GREMLIN Database
DUF637 - Possible hemagglutinin (DUF637)
PFAM: PF04830 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 172 (172)
Sequences: 904 (721)
Seq/√Len: 55.0
META: 0.612

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_C165_C6.3391.00
99_T104_G4.7531.00
5_A44_M3.7371.00
16_S27_T2.9411.00
158_A164_D2.8971.00
93_I96_G2.6971.00
126_G153_L2.6431.00
6_L10_A2.6301.00
123_A157_A2.6061.00
17_L27_T2.4571.00
17_L21_K2.4471.00
15_V19_N2.3411.00
11_S14_A2.2681.00
165_C171_G2.1711.00
46_T97_V2.1271.00
119_V160_A2.0821.00
2_A5_A2.0811.00
42_T102_N2.0401.00
99_T109_N1.9921.00
130_I153_L1.9621.00
167_A171_G1.9011.00
16_S30_D1.8881.00
127_A130_I1.8620.99
49_L97_V1.6710.99
40_L44_M1.6690.99
47_A51_A1.6520.99
134_G146_K1.6490.99
104_G109_N1.6410.99
127_A153_L1.6240.98
11_S15_V1.6010.98
154_G168_G1.5920.98
148_L152_A1.5790.98
80_L84_L1.5720.98
40_L43_S1.4720.97
155_C171_G1.4520.97
98_N102_N1.4300.97
36_S40_L1.4180.96
17_L31_L1.4080.96
123_A127_A1.3940.96
8_S40_L1.3810.96
155_C159_A1.3800.96
32_G36_S1.3510.95
153_L157_A1.3380.95
38_K102_N1.3360.95
41_A45_V1.3340.95
2_A6_L1.3260.95
1_A44_M1.3200.95
158_A162_G1.3130.94
3_N6_L1.3010.94
12_Q21_K1.2940.94
126_G129_A1.2840.94
131_G150_H1.2760.94
27_T30_D1.2270.92
3_N7_T1.2240.92
33_S36_S1.2210.92
7_T11_S1.2180.92
23_D26_A1.1990.91
115_L119_V1.1960.91
18_I30_D1.1900.91
16_S23_D1.1820.91
50_T54_D1.1780.91
119_V123_A1.1570.90
165_C168_G1.1480.89
161_T164_D1.1450.89
8_S12_Q1.1390.89
99_T103_G1.1370.89
119_V157_A1.1340.89
5_A8_S1.1300.89
165_C169_A1.1290.89
7_T10_A1.1260.88
91_A95_A1.1020.87
32_G40_L1.0990.87
28_L32_G1.0850.86
64_P67_N1.0680.86
131_G134_G1.0640.85
5_A9_L1.0630.85
130_I149_A1.0620.85
164_D167_A1.0540.85
123_A126_G1.0480.85
9_L40_L1.0240.83
152_A155_C1.0200.83
8_S13_A1.0010.82
16_S20_N1.0010.82
85_A88_L0.9850.81
64_P73_D0.9840.81
159_A165_C0.9830.81
151_A155_C0.9810.80
127_A172_A0.9730.80
31_L40_L0.9690.80
13_A27_T0.9570.79
24_L27_T0.9490.78
144_L148_L0.9400.77
6_L9_L0.9370.77
42_T101_I0.9340.77
65_G69_L0.9340.77
142_G146_K0.9210.76
6_L11_S0.9190.76
145_A149_A0.9100.75
146_K155_C0.8970.74
117_A121_T0.8950.74
158_A163_G0.8890.73
13_A17_L0.8790.73
107_G111_K0.8770.72
156_A159_A0.8760.72
27_T32_G0.8740.72
153_L167_A0.8730.72
57_A60_G0.8680.72
160_A164_D0.8620.71
36_S39_S0.8570.71
122_L163_G0.8530.70
137_L142_G0.8420.69
89_L92_V0.8380.69
139_L142_G0.8340.69
12_Q37_L0.8280.68
67_N70_P0.8240.68
3_N9_L0.8240.68
12_Q31_L0.8170.67
156_A161_T0.8100.66
78_S82_Q0.8090.66
8_S39_S0.8070.66
12_Q32_G0.7970.65
144_L147_K0.7930.65
134_G138_G0.7910.64
167_A170_I0.7890.64
99_T102_N0.7860.64
162_G170_I0.7860.64
79_G82_Q0.7830.64
49_L53_L0.7810.63
38_K115_L0.7770.63
4_A7_T0.7760.63
42_T50_T0.7750.63
157_A160_A0.7700.62
133_L149_A0.7650.62
153_L172_A0.7630.62
10_A15_V0.7490.60
73_D76_T0.7480.60
21_K32_G0.7450.60
6_L31_L0.7440.60
10_A27_T0.7430.60
74_L79_G0.7320.58
55_D58_L0.7310.58
91_A117_A0.7290.58
106_F115_L0.7260.58
9_L31_L0.7240.58
63_D66_T0.7240.58
12_Q16_S0.7230.57
135_D143_S0.7220.57
10_A14_A0.7180.57
32_G44_M0.7160.57
134_G149_A0.7140.57
27_T31_L0.7140.57
60_G64_P0.7100.56
70_P73_D0.7100.56
10_A19_N0.7090.56
1_A5_A0.7060.56
139_L143_S0.7040.55
84_L100_A0.6950.54
154_G158_A0.6940.54
1_A9_L0.6890.54
20_N26_A0.6840.53
39_S97_V0.6810.53
18_I22_G0.6800.53
133_L158_A0.6710.52
19_N30_D0.6680.52
127_A141_D0.6660.51
91_A121_T0.6660.51
76_T79_G0.6650.51
150_H154_G0.6600.51
60_G68_K0.6570.50
123_A153_L0.6550.50
151_A157_A0.6550.50
121_T125_E0.6520.50
145_A166_A0.6500.50
96_G107_G0.6470.49
63_D68_K0.6470.49
29_K32_G0.6460.49
83_F97_V0.6460.49
94_S113_A0.6460.49
87_Q121_T0.6440.49
1_A34_S0.6430.49
11_S157_A0.6420.49
56_G59_G0.6420.49
55_D62_T0.6350.48
77_W80_L0.6340.48
137_L140_A0.6330.48
144_L161_T0.6330.48
49_L90_Q0.6300.48
69_L72_A0.6290.47
106_F121_T0.6270.47
55_D59_G0.6270.47
123_A172_A0.6270.47
141_D146_K0.6260.47
50_T93_I0.6260.47
49_L54_D0.6250.47
12_Q40_L0.6240.47
43_S46_T0.6220.47
54_D89_L0.6200.46
55_D60_G0.6200.46
41_A44_M0.6170.46
113_A132_D0.6160.46
135_D139_L0.6120.46
4_A43_S0.6030.45
150_H153_L0.6030.45
21_K30_D0.6010.44
8_S36_S0.6000.44
147_K155_C0.5980.44
53_L93_I0.5950.44
84_L121_T0.5900.43
66_T70_P0.5870.43
53_L58_L0.5870.43
129_A133_L0.5860.43
163_G167_A0.5850.43
132_D146_K0.5840.43
92_V95_A0.5830.43
19_N23_D0.5770.42
111_K118_L0.5760.42
83_F88_L0.5750.42
159_A168_G0.5750.42
56_G60_G0.5750.42
110_L123_A0.5740.42
62_T65_G0.5700.41
98_N109_N0.5640.41
96_G106_F0.5630.40
72_A79_G0.5610.40
7_T19_N0.5610.40
29_K34_S0.5590.40
62_T66_T0.5580.40
26_A30_D0.5560.40
3_N23_D0.5550.40
69_L81_G0.5530.39
42_T97_V0.5470.39
133_L137_L0.5450.39
9_L13_A0.5430.38
60_G66_T0.5420.38
9_L16_S0.5410.38
20_N23_D0.5410.38
20_N28_L0.5370.38
35_D38_K0.5370.38
119_V166_A0.5350.38
29_K33_S0.5290.37
25_G28_L0.5290.37
158_A165_C0.5220.36
118_L123_A0.5210.36
147_K158_A0.5190.36
9_L36_S0.5170.36
55_D63_D0.5160.36
115_L122_L0.5160.36
169_A172_A0.5150.36
34_S41_A0.5090.35
36_S92_V0.5080.35
76_T80_L0.5080.35
104_G113_A0.5060.35
11_S19_N0.5060.35
88_L92_V0.5050.35
156_A165_C0.5040.35
139_L145_A0.5030.34
23_D33_S0.5010.34
38_K105_S0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q02A 1 0.2093 4.3 0.943 Contact Map
2b99A 3 0.4244 1.5 0.955 Contact Map
2qqpB 5 0.2907 1 0.959 Contact Map
2g3qA 1 0.1919 0.7 0.963 Contact Map
1uvqC 1 0.1163 0.7 0.963 Contact Map
1z96A 1 0.1744 0.7 0.964 Contact Map
1ifkA 9 0.2093 0.7 0.964 Contact Map
3s6pE 5 0.2907 0.6 0.965 Contact Map
2qb0B 2 0.343 0.6 0.965 Contact Map
3kw6A 1 0.1919 0.6 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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