GREMLIN Database
Transposase_31 - Putative transposase, YhgA-like
PFAM: PF04754 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 203 (194)
Sequences: 6281 (4971)
Seq/√Len: 356.9
META: 0.843

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_T62_R3.8081.00
91_R98_E3.6451.00
39_E60_R3.5911.00
78_Q88_R3.4271.00
141_K147_R3.1081.00
131_A145_D2.8311.00
78_Q85_M2.7721.00
90_L94_V2.6131.00
129_D145_D2.4491.00
18_R22_R2.4181.00
129_D147_R2.3621.00
85_M88_R2.2071.00
5_A52_E2.1571.00
152_D155_R2.1381.00
4_D8_K2.1091.00
41_V60_R2.0481.00
58_L96_I2.0131.00
157_S160_E2.0051.00
14_P18_R1.9701.00
37_T61_V1.9501.00
20_F151_I1.9451.00
81_P126_A1.9301.00
89_L116_V1.8961.00
47_D95_L1.8851.00
44_S54_E1.8391.00
95_L98_E1.8271.00
93_M114_P1.8261.00
45_F58_L1.7991.00
93_M112_V1.7931.00
93_M97_W1.7271.00
129_D132_D1.7261.00
97_W134_F1.7111.00
93_M146_F1.6781.00
127_P132_D1.6721.00
81_P125_T1.6661.00
86_A148_Y1.6181.00
32_L64_K1.6031.00
167_L171_L1.5901.00
40_L59_Y1.5561.00
30_V35_L1.5451.00
8_K44_S1.5361.00
108_K135_D1.5361.00
87_L94_V1.5351.00
85_M116_V1.5321.00
158_D176_H1.5261.00
60_R68_E1.5251.00
91_R94_V1.5061.00
99_R103_E1.5001.00
45_F55_S1.4911.00
34_D37_T1.4431.00
123_P155_R1.4361.00
62_R68_E1.3871.00
100_H110_P1.3701.00
7_F11_F1.3641.00
33_L61_V1.3611.00
172_L175_K1.3601.00
20_F24_F1.3281.00
16_V19_D1.3171.00
171_L174_L1.3141.00
91_R95_L1.3101.00
87_L91_R1.2961.00
53_R91_R1.2831.00
113_I149_L1.2801.00
171_L175_K1.2691.00
17_A59_Y1.2521.00
126_A148_Y1.2231.00
84_L133_L1.2051.00
34_D62_R1.2041.00
7_F117_L1.2041.00
100_H103_E1.1891.00
151_I164_R1.1781.00
130_L146_F1.1771.00
55_S58_L1.1721.00
176_H179_D1.1681.00
137_P140_A1.1621.00
79_S119_H1.1541.00
63_L69_A1.1511.00
142_Y149_L1.1471.00
134_F143_L1.1471.00
99_R102_K1.1421.00
169_A173_L1.1391.00
189_L192_L1.1351.00
185_L188_E1.1301.00
82_D88_R1.1281.00
21_L73_L1.1251.00
158_D175_K1.1201.00
10_L16_V1.1141.00
11_F170_A1.0901.00
19_D23_G1.0851.00
168_A171_L1.0651.00
67_R135_D1.0531.00
8_K54_E1.0521.00
78_Q82_D1.0451.00
10_L170_A1.0391.00
128_T147_R1.0251.00
60_R70_Y1.0241.00
22_R30_V1.0221.00
174_L177_I1.0161.00
13_D16_V1.0071.00
89_L114_P1.0031.00
170_A174_L1.0011.00
21_L71_V0.9851.00
172_L176_H0.9791.00
8_K52_E0.9761.00
168_A174_L0.9711.00
168_A175_K0.9681.00
70_Y100_H0.9671.00
2_P5_A0.9611.00
97_W112_V0.9471.00
118_Y154_S0.9461.00
90_L146_F0.9411.00
53_R95_L0.9371.00
130_L134_F0.9331.00
185_L189_L0.9241.00
169_A172_L0.9191.00
104_K107_K0.9161.00
93_M130_L0.9041.00
40_L57_L0.9031.00
181_D184_E0.8941.00
18_R35_L0.8921.00
82_D85_M0.8901.00
43_G55_S0.8891.00
19_D22_R0.8891.00
117_L153_L0.8871.00
17_A38_L0.8691.00
181_D185_L0.8591.00
191_E194_K0.8551.00
131_A140_A0.8401.00
12_S40_L0.8321.00
168_A172_L0.8271.00
18_R36_S0.8191.00
123_P154_S0.8191.00
156_Y160_E0.8141.00
84_L87_L0.8111.00
12_S57_L0.8081.00
40_L99_R0.8021.00
26_P29_L0.8011.00
119_H174_L0.7991.00
24_F151_I0.7981.00
57_L75_L0.7921.00
97_W109_L0.7901.00
58_L72_Y0.7891.00
27_E30_V0.7881.00
74_L114_P0.7881.00
170_A175_K0.7861.00
80_T88_R0.7851.00
116_V148_Y0.7791.00
55_S74_L0.7781.00
174_L178_R0.7751.00
186_L189_L0.7751.00
84_L101_L0.7651.00
167_L174_L0.7621.00
42_P45_F0.7411.00
5_A9_E0.7411.00
7_F77_H0.7401.00
44_S52_E0.7391.00
111_P143_L0.7391.00
188_E192_L0.7341.00
48_E51_R0.7301.00
169_A175_K0.7301.00
43_G99_R0.7261.00
22_R35_L0.7230.99
11_F17_A0.7220.99
151_I156_Y0.7150.99
87_L97_W0.7100.99
142_Y147_R0.7080.99
58_L70_Y0.7080.99
89_L146_F0.7050.99
173_L177_I0.7050.99
40_L43_G0.7050.99
47_D91_R0.7040.99
7_F174_L0.7040.99
184_E187_E0.7020.99
119_H153_L0.7010.99
87_L109_L0.6980.99
6_F10_L0.6970.99
45_F99_R0.6970.99
15_E19_D0.6970.99
14_P36_S0.6950.99
188_E191_E0.6930.99
33_L71_V0.6900.99
86_A133_L0.6870.99
98_E102_K0.6870.99
162_K165_R0.6850.99
8_K12_S0.6840.99
74_L96_I0.6830.99
24_F115_I0.6800.99
115_I151_I0.6800.99
32_L138_E0.6800.99
120_G123_P0.6780.99
167_L172_L0.6720.99
187_E190_L0.6720.99
84_L109_L0.6690.99
15_E18_R0.6680.99
90_L144_P0.6680.99
163_G168_A0.6670.99
83_P107_K0.6660.99
83_P108_K0.6610.99
11_F77_H0.6600.99
35_L38_L0.6560.99
187_E191_E0.6550.99
119_H152_D0.6540.99
63_L66_G0.6520.99
32_L136_P0.6510.99
86_A130_L0.6480.99
136_P139_L0.6470.99
96_I112_V0.6470.99
38_L59_Y0.6470.99
90_L130_L0.6420.99
12_S99_R0.6380.99
116_V150_L0.6380.99
81_P120_G0.6360.99
128_T150_L0.6350.99
183_L190_L0.6350.99
86_A126_A0.6320.99
25_L29_L0.6300.99
175_K179_D0.6260.99
21_L25_L0.6250.99
140_A145_D0.6210.98
28_E138_E0.6160.98
123_P152_D0.6160.98
43_G54_E0.6110.98
5_A50_L0.6080.98
111_P139_L0.6080.98
85_M124_W0.6060.98
128_T132_D0.6050.98
97_W100_H0.6030.98
85_M126_A0.6010.98
47_D53_R0.6000.98
17_A75_L0.6000.98
78_Q119_H0.5980.98
5_A46_V0.5970.98
183_L192_L0.5960.98
131_A143_L0.5940.98
153_L175_K0.5910.98
7_F21_L0.5820.98
170_A173_L0.5800.98
183_L188_E0.5780.98
191_E195_E0.5770.98
72_Y96_I0.5740.97
42_P99_R0.5740.97
169_A176_H0.5720.97
182_L186_L0.5680.97
130_L145_D0.5670.97
46_V74_L0.5660.97
87_L101_L0.5660.97
24_F164_R0.5650.97
29_L139_L0.5620.97
162_K188_E0.5610.97
28_E142_Y0.5600.97
33_L63_L0.5570.97
100_H106_K0.5570.97
179_D182_L0.5560.97
184_E194_K0.5510.97
6_F16_V0.5500.97
44_S74_L0.5500.97
7_F119_H0.5480.97
17_A73_L0.5480.97
70_Y110_P0.5470.97
159_E163_G0.5450.96
29_L77_H0.5400.96
176_H180_R0.5400.96
176_H181_D0.5400.96
111_P134_F0.5390.96
109_L133_L0.5380.96
45_F54_E0.5350.96
9_E13_D0.5330.96
97_W111_P0.5320.96
104_K108_K0.5310.96
180_R183_L0.5300.96
77_H119_H0.5300.96
190_L193_L0.5290.96
187_E192_L0.5270.96
188_E195_E0.5240.96
131_A134_F0.5230.96
48_E91_R0.5220.96
47_D51_R0.5190.95
83_P105_K0.5190.95
89_L93_M0.5170.95
74_L93_M0.5160.95
81_P122_R0.5160.95
94_V97_W0.5160.95
182_L185_L0.5140.95
54_E72_Y0.5100.95
183_L187_E0.5100.95
5_A8_K0.5040.95
187_E195_E0.5030.95
14_P59_Y0.5020.95
81_P118_Y0.5010.94
128_T148_Y0.5000.94
94_V98_E0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vldA 2 0.5862 5.4 0.951 Contact Map
2krcA 1 0.2414 3.5 0.955 Contact Map
3au4B 1 0.1576 3.4 0.955 Contact Map
2l2dA 1 0.2709 3 0.957 Contact Map
4bhvA 3 0.1281 2.8 0.957 Contact Map
1b0xA 2 0.335 2.3 0.959 Contact Map
3zh9B 1 0.5123 2.3 0.959 Contact Map
2wujA 2 0.2167 2.3 0.959 Contact Map
4anoA 1 0.8966 1.9 0.961 Contact Map
3wolA 2 0.936 1.9 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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