GREMLIN Database
DUF547 - Protein of unknown function, DUF547
PFAM: PF04784 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 106 (99)
Sequences: 15047 (10049)
Seq/√Len: 1010.0
META: 0.901

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_C83_C2.7891.00
93_N97_Q2.5221.00
74_F102_A2.4851.00
90_T93_N2.4351.00
52_D56_G2.3061.00
55_H59_R2.2781.00
23_K27_D2.1871.00
37_D51_D2.0661.00
42_T47_T2.0341.00
20_L41_I1.9581.00
8_E91_A1.9061.00
87_R101_A1.8841.00
74_F105_F1.8781.00
87_R100_D1.7651.00
85_P104_E1.7071.00
75_A89_Y1.6721.00
99_D103_R1.6721.00
58_L76_L1.6131.00
10_L14_I1.5811.00
5_S8_E1.5551.00
11_A91_A1.5381.00
21_T50_L1.5351.00
10_L72_I1.4311.00
6_R10_L1.4121.00
13_W53_I1.3851.00
33_I36_F1.3731.00
16_A20_L1.3661.00
10_L69_D1.3651.00
75_A98_L1.3611.00
100_D104_E1.3301.00
14_I75_A1.3251.00
10_L58_L1.3031.00
48_L52_D1.2821.00
93_N96_A1.2791.00
7_D95_D1.2791.00
71_R99_D1.2681.00
87_R97_Q1.2551.00
30_W33_I1.2391.00
61_N67_F1.1981.00
89_Y97_Q1.1971.00
89_Y101_A1.1721.00
71_R95_D1.1571.00
21_T79_A1.1491.00
32_R35_F1.1411.00
10_L94_L1.1351.00
54_E78_C1.1201.00
101_A104_E1.0991.00
90_T97_Q1.0981.00
24_L35_F1.0931.00
24_L41_I1.0901.00
48_L57_I1.0641.00
51_D55_H1.0511.00
31_K35_F1.0331.00
46_K57_I1.0301.00
13_W57_I1.0131.00
14_I76_L1.0051.00
17_Y78_C0.9861.00
96_A100_D0.9841.00
77_N83_C0.9821.00
6_R9_Q0.9701.00
94_L97_Q0.9611.00
95_D99_D0.9411.00
49_S52_D0.9331.00
7_D10_L0.9231.00
14_I89_Y0.9191.00
20_L40_F0.9111.00
60_P68_K0.9011.00
20_L43_V0.8711.00
87_R104_E0.8691.00
39_K49_S0.8591.00
20_L23_K0.8581.00
24_L40_F0.8341.00
44_G48_L0.8321.00
20_L24_L0.8251.00
25_I79_A0.8111.00
32_R36_F0.8081.00
9_Q61_N0.8031.00
30_W35_F0.7971.00
42_T45_G0.7971.00
97_Q101_A0.7891.00
24_L36_F0.7671.00
80_S83_C0.7621.00
72_I76_L0.7531.00
19_A22_I0.7511.00
31_K36_F0.7441.00
4_L44_G0.7431.00
99_D102_A0.7401.00
4_L8_E0.7391.00
71_R75_A0.7371.00
16_A41_I0.7351.00
52_D57_I0.7271.00
40_F47_T0.7151.00
58_L72_I0.7131.00
22_I86_L0.7111.00
9_Q67_F0.7051.00
24_L39_K0.6991.00
22_I25_I0.6961.00
48_L53_I0.6951.00
61_N68_K0.6871.00
30_W36_F0.6861.00
56_G60_P0.6841.00
13_W48_L0.6831.00
23_K41_I0.6761.00
81_I85_P0.6641.00
21_T36_F0.6551.00
94_L98_L0.6511.00
21_T35_F0.6481.00
73_H77_N0.6431.00
75_A101_A0.6411.00
16_A53_I0.6401.00
19_A26_L0.6401.00
43_V48_L0.6391.00
20_L53_I0.6331.00
13_W43_V0.6281.00
57_I61_N0.6271.00
74_F106_L0.6241.00
40_F49_S0.6141.00
30_W34_G0.6111.00
31_K34_G0.5971.00
21_T25_I0.5931.00
14_I98_L0.5921.00
14_I94_L0.5881.00
78_C84_P0.5791.00
70_P102_A0.5721.00
12_F44_G0.5701.00
23_K26_L0.5691.00
22_I26_L0.5681.00
37_D49_S0.5671.00
60_P67_F0.5601.00
73_H78_C0.5601.00
29_H33_I0.5441.00
71_R98_L0.5421.00
9_Q13_W0.5341.00
57_I60_P0.5331.00
24_L38_K0.5321.00
17_Y54_E0.5311.00
39_K42_T0.5301.00
14_I18_N0.5211.00
19_A23_K0.5191.00
53_I58_L0.5181.00
75_A94_L0.5171.00
77_N86_L0.5111.00
85_P101_A0.5101.00
54_E83_C0.5061.00
39_K47_T0.5041.00
4_L12_F0.5011.00
12_F43_V0.5001.00
38_K42_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3laxA 1 0.6226 22.6 0.891 Contact Map
4rh7A 1 0.9623 12.7 0.903 Contact Map
4s2rP 2 0.3774 12.5 0.903 Contact Map
3ctzA 2 0.3774 12 0.904 Contact Map
4d4iA 1 0.8868 9.3 0.909 Contact Map
4h62V 1 0.1604 6.9 0.914 Contact Map
3bb7A 1 0.5189 6.9 0.914 Contact Map
4rvnA 3 0.934 6.6 0.915 Contact Map
3izxA 3 0.934 5.8 0.917 Contact Map
3cs5A 2 0.3302 5.8 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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