GREMLIN Database
Mak16 - Mak16 protein C-terminal region
PFAM: PF04874 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 99 (98)
Sequences: 780 (578)
Seq/√Len: 58.4
META: 0.321

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_R13_R3.6061.00
58_E62_E3.4251.00
41_I49_W3.0021.00
3_K7_R2.6131.00
21_L24_A2.2281.00
41_I44_F2.1641.00
2_K5_E1.9941.00
46_E49_W1.9471.00
37_T44_F1.9431.00
61_E64_E1.9301.00
94_L97_L1.8541.00
14_K18_A1.7960.99
45_P49_W1.7540.99
91_E94_L1.7480.99
3_K6_R1.7140.99
2_K6_R1.6680.99
72_E76_E1.6580.99
42_Y49_W1.6360.99
60_E64_E1.6030.99
95_E98_E1.5890.99
46_E50_K1.5660.98
16_L27_K1.5660.98
43_N49_W1.5640.98
37_T40_D1.5200.98
12_E32_R1.4940.98
44_F49_W1.3800.96
73_E77_E1.3580.96
2_K10_R1.3430.96
53_L56_E1.2810.95
67_E75_E1.2800.95
81_E94_L1.2420.94
69_E73_E1.2420.94
64_E69_E1.2320.93
52_V59_E1.2050.93
25_I31_E1.1810.92
64_E68_E1.1540.91
8_E12_E1.1460.91
41_I48_V1.1450.91
59_E64_E1.1420.91
67_E71_E1.1320.90
81_E84_Y1.0960.89
25_I36_G1.0440.86
82_V86_E1.0400.86
16_L25_I1.0330.86
91_E95_E1.0290.85
20_K50_K1.0080.84
87_D90_E0.9980.84
42_Y52_V0.9980.84
40_D53_L0.9900.83
34_K45_P0.9840.83
66_E74_E0.9670.82
51_K57_E0.9640.81
17_A20_K0.9620.81
28_E32_R0.9410.80
9_A56_E0.9350.79
60_E66_E0.9330.79
30_L37_T0.9230.78
47_K50_K0.9190.78
14_K38_Y0.9110.77
42_Y48_V0.8990.77
90_E93_D0.8980.76
23_K49_W0.8970.76
43_N53_L0.8890.76
45_P48_V0.8840.75
31_E34_K0.8840.75
17_A44_F0.8830.75
21_L31_E0.8770.75
23_K38_Y0.8740.74
15_A19_A0.8720.74
17_A48_V0.8680.74
26_E43_N0.8620.73
4_V7_R0.8590.73
17_A23_K0.8520.73
6_R10_R0.8410.72
70_E74_E0.8360.71
26_E51_K0.8320.71
21_L26_E0.8290.71
63_E73_E0.8250.70
67_E70_E0.7980.68
6_R20_K0.7920.67
42_Y45_P0.7820.66
70_E73_E0.7800.66
93_D99_D0.7560.63
73_E79_E0.7550.63
81_E88_D0.7480.63
13_R35_S0.7400.62
61_E65_E0.7340.61
20_K36_G0.7330.61
37_T41_I0.7300.61
16_L22_E0.7230.60
18_A28_E0.7220.60
72_E87_D0.7190.59
71_E75_E0.7150.59
22_E45_P0.7090.58
88_D91_E0.7050.58
41_I45_P0.7040.58
89_E92_E0.6920.57
5_E16_L0.6910.56
6_R48_V0.6850.56
9_A13_R0.6850.56
31_E35_S0.6750.55
50_K57_E0.6730.55
11_R56_E0.6730.55
4_V20_K0.6720.54
18_A32_R0.6710.54
58_E61_E0.6710.54
63_E67_E0.6630.53
41_I52_V0.6580.53
7_R11_R0.6570.53
2_K9_A0.6440.51
39_G44_F0.6410.51
3_K8_E0.6410.51
38_Y44_F0.6380.51
46_E52_V0.6370.51
22_E43_N0.6330.50
64_E71_E0.6300.50
22_E26_E0.6220.49
82_V85_V0.6200.49
20_K37_T0.6180.48
45_P54_E0.6100.48
36_G44_F0.6000.46
30_L39_G0.6000.46
40_D45_P0.5980.46
74_E79_E0.5840.45
18_A27_K0.5790.44
9_A22_E0.5750.44
62_E77_E0.5740.44
27_K31_E0.5670.43
68_E76_E0.5630.42
23_K31_E0.5620.42
58_E66_E0.5620.42
12_E15_A0.5550.42
36_G40_D0.5520.41
15_A36_G0.5360.39
31_E39_G0.5340.39
21_L47_K0.5330.39
94_L98_E0.5290.39
36_G56_E0.5270.39
10_R48_V0.5270.39
4_V36_G0.5240.38
36_G50_K0.5220.38
63_E87_D0.5190.38
4_V39_G0.5170.37
89_E95_E0.5160.37
9_A20_K0.5130.37
12_E33_L0.5090.37
47_K88_D0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u7aA 1 0 77.1 0.854 Contact Map
4kblA 2 0 42.6 0.884 Contact Map
4fp9B 2 0.5455 18.2 0.903 Contact Map
2ca6A 1 0.4444 6 0.922 Contact Map
3ljcA 1 0.5657 2.8 0.934 Contact Map
4fbnA 1 0.3535 2.7 0.935 Contact Map
4gyiA 1 0.5859 2.4 0.936 Contact Map
4v1nR 1 0 2.4 0.936 Contact Map
1xrsA 2 0.596 2.1 0.938 Contact Map
4ipaA 1 0.0303 1.9 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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