GREMLIN Database
PAP_fibrillin - PAP_fibrillin
PFAM: PF04755 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 198 (194)
Sequences: 1291 (912)
Seq/√Len: 65.5
META: 0.437

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_E188_R5.1411.00
36_E178_T4.3331.00
50_L182_E4.0781.00
32_I194_L3.7621.00
114_K128_E3.1181.00
32_I186_I2.9911.00
32_I196_V2.8631.00
39_N44_P2.8091.00
41_T44_P2.4021.00
145_L149_L2.2591.00
16_R80_G2.2471.00
54_R85_V2.2461.00
122_R176_D2.2371.00
141_L144_P2.1671.00
51_L180_L2.1561.00
87_D90_T2.0991.00
138_L141_L2.0711.00
52_D88_V1.9951.00
122_R174_W1.9901.00
142_L145_L1.9581.00
141_L145_L1.9571.00
173_G191_K1.9091.00
145_L151_Q1.8841.00
148_T151_Q1.8711.00
27_E31_L1.8661.00
138_L142_L1.8591.00
177_I187_G1.8051.00
175_L187_G1.7791.00
43_R46_E1.7691.00
56_R81_Q1.7281.00
189_G193_S1.6910.99
6_E34_Q1.6640.99
14_T24_D1.6530.99
178_T188_R1.6500.99
123_V175_L1.6260.99
144_P148_T1.6010.99
144_P149_L1.5840.99
147_D151_Q1.5220.99
7_L28_I1.5060.99
56_R83_Y1.4580.98
11_I28_I1.4570.98
21_T24_D1.4490.98
29_E33_A1.4390.98
140_G150_S1.4310.98
86_I93_V1.4100.98
4_K181_D1.4030.98
3_L6_E1.3870.98
113_A127_F1.3870.98
6_E10_A1.3860.98
23_E27_E1.3670.97
60_T66_L1.3630.97
79_L82_I1.3430.97
14_T28_I1.3270.97
3_L31_L1.3160.97
62_S65_L1.3030.97
17_G20_A1.3010.96
152_V158_K1.2590.96
65_L189_G1.2510.96
39_N180_L1.2340.95
15_N19_L1.2280.95
187_G195_F1.2250.95
7_L11_I1.2110.95
39_N42_P1.2090.95
71_R75_P1.2060.95
4_K183_D1.2020.95
62_S66_L1.2000.94
178_T197_L1.2000.94
160_L163_D1.1800.94
3_L10_A1.1790.94
40_P44_P1.1760.94
139_K143_T1.1670.94
127_F189_G1.1620.93
57_L185_R1.1610.93
141_L148_T1.1510.93
146_Q150_S1.1480.93
29_E194_L1.1420.93
12_A20_A1.1340.93
143_T148_T1.1120.92
118_V124_Q1.1090.92
84_Q95_N1.0930.91
139_K142_L1.0780.91
25_R59_Y1.0690.90
85_V96_I1.0590.90
162_L166_I1.0540.90
174_W190_N1.0530.90
121_R127_F1.0490.89
173_G190_N1.0450.89
175_L195_F1.0350.89
95_N98_E1.0330.89
152_V155_G1.0260.88
31_L34_Q1.0240.88
145_L148_T1.0200.88
174_W178_T1.0100.88
173_G176_D0.9980.87
20_A59_Y0.9960.87
107_G111_V0.9950.87
47_A50_L0.9930.87
125_V175_L0.9730.85
138_L145_L0.9730.85
175_L189_G0.9700.85
84_Q127_F0.9640.85
122_R197_L0.9640.85
6_E9_E0.9510.84
40_P197_L0.9460.84
62_S189_G0.9430.84
65_L82_I0.9410.84
146_Q149_L0.9410.84
94_Y97_V0.9320.83
43_R120_P0.9270.83
64_E171_A0.9210.82
147_D150_S0.9090.81
150_S155_G0.9070.81
95_N127_F0.9050.81
138_L147_D0.9040.81
125_V189_G0.9030.81
167_P170_S0.9020.81
34_Q180_L0.9000.81
185_R189_G0.8970.80
14_T20_A0.8850.80
41_T47_A0.8790.79
177_I185_R0.8680.78
64_E68_L0.8670.78
168_G171_A0.8650.78
145_L150_S0.8610.78
191_K197_L0.8550.77
97_V175_L0.8550.77
142_L149_L0.8470.77
36_E53_G0.8420.76
123_V187_G0.8420.76
67_S70_Q0.8360.76
63_S66_L0.8350.76
161_P167_P0.8340.75
109_V132_L0.8290.75
15_N58_L0.8280.75
68_L74_L0.8280.75
80_G113_A0.8100.73
72_G75_P0.8090.73
58_L184_L0.8090.73
20_A24_D0.8090.73
139_K148_T0.7960.72
125_V185_R0.7890.71
149_L154_R0.7860.71
10_A14_T0.7830.71
140_G152_V0.7810.71
148_T154_R0.7800.70
106_E136_R0.7740.70
62_S177_I0.7740.70
111_V127_F0.7720.70
151_Q155_G0.7710.70
188_R194_L0.7690.69
161_P164_F0.7680.69
60_T93_V0.7660.69
61_T64_E0.7660.69
152_V156_I0.7660.69
176_D185_R0.7650.69
126_K172_Q0.7650.69
147_D155_G0.7640.69
161_P165_P0.7640.69
80_G83_Y0.7640.69
140_G144_P0.7600.68
93_V187_G0.7540.68
142_L148_T0.7520.68
64_E130_G0.7480.67
60_T82_I0.7400.66
138_L152_V0.7350.66
54_R99_L0.7340.66
48_L115_F0.7340.66
29_E59_Y0.7330.66
78_K100_S0.7300.65
146_Q151_Q0.7280.65
60_T173_G0.7250.65
94_Y98_E0.7250.65
138_L144_P0.7190.64
109_V115_F0.7180.64
68_L175_L0.7150.64
131_I134_L0.7150.64
149_L152_V0.7060.63
121_R176_D0.7060.63
87_D95_N0.7030.62
5_A19_L0.6870.61
123_V133_G0.6830.60
43_R102_L0.6820.60
113_A195_F0.6800.60
85_V94_Y0.6790.60
125_V195_F0.6790.60
179_Y186_I0.6780.60
86_I100_S0.6780.60
111_V119_S0.6770.59
88_V92_R0.6740.59
52_D87_D0.6720.59
35_L39_N0.6690.59
8_L11_I0.6680.58
18_L80_G0.6670.58
141_L147_D0.6660.58
10_A32_I0.6660.58
65_L86_I0.6640.58
18_L24_D0.6610.58
14_T19_L0.6610.58
162_L165_P0.6600.58
145_L152_V0.6590.57
12_A22_P0.6560.57
84_Q185_R0.6560.57
15_N72_G0.6470.56
30_E33_A0.6460.56
88_V98_E0.6460.56
123_V127_F0.6430.56
42_P47_A0.6420.55
62_S125_V0.6380.55
149_L153_P0.6340.55
145_L153_P0.6330.54
132_L144_P0.6300.54
66_L173_G0.6290.54
26_A30_E0.6250.53
111_V121_R0.6230.53
149_L155_G0.6220.53
40_P45_T0.6210.53
147_D152_V0.6210.53
73_R76_L0.6190.53
153_P159_F0.6190.53
10_A15_N0.6180.53
130_G133_G0.6150.52
44_P53_G0.6150.52
148_T152_V0.6140.52
13_G18_L0.6130.52
187_G197_L0.6110.52
176_D190_N0.6100.52
139_K144_P0.6090.52
64_E109_V0.6080.52
58_L183_D0.6050.51
143_T147_D0.5960.50
5_A9_E0.5950.50
64_E189_G0.5930.50
83_Y96_I0.5930.50
138_L149_L0.5910.50
67_S71_R0.5900.49
68_L75_P0.5880.49
39_N179_Y0.5870.49
165_P168_G0.5840.49
28_I59_Y0.5830.49
125_V130_G0.5820.48
132_L194_L0.5780.48
61_T178_T0.5760.48
16_R93_V0.5750.48
158_K163_D0.5750.48
139_K145_L0.5740.48
28_I33_A0.5740.48
62_S67_S0.5730.47
123_V195_F0.5730.47
16_R103_P0.5730.47
171_A175_L0.5710.47
120_P172_Q0.5700.47
144_P150_S0.5700.47
178_T187_G0.5700.47
175_L193_S0.5660.47
11_I45_T0.5650.46
68_L77_L0.5600.46
142_L151_Q0.5600.46
149_L156_I0.5600.46
183_D186_I0.5580.46
65_L97_V0.5560.45
60_T174_W0.5540.45
113_A175_L0.5470.44
159_F163_D0.5450.44
158_K194_L0.5430.44
13_G28_I0.5430.44
36_E57_L0.5430.44
8_L61_T0.5430.44
17_G25_R0.5410.44
158_K161_P0.5410.44
32_I117_P0.5400.44
58_L162_L0.5380.43
14_T17_G0.5340.43
144_P153_P0.5330.43
5_A13_G0.5290.42
70_Q73_R0.5270.42
3_L27_E0.5270.42
138_L148_T0.5250.42
113_A187_G0.5230.42
16_R20_A0.5200.41
136_R150_S0.5180.41
82_I133_G0.5160.41
192_G195_F0.5140.41
60_T65_L0.5130.40
67_S76_L0.5110.40
117_P120_P0.5100.40
30_E43_R0.5080.40
34_Q120_P0.5060.40
118_V122_R0.5040.39
6_E32_I0.5020.39
65_L93_V0.5000.39
76_L193_S0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gpeA 2 0.1919 8.1 0.94 Contact Map
2kvuA 1 0.2222 7.6 0.94 Contact Map
1mqbA 1 0.2424 7.6 0.941 Contact Map
2q80A 5 0.2828 6.2 0.943 Contact Map
3iynQ 5 0.2222 6.1 0.943 Contact Map
2ma3A 1 0.2626 6 0.943 Contact Map
2lnbA 1 0.2879 5.4 0.944 Contact Map
2rp4A 4 0.1061 5.4 0.944 Contact Map
4lttA 1 0.3636 5.4 0.944 Contact Map
4iabA 3 0.6515 5.3 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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