GREMLIN Database
DUF624 - Protein of unknown function, DUF624
PFAM: PF04854 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 77 (72)
Sequences: 6599 (5452)
Seq/√Len: 642.5
META: 0.763

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_W25_T4.1261.00
30_Y51_A2.9171.00
17_P20_T2.6301.00
3_I45_F2.1391.00
8_W28_L2.1361.00
23_P60_T1.9101.00
33_R37_R1.8361.00
14_C48_F1.8211.00
51_A55_N1.7471.00
26_T59_S1.7331.00
15_S21_I1.7201.00
57_K61_L1.6021.00
7_L45_F1.5321.00
32_T36_V1.5301.00
58_Q61_L1.5261.00
60_T63_G1.5231.00
22_G63_G1.4831.00
50_K54_E1.4781.00
4_L28_L1.4311.00
34_K47_D1.3691.00
31_V47_D1.3371.00
51_A54_E1.3121.00
30_Y34_K1.2411.00
72_L76_D1.2281.00
15_S18_V1.2181.00
26_T55_N1.2181.00
14_C49_F1.2091.00
66_L70_G1.1941.00
24_A52_F1.1861.00
34_K51_A1.1511.00
43_Y46_K1.1481.00
45_F49_F1.1261.00
49_F53_K1.1211.00
30_Y47_D1.1101.00
43_Y47_D1.0661.00
13_L17_P1.0651.00
63_G67_L1.0651.00
62_L66_L1.0621.00
56_F60_T1.0211.00
52_F56_F1.0181.00
15_S20_T0.9641.00
32_T35_W0.9621.00
25_T29_Y0.9531.00
29_Y32_T0.9501.00
35_W41_E0.9191.00
16_L19_V0.9081.00
27_A51_A0.8901.00
22_G59_S0.8891.00
27_A52_F0.8361.00
21_I25_T0.8361.00
14_C17_P0.8291.00
71_A74_Y0.8251.00
23_P52_F0.8211.00
58_Q62_L0.7971.00
71_A75_V0.7941.00
36_V39_E0.7871.00
31_V44_I0.7771.00
70_G74_Y0.7561.00
29_Y33_R0.7541.00
34_K39_E0.7501.00
47_D51_A0.7451.00
3_I7_L0.7401.00
7_L48_F0.7401.00
23_P56_F0.7361.00
35_W38_G0.7361.00
14_C24_A0.7341.00
41_E47_D0.7241.00
30_Y54_E0.7201.00
55_N59_S0.7031.00
22_G60_T0.6961.00
27_A31_V0.6951.00
5_N9_L0.6931.00
8_W29_Y0.6901.00
70_G73_L0.6771.00
34_K42_G0.6761.00
49_F52_F0.6691.00
35_W39_E0.6691.00
55_N58_Q0.6611.00
28_L32_T0.6521.00
59_S63_G0.6271.00
57_K60_T0.6241.00
8_W14_C0.6231.00
23_P27_A0.6111.00
19_V56_F0.6101.00
46_K50_K0.6021.00
42_G47_D0.5951.00
46_K49_F0.5941.00
33_R38_G0.5911.00
3_I6_L0.5861.00
67_L71_A0.5701.00
4_L32_T0.5661.00
14_C23_P0.5641.00
25_T28_L0.5641.00
72_L75_V0.5621.00
14_C52_F0.5591.00
24_A27_A0.5571.00
61_L65_I0.5571.00
1_L35_W0.5481.00
33_R36_V0.5461.00
23_P59_S0.5421.00
16_L20_T0.5411.00
38_G41_E0.5270.99
4_L31_V0.5270.99
31_V42_G0.5260.99
15_S19_V0.5160.99
31_V35_W0.5130.99
35_W47_D0.5090.99
8_W48_F0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tx3A 2 0.974 6.4 0.859 Contact Map
2zy9A 2 0.8701 5.3 0.864 Contact Map
3hzqA 3 0.3896 5.3 0.864 Contact Map
3j9pD 4 0.987 3.9 0.873 Contact Map
1rh5B 1 0.4286 3.7 0.873 Contact Map
2oarA 7 0.3896 2.7 0.882 Contact Map
4pl0A 2 0.5065 2.6 0.883 Contact Map
4tquM 1 0.4156 2.4 0.885 Contact Map
3j5pB 3 0.9221 2.3 0.887 Contact Map
4wl1A 3 0 2.3 0.887 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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