GREMLIN Database
ELMO_CED12 - ELMO/CED-12 family
PFAM: PF04727 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 156 (153)
Sequences: 1113 (756)
Seq/√Len: 61.1
META: 0.265

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_G131_Y5.9891.00
50_G55_T4.7601.00
24_E73_R4.5211.00
95_Y139_D3.7591.00
60_M64_G3.1921.00
67_N105_T2.8651.00
49_Q56_D2.8211.00
64_G102_I2.7851.00
67_N128_D2.6191.00
85_E139_D2.5101.00
19_E38_R2.4061.00
67_N127_F2.4001.00
49_Q58_R2.3781.00
67_N131_Y2.3091.00
70_Y129_E2.2131.00
49_Q55_T2.1691.00
29_L79_F2.0961.00
6_R66_E2.0541.00
70_Y132_C1.9081.00
49_Q103_N1.8371.00
108_L127_F1.8131.00
63_L127_F1.7951.00
101_G135_F1.7820.99
21_A66_E1.7620.99
57_F65_L1.6680.99
55_T58_R1.5800.99
50_G56_D1.4790.98
15_N22_L1.4490.98
57_F102_I1.4450.98
24_E28_A1.4280.98
63_L105_T1.4190.97
68_L98_A1.4100.97
151_D154_K1.3970.97
24_E69_L1.3660.97
96_P100_A1.3410.96
108_L130_L1.3210.96
105_T131_Y1.2870.95
148_T151_D1.2860.95
125_L129_E1.2630.95
99_V103_N1.2630.95
49_Q59_G1.2590.95
98_A102_I1.2430.94
53_P56_D1.2380.94
98_A105_T1.2180.94
71_F79_F1.2060.94
71_F132_C1.1860.93
4_E7_R1.1790.93
61_G64_G1.1750.93
58_R61_G1.1700.92
72_A79_F1.1670.92
48_F102_I1.1630.92
29_L46_L1.1380.91
60_M106_F1.1340.91
60_M102_I1.1280.91
22_L38_R1.1270.91
147_A151_D1.1150.91
63_L67_N1.1130.90
88_H91_A1.0680.89
12_D15_N1.0650.88
137_L141_L1.0540.88
63_L138_F1.0540.88
50_G59_G1.0540.88
41_E51_E1.0480.88
100_A138_F1.0450.87
29_L97_F1.0420.87
58_R103_N1.0360.87
11_F19_E1.0360.87
69_L73_R1.0100.86
7_R109_Y1.0040.85
10_P16_P1.0030.85
85_E95_Y1.0030.85
26_W43_W1.0010.85
27_K32_D0.9840.84
96_P147_A0.9750.84
55_T59_G0.9730.83
21_A69_L0.9610.83
49_Q102_I0.9580.82
35_L42_Q0.9480.82
56_D103_N0.9470.82
17_E51_E0.9440.81
41_E44_K0.9370.81
22_L65_L0.9360.81
38_R52_D0.9260.80
76_P80_Q0.9220.80
11_F18_H0.9040.79
11_F57_F0.8920.78
68_L101_G0.8900.77
128_D131_Y0.8880.77
104_I155_V0.8870.77
131_Y135_F0.8870.77
55_T150_M0.8830.77
86_Q95_Y0.8820.77
49_Q99_V0.8820.77
83_L86_Q0.8750.76
104_I139_D0.8660.76
21_A62_F0.8620.75
31_P35_L0.8460.74
62_F65_L0.8460.74
105_T127_F0.8380.73
95_Y101_G0.8360.73
141_L155_V0.8320.73
33_E144_E0.8260.72
107_M153_N0.8070.70
117_L121_C0.7990.69
22_L43_W0.7960.69
112_L115_G0.7950.69
140_R144_E0.7920.69
96_P126_A0.7910.69
85_E88_H0.7900.69
25_L36_P0.7880.68
28_A73_R0.7840.68
13_S38_R0.7820.68
83_L100_A0.7810.68
81_K85_E0.7730.67
75_Y95_Y0.7690.67
49_Q53_P0.7690.67
9_V62_F0.7660.66
110_E153_N0.7620.66
40_S50_G0.7540.65
105_T144_E0.7530.65
23_K27_K0.7340.63
6_R45_E0.7330.63
70_Y74_N0.7310.63
64_G109_Y0.7230.62
15_N18_H0.7080.60
43_W58_R0.7030.60
36_P42_Q0.7030.60
117_L120_E0.7010.59
101_G142_W0.7010.59
38_R54_A0.6990.59
101_G105_T0.6980.59
53_P102_I0.6910.58
29_L108_L0.6890.58
75_Y129_E0.6860.58
130_L135_F0.6860.58
18_H26_W0.6850.58
114_L117_L0.6840.57
30_F46_L0.6840.57
26_W40_S0.6770.57
43_W49_Q0.6760.57
28_A77_D0.6750.56
11_F40_S0.6710.56
25_L31_P0.6690.56
57_F152_F0.6620.55
46_L142_W0.6620.55
62_F66_E0.6580.55
57_F60_M0.6560.54
4_E8_K0.6560.54
98_A101_G0.6550.54
104_I134_A0.6540.54
141_L145_M0.6530.54
28_A72_A0.6500.54
23_K42_Q0.6460.53
113_R117_L0.6450.53
103_N112_L0.6450.53
18_H43_W0.6420.53
44_K99_V0.6410.53
11_F54_A0.6410.53
52_D55_T0.6340.52
65_L102_I0.6320.52
71_F134_A0.6320.52
141_L144_E0.6310.52
108_L114_L0.6310.52
3_L64_G0.6240.51
100_A104_I0.6230.51
28_A69_L0.6210.50
58_R99_V0.6150.50
48_F93_W0.6130.50
3_L108_L0.6120.49
106_F110_E0.6110.49
27_K34_E0.6070.49
82_L148_T0.6070.49
114_L135_F0.6050.49
75_Y98_A0.6040.48
35_L57_F0.6000.48
13_S52_D0.5960.48
60_M138_F0.5930.47
19_E23_K0.5900.47
49_Q150_M0.5880.47
71_F82_L0.5870.47
148_T153_N0.5870.47
17_E90_P0.5860.46
39_I52_D0.5850.46
68_L91_A0.5850.46
124_L128_D0.5840.46
43_W47_G0.5750.45
7_R63_L0.5710.45
44_K96_P0.5680.44
49_Q153_N0.5670.44
85_E151_D0.5630.44
145_M155_V0.5590.43
133_A145_M0.5570.43
43_W53_P0.5560.43
82_L95_Y0.5560.43
73_R104_I0.5540.43
23_K35_L0.5520.43
55_T103_N0.5510.43
85_E94_E0.5500.42
82_L139_D0.5460.42
9_V17_E0.5450.42
3_L46_L0.5450.42
64_G87_S0.5450.42
79_F108_L0.5440.42
59_G110_E0.5410.41
35_L38_R0.5400.41
70_Y131_Y0.5400.41
39_I42_Q0.5400.41
12_D130_L0.5390.41
95_Y99_V0.5370.41
43_W50_G0.5340.41
118_K122_N0.5340.41
40_S49_Q0.5330.41
52_D58_R0.5320.40
16_P20_R0.5320.40
66_E80_Q0.5280.40
133_A137_L0.5270.40
104_I108_L0.5260.40
112_L138_F0.5220.39
39_I153_N0.5200.39
78_S82_L0.5190.39
79_F97_F0.5170.39
77_D81_K0.5170.39
20_R72_A0.5170.39
64_G131_Y0.5140.38
97_F112_L0.5100.38
97_F114_L0.5060.38
84_L87_S0.5040.37
147_A155_V0.5030.37
44_K149_Y0.5020.37
58_R149_Y0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2y9yB 1 0.8846 15.7 0.931 Contact Map
3opbA 2 0.9551 4.7 0.945 Contact Map
2lhuA 1 0.2179 4.7 0.945 Contact Map
1uz3A 2 0.3269 3 0.951 Contact Map
1q15A 3 0.5449 2.9 0.951 Contact Map
1xkpA 1 0.8269 2.5 0.953 Contact Map
3qk9A 2 0.3141 2 0.955 Contact Map
3pevB 1 0.9038 1.8 0.956 Contact Map
2idbA 3 0.3141 1.5 0.958 Contact Map
2vj4A 1 0.8141 1.5 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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