GREMLIN Database
SMK-1 - Component of IIS longevity pathway SMK-1
PFAM: PF04802 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 191 (190)
Sequences: 581 (405)
Seq/√Len: 29.4
META: 0.25

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_T130_N4.6201.00
57_G73_R4.4461.00
20_N23_G4.1251.00
60_E73_R3.6541.00
13_H54_D3.1021.00
105_Y168_F2.7211.00
57_G60_E2.6951.00
125_S129_F2.6611.00
16_E73_R2.5870.99
31_M58_A2.5820.99
52_I56_V2.5340.99
48_S51_C2.4390.99
84_E94_L2.4280.99
72_H105_Y2.2220.98
9_L55_V2.1900.98
107_K116_D2.1280.98
107_K117_D2.1260.98
28_C31_M2.0390.97
15_C23_G2.0380.97
83_K164_D1.9580.96
16_E57_G1.9460.96
49_D102_R1.9230.96
74_E78_E1.9020.96
12_F16_E1.8960.96
43_F126_L1.8010.94
96_K100_T1.8010.94
128_F132_V1.7940.94
28_C63_P1.7770.94
47_L52_I1.7240.93
105_Y167_L1.7040.92
96_K99_Q1.6520.91
125_S180_Q1.6230.90
6_K35_I1.6070.90
163_R166_V1.6050.90
31_M55_V1.5860.89
145_L149_F1.5670.89
16_E24_L1.5280.87
188_F191_L1.5100.87
152_L165_L1.5100.87
164_D174_A1.4510.85
5_I102_R1.3840.82
38_N180_Q1.3680.81
138_L172_F1.3650.81
101_Y167_L1.3640.81
97_I168_F1.3360.79
109_V169_L1.3150.78
169_L187_L1.3040.78
78_E90_D1.3000.77
28_C65_F1.2990.77
64_D107_K1.2970.77
152_L171_E1.2960.77
110_V184_R1.2720.76
156_S167_L1.2470.74
98_H101_Y1.2280.73
14_M17_D1.2150.72
62_D113_R1.2000.71
110_V124_N1.1880.71
21_L25_H1.1870.71
21_L33_G1.1710.69
58_A165_L1.1630.69
121_S168_F1.1530.68
153_K156_S1.1490.68
82_F98_H1.1200.66
56_V76_L1.1200.66
80_A117_D1.1150.66
36_L58_A1.1120.65
107_K115_L1.1060.65
28_C62_D1.1040.65
52_I102_R1.1010.65
85_V135_V1.1000.65
32_K36_L1.0990.64
154_D158_D1.0980.64
60_E72_H1.0980.64
25_H63_P1.0830.63
108_D111_L1.0780.63
75_F78_E1.0630.62
59_L66_P1.0620.62
18_L23_G1.0540.61
65_F113_R1.0530.61
185_D188_F1.0500.61
96_K152_L1.0460.61
26_R30_I1.0440.60
75_F80_A1.0420.60
10_D22_E1.0420.60
32_K62_D1.0260.59
177_K183_A1.0240.59
47_L165_L1.0210.59
44_E180_Q1.0130.58
65_F112_P1.0080.58
98_H102_R1.0070.58
42_L48_S1.0050.57
3_D146_K1.0040.57
113_R116_D1.0020.57
98_H130_N1.0010.57
84_E100_T1.0010.57
138_L144_F1.0000.57
17_D23_G0.9950.57
162_R170_Q0.9920.56
167_L187_L0.9910.56
99_Q130_N0.9750.55
97_I102_R0.9740.55
142_E159_D0.9490.53
177_K181_P0.9470.53
78_E91_P0.9470.53
7_K30_I0.9440.53
107_K177_K0.9420.53
19_E88_I0.9400.52
36_L111_L0.9370.52
22_E158_D0.9360.52
151_Q168_F0.9350.52
154_D161_R0.9310.52
56_V106_L0.9240.51
59_L73_R0.9220.51
65_F70_A0.9130.50
152_L162_R0.9120.50
22_E42_L0.9120.50
115_L120_F0.9050.50
84_E87_P0.9040.50
30_I184_R0.9040.50
114_V123_L0.9010.49
37_L87_P0.8980.49
9_L58_A0.8880.48
47_L172_F0.8870.48
116_D119_T0.8860.48
59_L145_L0.8830.48
149_F180_Q0.8810.48
24_L27_L0.8800.48
116_D177_K0.8740.47
168_F179_L0.8680.47
105_Y110_V0.8650.46
44_E157_T0.8640.46
71_N74_E0.8590.46
113_R117_D0.8560.46
115_L118_N0.8540.46
10_D17_D0.8500.45
14_M187_L0.8480.45
83_K158_D0.8480.45
32_K137_H0.8440.45
39_D180_Q0.8370.44
34_I72_H0.8370.44
133_E157_T0.8340.44
12_F46_L0.8320.44
5_I9_L0.8310.44
107_K113_R0.8290.44
5_I51_C0.8240.43
26_R123_L0.8230.43
141_D165_L0.8200.43
182_P189_K0.8160.43
113_R119_T0.8070.42
143_K154_D0.8030.42
128_F134_I0.7880.41
86_I161_R0.7870.40
7_K25_H0.7800.40
15_C45_I0.7790.40
29_N124_N0.7780.40
5_I10_D0.7760.40
103_L165_L0.7730.39
39_D93_L0.7710.39
176_S179_L0.7690.39
181_P185_D0.7670.39
37_L56_V0.7500.38
2_E6_K0.7450.37
79_T184_R0.7450.37
43_F122_T0.7400.37
78_E183_A0.7390.37
181_P186_A0.7380.37
89_K136_S0.7370.37
89_K92_E0.7370.37
126_L131_Q0.7310.36
155_P160_E0.7290.36
24_L76_L0.7280.36
49_D96_K0.7260.36
168_F171_E0.7200.36
77_K124_N0.7170.35
97_I100_T0.7120.35
141_D149_F0.7060.35
62_D108_D0.7030.34
176_S181_P0.7020.34
107_K111_L0.7010.34
54_D123_L0.6980.34
43_F150_A0.6950.34
159_D186_A0.6920.34
115_L119_T0.6920.34
132_V180_Q0.6870.33
9_L13_H0.6860.33
65_F90_D0.6760.32
75_F101_Y0.6760.32
153_K157_T0.6760.32
53_M59_L0.6740.32
153_K167_L0.6710.32
103_L171_E0.6700.32
51_C167_L0.6700.32
4_Y164_D0.6670.32
138_L150_A0.6670.32
83_K162_R0.6640.32
100_T104_Q0.6610.31
35_I90_D0.6600.31
82_F97_I0.6600.31
54_D105_Y0.6590.31
51_C90_D0.6560.31
116_D175_L0.6560.31
67_Q169_L0.6550.31
28_C113_R0.6510.31
89_K141_D0.6490.31
4_Y139_Q0.6440.30
3_D6_K0.6420.30
111_L169_L0.6380.30
101_Y163_R0.6360.30
158_D188_F0.6340.30
92_E155_P0.6310.29
169_L173_C0.6280.29
151_Q165_L0.6250.29
96_K130_N0.6230.29
36_L172_F0.6220.29
49_D162_R0.6200.29
38_N179_L0.6200.29
65_F69_K0.6180.29
37_L63_P0.6110.28
144_F165_L0.6090.28
6_K51_C0.6090.28
102_R176_S0.6090.28
42_L95_S0.6060.28
138_L179_L0.6020.28
30_I92_E0.6010.27
20_N62_D0.6000.27
27_L58_A0.5950.27
55_V133_E0.5950.27
129_F180_Q0.5920.27
51_C95_S0.5920.27
79_T95_S0.5910.27
40_T129_F0.5890.27
66_P119_T0.5890.27
5_I34_I0.5880.27
2_E11_L0.5870.27
159_D166_V0.5870.27
61_Y177_K0.5860.27
5_I8_L0.5850.26
5_I56_V0.5830.26
64_D120_F0.5800.26
47_L144_F0.5780.26
25_H96_K0.5760.26
155_P158_D0.5700.26
45_I82_F0.5680.25
14_M18_L0.5650.25
37_L173_C0.5560.25
93_L175_L0.5530.25
113_R177_K0.5530.25
76_L98_H0.5520.25
101_Y174_A0.5510.24
9_L51_C0.5490.24
63_P99_Q0.5480.24
48_S58_A0.5470.24
131_Q170_Q0.5460.24
10_D14_M0.5410.24
117_D178_N0.5390.24
46_L55_V0.5380.24
125_S133_E0.5370.24
44_E62_D0.5370.24
48_S88_I0.5360.24
5_I158_D0.5350.24
87_P138_L0.5320.23
3_D156_S0.5260.23
16_E60_E0.5250.23
96_K139_Q0.5230.23
29_N127_I0.5230.23
31_M65_F0.5210.23
107_K119_T0.5190.23
39_D126_L0.5190.23
165_L175_L0.5180.23
178_N184_R0.5170.23
39_D116_D0.5170.23
120_F137_H0.5150.22
120_F131_Q0.5150.22
103_L162_R0.5150.22
72_H75_F0.5120.22
38_N121_S0.5100.22
21_L160_E0.5080.22
146_K166_V0.5070.22
24_L57_G0.5070.22
14_M44_E0.5050.22
49_D108_D0.5030.22
112_P165_L0.5020.22
11_L174_A0.5020.22
60_E106_L0.5010.22
2_E5_I0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fgaB 2 0.8325 28.9 0.939 Contact Map
2nppB 1 0.8325 23.1 0.942 Contact Map
2jakA 1 0.8063 9.4 0.951 Contact Map
1w9cA 2 0.4398 8.6 0.952 Contact Map
3ibvA 1 0.3927 8.2 0.953 Contact Map
3u0rA 1 0.8796 7.7 0.953 Contact Map
4eswA 2 0.445 6.9 0.954 Contact Map
3e3rA 2 0.5079 4.3 0.958 Contact Map
3qh6A 2 0.2723 3.7 0.96 Contact Map
4f7zA 1 0.801 3.6 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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