L27_F0.5930.53
136_C148_S0.5910.52
57_D61_D0.5900.52
63_R85_A0.5820.51
8_S87_A0.5810.51
12_G20_L0.5810.51
70_R114_F0.5770.51
107_S154_D0.5760.51
144_C159_F0.5730.50
138_R145_R0.5710.50
121_N125_M0.5680.50
23_S39_A0.5670.49
19_A80_L0.5630.49
87_A90_G0.5620.49
25_A78_R0.5610.49
51_L54_E0.5570.48
108_A111_R0.5570.48
18_A23_S0.5550.48
96_Q153_S0.5520.48
38_A49_A0.5490.47
85_A112_R0.5460.47
77_E126_K0.5430.47
85_A117_L0.5430.47
100_L109_L0.5420.46
22_L30_L0.5420.46
136_C147_P0.5390.46
15_A88_C0.5360.46
16_L83_I0.5350.46
98_L114_F0.5340.45
50_P53_A0.5310.45
55_R80_L0.5300.45
57_D89_M0.5300.45
58_E90_G0.5260.44
102_S124_D0.5250.44
55_R145_R0.5250.44
102_S108_A0.5240.44
44_L48_G0.5230.44
31_L36_P0.5230.44
32_A75_E0.5200.44
131_L135_L0.5160.43
35_F154_D0.5150.43
136_C143_L0.5140.43
82_A86_R0.5070.42
106_L125_M0.5070.42
109_L114_F0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fspA 1 0.9062 71 0.929 Contact Map
1kg2A 1 0.9062 70.1 0.929 Contact Map
1ornA 1 0.9062 69.1 0.929 Contact Map
2abkA 1 0.9062 68.4 0.93 Contact Map
1keaA 2 0.9062 55 0.935 Contact Map
3n5nX 1 0.9 51.1 0.937 Contact Map
4unfA 1 0.9187 38.1 0.942 Contact Map
4uobA 1 0.9187 29.6 0.945 Contact Map
1z67A 1 0.3812 8.3 0.957 Contact Map
4fzvB 1 0.675 8.3 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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