GREMLIN Database
OST3_OST6 - OST3 / OST6 family
PFAM: PF04756 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 152 (149)
Sequences: 655 (512)
Seq/√Len: 42.0
META: 0.243

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_A100_F4.0091.00
72_F78_P3.1821.00
62_V66_F3.1711.00
84_D88_G3.0041.00
80_Y105_Q2.9941.00
93_A100_F2.9061.00
27_T31_V2.7341.00
25_A29_L2.7181.00
78_P101_G2.6791.00
91_Y106_I2.5511.00
71_M76_R2.4591.00
18_P24_I2.4001.00
73_N104_T2.3011.00
70_Q73_N2.2141.00
135_R139_I2.1791.00
63_I67_T2.1410.99
71_M75_I2.1280.99
71_M111_Y2.0480.99
4_I8_T2.0120.99
63_I104_T1.9990.99
34_G113_L1.9800.99
65_L70_Q1.8830.99
99_Q103_E1.8320.98
72_F104_T1.8050.98
118_L145_I1.8020.98
74_H91_Y1.7990.98
64_L109_A1.7660.98
138_V148_F1.7440.98
14_I102_A1.5830.96
110_L148_F1.4990.94
6_E9_G1.4400.93
73_N78_P1.4070.92
66_F71_M1.3970.92
32_L35_G1.3960.92
58_G62_V1.2600.87
5_S10_V1.2410.86
52_R70_Q1.2250.85
66_F104_T1.2200.85
109_A113_L1.2150.85
139_I146_F1.2030.84
35_G40_V1.2020.84
20_Y25_A1.1990.84
81_V101_G1.1910.84
37_L46_F1.1910.84
5_S8_T1.1890.84
38_Y144_L1.1720.83
38_Y42_N1.1720.83
37_L40_V1.1650.82
66_F72_F1.1650.82
101_G111_Y1.1620.82
30_L34_G1.1500.82
20_Y56_A1.1470.81
70_Q104_T1.1410.81
109_A116_L1.1250.80
28_L32_L1.1150.80
90_S100_F1.0980.79
137_A141_W1.0960.78
39_L92_F1.0930.78
100_F115_A1.0930.78
94_G123_E1.0860.78
90_S94_G1.0750.77
66_F105_Q1.0710.77
33_G38_Y1.0580.76
21_S107_V1.0480.75
13_P106_I1.0410.75
82_A90_S1.0380.74
81_V102_A1.0370.74
7_R39_L1.0340.74
92_F111_Y1.0320.74
78_P84_D1.0300.74
2_E5_S1.0250.74
128_I134_Q1.0150.73
5_S11_Q1.0030.72
54_L58_G1.0000.72
30_L57_A0.9970.71
71_M104_T0.9780.70
16_R73_N0.9640.69
130_D143_A0.9630.69
82_A108_A0.9560.68
120_L147_V0.9520.68
66_F111_Y0.9420.67
37_L77_G0.9410.67
8_T11_Q0.9370.67
32_L51_N0.9360.67
26_L145_I0.9310.66
142_L145_I0.9300.66
139_I144_L0.9280.66
82_A96_S0.9220.65
30_L113_L0.9220.65
102_A137_A0.9200.65
60_L128_I0.9200.65
24_I37_L0.9170.65
31_V138_V0.9110.64
92_F106_I0.9090.64
69_G103_E0.8800.62
71_M105_Q0.8790.62
54_L81_V0.8780.62
26_L32_L0.8760.61
56_A60_L0.8700.61
3_F52_R0.8690.61
66_F108_A0.8660.60
137_A140_V0.8610.60
76_R111_Y0.8580.60
113_L148_F0.8580.60
40_V44_L0.8560.60
119_I124_A0.8420.58
4_I21_S0.8410.58
82_A102_A0.8160.56
56_A108_A0.8150.56
55_W76_R0.8120.55
66_F96_S0.8070.55
111_Y114_L0.8040.55
93_A96_S0.8030.55
52_R71_M0.8000.54
82_A94_G0.8000.54
136_I144_L0.7900.53
31_V58_G0.7810.53
64_L112_G0.7780.52
112_G115_A0.7660.51
2_E6_E0.7650.51
142_L146_F0.7610.51
79_P101_G0.7560.50
71_M95_G0.7540.50
140_V143_A0.7510.50
111_Y121_L0.7450.49
41_R107_V0.7310.48
108_A115_A0.7300.48
98_N130_D0.7250.47
117_G123_E0.7250.47
105_Q112_G0.7170.47
130_D135_R0.7150.46
90_S93_A0.7130.46
31_V62_V0.7090.46
63_I111_Y0.7070.46
62_V77_G0.7050.45
118_L122_T0.7040.45
59_S63_I0.7030.45
101_G145_I0.7020.45
3_F135_R0.7010.45
84_D102_A0.6970.45
64_L67_T0.6950.45
92_F138_V0.6950.45
66_F109_A0.6900.44
66_F70_Q0.6870.44
139_I143_A0.6870.44
117_G141_W0.6850.44
17_P68_S0.6800.43
56_A63_I0.6730.43
4_I7_R0.6700.42
61_I116_L0.6690.42
31_V54_L0.6660.42
31_V143_A0.6630.42
9_G12_I0.6570.41
76_R97_Q0.6510.41
53_N56_A0.6500.40
42_N46_F0.6490.40
71_M97_Q0.6480.40
128_I140_V0.6480.40
133_K142_L0.6480.40
40_V43_P0.6450.40
30_L58_G0.6430.40
93_A98_N0.6410.40
60_L151_F0.6380.39
69_G99_Q0.6320.39
21_S24_I0.6200.38
62_V140_V0.6200.38
107_V111_Y0.6180.38
116_L148_F0.6180.38
53_N139_I0.6110.37
92_F147_V0.6100.37
7_R10_V0.6050.36
115_A119_I0.6040.36
101_G105_Q0.6040.36
21_S54_L0.6040.36
25_A97_Q0.6040.36
17_P71_M0.6020.36
45_I148_F0.6010.36
71_M101_G0.5970.36
68_S71_M0.5950.36
100_F110_L0.5930.35
104_T112_G0.5840.35
33_G113_L0.5830.35
71_M114_L0.5830.35
65_L128_I0.5700.33
82_A89_I0.5670.33
132_K142_L0.5620.33
26_L107_V0.5600.33
37_L44_L0.5600.33
92_F107_V0.5580.32
144_L148_F0.5580.32
81_V115_A0.5540.32
34_G136_I0.5520.32
27_T34_G0.5500.32
143_A146_F0.5470.32
33_G61_I0.5460.31
141_W145_I0.5460.31
62_V65_L0.5440.31
45_I51_N0.5420.31
6_E38_Y0.5420.31
77_G107_V0.5410.31
19_N74_H0.5390.31
29_L146_F0.5340.30
71_M98_N0.5320.30
89_I102_A0.5310.30
10_V21_S0.5300.30
76_R107_V0.5300.30
32_L136_I0.5290.30
11_Q22_K0.5290.30
3_F6_E0.5270.30
31_V131_P0.5260.30
26_L30_L0.5220.30
76_R121_L0.5220.30
38_Y44_L0.5210.29
30_L144_L0.5160.29
63_I105_Q0.5150.29
142_L149_F0.5100.29
18_P26_L0.5090.29
92_F126_P0.5080.28
107_V128_I0.5060.28
113_L127_R0.5060.28
17_P55_W0.5030.28
90_S108_A0.5030.28
104_T111_Y0.5020.28
115_A129_K0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4h33A 3 0.5 11.8 0.926 Contact Map
4qi1A 3 0.3026 6.6 0.934 Contact Map
1lnqA 6 0.4737 5.4 0.937 Contact Map
2jafA 3 0.3684 5 0.938 Contact Map
4qinA 2 0.5066 4.4 0.94 Contact Map
4fbzA 3 0.375 4 0.94 Contact Map
4l35A 3 0.3487 3.8 0.941 Contact Map
4m64A 1 0.8618 3.5 0.942 Contact Map
4xtlA 1 0.4408 3.4 0.942 Contact Map
3dl8G 1 0.5658 3.2 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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