GREMLIN Database
TIMELESS - Timeless protein
PFAM: PF04821 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 269 (265)
Sequences: 529 (400)
Seq/√Len: 24.5
META: 0.153

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_Y43_D4.4991.00
4_L47_I3.8371.00
168_I207_L3.3481.00
62_L137_L3.2941.00
96_K144_I3.1641.00
40_V65_L3.0141.00
14_D20_R3.0111.00
69_T202_E2.9241.00
260_H264_G2.8150.99
10_E17_R2.7870.99
259_R263_F2.5110.99
15_L39_L2.4230.98
52_K56_K2.3680.98
93_L145_P2.3560.98
17_R50_Q2.2490.97
48_L58_A2.2270.97
11_C14_D2.1590.97
237_L244_E2.0840.96
16_K63_E2.0610.95
14_D18_W2.0200.95
69_T140_N1.9940.95
67_N132_E1.9940.95
35_G91_A1.9650.94
59_L133_L1.9610.94
37_A185_S1.9170.93
80_E141_I1.9090.93
26_N209_K1.8580.92
69_T139_R1.7940.91
239_A242_Q1.7790.90
43_D47_I1.7710.90
63_E132_E1.7600.90
47_I122_E1.7500.90
16_K31_A1.7470.90
66_V137_L1.7130.89
63_E136_Y1.7080.88
246_A250_S1.6860.88
135_L181_L1.6690.87
17_R46_P1.6680.87
13_K201_L1.6610.87
259_R264_G1.6580.87
115_P202_E1.6540.87
63_E67_N1.6470.86
238_S242_Q1.6370.86
17_R213_P1.6330.86
92_L99_I1.6270.86
165_S265_T1.6240.86
221_M225_R1.5980.85
47_I253_R1.5800.84
14_D17_R1.5620.83
258_T269_V1.5500.83
225_R230_K1.5470.83
129_G265_T1.5190.82
136_Y199_L1.5180.82
85_Y206_L1.5150.81
27_R83_R1.4940.80
9_L27_R1.4860.80
164_Q196_W1.4750.80
203_I269_V1.4550.79
67_N136_Y1.4480.78
4_L8_C1.4360.78
248_K257_P1.3950.76
240_L248_K1.3740.74
59_L99_I1.3690.74
63_E70_W1.3680.74
64_L185_S1.3560.73
19_L63_E1.3510.73
170_A183_L1.3290.72
65_L235_D1.3130.71
204_I208_F1.3040.70
52_K106_K1.3020.70
243_K247_M1.2890.70
170_A216_L1.2840.69
242_Q246_A1.2830.69
12_L16_K1.2670.68
180_L200_V1.2600.68
138_F176_V1.2590.68
143_A206_L1.2550.67
138_F199_L1.2500.67
8_C23_D1.2450.67
40_V68_L1.2410.67
111_L133_L1.2330.66
45_L220_S1.2220.65
141_I167_L1.2220.65
19_L35_G1.2180.65
62_L65_L1.2140.65
88_L124_T1.2140.65
31_A133_L1.2070.64
81_H176_V1.2010.64
183_L230_K1.2000.64
127_D140_N1.1880.63
4_L33_C1.1710.62
21_R30_V1.1680.62
36_E138_F1.1670.62
220_S230_K1.1510.61
98_A184_A1.1460.60
19_L34_L1.1420.60
124_T269_V1.1420.60
245_K249_R1.1390.60
235_D238_S1.1340.59
135_L183_L1.1250.59
38_N41_Q1.1230.59
138_F152_K1.1220.59
260_H263_F1.1220.59
146_P164_Q1.1170.58
248_K252_A1.1160.58
62_L108_L1.1160.58
98_A178_D1.1120.58
64_L168_I1.1100.58
258_T265_T1.1100.58
116_L184_A1.1040.57
108_L134_V1.1030.57
122_E256_A1.1000.57
65_L138_F1.1000.57
135_L139_R1.0890.56
13_K60_A1.0890.56
129_G132_E1.0830.56
16_K70_W1.0760.55
131_I170_A1.0750.55
135_L140_N1.0670.55
34_L37_A1.0650.55
12_L29_D1.0480.53
57_L208_F1.0480.53
57_L99_I1.0460.53
45_L49_A1.0460.53
154_S210_G1.0450.53
200_V269_V1.0440.53
220_S224_Q1.0420.53
59_L207_L1.0340.52
177_L180_L1.0320.52
221_M224_Q1.0260.52
181_L186_N1.0250.52
166_A207_L1.0240.52
7_D43_D1.0180.51
264_G267_I1.0130.51
230_K242_Q1.0120.51
224_Q227_T1.0080.50
16_K133_L1.0050.50
7_D204_I1.0020.50
87_Q178_D0.9970.50
66_V133_L0.9970.50
186_N202_E0.9970.50
5_G14_D0.9960.50
8_C130_I0.9950.50
2_Y14_D0.9930.49
27_R112_L0.9920.49
6_D11_C0.9860.49
193_F207_L0.9850.49
112_L178_D0.9830.49
130_I215_K0.9820.49
105_L174_Q0.9820.49
4_L54_D0.9810.49
37_A82_H0.9810.49
169_W173_E0.9780.48
13_K26_N0.9760.48
230_K249_R0.9750.48
17_R20_R0.9740.48
65_L204_I0.9710.48
23_D63_E0.9650.47
11_C43_D0.9620.47
6_D127_D0.9550.47
4_L39_L0.9510.46
35_G145_P0.9480.46
115_P187_M0.9380.45
13_K41_Q0.9380.45
14_D30_V0.9350.45
9_L60_A0.9320.45
4_L51_W0.9310.45
45_L110_R0.9260.45
202_E207_L0.9260.45
95_Y172_H0.9250.45
142_L211_Q0.9180.44
166_A173_E0.9160.44
19_L68_L0.9120.44
135_L196_W0.9120.44
16_K20_R0.9110.44
213_P245_K0.9100.43
226_S229_E0.9050.43
45_L179_L0.9040.43
84_H88_L0.9030.43
64_L100_L0.8980.43
177_L205_Y0.8960.43
175_G178_D0.8880.42
265_T268_W0.8840.42
125_E266_T0.8810.41
6_D72_I0.8770.41
23_D62_L0.8750.41
10_E20_R0.8740.41
226_S230_K0.8730.41
60_A116_L0.8700.41
17_R115_P0.8650.40
186_N207_L0.8620.40
72_I231_K0.8580.40
233_D236_E0.8530.40
234_S239_A0.8470.39
76_F141_I0.8450.39
20_R128_E0.8450.39
90_L269_V0.8440.39
106_K131_I0.8400.39
223_E232_A0.8390.39
7_D112_L0.8340.38
252_A255_N0.8310.38
105_L217_A0.8300.38
45_L124_T0.8290.38
232_A250_S0.8280.38
112_L115_P0.8280.38
180_L262_R0.8220.37
18_W33_C0.8200.37
29_D39_L0.8190.37
249_R252_A0.8170.37
39_L183_L0.8130.37
159_E168_I0.8120.37
49_A91_A0.8090.37
240_L243_K0.8070.36
11_C16_K0.8070.36
162_I190_D0.8030.36
44_L98_A0.7940.36
24_D63_E0.7940.36
10_E14_D0.7930.35
52_K199_L0.7930.35
96_K165_S0.7930.35
111_L130_I0.7910.35
5_G11_C0.7910.35
37_A46_P0.7890.35
223_E228_S0.7880.35
178_D249_R0.7790.35
108_L125_E0.7740.34
216_L221_M0.7730.34
15_L197_N0.7730.34
221_M226_S0.7690.34
62_L196_W0.7690.34
184_A246_A0.7680.34
13_K46_P0.7650.34
18_W30_V0.7620.33
184_A200_V0.7610.33
65_L137_L0.7570.33
153_L157_G0.7520.33
166_A169_W0.7500.33
31_A67_N0.7480.33
5_G123_R0.7460.32
19_L25_D0.7460.32
137_L231_K0.7410.32
233_D239_A0.7400.32
37_A144_I0.7400.32
2_Y20_R0.7400.32
48_L240_L0.7390.32
230_K233_D0.7340.32
62_L138_F0.7320.32
121_E240_L0.7310.32
77_E80_E0.7310.32
114_P117_A0.7300.31
251_Y256_A0.7280.31
67_N70_W0.7270.31
21_R45_L0.7220.31
123_R202_E0.7210.31
4_L16_K0.7200.31
117_A213_P0.7200.31
247_M251_Y0.7200.31
60_A196_W0.7190.31
59_L132_E0.7190.31
70_W126_R0.7180.31
21_R25_D0.7170.31
102_S207_L0.7160.31
9_L59_L0.7060.30
225_R228_S0.7050.30
222_D240_L0.7050.30
109_V176_V0.7010.30
178_D184_A0.6970.29
235_D239_A0.6930.29
234_S241_L0.6920.29
118_K208_F0.6910.29
70_W136_Y0.6900.29
138_F169_W0.6880.29
29_D33_C0.6870.29
46_P203_I0.6870.29
130_I214_E0.6850.29
8_C18_W0.6840.29
183_L212_D0.6810.28
31_A165_S0.6810.28
17_R30_V0.6790.28
141_I162_I0.6780.28
154_S160_D0.6780.28
212_D224_Q0.6770.28
158_A200_V0.6730.28
167_L178_D0.6720.28
10_E21_R0.6670.28
51_W98_A0.6610.27
19_L137_L0.6600.27
59_L127_D0.6600.27
126_R198_L0.6570.27
62_L210_G0.6550.27
223_E226_S0.6550.27
64_L212_D0.6530.27
133_L186_N0.6530.27
54_D68_L0.6500.27
12_L174_Q0.6480.27
62_L132_E0.6480.27
129_G182_T0.6470.27
49_A89_Q0.6470.27
94_G104_V0.6420.26
13_K125_E0.6410.26
8_C63_E0.6410.26
43_D88_L0.6370.26
183_L200_V0.6370.26
102_S146_P0.6330.26
87_Q217_A0.6330.26
171_L176_V0.6320.26
20_R161_E0.6310.26
151_E155_D0.6300.26
242_Q245_K0.6260.25
39_L198_L0.6230.25
47_I210_G0.6220.25
83_R171_L0.6210.25
21_R27_R0.6190.25
99_I186_N0.6160.25
113_L117_A0.6160.25
137_L215_K0.6130.25
41_Q72_I0.6130.25
246_A249_R0.6120.25
100_L108_L0.6110.25
35_G199_L0.6110.25
191_F194_Q0.6060.24
63_E265_T0.6040.24
4_L11_C0.6040.24
39_L130_I0.6030.24
47_I88_L0.6030.24
206_L209_K0.5960.24
26_N168_I0.5960.24
83_R248_K0.5960.24
152_K155_D0.5930.24
58_A107_A0.5900.23
179_L252_A0.5870.23
61_C131_I0.5850.23
64_L128_E0.5840.23
167_L197_N0.5830.23
247_M252_A0.5800.23
46_P102_S0.5790.23
40_V148_P0.5780.23
187_M200_V0.5780.23
5_G127_D0.5760.23
178_D213_P0.5760.23
144_I171_L0.5740.23
66_V132_E0.5730.23
98_A131_I0.5680.22
127_D135_L0.5670.22
18_W29_D0.5620.22
44_L68_L0.5610.22
37_A90_L0.5590.22
33_C37_A0.5590.22
146_P167_L0.5580.22
15_L261_S0.5580.22
11_C18_W0.5560.22
226_S232_A0.5520.22
120_R203_I0.5510.22
182_T185_S0.5510.22
121_E241_L0.5500.21
64_L178_D0.5490.21
70_W182_T0.5460.21
213_P224_Q0.5460.21
2_Y118_K0.5440.21
92_L165_S0.5440.21
63_E133_L0.5430.21
129_G136_Y0.5410.21
68_L85_Y0.5390.21
116_L217_A0.5390.21
188_G193_F0.5370.21
45_L230_K0.5370.21
105_L138_F0.5360.21
18_W36_E0.5360.21
115_P134_V0.5350.21
15_L96_K0.5330.21
138_F142_L0.5310.21
177_L203_I0.5290.20
38_N42_N0.5280.20
230_K245_K0.5270.20
48_L171_L0.5270.20
46_P71_P0.5260.20
238_S241_L0.5250.20
227_T250_S0.5230.20
41_Q94_G0.5230.20
29_D127_D0.5220.20
258_T264_G0.5220.20
108_L112_L0.5180.20
147_P181_L0.5180.20
194_Q198_L0.5170.20
227_T248_K0.5150.20
99_I137_L0.5140.20
200_V233_D0.5120.20
232_A245_K0.5120.20
58_A70_W0.5090.20
67_N164_Q0.5080.20
69_T127_D0.5070.19
132_E198_L0.5060.19
19_L136_Y0.5030.19
63_E68_L0.5030.19
40_V231_K0.5010.19
148_P216_L0.5010.19
168_I266_T0.5000.19
61_C126_R0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4db6A 1 0.6914 58.3 0.946 Contact Map
4uaeA 1 0.5836 40 0.951 Contact Map
4cb9A 1 0.803 30.9 0.954 Contact Map
3opbA 2 0.6617 27.4 0.955 Contact Map
3nmzA 2 0.7286 25.3 0.956 Contact Map
4mfuA 2 0.8364 20.4 0.958 Contact Map
1xqrA 1 0.5985 17.2 0.959 Contact Map
4yc7B 1 0.5874 16.6 0.96 Contact Map
4b8jA 1 0.6877 14.8 0.961 Contact Map
3nmwA 1 0.6543 13.7 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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