GREMLIN Database
DUF630 - Protein of unknown function (DUF630)
PFAM: PF04783 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 59 (59)
Sequences: 560 (253)
Seq/√Len: 32.9
META: 0.093

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_C14_V3.8121.00
49_G59_E2.9271.00
12_E28_V2.2780.99
21_K25_K2.2590.99
46_R49_G2.1140.98
53_R57_E1.9050.97
8_L38_H1.8930.97
39_V57_E1.7990.96
19_E27_A1.7630.95
24_I32_Y1.5360.91
37_A49_G1.5220.90
2_G20_R1.5130.90
27_A51_A1.4610.88
23_L35_A1.4050.86
47_N50_A1.3870.85
28_V48_V1.3810.85
3_C6_S1.3650.84
23_L26_Q1.3480.84
26_Q53_R1.2790.80
34_L38_H1.2620.79
2_G6_S1.2160.77
20_R31_R1.1690.74
21_K35_A1.1470.72
3_C9_D1.1270.71
54_R58_G1.1030.69
24_I36_A1.0850.68
10_D19_E1.0250.64
10_D30_A1.0210.63
35_A40_A1.0110.63
15_A39_V0.9970.61
28_V31_R0.9890.61
37_A55_F0.9850.60
8_L14_V0.9720.59
22_R49_G0.9690.59
5_A16_L0.9660.59
15_A25_K0.9270.56
16_L36_A0.9220.55
10_D58_G0.9050.54
28_V45_L0.8660.51
35_A39_V0.8650.51
33_A47_N0.8650.51
7_K53_R0.8540.50
35_A38_H0.8530.50
24_I58_G0.8400.49
30_A48_V0.8250.47
18_K25_K0.8230.47
49_G55_F0.8220.47
18_K55_F0.7940.45
40_A46_R0.7660.42
4_S49_G0.7470.41
1_M7_K0.7460.41
29_D34_L0.7370.40
29_D42_I0.7180.39
5_A39_V0.7160.38
34_L37_A0.7130.38
9_D14_V0.6920.37
2_G35_A0.6860.36
7_K13_A0.6810.36
37_A45_L0.6740.35
10_D15_A0.6720.35
29_D51_A0.6630.34
4_S19_E0.6580.34
25_K51_A0.6560.34
48_V52_L0.6460.33
10_D17_C0.6400.33
23_L38_H0.6260.32
39_V43_Q0.6230.31
27_A56_A0.6170.31
8_L48_V0.6150.31
4_S41_Y0.6140.31
2_G7_K0.5890.29
23_L56_A0.5850.29
19_E41_Y0.5840.29
11_E32_Y0.5790.28
25_K46_R0.5750.28
51_A56_A0.5720.28
29_D32_Y0.5690.28
5_A23_L0.5690.28
5_A21_K0.5680.28
13_A42_I0.5650.27
1_M6_S0.5610.27
17_C44_S0.5560.27
13_A38_H0.5230.25
39_V42_I0.5210.25
14_V50_A0.5170.24
4_S40_A0.5110.24
4_S16_L0.5010.23
16_L24_I0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uekA 1 1 12.2 0.885 Contact Map
4a0dA 1 0.8814 9.7 0.89 Contact Map
4ijrA 2 0.8644 6.7 0.898 Contact Map
2ehbA 1 0.7797 5.3 0.902 Contact Map
4exbA 2 0.8644 5.1 0.903 Contact Map
1nh1A 1 0.6271 5 0.904 Contact Map
1zgdA 1 0.8644 4.8 0.904 Contact Map
1pz1A 1 0.8814 4.8 0.904 Contact Map
3v0sA 1 0.8136 3.6 0.91 Contact Map
1pyfA 1 0.8814 3.4 0.911 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0043 seconds.