GREMLIN Database
PLAC8 - PLAC8 family
PFAM: PF04749 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 83 (82)
Sequences: 3584 (2703)
Seq/√Len: 298.5
META: 0.445

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_R65_D3.6501.00
67_L71_C2.9601.00
18_G25_T2.6411.00
5_L68_V2.5941.00
18_G78_C2.5741.00
16_C20_F2.5261.00
49_R79_Q2.2291.00
45_S69_H2.1771.00
52_I80_E2.1611.00
68_V76_A1.8951.00
69_H80_E1.7841.00
74_P78_C1.7611.00
30_A34_G1.6471.00
76_A80_E1.6061.00
3_T82_R1.4981.00
60_G65_D1.4631.00
69_H76_A1.3841.00
24_V28_Q1.3611.00
9_F12_C1.3331.00
53_R60_G1.3221.00
45_S80_E1.3031.00
61_S64_G1.2931.00
29_N80_E1.2821.00
51_K55_K1.2811.00
4_G7_D1.2531.00
29_N81_A1.2101.00
66_C70_C1.2101.00
25_T29_N1.1901.00
78_C82_R1.1441.00
17_L28_Q1.1361.00
3_T83_E1.1321.00
14_T17_L1.1181.00
3_T10_S1.1051.00
17_L25_T1.0971.00
28_Q32_R1.0941.00
46_C62_P1.0901.00
72_C75_C1.0641.00
27_G31_E1.0581.00
11_D14_T1.0501.00
14_T81_A1.0471.00
47_A50_T1.0351.00
64_G68_V1.0271.00
11_D82_R1.0151.00
7_D10_S1.0021.00
25_T81_A0.9961.00
47_A51_K0.9901.00
30_A48_L0.9861.00
45_S73_P0.9721.00
24_V27_G0.9711.00
17_L24_V0.9591.00
29_N33_L0.9281.00
14_T78_C0.9171.00
17_L21_C0.9101.00
27_G30_A0.9001.00
26_F29_N0.8961.00
1_W80_E0.8601.00
39_G42_C0.8511.00
45_S76_A0.8471.00
50_T62_P0.8371.00
1_W58_I0.8351.00
40_C43_I0.8341.00
64_G67_L0.8341.00
48_L80_E0.8341.00
29_N32_R0.8291.00
27_G32_R0.8101.00
26_F77_L0.8041.00
50_T54_E0.7880.99
70_C73_P0.7770.99
26_F48_L0.7670.99
2_S83_E0.7670.99
3_T78_C0.7450.99
15_C19_C0.7440.99
48_L51_K0.7400.99
58_I62_P0.7390.99
46_C66_C0.7380.99
77_L80_E0.7380.99
8_C75_C0.7330.99
29_N77_L0.7280.99
76_A79_Q0.7280.99
28_Q81_A0.7180.99
46_C50_T0.7080.99
62_P66_C0.7000.99
56_Y83_E0.6950.99
20_F23_C0.6910.99
11_D15_C0.6850.99
21_C24_V0.6840.99
3_T14_T0.6770.98
32_R81_A0.6700.98
46_C69_H0.6660.98
10_S14_T0.6650.98
63_C67_L0.6520.98
3_T7_D0.6430.98
57_G83_E0.6260.97
23_C27_G0.6150.97
10_S82_R0.6130.97
26_F44_Y0.5920.96
25_T30_A0.5850.96
16_C19_C0.5780.96
14_T18_G0.5690.95
68_V72_C0.5690.95
12_C16_C0.5680.95
26_F30_A0.5680.95
33_L51_K0.5640.95
54_E62_P0.5590.95
25_T28_Q0.5570.95
47_A62_P0.5500.94
19_C74_P0.5480.94
45_S77_L0.5440.94
60_G64_G0.5410.94
56_Y59_P0.5350.94
41_G44_Y0.5350.94
48_L62_P0.5340.94
18_G77_L0.5330.94
13_G17_L0.5270.93
49_R52_I0.5250.93
9_F36_L0.5220.93
19_C22_P0.5190.93
2_S14_T0.5110.92
53_R58_I0.5110.92
39_G70_C0.5110.92
44_Y48_L0.5050.92
39_G43_I0.5000.91
1_W53_R0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a8lA 2 0.5181 2.4 0.909 Contact Map
2c31A 4 0.6024 1.3 0.921 Contact Map
2ywmA 3 0.506 1 0.926 Contact Map
2q28A 4 0.6024 1 0.927 Contact Map
3nznA 4 0.5181 1 0.928 Contact Map
1fs1B 2 0.6386 0.9 0.929 Contact Map
4i6xA 1 0.506 0.9 0.93 Contact Map
2ihtA 4 0.5542 0.8 0.93 Contact Map
1q6zA 4 0.5542 0.8 0.932 Contact Map
2co5A 2 0.3976 0.8 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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