GREMLIN Database
Far-17a_AIG1 - FAR-17a/AIG1-like protein
PFAM: PF04750 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 204 (197)
Sequences: 909 (731)
Seq/√Len: 52.1
META: 0.279

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_G86_V3.8261.00
116_H120_T3.2121.00
13_Y16_S2.6131.00
93_L101_V2.4211.00
11_A15_Y2.3881.00
87_S123_L2.2581.00
33_Y157_W2.2441.00
152_L156_L2.2421.00
48_Q83_E2.2001.00
164_V167_F2.1171.00
72_D75_F2.0731.00
101_V172_F2.0101.00
13_Y19_Y1.9851.00
6_H59_D1.9581.00
44_G48_Q1.9551.00
176_L184_F1.9360.99
42_I118_L1.8690.99
91_W100_L1.8390.99
17_F20_L1.8270.99
5_L9_A1.8130.99
18_Y22_Q1.7340.99
87_S122_P1.7330.99
19_Y27_P1.7300.99
143_G196_Y1.7250.99
121_L125_L1.7170.99
68_L72_D1.7050.99
71_R75_F1.6720.99
90_Y94_Y1.6690.98
159_E168_W1.6400.98
35_G39_Y1.6330.98
161_C165_N1.6300.98
38_K44_G1.6240.98
34_G157_W1.6090.98
33_Y160_L1.5900.98
159_E181_R1.5760.98
7_L11_A1.5740.98
11_A14_A1.5500.98
191_L195_L1.5470.97
129_D135_R1.5440.97
157_W161_C1.5400.97
26_L29_K1.5360.97
63_T69_F1.5200.97
21_S29_K1.5130.97
16_S19_Y1.4930.97
128_L132_L1.4770.97
16_S20_L1.4680.97
140_R200_E1.4350.96
11_A17_F1.4330.96
68_L71_R1.4290.96
41_T119_H1.4240.96
124_V129_D1.4040.96
141_K145_A1.3950.95
119_H170_Y1.3950.95
14_A18_Y1.3890.95
63_T68_L1.3690.95
65_S69_F1.3590.95
98_P107_D1.3470.94
70_L74_L1.3450.94
65_S68_L1.3440.94
7_L14_A1.3350.94
11_A26_L1.3300.94
186_A194_L1.3210.94
45_L91_W1.3070.93
99_E104_K1.2960.93
34_G37_F1.2840.93
85_F89_L1.2800.93
18_Y21_S1.2760.93
96_I100_L1.2740.93
115_N122_P1.2720.92
162_Y173_L1.2710.92
156_L182_V1.2640.92
98_P101_V1.2640.92
103_P166_G1.2560.92
93_L98_P1.2430.92
50_I56_L1.2400.92
118_L129_D1.2400.92
48_Q80_F1.2370.91
24_P27_P1.2300.91
7_L22_Q1.2260.91
187_V193_L1.2220.91
6_H15_Y1.2170.91
111_P116_H1.2170.91
14_A19_Y1.2010.90
69_F72_D1.1970.90
20_L26_L1.1960.90
12_S17_F1.1930.90
177_S180_G1.1910.90
67_L71_R1.1870.90
13_Y17_F1.1850.90
38_K158_V1.1750.89
188_S191_L1.1650.89
9_A13_Y1.1480.88
17_F24_P1.1310.87
14_A21_S1.1260.87
21_S24_P1.1220.87
9_A17_F1.1170.87
19_Y23_L1.1050.86
9_A16_S1.1020.86
195_L199_G1.1010.86
24_P28_N1.0920.85
12_S16_S1.0870.85
14_A20_L1.0820.85
181_R192_A1.0800.85
24_P29_K1.0790.85
123_L127_L1.0760.84
20_L27_P1.0740.84
144_L148_L1.0610.84
90_Y115_N1.0220.81
55_A59_D1.0220.81
14_A17_F1.0140.81
113_W138_P1.0130.81
42_I171_P1.0090.80
7_L21_S1.0090.80
196_Y200_E1.0000.80
50_I82_L0.9970.80
23_L26_L0.9930.79
35_G40_L0.9840.79
198_L202_L0.9820.79
15_Y22_Q0.9750.78
23_L29_K0.9710.78
137_Y157_W0.9710.78
47_L51_Y0.9610.77
80_F199_G0.9520.76
91_W154_Y0.9490.76
13_Y23_L0.9480.76
112_L116_H0.9350.75
23_L27_P0.9210.74
83_E122_P0.9170.74
184_F188_S0.9140.73
197_L201_K0.9140.73
47_L79_A0.9130.73
39_Y198_L0.9130.73
10_L17_F0.9110.73
6_H11_A0.9100.73
159_E185_F0.9050.73
173_L181_R0.8980.72
98_P102_Y0.8950.72
40_L173_L0.8890.71
17_F39_Y0.8870.71
17_F29_K0.8870.71
18_Y27_P0.8850.71
180_G183_V0.8830.71
8_L14_A0.8790.70
18_Y23_L0.8770.70
18_Y26_L0.8650.69
39_Y76_A0.8530.68
25_N29_K0.8520.68
20_L29_K0.8500.68
14_A24_P0.8420.67
90_Y133_F0.8310.66
140_R143_G0.8270.66
131_L134_P0.8260.66
37_F46_L0.8250.65
40_L45_L0.8230.65
127_L137_Y0.8220.65
41_T171_P0.8220.65
22_Q26_L0.8170.65
34_G41_T0.8090.64
17_F21_S0.8030.63
59_D135_R0.8010.63
73_N146_L0.7990.63
19_Y24_P0.7980.63
45_L122_P0.7970.63
10_L23_L0.7870.62
183_V201_K0.7810.61
22_Q29_K0.7790.61
48_Q51_Y0.7740.61
17_F22_Q0.7720.60
90_Y120_T0.7720.60
100_L110_I0.7590.59
85_F188_S0.7580.59
105_A108_G0.7530.58
90_Y116_H0.7520.58
82_L90_Y0.7500.58
5_L16_S0.7480.58
122_P165_N0.7470.58
97_D101_V0.7460.58
17_F27_P0.7460.58
148_L193_L0.7430.57
162_Y166_G0.7430.57
190_V194_L0.7400.57
10_L29_K0.7400.57
86_V93_L0.7380.57
81_P115_N0.7340.56
10_L13_Y0.7330.56
48_Q122_P0.7330.56
19_Y26_L0.7320.56
192_A196_Y0.7320.56
66_R153_A0.7310.56
83_E117_Y0.7280.56
19_Y22_Q0.7200.55
115_N168_W0.7190.55
91_W97_D0.7180.55
119_H154_Y0.7160.55
15_Y27_P0.7130.54
35_G172_F0.6990.53
72_D76_A0.6980.53
11_A18_Y0.6940.52
44_G51_Y0.6920.52
187_V191_L0.6840.51
51_Y75_F0.6840.51
9_A26_L0.6790.51
13_Y18_Y0.6750.50
111_P127_L0.6720.50
8_L156_L0.6710.50
125_L173_L0.6710.50
156_L189_A0.6710.50
51_Y55_A0.6700.50
11_A21_S0.6650.49
10_L16_S0.6640.49
38_K90_Y0.6630.49
7_L17_F0.6610.49
111_P118_L0.6560.48
25_N28_N0.6560.48
168_W174_N0.6520.48
13_Y26_L0.6470.47
45_L181_R0.6470.47
18_Y24_P0.6450.47
72_D77_V0.6440.47
156_L160_L0.6380.46
120_T124_V0.6370.46
172_F184_F0.6320.46
5_L21_S0.6250.45
46_L50_I0.6220.45
62_K69_F0.6210.45
18_Y29_K0.6190.44
59_D81_P0.6140.44
22_Q25_N0.6120.44
91_W94_Y0.6120.44
160_L202_L0.6090.43
137_Y196_Y0.6090.43
130_L137_Y0.6080.43
155_L185_F0.6060.43
165_N168_W0.6030.43
121_L126_L0.6030.43
21_S25_N0.6020.43
141_K163_S0.6000.43
108_G131_L0.5980.42
97_D176_L0.5960.42
91_W103_P0.5960.42
43_W153_A0.5960.42
104_K132_L0.5950.42
137_Y140_R0.5950.42
9_A21_S0.5940.42
39_Y43_W0.5920.42
122_P130_L0.5900.41
65_S70_L0.5860.41
100_L103_P0.5810.41
81_P135_R0.5800.40
103_P110_I0.5790.40
8_L28_N0.5780.40
94_Y115_N0.5760.40
81_P138_P0.5720.40
58_A61_L0.5700.39
97_D184_F0.5650.39
38_K115_N0.5630.39
123_L151_A0.5630.39
147_L195_L0.5610.39
15_Y19_Y0.5610.39
6_H17_F0.5600.38
61_L65_S0.5590.38
180_G184_F0.5590.38
16_S21_S0.5580.38
15_Y18_Y0.5570.38
83_E135_R0.5560.38
11_A22_Q0.5520.38
170_Y173_L0.5510.38
49_T53_G0.5510.38
19_Y25_N0.5490.37
91_W98_P0.5470.37
7_L56_L0.5470.37
139_S142_K0.5450.37
139_S187_V0.5430.37
39_Y86_V0.5410.37
115_N138_P0.5410.37
85_F192_A0.5380.36
7_L29_K0.5370.36
21_S26_L0.5350.36
14_A22_Q0.5300.36
32_A42_I0.5290.35
81_P103_P0.5260.35
93_L150_F0.5250.35
48_Q52_F0.5230.35
46_L88_V0.5180.34
48_Q90_Y0.5180.34
150_F153_A0.5160.34
64_L75_F0.5140.34
38_K157_W0.5130.34
179_P198_L0.5130.34
136_R167_F0.5130.34
154_Y170_Y0.5100.34
9_A28_N0.5090.34
83_E185_F0.5090.34
12_S24_P0.5080.33
16_S25_N0.5020.33
13_Y29_K0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jb0M 1 0.152 3.4 0.949 Contact Map
2kv5A 1 0.1324 2.4 0.953 Contact Map
4hfiA 3 0.4461 1.8 0.956 Contact Map
4knfA 3 0.7451 1.5 0.958 Contact Map
4b19A 1 0.1275 1.2 0.96 Contact Map
3ddlA 2 0.7696 1.2 0.96 Contact Map
2f95B 2 0.2402 1.1 0.961 Contact Map
3wmmA 3 0.152 1.1 0.961 Contact Map
1xrdA 1 0.1422 1 0.962 Contact Map
4fbzA 3 0.7451 1 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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