DUF632 - PFAM28P - GREMLIN Contacts

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DUF632 - Protein of unknown function (DUF632)

PFAM:	PF04782	Sequences: LLEVVKEIEDQFLKASESGKEVSRMLEAGKLHYHSSFAELKGSVYHEPSAKVLSVITWSRSSSSRSSKDDLDDMGSGSHSSTLDKLYAWEKKLYDEVKAEEKLRIEYEKKCKQLRKQDEKGAESSKIDKTRAAVRDLHTRIRVAIQSVDSISSRIEKLRDEELQPQLVELIQGLMRMWKSMLECHQVQFQIISEAKSLDSSTSSKPTSESHRQATLQLEAELQNWHSSFCKWIKAQKSYVEALNGWLKLCLIPIESSSKYEPEETPDGISPFPGAPPIFVLCNDWSQALDRLPDKEVSEAIKSFAAVVHH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	310 (308)
Sequences:	620 (379)
Seq/√Len:	21.6
META:	0.018

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
79_H	239_Y	7.037	1.00
54_S	57_T	4.182	1.00
21_E	176_R	3.631	1.00
211_H	215_T	3.590	1.00
117_Q	130_T	3.030	0.99
51_K	56_I	2.780	0.99
9_E	13_L	2.688	0.99
110_K	167_L	2.683	0.99
69_D	72_D	2.671	0.99
74_M	77_G	2.627	0.99
148_V	304_F	2.619	0.98
54_S	63_S	2.535	0.98
82_T	166_Q	2.476	0.98
198_L	290_D	2.396	0.97
113_Q	117_Q	2.339	0.97
67_S	71_L	2.324	0.97
18_S	99_A	2.236	0.96
162_E	174_L	2.155	0.95
66_S	70_D	2.109	0.94
98_K	141_I	2.062	0.93
147_S	295_K	2.050	0.93
68_K	71_L	2.048	0.93
68_K	72_D	1.994	0.92
215_T	234_K	1.973	0.92
6_K	18_S	1.973	0.92
74_M	169_E	1.929	0.91
157_K	161_E	1.898	0.90
114_L	130_T	1.875	0.90
6_K	65_R	1.869	0.90
139_T	301_I	1.862	0.89
26_L	159_R	1.838	0.89
55_V	58_W	1.776	0.87
233_I	303_S	1.771	0.87
237_K	290_D	1.738	0.86
158_L	305_A	1.738	0.86
92_K	97_V	1.732	0.86
21_E	278_I	1.726	0.85
190_Q	194_E	1.711	0.85
117_Q	122_A	1.688	0.84
96_E	247_L	1.675	0.84
50_A	60_R	1.670	0.83
89_W	143_V	1.658	0.83
52_V	56_I	1.638	0.82
8_I	148_V	1.633	0.82
94_Y	250_C	1.594	0.80
118_D	289_L	1.592	0.80
22_V	73_D	1.551	0.78
219_E	309_H	1.537	0.78
92_K	98_K	1.536	0.78
119_E	131_R	1.523	0.77
9_E	202_T	1.510	0.76
123_E	240_V	1.503	0.76
52_V	55_V	1.491	0.76
89_W	96_E	1.463	0.74
108_E	118_D	1.462	0.74
275_A	279_F	1.461	0.74
54_S	58_W	1.459	0.74
225_W	304_F	1.450	0.73
16_S	305_A	1.444	0.73
50_A	64_S	1.426	0.72
151_I	237_K	1.423	0.72
179_K	229_F	1.409	0.71
241_E	284_D	1.396	0.71
244_N	300_A	1.394	0.70
32_H	39_E	1.370	0.69
267_D	270_S	1.367	0.69
77_G	228_S	1.361	0.69
22_V	26_L	1.359	0.68
23_S	27_E	1.359	0.68
59_S	63_S	1.353	0.68
161_E	279_F	1.344	0.68
239_Y	308_V	1.343	0.67
5_V	171_I	1.340	0.67
74_M	78_S	1.336	0.67
33_Y	139_T	1.336	0.67
186_Q	236_Q	1.333	0.67
263_E	272_F	1.325	0.66
52_V	58_W	1.321	0.66
41_K	46_H	1.320	0.66
3_E	304_F	1.317	0.66
66_S	306_A	1.310	0.65
79_H	129_K	1.310	0.65
52_V	278_I	1.301	0.65
140_R	159_R	1.294	0.65
258_S	262_P	1.284	0.64
88_A	181_M	1.284	0.64
16_S	20_K	1.272	0.63
131_R	136_D	1.272	0.63
155_I	209_E	1.267	0.63
78_S	212_R	1.266	0.63
119_E	174_L	1.266	0.63
42_G	278_I	1.256	0.62
267_D	273_P	1.236	0.61
49_S	53_L	1.234	0.61
85_K	119_E	1.232	0.61
267_D	272_F	1.230	0.60
179_K	227_S	1.227	0.60
54_S	59_S	1.223	0.60
288_A	301_I	1.221	0.60
9_E	79_H	1.218	0.60
104_R	297_V	1.213	0.59
30_K	33_Y	1.204	0.59
5_V	291_R	1.203	0.59
175_M	309_H	1.195	0.58
13_L	79_H	1.191	0.58
229_F	293_P	1.191	0.58
50_A	54_S	1.188	0.58
268_G	273_P	1.183	0.57
31_L	190_Q	1.183	0.57
53_L	57_T	1.174	0.57
214_A	237_K	1.167	0.56
254_I	275_A	1.163	0.56
141_I	229_F	1.162	0.56
37_F	106_E	1.162	0.56
224_N	228_S	1.156	0.56
254_I	257_S	1.150	0.55
89_W	152_S	1.150	0.55
124_S	242_A	1.149	0.55
158_L	199_D	1.142	0.55
260_Y	263_E	1.136	0.54
219_E	300_A	1.134	0.54
25_M	308_V	1.130	0.54
247_L	278_I	1.129	0.54
66_S	71_L	1.120	0.53
7_E	229_F	1.120	0.53
36_S	39_E	1.117	0.53
209_E	240_V	1.116	0.53
258_S	309_H	1.108	0.52
14_K	56_I	1.106	0.52
67_S	72_D	1.096	0.52
186_Q	242_A	1.093	0.51
6_K	299_E	1.088	0.51
168_V	260_Y	1.088	0.51
77_G	107_Y	1.087	0.51
255_E	258_S	1.084	0.51
22_V	247_L	1.082	0.51
73_D	120_K	1.082	0.51
35_S	304_F	1.080	0.51
27_E	159_R	1.078	0.50
30_K	289_L	1.078	0.50
27_E	123_E	1.074	0.50
7_E	30_K	1.074	0.50
25_M	74_M	1.074	0.50
270_S	273_P	1.074	0.50
241_E	290_D	1.073	0.50
290_D	295_K	1.068	0.50
230_C	287_Q	1.064	0.49
94_Y	98_K	1.063	0.49
258_S	261_E	1.057	0.49
28_A	53_L	1.055	0.49
53_L	59_S	1.054	0.49
240_V	281_L	1.052	0.49
288_A	299_E	1.048	0.48
133_A	150_S	1.045	0.48
27_E	219_E	1.044	0.48
247_L	279_F	1.037	0.48
91_K	198_L	1.036	0.48
61_S	65_R	1.035	0.47
54_S	60_R	1.032	0.47
51_K	55_V	1.027	0.47
271_P	274_G	1.022	0.47
118_D	304_F	1.017	0.46
108_E	304_F	1.012	0.46
6_K	174_L	1.012	0.46
248_K	289_L	1.011	0.46
248_K	301_I	1.007	0.46
77_G	173_G	1.000	0.45
6_K	64_S	0.997	0.45
158_L	175_M	0.996	0.45
35_S	42_G	0.990	0.44
141_I	222_L	0.988	0.44
247_L	251_L	0.988	0.44
51_K	54_S	0.988	0.44
174_L	185_H	0.987	0.44
27_E	85_K	0.983	0.44
49_S	236_Q	0.983	0.44
89_W	247_L	0.977	0.44
84_D	167_L	0.976	0.44
49_S	52_V	0.973	0.43
207_T	211_H	0.970	0.43
21_E	63_S	0.969	0.43
209_E	213_Q	0.961	0.43
211_H	217_Q	0.959	0.42
12_F	19_G	0.958	0.42
88_A	167_L	0.957	0.42
241_E	283_N	0.955	0.42
82_T	282_C	0.954	0.42
244_N	279_F	0.952	0.42
5_V	8_I	0.951	0.42
127_I	187_V	0.949	0.42
18_S	181_M	0.947	0.42
25_M	164_Q	0.942	0.41
207_T	238_S	0.941	0.41
56_I	60_R	0.941	0.41
120_K	143_V	0.939	0.41
13_L	233_I	0.936	0.41
6_K	239_Y	0.935	0.41
215_T	237_K	0.933	0.41
87_Y	271_P	0.933	0.41
120_K	200_S	0.933	0.41
108_E	139_T	0.927	0.40
33_Y	36_S	0.927	0.40
117_Q	124_S	0.920	0.40
265_T	268_G	0.918	0.40
8_I	151_I	0.915	0.40
78_S	152_S	0.906	0.39
4_V	196_K	0.906	0.39
171_I	278_I	0.906	0.39
27_E	152_S	0.902	0.39
259_K	264_E	0.895	0.38
254_I	297_V	0.895	0.38
27_E	305_A	0.895	0.38
240_V	256_S	0.887	0.38
265_T	269_I	0.883	0.38
22_V	109_K	0.879	0.37
104_R	240_V	0.877	0.37
109_K	283_N	0.877	0.37
28_A	289_L	0.875	0.37
133_A	242_A	0.874	0.37
78_S	89_W	0.874	0.37
16_S	181_M	0.873	0.37
211_H	289_L	0.872	0.37
24_R	85_K	0.868	0.37
118_D	131_R	0.867	0.37
106_E	195_A	0.864	0.36
193_S	303_S	0.863	0.36
104_R	182_L	0.863	0.36
103_L	251_L	0.857	0.36
154_R	238_S	0.854	0.36
164_Q	281_L	0.852	0.36
27_E	114_L	0.844	0.35
15_A	293_P	0.843	0.35
106_E	134_V	0.841	0.35
181_M	185_H	0.839	0.35
99_A	132_A	0.837	0.35
21_E	174_L	0.836	0.35
216_L	289_L	0.836	0.35
27_E	130_T	0.833	0.34
55_V	59_S	0.832	0.34
265_T	272_F	0.831	0.34
111_C	136_D	0.830	0.34
96_E	285_W	0.827	0.34
3_E	108_E	0.826	0.34
83_L	160_D	0.822	0.34
231_K	290_D	0.821	0.34
45_Y	52_V	0.821	0.34
192_I	276_P	0.820	0.34
87_Y	153_S	0.815	0.33
64_S	300_A	0.809	0.33
22_V	95_D	0.807	0.33
104_R	145_I	0.802	0.33
214_A	220_A	0.801	0.33
37_F	40_L	0.800	0.32
89_W	92_K	0.799	0.32
108_E	134_V	0.799	0.32
14_K	116_K	0.798	0.32
252_I	258_S	0.797	0.32
41_K	309_H	0.793	0.32
12_F	174_L	0.793	0.32
305_A	308_V	0.793	0.32
189_F	195_A	0.791	0.32
138_H	195_A	0.789	0.32
126_K	265_T	0.789	0.32
135_R	139_T	0.788	0.32
266_P	271_P	0.786	0.32
59_S	64_S	0.786	0.32
107_Y	198_L	0.786	0.32
41_K	169_E	0.785	0.32
6_K	228_S	0.784	0.32
207_T	232_W	0.783	0.31
209_E	212_R	0.781	0.31
58_W	61_S	0.780	0.31
139_T	289_L	0.779	0.31
25_M	274_G	0.779	0.31
129_K	173_G	0.777	0.31
75_G	107_Y	0.776	0.31
111_C	277_P	0.775	0.31
147_S	304_F	0.774	0.31
186_Q	208_S	0.772	0.31
155_I	309_H	0.767	0.31
11_Q	187_V	0.762	0.30
244_N	278_I	0.762	0.30
19_G	214_A	0.761	0.30
267_D	271_P	0.755	0.30
85_K	130_T	0.753	0.30
9_E	278_I	0.749	0.30
89_W	145_I	0.748	0.29
194_E	225_W	0.747	0.29
167_L	208_S	0.745	0.29
31_L	105_I	0.745	0.29
144_A	149_D	0.744	0.29
232_W	250_C	0.743	0.29
22_V	184_C	0.742	0.29
29_G	105_I	0.740	0.29
76_S	120_K	0.738	0.29
117_Q	244_N	0.734	0.29
56_I	59_S	0.731	0.29
113_Q	223_Q	0.730	0.28
49_S	168_V	0.729	0.28
251_L	259_K	0.723	0.28
76_S	109_K	0.720	0.28
27_E	167_L	0.717	0.28
101_E	109_K	0.716	0.28
41_K	64_S	0.713	0.28
205_K	302_K	0.713	0.28
24_R	241_E	0.711	0.27
35_S	243_L	0.708	0.27
67_S	70_D	0.705	0.27
25_M	132_A	0.703	0.27
19_G	98_K	0.703	0.27
12_F	218_L	0.703	0.27
178_W	246_W	0.700	0.27
145_I	277_P	0.696	0.27
8_I	192_I	0.692	0.26
64_S	167_L	0.690	0.26
7_E	128_D	0.689	0.26
56_I	64_S	0.688	0.26
7_E	12_F	0.688	0.26
191_I	244_N	0.684	0.26
2_L	134_V	0.684	0.26
205_K	237_K	0.683	0.26
21_E	240_V	0.683	0.26
183_E	203_S	0.679	0.26
97_V	178_W	0.673	0.25
123_E	141_I	0.672	0.25
28_A	32_H	0.670	0.25
138_H	148_V	0.667	0.25
87_Y	304_F	0.665	0.25
31_L	149_D	0.664	0.25
182_L	287_Q	0.663	0.25
234_K	301_I	0.663	0.25
17_E	54_S	0.659	0.25
95_D	261_E	0.657	0.25
120_K	124_S	0.650	0.24
176_R	192_I	0.645	0.24
268_G	271_P	0.644	0.24
42_G	45_Y	0.644	0.24
72_D	127_I	0.643	0.24
32_H	57_T	0.643	0.24
158_L	185_H	0.640	0.24
79_H	138_H	0.639	0.24
185_H	239_Y	0.637	0.24
206_P	288_A	0.633	0.23
41_K	112_K	0.632	0.23
162_E	221_E	0.631	0.23
85_K	140_R	0.631	0.23
22_V	154_R	0.629	0.23
226_H	287_Q	0.628	0.23
51_K	57_T	0.627	0.23
23_S	35_S	0.625	0.23
247_L	261_E	0.625	0.23
5_V	195_A	0.624	0.23
219_E	282_C	0.623	0.23
1_L	242_A	0.622	0.23
143_V	192_I	0.622	0.23
192_I	195_A	0.621	0.23
99_A	160_D	0.621	0.23
153_S	195_A	0.621	0.23
146_Q	211_H	0.620	0.23
192_I	229_F	0.618	0.23
269_I	272_F	0.618	0.23
8_I	255_E	0.615	0.23
17_E	115_R	0.614	0.23
49_S	59_S	0.613	0.22
2_L	18_S	0.613	0.22
52_V	62_S	0.612	0.22
245_G	248_K	0.612	0.22
82_T	141_I	0.610	0.22
208_S	211_H	0.610	0.22
89_W	159_R	0.608	0.22
150_S	298_S	0.606	0.22
41_K	300_A	0.605	0.22
182_L	190_Q	0.603	0.22
251_L	276_P	0.602	0.22
127_I	201_S	0.598	0.22
27_E	78_S	0.598	0.22
264_E	270_S	0.594	0.22
77_G	166_Q	0.593	0.22
228_S	288_A	0.593	0.22
88_A	247_L	0.589	0.21
121_G	169_E	0.586	0.21
93_L	246_W	0.584	0.21
124_S	244_N	0.584	0.21
84_D	164_Q	0.584	0.21
109_K	249_L	0.583	0.21
22_V	121_G	0.583	0.21
169_E	174_L	0.581	0.21
208_S	306_A	0.581	0.21
46_H	56_I	0.581	0.21
135_R	236_Q	0.580	0.21
85_K	115_R	0.579	0.21
7_E	286_S	0.579	0.21
107_Y	259_K	0.579	0.21
43_S	46_H	0.578	0.21
109_K	287_Q	0.578	0.21
180_S	215_T	0.578	0.21
8_I	132_A	0.577	0.21
81_S	232_W	0.577	0.21
172_Q	244_N	0.576	0.21
18_S	189_F	0.576	0.21
86_L	92_K	0.575	0.21
139_T	167_L	0.573	0.21
84_D	204_S	0.573	0.21
67_S	73_D	0.573	0.21
70_D	73_D	0.573	0.21
66_S	117_Q	0.571	0.21
48_P	52_V	0.570	0.21
48_P	59_S	0.569	0.20
103_L	192_I	0.569	0.20
49_S	225_W	0.568	0.20
97_V	198_L	0.568	0.20
263_E	273_P	0.567	0.20
42_G	158_L	0.567	0.20
89_W	251_L	0.566	0.20
149_D	171_I	0.565	0.20
49_S	55_V	0.564	0.20
50_A	55_V	0.564	0.20
179_K	214_A	0.562	0.20
255_E	275_A	0.561	0.20
28_A	36_S	0.561	0.20
131_R	215_T	0.559	0.20
207_T	249_L	0.555	0.20
109_K	198_L	0.554	0.20
159_R	169_E	0.554	0.20
70_D	91_K	0.553	0.20
235_A	276_P	0.552	0.20
115_R	118_D	0.551	0.20
112_K	237_K	0.549	0.20
30_K	81_S	0.548	0.20
138_H	147_S	0.543	0.19
158_L	263_E	0.543	0.19
242_A	286_S	0.542	0.19
133_A	277_P	0.540	0.19
19_G	303_S	0.540	0.19
138_H	167_L	0.539	0.19
3_E	123_E	0.537	0.19
98_K	237_K	0.535	0.19
261_E	308_V	0.534	0.19
48_P	53_L	0.532	0.19
265_T	270_S	0.531	0.19
192_I	220_A	0.530	0.19
82_T	162_E	0.527	0.19
133_A	264_E	0.526	0.19
34_H	37_F	0.525	0.19
8_I	200_S	0.525	0.19
85_K	136_D	0.525	0.19
5_V	200_S	0.524	0.19
277_P	292_L	0.524	0.19
222_L	281_L	0.522	0.19
84_D	88_A	0.519	0.18
56_I	292_L	0.516	0.18
244_N	252_I	0.514	0.18
244_N	301_I	0.514	0.18
159_R	278_I	0.511	0.18
193_S	237_K	0.509	0.18
30_K	85_K	0.506	0.18
124_S	271_P	0.504	0.18
118_D	225_W	0.503	0.18
51_K	58_W	0.501	0.18
151_I	208_S	0.500	0.18
130_T	133_A	0.500	0.18
79_H	263_E	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4avmA	2	0.5806	31.9	0.973	Contact Map
4fzsA	2	0.5581	24.5	0.974	Contact Map
1w9cA	2	0.3419	12.7	0.977	Contact Map
2j9uA	1	0.2774	11.7	0.978	Contact Map
1dvkA	2	0.4258	11	0.978	Contact Map
2j9wA	1	0.3258	10.5	0.978	Contact Map
1uruA	2	0.5968	9.6	0.978	Contact Map
4g78A	1	0.4161	9	0.979	Contact Map
3e7kA	4	0.1806	8.8	0.979	Contact Map
3ol3A	2	0.1742	7.2	0.98	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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