GREMLIN Database
Ovate - Transcriptional repressor, ovate
PFAM: PF04844 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 58 (57)
Sequences: 790 (373)
Seq/√Len: 49.3
META: 0.089

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_C37_L3.3961.00
1_S7_D3.3471.00
12_M35_L2.4141.00
26_D30_L2.3441.00
8_F31_L2.0231.00
12_M31_L1.9040.99
22_R34_Y1.8970.99
3_D6_E1.8340.99
28_E33_C1.5410.97
28_E32_A1.5080.97
30_L37_L1.4980.96
44_G48_G1.4310.95
6_E47_V1.4230.95
34_Y41_E1.3920.95
14_E34_Y1.3710.94
25_E44_G1.3580.94
40_K49_A1.3360.93
5_Y52_D1.3350.93
31_L35_L1.2690.91
24_W53_L1.1990.89
15_M43_H1.1510.87
8_F11_S1.1200.85
46_I50_F1.0950.84
32_A47_V1.0740.83
6_E23_D1.0600.82
18_E21_I1.0590.82
8_F12_M1.0570.82
30_L33_C1.0520.81
15_M30_L1.0300.80
48_G55_V0.9970.78
7_D11_S0.9860.77
13_V21_I0.9750.76
22_R57_L0.9330.73
10_R34_Y0.9030.70
1_S4_P0.8930.69
23_D53_L0.8870.69
6_E44_G0.8680.67
10_R56_D0.8600.67
12_M54_W0.8470.65
12_M52_D0.8370.64
33_C47_V0.8360.64
27_L31_L0.8330.64
10_R17_V0.8300.64
28_E42_H0.8060.61
42_H45_V0.8060.61
6_E10_R0.7970.61
49_A56_D0.7970.61
36_S51_V0.7960.60
2_E17_V0.7860.60
5_Y51_V0.7830.59
14_E33_C0.7440.55
2_E23_D0.7210.53
35_L47_V0.7130.52
14_E28_E0.7090.52
24_W48_G0.7080.52
16_I48_G0.7050.51
29_E44_G0.7040.51
28_E51_V0.7000.51
5_Y43_H0.6840.49
6_E29_E0.6820.49
45_V49_A0.6780.49
35_L43_H0.6770.49
2_E45_V0.6660.47
8_F46_I0.6640.47
17_V45_V0.6440.45
18_E26_D0.6420.45
32_A40_K0.6370.44
24_W55_V0.6330.44
45_V48_G0.6330.44
21_I54_W0.6320.44
16_I54_W0.6280.44
1_S15_M0.6160.42
10_R23_D0.6020.41
31_L52_D0.6000.41
1_S5_Y0.5980.41
34_Y53_L0.5810.39
8_F35_L0.5600.37
20_G24_W0.5460.36
18_E23_D0.5330.34
23_D40_K0.5330.34
11_S38_N0.5210.33
13_V55_V0.5210.33
22_R26_D0.5090.32
14_E41_E0.5040.32
29_E37_L0.5010.32
17_V48_G0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ionA 1 0.931 44.4 0.857 Contact Map
2nszA 1 0.931 43.1 0.858 Contact Map
2zu6B 1 0.9655 33.7 0.865 Contact Map
2rg8A 1 0.9655 29.8 0.869 Contact Map
1ug3A 1 0.9655 26.8 0.872 Contact Map
3eiqC 1 0.9655 23.7 0.875 Contact Map
2xwvA 1 0.7241 22 0.878 Contact Map
3l6aA 1 0.9138 16.9 0.884 Contact Map
1ji6A 1 1 12.1 0.891 Contact Map
4bzjA 2 0.8621 7.5 0.901 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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