GREMLIN Database
DUF647 - Vitamin B6 photo-protection and homoeostasis
PFAM: PF04884 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 240 (233)
Sequences: 721 (485)
Seq/√Len: 31.8
META: 0.312

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
117_E138_K4.7001.00
210_Y214_R4.1621.00
40_F183_L4.0041.00
73_W78_G3.7791.00
117_E134_A3.5431.00
224_L232_L2.7851.00
127_F131_A2.7441.00
98_D101_R2.6201.00
113_A134_A2.5871.00
41_A207_L2.5461.00
111_D208_H2.4530.99
23_S159_R2.4040.99
74_V184_G2.3210.99
126_L129_P2.3150.99
113_A137_L2.2590.99
208_H212_N2.2100.99
169_D173_E2.1990.99
35_D38_Q2.1920.99
107_D212_N2.1200.98
128_L131_A2.0340.98
50_T80_G2.0060.98
70_A152_L1.9780.97
21_P24_V1.9660.97
96_D161_N1.9530.97
47_V138_K1.9400.97
57_V66_P1.8590.96
19_G23_S1.8590.96
156_F180_G1.8490.96
120_T127_F1.8480.96
158_R222_R1.8190.96
153_T164_D1.8020.95
60_G66_P1.7280.94
73_W77_D1.7150.94
142_G146_G1.7150.94
152_L219_V1.7030.94
38_Q107_D1.6880.93
143_V166_S1.6860.93
34_W214_R1.6660.93
229_A233_L1.6620.93
230_S234_S1.6580.93
49_A53_L1.5920.91
32_Q169_D1.5860.91
178_L184_G1.5680.91
94_S98_D1.5470.90
179_L182_L1.5410.90
59_V65_S1.4910.88
180_G184_G1.4740.88
81_R177_S1.4740.88
79_L114_M1.4610.87
10_F13_D1.4410.87
42_S110_N1.4380.86
34_W165_V1.4380.86
149_R165_V1.4360.86
107_D142_G1.4350.86
156_F184_G1.4280.86
16_L21_P1.4250.86
207_L211_A1.3820.84
81_R84_R1.3820.84
135_N138_K1.3650.83
34_W37_L1.3520.83
39_A173_E1.3090.81
24_V28_Y1.3080.81
70_A73_W1.3060.80
39_A42_S1.3060.80
49_A200_A1.2840.79
22_D159_R1.2410.77
43_S169_D1.2380.77
151_A164_D1.2360.77
153_T169_D1.2320.76
32_Q36_S1.2270.76
174_T177_S1.2210.76
128_L135_N1.2200.76
153_T170_G1.2150.75
122_L214_R1.2130.75
36_S176_V1.2110.75
186_L193_S1.2090.75
203_L207_L1.2050.75
87_F177_S1.2040.75
111_D121_P1.1990.74
83_G96_D1.1980.74
73_W80_G1.1940.74
47_V70_A1.1870.74
157_A161_N1.1830.73
141_C145_A1.1750.73
186_L203_L1.1740.73
74_V80_G1.1730.73
84_R170_G1.1700.73
39_A43_S1.1510.71
101_R104_L1.1370.70
32_Q35_D1.1310.70
160_G223_T1.1260.70
84_R177_S1.1180.69
112_L209_L1.1090.68
35_D39_A1.1050.68
181_L184_G1.1010.68
87_F143_V1.0990.68
76_K96_D1.0980.68
120_T197_V1.0940.67
86_L104_L1.0900.67
69_A100_K1.0880.67
150_A221_L1.0870.67
227_Q231_I1.0860.67
84_R109_L1.0760.66
7_L124_P1.0740.66
118_L201_F1.0710.66
149_R166_S1.0570.65
42_S141_C1.0550.64
118_L198_W1.0140.61
159_R237_L1.0120.61
192_G197_V1.0100.61
169_D175_V0.9970.60
147_A233_L0.9960.60
50_T73_W0.9890.59
62_A108_I0.9890.59
120_T135_N0.9890.59
110_N155_H0.9880.59
79_L223_T0.9850.59
30_P33_I0.9820.59
52_A154_Q0.9810.59
16_L23_S0.9770.58
116_L199_A0.9720.58
35_D110_N0.9680.58
147_A172_Q0.9650.57
76_K135_N0.9590.57
106_A208_H0.9560.57
221_L232_L0.9550.57
35_D148_T0.9540.57
183_L196_A0.9530.57
106_A121_P0.9490.56
91_F163_A0.9450.56
73_W83_G0.9440.56
198_W205_T0.9370.55
15_F28_Y0.9350.55
20_Y195_T0.9280.54
86_L89_S0.9270.54
17_P28_Y0.9220.54
26_P204_L0.9210.54
112_L219_V0.9210.54
73_W135_N0.9190.54
231_I234_S0.9080.53
111_D145_A0.9070.53
30_P133_L0.9040.53
27_D30_P0.9010.52
50_T54_L0.9000.52
49_A118_L0.8940.52
16_L19_G0.8890.51
135_N221_L0.8880.51
156_F181_L0.8860.51
42_S176_V0.8740.50
113_A116_L0.8740.50
80_G135_N0.8710.50
63_S86_L0.8680.50
41_A124_P0.8650.49
11_L14_V0.8630.49
69_A103_R0.8610.49
73_W164_D0.8590.49
26_P162_L0.8520.48
119_L209_L0.8520.48
111_D212_N0.8520.48
23_S210_Y0.8480.48
27_D155_H0.8470.48
35_D169_D0.8460.48
37_L211_A0.8430.48
98_D119_L0.8430.48
56_G68_A0.8420.47
65_S212_N0.8400.47
38_Q142_G0.8380.47
30_P112_L0.8310.47
6_S9_S0.8300.46
86_L206_A0.8260.46
146_G170_G0.8220.46
95_F164_D0.8200.46
150_A171_S0.8190.46
89_S102_W0.8170.45
15_F175_V0.8160.45
73_W161_N0.8160.45
27_D152_L0.8140.45
22_D26_P0.8110.45
49_A181_L0.8110.45
73_W163_A0.8090.45
40_F179_L0.8090.45
139_A155_H0.8050.44
161_N164_D0.8020.44
15_F164_D0.8010.44
26_P30_P0.8010.44
53_L131_A0.7970.44
188_A192_G0.7930.43
28_Y172_Q0.7840.43
212_N225_N0.7830.43
31_Y167_A0.7820.43
76_K197_V0.7800.42
47_V184_G0.7780.42
201_F205_T0.7760.42
31_Y149_R0.7760.42
148_T201_F0.7760.42
90_R232_L0.7680.42
202_L206_A0.7680.42
81_R174_T0.7670.41
133_L163_A0.7660.41
46_G114_M0.7560.41
179_L203_L0.7530.40
139_A142_G0.7520.40
72_N76_K0.7520.40
35_D42_S0.7500.40
22_D130_L0.7500.40
115_G201_F0.7470.40
7_L29_L0.7460.40
120_T148_T0.7430.40
34_W162_L0.7410.39
234_S238_E0.7410.39
64_A106_A0.7370.39
9_S229_A0.7360.39
68_A78_G0.7340.39
73_W76_K0.7320.39
83_G176_V0.7300.39
63_S186_L0.7280.38
207_L220_V0.7280.38
160_G199_A0.7240.38
98_D227_Q0.7240.38
6_S11_L0.7230.38
162_L222_R0.7190.38
12_R203_L0.7180.38
130_L165_V0.7020.36
106_A212_N0.7010.36
179_L183_L0.7010.36
108_I182_L0.7010.36
56_G83_G0.6990.36
98_D118_L0.6990.36
97_S160_G0.6970.36
35_D48_L0.6950.36
83_G139_A0.6950.36
67_T180_G0.6930.36
98_D226_R0.6930.36
129_P229_A0.6920.36
229_A236_F0.6910.36
153_T162_L0.6910.36
63_S95_F0.6900.35
196_A203_L0.6900.35
78_G99_P0.6890.35
8_R12_R0.6820.35
61_D165_V0.6710.34
102_W105_F0.6680.34
143_V152_L0.6680.34
41_A113_A0.6640.34
133_L137_L0.6640.34
79_L186_L0.6630.33
8_R11_L0.6590.33
61_D207_L0.6490.32
57_V80_G0.6490.32
110_N208_H0.6470.32
102_W163_A0.6420.32
61_D160_G0.6360.32
114_M181_L0.6340.31
143_V146_G0.6340.31
87_F198_W0.6320.31
83_G87_F0.6310.31
125_S129_P0.6310.31
26_P220_V0.6280.31
67_T71_L0.6250.31
80_G96_D0.6200.30
19_G22_D0.6200.30
63_S206_A0.6190.30
145_A169_D0.6190.30
149_R153_T0.6140.30
186_L221_L0.6140.30
50_T84_R0.6130.30
110_N141_C0.6130.30
84_R166_S0.6130.30
138_K168_K0.6130.30
171_S184_G0.6100.30
70_A74_V0.6080.30
99_P137_L0.6070.30
133_L235_E0.6050.29
99_P184_G0.6020.29
106_A145_A0.6010.29
81_R142_G0.5990.29
125_S133_L0.5980.29
155_H173_E0.5980.29
84_R146_G0.5970.29
50_T92_G0.5970.29
42_S46_G0.5960.29
149_R171_S0.5950.29
53_L108_I0.5930.29
112_L119_L0.5920.29
70_A188_A0.5910.28
8_R13_D0.5910.28
141_C149_R0.5900.28
38_Q42_S0.5890.28
62_A77_D0.5860.28
180_G204_L0.5850.28
47_V74_V0.5850.28
67_T70_A0.5840.28
34_W210_Y0.5820.28
214_R217_R0.5780.28
35_D142_G0.5780.28
78_G123_F0.5770.28
96_D127_F0.5770.28
112_L115_G0.5750.27
110_N173_E0.5740.27
148_T178_L0.5730.27
11_L159_R0.5730.27
142_G173_E0.5720.27
31_Y177_S0.5660.27
103_R145_A0.5640.27
132_C231_I0.5630.27
84_R148_T0.5630.27
116_L133_L0.5630.27
47_V181_L0.5610.26
8_R22_D0.5610.26
161_N215_A0.5610.26
69_A92_G0.5590.26
170_G177_S0.5590.26
189_S218_S0.5550.26
73_W118_L0.5520.26
47_V54_L0.5510.26
156_F169_D0.5490.26
53_L209_L0.5480.26
158_R236_F0.5470.26
44_I79_L0.5460.26
14_V99_P0.5420.25
92_G120_T0.5410.25
183_L218_S0.5390.25
66_P93_S0.5350.25
114_M201_F0.5340.25
106_A110_N0.5330.25
76_K127_F0.5290.25
119_L234_S0.5280.24
137_L178_L0.5270.24
27_D208_H0.5270.24
131_A188_A0.5260.24
107_D146_G0.5250.24
100_K103_R0.5230.24
186_L235_E0.5230.24
39_A106_A0.5220.24
69_A117_E0.5220.24
92_G100_K0.5200.24
31_Y43_S0.5190.24
8_R30_P0.5160.24
13_D22_D0.5140.24
87_F147_A0.5140.24
37_L195_T0.5120.23
134_A174_T0.5120.23
60_G64_A0.5120.23
183_L221_L0.5110.23
115_G191_V0.5080.23
127_F181_L0.5070.23
225_N228_R0.5070.23
108_I209_L0.5030.23
147_A237_L0.5000.23
103_R228_R0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wdoA 1 0.8625 25 0.96 Contact Map
2cfqA 1 0.8583 23.7 0.96 Contact Map
4m64A 1 0.8917 21.5 0.961 Contact Map
4c8dA 1 0.2208 16.3 0.963 Contact Map
1pw4A 1 0.8875 13.5 0.964 Contact Map
2gfpA 2 0.8292 12.6 0.965 Contact Map
4zw9A 1 0.8708 10.1 0.966 Contact Map
4j05A 3 0.8792 7.9 0.968 Contact Map
4u4vA 1 0.8875 6.1 0.97 Contact Map
3na2A 2 0.225 3.4 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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