GREMLIN Database
Pex2_Pex12 - Pex2 / Pex12 amino terminal region
PFAM: PF04757 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 225 (207)
Sequences: 1395 (965)
Seq/√Len: 67.1
META: 0.143

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_E92_Y6.6461.00
92_Y96_K3.6901.00
29_W32_E3.2561.00
52_T87_L3.1451.00
213_I221_W2.4591.00
189_L193_L2.4091.00
194_V197_A2.2601.00
41_Y51_A2.0981.00
190_N194_V2.0911.00
201_L204_F2.0861.00
32_E96_K2.0821.00
149_L164_R2.0401.00
35_L88_V2.0241.00
46_L62_R1.9761.00
43_R47_L1.9011.00
192_Q195_W1.8821.00
191_R195_W1.8641.00
202_L205_L1.8501.00
191_R194_V1.8361.00
162_S166_L1.8211.00
130_R134_L1.8061.00
35_L92_Y1.7811.00
31_D96_K1.7701.00
215_F218_F1.7611.00
55_E159_Y1.7491.00
189_L192_Q1.7441.00
190_N197_A1.7000.99
76_S79_Q1.6740.99
62_R163_K1.6710.99
107_L114_D1.6370.99
215_F221_W1.6280.99
159_Y163_K1.5910.99
192_Q196_H1.5790.99
55_E153_Y1.5780.99
214_F219_L1.5770.99
63_V171_V1.5710.99
158_Y164_R1.5610.99
188_E206_L1.5500.99
6_S15_V1.5270.99
55_E58_Y1.5040.99
119_W122_R1.5020.99
218_F221_W1.4970.99
83_Y87_L1.4650.98
192_Q197_A1.4610.98
194_V199_T1.4480.98
191_R196_H1.4480.98
4_L7_L1.4260.98
214_F218_F1.4190.98
192_Q199_T1.4150.98
53_L58_Y1.4120.98
51_A55_E1.3990.98
46_L51_A1.3980.98
53_L94_K1.3840.98
210_L214_F1.3770.98
82_L86_L1.3730.98
21_G24_L1.3710.98
42_E62_R1.3580.97
189_L196_H1.3530.97
21_G25_P1.3420.97
115_L118_S1.3410.97
217_K221_W1.3380.97
197_A203_G1.3270.97
88_V147_L1.3050.97
61_K177_D1.3000.97
82_L166_L1.2890.97
190_N193_L1.2880.97
191_R197_A1.2860.97
213_I217_K1.2770.96
163_K170_Y1.2500.96
85_L89_L1.2340.96
115_L120_R1.2330.96
190_N195_W1.2200.95
214_F221_W1.2180.95
196_H200_E1.1880.95
129_R133_K1.1870.95
217_K220_E1.1860.94
209_L212_S1.1850.94
195_W198_F1.1820.94
115_L119_W1.1770.94
131_L135_Y1.1730.94
193_L200_E1.1730.94
86_L166_L1.1670.94
190_N200_E1.1570.94
7_L11_Q1.1550.94
31_D35_L1.1360.93
67_S72_G1.1340.93
118_S122_R1.1150.92
10_P14_Y1.1060.92
148_H152_F1.0980.92
201_L207_P1.0940.92
193_L196_H1.0920.92
75_L78_R1.0900.92
10_P18_V1.0850.91
194_V200_E1.0850.91
50_N61_K1.0820.91
189_L195_W1.0810.91
124_K127_L1.0780.91
196_H199_T1.0710.91
152_F156_G1.0620.90
55_E62_R1.0590.90
35_L38_D1.0520.90
74_P144_L1.0440.90
51_A86_L1.0410.90
31_D62_R1.0310.89
141_L165_L1.0310.89
29_W97_L1.0220.89
214_F217_K1.0200.89
116_S119_W1.0160.88
210_L213_I1.0110.88
185_V188_E1.0060.88
2_E14_Y1.0010.88
122_R126_R0.9980.88
193_L198_F0.9940.87
36_L151_L0.9830.87
203_G207_P0.9800.87
42_E83_Y0.9780.86
190_N198_F0.9740.86
9_R17_R0.9660.86
146_A150_A0.9640.86
133_K137_S0.9600.85
195_W199_T0.9590.85
193_L197_A0.9490.85
8_L15_V0.9460.85
36_L93_L0.9450.85
20_A23_R0.9430.84
214_F222_W0.9420.84
83_Y168_I0.9400.84
198_F203_G0.9380.84
199_T202_L0.9380.84
62_R83_Y0.9370.84
122_R147_L0.9310.84
153_Y159_Y0.9300.84
196_H202_L0.9200.83
6_S10_P0.9180.83
42_E45_T0.9090.82
120_R123_L0.9080.82
210_L217_K0.9060.82
39_L43_R0.9060.82
52_T159_Y0.9030.82
118_S121_E0.9020.82
189_L197_A0.8980.81
96_K161_L0.8870.81
199_T203_G0.8790.80
39_L84_L0.8760.80
32_E90_L0.8740.80
45_T57_Y0.8690.79
71_T77_R0.8660.79
191_R200_E0.8660.79
89_L122_R0.8630.79
131_L137_S0.8600.78
212_S219_L0.8590.78
192_Q203_G0.8550.78
191_R208_L0.8530.78
29_W92_Y0.8520.78
58_Y163_K0.8510.78
7_L10_P0.8410.77
108_R114_D0.8390.77
68_D72_G0.8300.76
100_L137_S0.8260.76
75_L80_R0.8260.76
204_F207_P0.8180.75
190_N203_G0.8170.75
41_Y152_F0.8150.75
195_W200_E0.8150.75
192_Q198_F0.8100.74
127_L130_R0.8060.74
116_S120_R0.8030.74
152_F155_N0.8010.73
42_E46_L0.8000.73
116_S123_L0.7990.73
216_L221_W0.7950.73
190_N199_T0.7940.73
31_D147_L0.7940.73
173_L177_D0.7920.73
55_E192_Q0.7920.73
40_L169_R0.7840.72
76_S123_L0.7810.71
219_L222_W0.7790.71
12_L33_I0.7770.71
2_E11_Q0.7750.71
149_L161_L0.7700.70
16_L19_L0.7670.70
51_A56_E0.7660.70
216_L222_W0.7660.70
58_Y62_R0.7650.70
193_L199_T0.7580.69
66_P70_P0.7560.69
42_E101_L0.7560.69
97_L160_S0.7520.69
14_Y18_V0.7500.68
52_T178_P0.7480.68
119_W123_L0.7460.68
212_S215_F0.7390.67
9_R93_L0.7350.67
76_S80_R0.7340.67
34_Y161_L0.7340.67
66_P72_G0.7330.67
146_A161_L0.7300.66
83_Y163_K0.7300.66
14_Y136_P0.7230.66
149_L158_Y0.7210.65
120_R133_K0.7200.65
56_E162_S0.7170.65
45_T80_R0.7170.65
126_R130_R0.7140.65
41_Y201_L0.7080.64
121_E128_R0.7050.64
158_Y169_R0.7050.64
50_N70_P0.7030.63
75_L79_Q0.7020.63
3_E7_L0.6980.63
97_L131_L0.6970.63
9_R95_A0.6970.63
82_L169_R0.6960.63
202_L208_L0.6930.62
55_E83_Y0.6910.62
132_L135_Y0.6890.62
195_W207_P0.6880.62
153_Y158_Y0.6870.62
116_S122_R0.6840.61
120_R124_K0.6800.61
1_D54_G0.6780.61
117_R122_R0.6750.60
210_L220_E0.6730.60
115_L123_L0.6700.60
192_Q200_E0.6660.59
45_T56_E0.6640.59
13_R25_P0.6630.59
46_L84_L0.6630.59
215_F219_L0.6620.59
74_P80_R0.6610.59
14_Y132_L0.6440.57
19_L23_R0.6420.56
51_A163_K0.6420.56
85_L93_L0.6400.56
135_Y139_N0.6390.56
131_L165_L0.6380.56
189_L200_E0.6370.56
45_T49_G0.6360.56
89_L208_L0.6270.55
69_S72_G0.6260.55
125_S130_R0.6240.54
12_L60_L0.6220.54
37_L148_H0.6210.54
162_S168_I0.6210.54
189_L198_F0.6160.53
215_F222_W0.6150.53
191_R198_F0.6150.53
46_L91_P0.6150.53
194_V198_F0.6130.53
127_L139_N0.5960.51
108_R117_R0.5960.51
42_E59_G0.5950.51
160_S163_K0.5950.51
6_S22_A0.5930.51
7_L12_L0.5920.51
32_E60_L0.5840.50
16_L217_K0.5830.49
22_A25_P0.5830.49
146_A160_S0.5820.49
189_L194_V0.5730.48
14_Y101_L0.5730.48
32_E39_L0.5720.48
2_E19_L0.5720.48
84_L88_V0.5660.47
212_S217_K0.5660.47
116_S125_S0.5600.47
143_E153_Y0.5570.46
132_L137_S0.5550.46
29_W38_D0.5500.46
117_R120_R0.5500.46
41_Y56_E0.5500.46
133_K167_G0.5490.45
14_Y151_L0.5460.45
118_S123_L0.5420.45
132_L139_N0.5390.44
101_L131_L0.5370.44
131_L139_N0.5340.44
55_E163_K0.5340.44
67_S70_P0.5340.44
53_L214_F0.5330.44
197_A202_L0.5320.43
124_K138_L0.5310.43
54_G164_R0.5290.43
211_A216_L0.5290.43
135_Y138_L0.5290.43
13_R93_L0.5240.43
83_Y153_Y0.5240.43
76_S85_L0.5240.43
114_D198_F0.5220.42
37_L170_Y0.5220.42
44_L53_L0.5210.42
187_Y200_E0.5200.42
4_L16_L0.5180.42
90_L201_L0.5180.42
69_S118_S0.5160.42
126_R131_L0.5160.42
95_A151_L0.5130.41
33_I85_L0.5130.41
30_F38_D0.5120.41
41_Y193_L0.5060.40
118_S125_S0.5060.40
153_Y195_W0.5060.40
53_L163_K0.5060.40
107_L125_S0.5050.40
76_S138_L0.5030.40
190_N201_L0.5020.40
51_A62_R0.5010.40
49_G80_R0.5010.40
85_L127_L0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1l8kA 1 0.2 2.6 0.956 Contact Map
5bu6A 2 0.3067 1.5 0.962 Contact Map
2ce7A 3 0.2356 1.4 0.962 Contact Map
3kalA 2 0.3556 1.3 0.963 Contact Map
4ww0A 4 0.2356 1.3 0.963 Contact Map
2kmtA 2 0.1644 1.3 0.963 Contact Map
4q9hA 1 0.2711 1.3 0.963 Contact Map
2di4A 3 0.2667 1.2 0.963 Contact Map
4m8nA 2 0.2889 1.2 0.964 Contact Map
3vubA 2 0.1644 1.1 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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