GREMLIN Database
DUF632 - Protein of unknown function (DUF632)
PFAM: PF04782 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 310 (308)
Sequences: 620 (379)
Seq/√Len: 21.6
META: 0.018

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_H239_Y7.0371.00
54_S57_T4.1821.00
21_E176_R3.6311.00
211_H215_T3.5901.00
117_Q130_T3.0300.99
51_K56_I2.7800.99
9_E13_L2.6880.99
110_K167_L2.6830.99
69_D72_D2.6710.99
74_M77_G2.6270.99
148_V304_F2.6190.98
54_S63_S2.5350.98
82_T166_Q2.4760.98
198_L290_D2.3960.97
113_Q117_Q2.3390.97
67_S71_L2.3240.97
18_S99_A2.2360.96
162_E174_L2.1550.95
66_S70_D2.1090.94
98_K141_I2.0620.93
147_S295_K2.0500.93
68_K71_L2.0480.93
68_K72_D1.9940.92
215_T234_K1.9730.92
6_K18_S1.9730.92
74_M169_E1.9290.91
157_K161_E1.8980.90
114_L130_T1.8750.90
6_K65_R1.8690.90
139_T301_I1.8620.89
26_L159_R1.8380.89
55_V58_W1.7760.87
233_I303_S1.7710.87
237_K290_D1.7380.86
158_L305_A1.7380.86
92_K97_V1.7320.86
21_E278_I1.7260.85
190_Q194_E1.7110.85
117_Q122_A1.6880.84
96_E247_L1.6750.84
50_A60_R1.6700.83
89_W143_V1.6580.83
52_V56_I1.6380.82
8_I148_V1.6330.82
94_Y250_C1.5940.80
118_D289_L1.5920.80
22_V73_D1.5510.78
219_E309_H1.5370.78
92_K98_K1.5360.78
119_E131_R1.5230.77
9_E202_T1.5100.76
123_E240_V1.5030.76
52_V55_V1.4910.76
89_W96_E1.4630.74
108_E118_D1.4620.74
275_A279_F1.4610.74
54_S58_W1.4590.74
225_W304_F1.4500.73
16_S305_A1.4440.73
50_A64_S1.4260.72
151_I237_K1.4230.72
179_K229_F1.4090.71
241_E284_D1.3960.71
244_N300_A1.3940.70
32_H39_E1.3700.69
267_D270_S1.3670.69
77_G228_S1.3610.69
22_V26_L1.3590.68
23_S27_E1.3590.68
59_S63_S1.3530.68
161_E279_F1.3440.68
239_Y308_V1.3430.67
5_V171_I1.3400.67
74_M78_S1.3360.67
33_Y139_T1.3360.67
186_Q236_Q1.3330.67
263_E272_F1.3250.66
52_V58_W1.3210.66
41_K46_H1.3200.66
3_E304_F1.3170.66
66_S306_A1.3100.65
79_H129_K1.3100.65
52_V278_I1.3010.65
140_R159_R1.2940.65
258_S262_P1.2840.64
88_A181_M1.2840.64
16_S20_K1.2720.63
131_R136_D1.2720.63
155_I209_E1.2670.63
78_S212_R1.2660.63
119_E174_L1.2660.63
42_G278_I1.2560.62
267_D273_P1.2360.61
49_S53_L1.2340.61
85_K119_E1.2320.61
267_D272_F1.2300.60
179_K227_S1.2270.60
54_S59_S1.2230.60
288_A301_I1.2210.60
9_E79_H1.2180.60
104_R297_V1.2130.59
30_K33_Y1.2040.59
5_V291_R1.2030.59
175_M309_H1.1950.58
13_L79_H1.1910.58
229_F293_P1.1910.58
50_A54_S1.1880.58
268_G273_P1.1830.57
31_L190_Q1.1830.57
53_L57_T1.1740.57
214_A237_K1.1670.56
254_I275_A1.1630.56
141_I229_F1.1620.56
37_F106_E1.1620.56
224_N228_S1.1560.56
254_I257_S1.1500.55
89_W152_S1.1500.55
124_S242_A1.1490.55
158_L199_D1.1420.55
260_Y263_E1.1360.54
219_E300_A1.1340.54
25_M308_V1.1300.54
247_L278_I1.1290.54
66_S71_L1.1200.53
7_E229_F1.1200.53
36_S39_E1.1170.53
209_E240_V1.1160.53
258_S309_H1.1080.52
14_K56_I1.1060.52
67_S72_D1.0960.52
186_Q242_A1.0930.51
6_K299_E1.0880.51
168_V260_Y1.0880.51
77_G107_Y1.0870.51
255_E258_S1.0840.51
22_V247_L1.0820.51
73_D120_K1.0820.51
35_S304_F1.0800.51
27_E159_R1.0780.50
30_K289_L1.0780.50
27_E123_E1.0740.50
7_E30_K1.0740.50
25_M74_M1.0740.50
270_S273_P1.0740.50
241_E290_D1.0730.50
290_D295_K1.0680.50
230_C287_Q1.0640.49
94_Y98_K1.0630.49
258_S261_E1.0570.49
28_A53_L1.0550.49
53_L59_S1.0540.49
240_V281_L1.0520.49
288_A299_E1.0480.48
133_A150_S1.0450.48
27_E219_E1.0440.48
247_L279_F1.0370.48
91_K198_L1.0360.48
61_S65_R1.0350.47
54_S60_R1.0320.47
51_K55_V1.0270.47
271_P274_G1.0220.47
118_D304_F1.0170.46
108_E304_F1.0120.46
6_K174_L1.0120.46
248_K289_L1.0110.46
248_K301_I1.0070.46
77_G173_G1.0000.45
6_K64_S0.9970.45
158_L175_M0.9960.45
35_S42_G0.9900.44
141_I222_L0.9880.44
247_L251_L0.9880.44
51_K54_S0.9880.44
174_L185_H0.9870.44
27_E85_K0.9830.44
49_S236_Q0.9830.44
89_W247_L0.9770.44
84_D167_L0.9760.44
49_S52_V0.9730.43
207_T211_H0.9700.43
21_E63_S0.9690.43
209_E213_Q0.9610.43
211_H217_Q0.9590.42
12_F19_G0.9580.42
88_A167_L0.9570.42
241_E283_N0.9550.42
82_T282_C0.9540.42
244_N279_F0.9520.42
5_V8_I0.9510.42
127_I187_V0.9490.42
18_S181_M0.9470.42
25_M164_Q0.9420.41
207_T238_S0.9410.41
56_I60_R0.9410.41
120_K143_V0.9390.41
13_L233_I0.9360.41
6_K239_Y0.9350.41
215_T237_K0.9330.41
87_Y271_P0.9330.41
120_K200_S0.9330.41
108_E139_T0.9270.40
33_Y36_S0.9270.40
117_Q124_S0.9200.40
265_T268_G0.9180.40
8_I151_I0.9150.40
78_S152_S0.9060.39
4_V196_K0.9060.39
171_I278_I0.9060.39
27_E152_S0.9020.39
259_K264_E0.8950.38
254_I297_V0.8950.38
27_E305_A0.8950.38
240_V256_S0.8870.38
265_T269_I0.8830.38
22_V109_K0.8790.37
104_R240_V0.8770.37
109_K283_N0.8770.37
28_A289_L0.8750.37
133_A242_A0.8740.37
78_S89_W0.8740.37
16_S181_M0.8730.37
211_H289_L0.8720.37
24_R85_K0.8680.37
118_D131_R0.8670.37
106_E195_A0.8640.36
193_S303_S0.8630.36
104_R182_L0.8630.36
103_L251_L0.8570.36
154_R238_S0.8540.36
164_Q281_L0.8520.36
27_E114_L0.8440.35
15_A293_P0.8430.35
106_E134_V0.8410.35
181_M185_H0.8390.35
99_A132_A0.8370.35
21_E174_L0.8360.35
216_L289_L0.8360.35
27_E130_T0.8330.34
55_V59_S0.8320.34
265_T272_F0.8310.34
111_C136_D0.8300.34
96_E285_W0.8270.34
3_E108_E0.8260.34
83_L160_D0.8220.34
231_K290_D0.8210.34
45_Y52_V0.8210.34
192_I276_P0.8200.34
87_Y153_S0.8150.33
64_S300_A0.8090.33
22_V95_D0.8070.33
104_R145_I0.8020.33
214_A220_A0.8010.33
37_F40_L0.8000.32
89_W92_K0.7990.32
108_E134_V0.7990.32
14_K116_K0.7980.32
252_I258_S0.7970.32
41_K309_H0.7930.32
12_F174_L0.7930.32
305_A308_V0.7930.32
189_F195_A0.7910.32
138_H195_A0.7890.32
126_K265_T0.7890.32
135_R139_T0.7880.32
266_P271_P0.7860.32
59_S64_S0.7860.32
107_Y198_L0.7860.32
41_K169_E0.7850.32
6_K228_S0.7840.32
207_T232_W0.7830.31
209_E212_R0.7810.31
58_W61_S0.7800.31
139_T289_L0.7790.31
25_M274_G0.7790.31
129_K173_G0.7770.31
75_G107_Y0.7760.31
111_C277_P0.7750.31
147_S304_F0.7740.31
186_Q208_S0.7720.31
155_I309_H0.7670.31
11_Q187_V0.7620.30
244_N278_I0.7620.30
19_G214_A0.7610.30
267_D271_P0.7550.30
85_K130_T0.7530.30
9_E278_I0.7490.30
89_W145_I0.7480.29
194_E225_W0.7470.29
167_L208_S0.7450.29
31_L105_I0.7450.29
144_A149_D0.7440.29
232_W250_C0.7430.29
22_V184_C0.7420.29
29_G105_I0.7400.29
76_S120_K0.7380.29
117_Q244_N0.7340.29
56_I59_S0.7310.29
113_Q223_Q0.7300.28
49_S168_V0.7290.28
251_L259_K0.7230.28
76_S109_K0.7200.28
27_E167_L0.7170.28
101_E109_K0.7160.28
41_K64_S0.7130.28
205_K302_K0.7130.28
24_R241_E0.7110.27
35_S243_L0.7080.27
67_S70_D0.7050.27
25_M132_A0.7030.27
19_G98_K0.7030.27
12_F218_L0.7030.27
178_W246_W0.7000.27
145_I277_P0.6960.27
8_I192_I0.6920.26
64_S167_L0.6900.26
7_E128_D0.6890.26
56_I64_S0.6880.26
7_E12_F0.6880.26
191_I244_N0.6840.26
2_L134_V0.6840.26
205_K237_K0.6830.26
21_E240_V0.6830.26
183_E203_S0.6790.26
97_V178_W0.6730.25
123_E141_I0.6720.25
28_A32_H0.6700.25
138_H148_V0.6670.25
87_Y304_F0.6650.25
31_L149_D0.6640.25
182_L287_Q0.6630.25
234_K301_I0.6630.25
17_E54_S0.6590.25
95_D261_E0.6570.25
120_K124_S0.6500.24
176_R192_I0.6450.24
268_G271_P0.6440.24
42_G45_Y0.6440.24
72_D127_I0.6430.24
32_H57_T0.6430.24
158_L185_H0.6400.24
79_H138_H0.6390.24
185_H239_Y0.6370.24
206_P288_A0.6330.23
41_K112_K0.6320.23
162_E221_E0.6310.23
85_K140_R0.6310.23
22_V154_R0.6290.23
226_H287_Q0.6280.23
51_K57_T0.6270.23
23_S35_S0.6250.23
247_L261_E0.6250.23
5_V195_A0.6240.23
219_E282_C0.6230.23
1_L242_A0.6220.23
143_V192_I0.6220.23
192_I195_A0.6210.23
99_A160_D0.6210.23
153_S195_A0.6210.23
146_Q211_H0.6200.23
192_I229_F0.6180.23
269_I272_F0.6180.23
8_I255_E0.6150.23
17_E115_R0.6140.23
49_S59_S0.6130.22
2_L18_S0.6130.22
52_V62_S0.6120.22
245_G248_K0.6120.22
82_T141_I0.6100.22
208_S211_H0.6100.22
89_W159_R0.6080.22
150_S298_S0.6060.22
41_K300_A0.6050.22
182_L190_Q0.6030.22
251_L276_P0.6020.22
127_I201_S0.5980.22
27_E78_S0.5980.22
264_E270_S0.5940.22
77_G166_Q0.5930.22
228_S288_A0.5930.22
88_A247_L0.5890.21
121_G169_E0.5860.21
93_L246_W0.5840.21
124_S244_N0.5840.21
84_D164_Q0.5840.21
109_K249_L0.5830.21
22_V121_G0.5830.21
169_E174_L0.5810.21
208_S306_A0.5810.21
46_H56_I0.5810.21
135_R236_Q0.5800.21
85_K115_R0.5790.21
7_E286_S0.5790.21
107_Y259_K0.5790.21
43_S46_H0.5780.21
109_K287_Q0.5780.21
180_S215_T0.5780.21
8_I132_A0.5770.21
81_S232_W0.5770.21
172_Q244_N0.5760.21
18_S189_F0.5760.21
86_L92_K0.5750.21
139_T167_L0.5730.21
84_D204_S0.5730.21
67_S73_D0.5730.21
70_D73_D0.5730.21
66_S117_Q0.5710.21
48_P52_V0.5700.21
48_P59_S0.5690.20
103_L192_I0.5690.20
49_S225_W0.5680.20
97_V198_L0.5680.20
263_E273_P0.5670.20
42_G158_L0.5670.20
89_W251_L0.5660.20
149_D171_I0.5650.20
49_S55_V0.5640.20
50_A55_V0.5640.20
179_K214_A0.5620.20
255_E275_A0.5610.20
28_A36_S0.5610.20
131_R215_T0.5590.20
207_T249_L0.5550.20
109_K198_L0.5540.20
159_R169_E0.5540.20
70_D91_K0.5530.20
235_A276_P0.5520.20
115_R118_D0.5510.20
112_K237_K0.5490.20
30_K81_S0.5480.20
138_H147_S0.5430.19
158_L263_E0.5430.19
242_A286_S0.5420.19
133_A277_P0.5400.19
19_G303_S0.5400.19
138_H167_L0.5390.19
3_E123_E0.5370.19
98_K237_K0.5350.19
261_E308_V0.5340.19
48_P53_L0.5320.19
265_T270_S0.5310.19
192_I220_A0.5300.19
82_T162_E0.5270.19
133_A264_E0.5260.19
34_H37_F0.5250.19
8_I200_S0.5250.19
85_K136_D0.5250.19
5_V200_S0.5240.19
277_P292_L0.5240.19
222_L281_L0.5220.19
84_D88_A0.5190.18
56_I292_L0.5160.18
244_N252_I0.5140.18
244_N301_I0.5140.18
159_R278_I0.5110.18
193_S237_K0.5090.18
30_K85_K0.5060.18
124_S271_P0.5040.18
118_D225_W0.5030.18
51_K58_W0.5010.18
151_I208_S0.5000.18
130_T133_A0.5000.18
79_H263_E0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4avmA 2 0.5806 31.9 0.973 Contact Map
4fzsA 2 0.5581 24.5 0.974 Contact Map
1w9cA 2 0.3419 12.7 0.977 Contact Map
2j9uA 1 0.2774 11.7 0.978 Contact Map
1dvkA 2 0.4258 11 0.978 Contact Map
2j9wA 1 0.3258 10.5 0.978 Contact Map
1uruA 2 0.5968 9.6 0.978 Contact Map
4g78A 1 0.4161 9 0.979 Contact Map
3e7kA 4 0.1806 8.8 0.979 Contact Map
3ol3A 2 0.1742 7.2 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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